公开(公告)号：EP1315966B1

公开(公告)日：2007-10-03

申请号：EP01968093.3

申请日：2001-08-24

申请人： Ortho-McNeil Pharmaceutical, Inc.

发明人： THURMOND, Robin ,  SUN, Siquan ,  KARLSSON, Lars

IPC分类号： G01N33/535 ,  G01N33/545 ,  C12Q1/37 ,  G01N33/573

CPC分类号： G01N33/573 ,  C12Q1/37 ,  G01N2333/8139 ,  G01N2333/96466 ,  Y10S435/962 ,  Y10S436/811 ,  Y10S436/813 ,  Y10S436/825 ,  Y10T436/25125 ,  Y10T436/25375

摘要： The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant chain (Ii), in particular the p10 Ii fragment, in blood of dosed patients.

公开(公告)号：EP1595143A1

公开(公告)日：2005-11-16

申请号：EP04710306.4

申请日：2004-02-12

申请人： AUSTRALIAN INSTITUTE OF MARINE SCIENCE ,  Cleveland Biosensors Pty Ltd

发明人： ROBILLOT, Cédric, Emile, François

IPC分类号： G01N33/53 ,  C07D487/14

CPC分类号： C07D487/20 ,  G01N33/54306 ,  G01N2333/8139

摘要： A method for capturing a saxiphilin to allow for detection, characterisation, isolation an/or purification of said saxiphilin or its ligand, comprising: (1) providing a PST conjugate comprising a PST moiety bound via a linker through a site other than the binding site for saxiphilin directly or indirectly to a biotin moiety; (2) exposing the PST conjugate to a sample putatively containing said saxiphilin to create a reaction mixture and to (strept)avidin; and (3) allowing binding through the PST moiety to the saxiphilin and through the biotin moiety to (strept)avidin to form a captured PST complex.

公开(公告)号：EP1590664A1

公开(公告)日：2005-11-02

申请号：EP03783356.3

申请日：2003-11-13

申请人： Ciphergen Biosystems, Inc.

发明人： BUHIMSCHI, Irina, A. ,  CHRISTNER, Robert ,  BUHIMSCHI, Catalin, S. ,  WEINER, Carl, P.

IPC分类号： G01N33/48

CPC分类号： G01N33/6893 ,  G01N33/689 ,  G01N2333/471 ,  G01N2333/4745 ,  G01N2333/5752 ,  G01N2333/5756 ,  G01N2333/70539 ,  G01N2333/78 ,  G01N2333/8139 ,  G01N2800/36 ,  G01N2800/368

摘要： Assessing fetal health and maturity, and the integrity and health of the amnion, is effected via protein profiling of vaginal fluid, thereby to identify various abnormal conditions during pregnancy. This approach also provides a means for gauging the duration and/or magnitude of intraamniotic/fetal inflammation that occurs during pregnancy.

公开(公告)号：EP1315966A4

公开(公告)日：2005-07-27

申请号：EP01968093

申请日：2001-08-24

申请人： ORTHO MCNEIL PHARM INC

发明人： THURMOND ROBIN ,  SUN SIQUAN ,  KARLSSON LARS

IPC分类号： G01N33/53 ,  C12Q1/37 ,  G01N33/573 ,  G01N33/535 ,  G01N33/545

CPC分类号： G01N33/573 ,  C12Q1/37 ,  G01N2333/8139 ,  G01N2333/96466 ,  Y10S435/962 ,  Y10S436/811 ,  Y10S436/813 ,  Y10S436/825 ,  Y10T436/25125 ,  Y10T436/25375

摘要： The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant chain (Ii), in particular the p10 Ii fragment, in blood of dosed patients.

公开(公告)号：EP1272212A2

公开(公告)日：2003-01-08

申请号：EP01925666.8

申请日：2001-04-17

申请人： The Queen's University of Belfast

发明人： LAMEY, Philip-John ,  LUNDY, Fionnuala, Teresa ,  SHAW, Christopher

IPC分类号： A61K38/57 ,  C07K14/81 ,  G01N33/68

CPC分类号： C07K14/8139 ,  A61K38/00 ,  G01N2333/8139 ,  Y10S530/83

摘要： The present invention relates to the use of Cystatin in predicting onset of migraines. The invention also relates to the use of Cystatin as a vasodilatory agent. The invention also relates to antagonists to Cystatin for use in preventing and treating migraine attacks.

公开(公告)号：EP1172443A1

公开(公告)日：2002-01-16

申请号：EP00909724.7

申请日：2000-03-17

申请人： YAMANOUCHI PHARMACEUTICAL CO. LTD.

发明人： OHMORI, Junya, Yamanouchi Pharmaceutical Co., ,  OHTSUKA, Tomokazu, Yamanouchi Pharmaceutical Co., ,  YATSUGI, Shin-ichi, Yamanouchi Pharmaceutical Co., ,  OHNO, Kazushige, Yamanouchi Pharmaceutical Co.,Ltd

IPC分类号： C12Q1/37 ,  C12N9/99 ,  C07D497/20 ,  C07D497/22 ,  A61K31/438 ,  A61K31/4747 ,  A61P43/00

CPC分类号： C07D235/20 ,  A61K31/438 ,  A61K31/4747 ,  C12Q1/37 ,  G01N2333/8139 ,  G01N2333/96466 ,  G01N2500/00

摘要： A method for screening a cysteine protease inhibitor of which cysteine protease inhibitory activity is enhanced in the presence of endogenous polyvalent metal ion, which comprises treating a cysteine protease with a test compound in the presence of the polyvalent metal ion, and a pharmaceutical composition for treating apoptosis-associated diseases, which contains as the active ingredient a cysteine protease inhibitor of which cysteine protease inhibitory activity is enhanced in the presence of endogenous polyvalent metal ion.

摘要翻译： 一种半胱氨酸蛋白酶抑制剂的筛选方法，其中半胱氨酸蛋白酶抑制活性在内源性多价金属离子的存在下得到增强，其包括在多价金属离子存在下用受试化合物处理半胱氨酸蛋白酶，以及用于治疗 包含作为活性成分的半胱氨酸蛋白酶抑制剂的细胞凋亡相关疾病，其中半胱氨酸蛋白酶抑制活性在内源性多价金属离子存在下得到增强。

公开(公告)号：EP1123509A2

公开(公告)日：2001-08-16

申请号：EP99971091.6

申请日：1999-10-22

申请人： Nitsch, Roger

发明人： NITSCH, Roger ,  GROWDON, John

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  G01N2333/8139 ,  G01N2800/2821

摘要： A method for diagnosing or prognosing Alzheimer's disease in a subject, or determining whether a subject is at increased risk of developing Alzheimer's disease, comprising: determining a level, or an activity, or both said level and said activity, of transcription product and/or a translation product of (i) a cystatin C gene or (ii) a polymorphic variant of a cystatin C gene in a sample from said subject; and comparing said level, or said activity, or both said level and said activity, of said transcription product and/or said translation product to a reference value representing a known disease or health status, thereby diagnosing or prognosing Alzheimer's disease in said subject, or determining whether said subject is at increased risk of developing Alzheimer's disease.

公开(公告)号：EP3011345B1

公开(公告)日：2017-10-04

申请号：EP14752744.4

申请日：2014-08-06

申请人： Alexion Pharmaceuticals, Inc.

发明人： MCKNIGHT, Susan Faas ,  COFIELL, Roxanne ,  KUKREJA, Anjli ,  BEDARD, Krystin, A. ,  YAN, Yan

IPC分类号： C07K16/18 ,  G01N33/68 ,  A61K39/00

CPC分类号： G01N33/6893 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/76 ,  G01N33/6863 ,  G01N2333/4716 ,  G01N2333/485 ,  G01N2333/522 ,  G01N2333/5412 ,  G01N2333/5421 ,  G01N2333/5434 ,  G01N2333/545 ,  G01N2333/57 ,  G01N2333/70503 ,  G01N2333/70525 ,  G01N2333/70539 ,  G01N2333/7151 ,  G01N2333/7452 ,  G01N2333/75 ,  G01N2333/775 ,  G01N2333/8139 ,  G01N2333/8146 ,  G01N2333/974 ,  G01N2800/226 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52

公开(公告)号：EP2683399A2

公开(公告)日：2014-01-15

申请号：EP12707757.6

申请日：2012-03-07

申请人： Bioquanta ,  Bioquanta Corp. ,  Assistance Publique Hôpitaux De Paris

发明人： CONTI, Marc ,  LORIC, Sylvain ,  MANIVET, Philippe ,  CARADEC, Josselin ,  KEUMEUGNI KWEMO, Carlosse ,  MATAR, Corine ,  REVAUD, Déborah

IPC分类号： A61K38/57 ,  A61P15/08 ,  G01N33/50

CPC分类号： C07K14/8139 ,  A61K38/57 ,  C12N5/0604 ,  C12N2501/734 ,  G01N33/50 ,  G01N33/689 ,  G01N33/6893 ,  G01N2333/8139 ,  G01N2800/367

摘要： The present invention concerns a polypeptide comprising the N-terminal fragment of a cystatin, and/or a cystatin expression inducer for use for the treatment of sterility and/or infertility, and a method of diagnosing and/or predicting sterility and/or infertility of a subject and/or of a couple of subjects, which method comprises measuring the level of at least one cystatin in a biological sample of a male subject and/or measuring the level of at least one cystatin in a biological sample of a female subject, and optionally measuring further the level of at least one cathepsin in a biological sample of said male of female subject.

摘要翻译： 本发明涉及包含半胱氨酸蛋白酶抑制剂的N-末端片段和/或用于治疗无菌和/或不孕症的半胱氨酸蛋白酶抑制剂表达诱导剂的多肽，以及诊断和/或预测不育和/或不孕不育的方法 受试者和/或几个受试者，所述方法包括测量男性受试者的生物样品中至少一种半胱氨酸蛋白酶抑制剂的水平和/或测量女性受试者的生物样品中至少一种半胱氨酸蛋白酶抑制剂的水平。

公开(公告)号：EP2462447A1

公开(公告)日：2012-06-13

申请号：EP10807276.0

申请日：2010-08-06

申请人： Rules-Based Medicine, Inc.

发明人： SPAIN, Michael, D. ,  MAPES, James, P. ,  LABRIE, Samuel, T. ,  MCDADE, Ralph, L. ,  EISINGER, Dominic ,  BALLARD, Karri, L.

IPC分类号： G01N33/566 ,  G01N33/53

CPC分类号： G01N33/6893 ,  G01N33/5302 ,  G01N33/566 ,  G01N2333/47 ,  G01N2333/4703 ,  G01N2333/4706 ,  G01N2333/4725 ,  G01N2333/4727 ,  G01N2333/475 ,  G01N2333/52 ,  G01N2333/70503 ,  G01N2333/70539 ,  G01N2333/765 ,  G01N2333/775 ,  G01N2333/8139 ,  G01N2333/8146 ,  G01N2333/82 ,  G01N2333/91177 ,  G01N2800/34 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60 ,  Y10T436/147777

摘要： Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.