摘要:
A vascular structure (24), including an artery, vein or vessel, with a peripheral wall (40) defining a cavity (32) and having a localized abnormal wall (20) is treated by inserting a device (44) of a hydrogel material into the cavity (32); and then hydrating and expanding the hydrogel material until the device (44) occludes the localized abnormal wall (20), sealing it from the cavity (32) of the vascular structure (24). For delivery and placement of the hydrogel implant (44) a catheter (80) is provided comprising an expandable balloon (84) affixed to the distal end of the catheter (80).
摘要:
A method of generating a population of cells useful for treating a nerve disease or disorder in a subject, the method comprising up-regulating a level of at least one exogenous mi RNA in mesenchymal stem cells (MSCs) and/or down-regulating a level of at least one mi RNA using a polynucleotide agent that hybridizes to the mi RNA, thereby generating the population of cells useful for treating the nerve disease or disorder. Isolated populations of cells generated thereby and uses thereof are also provided.
摘要:
Some embodiments comprise methods, systems, and compositions to produce and/or administer modified exosomes or other vesicles containing one or more selected microRNAs, including but not limited to, miR-146b. Some embodiments also comprise the therapeutic administration and use of such modified exosomes and/or producer cells to treat mammalian injuries and diseases, including in human beings.