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21.发明公开3,5-DISUBSTITUTED- 1,2,4 -OXADIAZOLES AND ANALOGS AS AC TIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF 审中-公开3.5二取代1,2,4-恶二唑及其类似物的激活caspase和介绍凋亡及使用
公开(公告)号：EP1581213A4
公开(公告)日：2008-11-19
申请号：EP03808469
申请日：2003-12-18
申请人： CYTOVIA INC
IPC分类号： A61K31/4245 , A61K31/4439 , A61K31/443 , A61K31/4525 , A61K31/496 , A61K31/5377 , A61P17/00 , A61P17/06 , A61P29/00 , A61P31/12 , A61P35/00 , C07D413/04 , C07D413/14
CPC分类号： A61K31/4245 , A61K31/4439
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22.发明公开SUBSTITUTED N-ARYL-9-OXO-9H-FLUORENE-1-CARBOXAMIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS 审中-公开取代的N-芳基-9-氧代-9H-芴-1-羧酰胺和胱天蛋白酶和凋亡触发器的类似物作为资产GATES
公开(公告)号：EP1804786A4
公开(公告)日：2008-01-02
申请号：EP05802540
申请日：2005-09-29
申请人： CYTOVIA INC
IPC分类号： A61K31/343 , A61K31/165 , A61K31/381 , A61K31/403 , A61P29/00 , A61P35/00 , C07D209/82 , C07D209/88
CPC分类号： C07D209/88 , A61K31/165 , A61K31/167 , A61K31/343 , A61K31/381 , A61K31/403
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23.发明公开SUBSTITUTED 4-ARYL-3-(3-ARYL-1-OXO-2-PROPENYL)-2(1H)-QUINOLINONES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF 审中-公开取代的4-芳基-3-（3-芳基-1-氧代-2-丙烯基）-2（1H）-quinolinones和类似物作为胱天蛋白酶的活化剂和细胞凋亡诱导剂及其用途
公开(公告)号：EP1404329A4
公开(公告)日：2006-11-02
申请号：EP02741817
申请日：2002-06-04
申请人： CYTOVIA INC
IPC分类号： A61K31/47 , A61K31/00 , A61K31/4704 , A61K31/4709 , A61K45/06 , C07D215/22 , C07D215/227 , C07D405/04
CPC分类号： C07D215/227 , A61K31/4704 , A61K31/4709 , A61K45/06 , C07D405/04 , A61K2300/00
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24.发明公开SUBSTITUTED 4-ARYL-4H-PYRROLO 2,3-H CHROMENES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF 审中-公开取代的4-芳基-4H-吡咯并C2,3-H]色烯及其类似物作为胱天蛋白酶的活化剂和细胞凋亡诱导剂和它们的使用
公开(公告)号：EP1509515A4
公开(公告)日：2006-07-05
申请号：EP03724599
申请日：2003-05-16
申请人： CYTOVIA INC , SHIRE BIOCHEM INC
发明人： CAI SUI XIONG , JIANG SONGCHUN , KEMNITZER WILLIAM E , ZHANG HONG , ATTARDO GIORGIO , DENIS REAL
IPC分类号： C07D491/04 , C07D491/052 , A61K31/407 , A61K31/4188 , A61K31/4439 , A61K31/497 , A61K31/498 , A61K45/00 , A61P1/04 , A61P17/02 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P43/00
CPC分类号： C07D491/04
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25.发明公开SUBSTITUTED 4 i H /i -CHROMENES AND ANALOGS AS ACTIVATORS OFGASP ASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF 有权取代-4H-色和GASPASEN类似物作为资产盖茨和凋亡的电感器，其使用
公开(公告)号：EP1392683A4
公开(公告)日：2005-10-26
申请号：EP02741704
申请日：2002-05-16
申请人： CYTOVIA INC
发明人： CAI SUI XIONG , ZHANG HONG , JIANG SONGCHUN , STORER RICHARD
IPC分类号： A61K31/35 , A61K31/352 , A61K31/38 , A61K31/382 , A61K31/40 , A61K31/4025 , A61K31/407 , A61K31/415 , A61K31/4188 , A61K31/44 , A61K31/453 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5377 , A61K33/24 , A61K45/06 , A61P1/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07D215/54 , C07D311/58 , C07D311/64 , C07D335/06 , C07D405/04 , C07D491/04 , C07D491/052 , C07D493/04 , C07D495/04 , C07D409/00 , C07D207/00 , C07D209/02 , C07D231/00 , C07D233/02 , C07D241/36 , C07D265/30 , C07D311/04 , C07D401/00 , C07D403/00 , C07D405/00
CPC分类号： C07D335/06 , A61K31/35 , A61K31/353 , A61K31/38 , A61K31/40 , A61K31/407 , A61K31/415 , A61K31/44 , A61K31/47 , A61K31/495 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/535 , A61K33/24 , A61K45/06 , C07D215/54 , C07D311/58 , C07D311/64 , C07D405/04 , C07D491/04 , C07D493/04 , C07D495/04 , A61K2300/00
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26.发明公开GAMBOGIC ACID, ANALOGS AND DERIVATIVES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS 有权GAMBOGISCHE ACID，模拟和衍生物CASPASENAKTIVATOREN和凋亡的归纳
公开(公告)号：EP1180991A4
公开(公告)日：2005-10-12
申请号：EP00905839
申请日：2000-02-01
申请人： CYTOVIA INC
发明人： CAI SUI XIONG , ZHANG HAN-ZHONG , WANG YAN , TSENG BEN , KASIBHATLA SHAILAJA , DREWE JOHN A
IPC分类号： A61K31/352 , A61K31/4025 , A61K31/4178 , A61K31/4188 , A61K31/4433 , A61K31/453 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/5513 , C07D493/20 , C07D493/22 , C07D519/00 , A61P17/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06
CPC分类号： C07D493/20 , A61K31/352 , A61K31/4025 , A61K31/4178 , A61K31/4188 , A61K31/4433 , A61K31/453 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/5513 , C07D493/22 , C07D519/00
摘要： The present invention is directed to gambogic acid, analogs and derivatives thereof, represented by general Formulae (I-III) wherein R1-R5 are defined herein. The present invention also relates to the discovery that compounds having Formulae (I-III) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled cell growth and spread of abnormal cells occurs.
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公开(公告)号：EP1392283A4
公开(公告)日：2004-10-20
申请号：EP02731803
申请日：2002-05-16
申请人： CYTOVIA INC , SHIRE BIOCHEM INC
发明人： CAI SUI XIONG , ZHANG HONG , KEMNITZER WILLIAM E , JIANG SONGCHUN , DREWE JOHN A , STORER RICHARD
IPC分类号： A61K31/35 , A61K31/385 , A61K31/47 , C07D215/54 , C07D221/10 , C07D311/16 , C07D311/58 , C07D335/06 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D513/04 , A61P35/00 , C07D215/16 , C07D215/20 , C07D311/04 , C07D335/04
CPC分类号： C07D335/06 , A61K31/35 , A61K31/385 , A61K31/47 , C07D215/54 , C07D221/10 , C07D311/16 , C07D311/58 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D513/04
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28.发明公开
公开(公告)号：EP1165490A4
公开(公告)日：2002-09-18
申请号：EP00917859
申请日：2000-03-15
申请人： CYTOVIA INC
发明人： CAI SUI XIONG , WANG YAN , WEBER ECKARD , MILLS GORDON B , GREEN DOUGLAS R
IPC分类号： C12N9/99 , A61K9/02 , A61K9/06 , A61K9/08 , A61K9/22 , A61K31/27 , A61K31/381 , A61K38/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P7/00 , A61P7/06 , A61P9/00 , A61P13/10 , A61P13/12 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/14 , A61P17/16 , A61P19/02 , A61P19/08 , A61P25/00 , A61P25/32 , A61P27/02 , A61P29/00 , A61P37/00 , A61P39/00 , A61P43/00 , C07C271/22 , C07C271/24 , C07C271/28 , C07D333/38 , C07D333/40 , C07K5/023 , C07K7/02 , C12N5/04 , C12N5/06 , C07C229/00 , A01N37/00 , A01N37/10 , A01N37/12 , C07C69/74 , C07C205/00
CPC分类号： C07D333/38 , C07C271/22 , C07C271/24 , C07C271/28 , C07C2601/08 , C07C2601/14
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