公开(公告)号：EP1444507A4

公开(公告)日：2005-03-23

申请号：EP02803226

申请日：2002-11-13

申请人： CALIPER LIFE SCIENCES INC

发明人： BROOKS CARLTON F ,  JENSEN MORTEN JUEL ,  STERN SETH

IPC分类号： B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  G01N27/447 ,  G01N27/02 ,  C10G32/00 ,  G01F1/64

CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00873 ,  B01J2219/0093 ,  B01J2219/0095 ,  B01J2219/00952 ,  B01J2219/00961 ,  B01L3/5027 ,  B01L7/52 ,  B01L2200/10 ,  B01L2200/147 ,  B01L2300/1827 ,  B01L2300/185 ,  B01L2400/0418 ,  G01N27/44791

摘要： Methods and systems for effecting a parameter and detecting a parameter using two electric signals are described.

公开(公告)号：EP1511976A1

公开(公告)日：2005-03-09

申请号：EP03729698.5

申请日：2003-05-07

申请人： Bremauer, Ben

发明人： Bremauer, Ben

IPC分类号： G01F11/04 ,  G01N31/16 ,  G01N21/25

CPC分类号： G01N1/38 ,  B01F15/0217 ,  B01F15/0237 ,  B01F15/0279 ,  B01J19/0093 ,  B01J19/185 ,  B01J2219/00788 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00952 ,  B01J2219/00986 ,  C02F1/008 ,  C02F1/686 ,  C02F1/76 ,  C02F2103/023 ,  C02F2103/42 ,  C02F2209/00 ,  C02F2209/005 ,  G01F11/021 ,  G01N21/11 ,  G01N21/79 ,  G01N31/16 ,  G01N33/18

摘要： An apparatus and method for measuring a range of small volumes of fluids to a high degree of precision, said apparatus including: a) a single reaction chamber (20); b) a piston (30) operable within said chamber to selectively and precisely vary the internal volume of said chamber; c) a first inlet (41) to said chamber in communication with one or more fluid sources of which a portion of a first fluid of said one or more fluids is adapted to be drawn into said chamber; d) at least one further inlet (43) including a second inlet to said chamber in communication with one or more fluid sources of which a portion of a second fluid of said one or more fluids is adapted to be drawn into said chamber; and e) a sealable outlet (45), wherein said piston is adapted to progressive draw said portion of a second fluid into said chamber until either accurare metering of a volume of said first or second portion of fluid is achived or a reaction involving said first and second portions in said chamber (such as a titration reaction) is completed.

公开(公告)号：EP1265700B1

公开(公告)日：2005-01-19

申请号：EP01914751.1

申请日：2001-03-07

申请人： Symyx Technologies, Inc.

发明人： BERGH, H., Sam ,  ENGSTROM, James, R. ,  GUAN, Shenheng ,  PINKAS, Daniel, Meron ,  SELF, Kyle, W.

IPC分类号： B01J19/00

CPC分类号： B01L7/525 ,  B01J4/00 ,  B01J19/004 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00038 ,  B01J2219/00306 ,  B01J2219/00317 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00389 ,  B01J2219/00452 ,  B01J2219/00479 ,  B01J2219/00585 ,  B01J2219/0068 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00783 ,  B01J2219/00891 ,  B01J2219/00952 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L7/54 ,  B01L2200/143 ,  B01L2300/0883 ,  B01L2400/06 ,  C40B30/08 ,  C40B40/18 ,  C40B60/14 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

摘要： Parallel flow reaction systems comprising four or more reaction channels are disclosed. Distribution systems, and parallel flow reaction systems comprising such distribution systems are also disclosed. Specifically, the distribution systems comprise one or more subsystems, including for example, a flow-partitioning subsystem for providing a different flow rate to each of the four or more reactors, a pressure-partitioning subsystem for providing a different reaction pressure in the reaction cavity of each of the four or more reactors, and a feed-composition subsystem for providing a different feed composition to each of the four or more reactors. In preferred embodiments, the one or more subsystems can comprise at least one set of four or more flow restrictors, each of the four or more flow restrictors having a flow resistance that varies relative to other flow restrictors in the set.

公开(公告)号：EP1487763A2

公开(公告)日：2004-12-22

申请号：EP03712355.1

申请日：2003-03-14

申请人： Hammersmith Imanet, Ltd

发明人： BRADY, Frank,Hammersmith Imanet Limited ,  LUTHRA, Sajinder K.,Hammersmith Imanet Limited ,  GILLIES, James, Millar ,  JEFFERY, Nicholas T.Hammersmith Imanet Limited

IPC分类号： C07B59/00 ,  B01J19/00

CPC分类号： C07H5/02 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00952 ,  B01L3/5027 ,  B01L3/502715 ,  C07B59/00 ,  C07B59/001 ,  C07B59/002 ,  C07B59/005 ,  C07C211/48 ,  C07C229/36 ,  C07D223/16 ,  C07D401/04

摘要： This invention relates to the miniaturisation of radiosyntheses onto microfabricateddevices, and in particular to use of microfabricated devices for radiosynthesis, isolation, and analysis of radiotracers for use in Positron Emission Tomography (PET).

公开(公告)号：EP0791238B1

公开(公告)日：2004-09-22

申请号：EP95939862.9

申请日：1995-11-09

申请人： Orchid BioSciences, Inc.

发明人： ZANZUCCHI, Peter, J. ,  CHERUKURI, Satyam, C. ,  MCBRIDE, Sterling, E. ,  DEMERS, Robert, R. ,  LEVINE, Aaron, W.

IPC分类号： H02K44/02 ,  H02K44/04 ,  H01J41/18 ,  F04D33/00 ,  B01J4/02 ,  B01J19/00 ,  B01L3/00

CPC分类号： B01L3/502738 ,  B01F5/0601 ,  B01F13/0077 ,  B01F15/0264 ,  B01J4/02 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00353 ,  B01J2219/00358 ,  B01J2219/00369 ,  B01J2219/00389 ,  B01J2219/00488 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00536 ,  B01J2219/00547 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/0068 ,  B01J2219/00686 ,  B01J2219/00698 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00891 ,  B01J2219/00952 ,  B01J2219/00995 ,  B01L3/5025 ,  B01L3/50273 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0633 ,  B01L2400/0688 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  C40B70/00 ,  F04B19/006 ,  G01N33/54366 ,  H02N11/006

摘要： The present invention provides a liquid distribution system, which is useful in a number of contexts, including in accomplishing various synthetic, diagnostic and drug screening reactions. The distribution system can comprise an alpha reservoir (200A) and a beta reservoir (200B), a first set of parallel and adjacent first and second feeder channels (211A-211B) and a second set of parallel and adjacent third and fourth feeder channels (211C-211D) which are offset from the first and second feed channels (211A-211B), wherein (a) the first (211A) and third (211C) feeder channels are connected to the alpha reservoir (200A) via a first connector channel (211A) that is situated above or below the second (211B) and fourth feeder channels (211D) and are independent of the beta reservoir and (b) the second (211B) and fourth feeder channels (211D) are connected to the beta reservoir via a second connector channel (211B) that it situated above or below the first and third feeder channels (211A and 211C) and are independent of the alpha reservoir (200A). The distribution system is preferably a microscale distribution system. Various particular mechanisms for controlling flow into a liquid distribution system are described.

公开(公告)号：EP1284158A3

公开(公告)日：2004-04-14

申请号：EP02405671.5

申请日：2002-08-07

申请人： Eidgenössische Technische Hochschule Zürich

发明人： Brand, Oliver ,  Held, Martin ,  Hierlemann, Andreas ,  Lange Dirk

IPC分类号： B01J19/00

CPC分类号： B01J19/0093 ,  B01J19/0046 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00916 ,  B01J2219/0095 ,  B01J2219/00952 ,  B01L3/50851 ,  G01N35/028 ,  G01N2035/00158

摘要： Ein System zur Beobachtung oder Überwachung von biologischen und chemischen Prozessen in einer Mehrzahl kleiner Behältnisse, z.B. einer Mikrotiteranordnung, zeichnet sich dadurch aus, dass pro Behältnis (6) mindestens ein Mikrosensor vorgesehen ist, der unmittelbar vorgegebene Prozessgrössen ermittelt und/oder vorbestimmte Substanzen detektiert und daraus entsprechende elektrische Signale generiert. Eine nachgeschaltete Auswerte- und Steuereinheit (4, 14) aktiviert diese Mikrosensoren und empfängt/verarbeitet die von den Mikrosensoren gelieferten Signale. Zusätzlich können Heiz- oder Kühlelemente in den Behältnissen angeordnet sein, die ebenfalls von der Auswerte- und Steuereinheit (4, 14) gesteuert werden und ggf. in Abhängigkeit von Signalen der Mikrosensoren die Behältnis-Temperatur regeln. Mikrosensor und/oder Heiz/Kühlelement und/oder Teile der Auswerte- und Steuereinheit (4, 14) werden vorzugsweise in Moduln auf einem gemeinsamen Siliziumsubstrat integriert.

公开(公告)号：EP1064090B1

公开(公告)日：2003-09-24

申请号：EP99912761.6

申请日：1999-03-17

申请人： Cepheid

发明人： NORTHRUP, M., Allen ,  PETERSEN, Kurt, E. ,  McMILLAN, William, A. ,  KOVACS, Gregory, T., A.

IPC分类号： B01J19/00

CPC分类号： G01N27/44743 ,  B01J19/0093 ,  B01J2219/00853 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00909 ,  B01J2219/00912 ,  B01J2219/00952 ,  B01J2219/0097 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2300/0681 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2300/1883 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0633 ,  B01L2400/0655 ,  G01N30/6095

摘要： A sample-processing device (150) comprises a unitary body (152), preferably a molded polymeric part, having formed therein a reaction chamber (154) for chemically reacting a sample, a separation region (158) for separating components of the sample, and a transition region (156) connecting the reaction chamber (154) to the separation region (158). The reaction chamber (154), transition region (156), and separation region (158) are formed in and enclosed by the unitary body (152). Additionally, the transition region (156) includes at least one flow restrictor (180) for controlling the flow of fluid between the reaction chamber (154) and the separation region (158). Further, the portion of the unitary body (152) defining the transition region (156) has lower thermal conduction than the portion of the body defining the reaction chamber (154) so that the transition region (156) thermally isolates the reaction chamber (154) from the separation region (156). In a preferred embodiment, the reaction chamber (154) is an amplification chamber for amplifying nucleic acid in the sample, and the separation region (158) comprises an electrophoresis column or capillary containing a suitable matrix material, such as electrophoresis gel or buffer, for separating nucleic acid fragments in the sample. Electrodes (167, 168, 169) are embedded in the body (152) for forcing the sample to flow from the reaction chamber (154) to the separation region (158). The unitary body (152) may also be surrounded by external, functional components such as an optical detector (186) for detecting separated components of the sample.

公开(公告)号：EP1214630A2

公开(公告)日：2002-06-19

申请号：EP00947600.3

申请日：2000-07-21

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： BEEBE, David, J. ,  MOORE, Jeffrey, S.

IPC分类号： G03F7/00 ,  C08J5/00 ,  B29C67/00 ,  B01L3/00 ,  B01J19/00

CPC分类号： G03F7/00 ,  B01J19/0093 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00891 ,  B01J2219/00925 ,  B01J2219/00936 ,  B01J2219/00952 ,  B01J2219/00966 ,  B01L3/502707 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502776 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0883 ,  B01L2300/16 ,  B01L2300/161 ,  B01L2400/0661 ,  G03F7/0035

摘要： Microfabricated devices and methods of manufacturing the devices are disclosed. The devices are manufactured from a substrate having microscale fluid channels, and polymerizing a polymerizable mixture in the channels to form stimuli-responsive operating components of the device. The operating components can be functional or structural components. The method of manufacture obviates the traditional assembly of microscale components to form a device because the microscale components are formed in situ or within the device.

公开(公告)号：EP1165227A1

公开(公告)日：2002-01-02

申请号：EP00920456.1

申请日：2000-02-25

申请人： Clondiag Chip Technologies GmbH

发明人： KÖHLER, Johann, Michael

IPC分类号： B01J19/00 ,  B01L3/00

CPC分类号： G01N30/56 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00313 ,  B01J2219/00351 ,  B01J2219/00423 ,  B01J2219/00459 ,  B01J2219/005 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00833 ,  B01J2219/00891 ,  B01J2219/00907 ,  B01J2219/00952 ,  B01L3/5027 ,  C40B60/14 ,  G01N30/58 ,  G01N30/6095 ,  G01N2030/565 ,  Y10T436/2575

摘要： The invention relates to a microcolumn reactor for carrying out reactions on solid phases and/or with biological cells. The aim of the invention is to provide a microcolumn reactor for processes of synthesis and separation on small sample volumina that replaces an alternating sequence of binding and elution processes on a phase that is stationary bound during a test series and makes it possible to exchange the stationary phase, for example once it has been loaded. To this end, the microcolumn reactor consists of at least one first and one second substrate wafer (1; 2) that are linked with one another across their surfaces. At least one of the substrate wafers (1; 2) is provided with an elongate channel (3) which comprises in a defined section (a) of its length two passage openings (41, 42) that are implemented in the opposite substrate wafer. Said openings (41, 42) are separated from the channel (3) by a partially permeable sieve-type membrane (5). The areas of acceptance (51) of said membrane have a diameter that is chosen in such a manner as to specifically prevent microbeads and/or cells introduced into the channel from entering the passage openings (41, 42). The channel (3) is provided with at least two further openings (61, 62) outside the section (a) that is comprised by the passage openings (41, 42). Said further openings permit the microbeads and/or cells that are provided above the section (a) to be introduced and/or displaced by applying a fluid pressure (p). Means are provided that temporarily close at least one of the passage openings (41, 42) and one of the openings (61, 62).

公开(公告)号：EP1128075A2

公开(公告)日：2001-08-29

申请号：EP00111659.9

申请日：2000-05-31

申请人： FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

发明人： Endres, Hanns-Erik, Dr. ,  Richter, Martin, Dr.

IPC分类号： F15C5/00 ,  F04B43/04 ,  B01J19/00

CPC分类号： F16K99/0001 ,  B01F5/0256 ,  B01F13/0059 ,  B01F15/00123 ,  B01F15/0244 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00907 ,  B01J2219/00952 ,  F04B43/043 ,  F15C5/00 ,  F16K99/0007 ,  F16K99/0057 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0094

摘要： Vorgeschlagen wird eine Mikromembranpumpe und/oder ein Mikromischer, mit einer Antriebsmembran (10), mindestens einem Einlass und mindestens einem Auslass (3), und einem Pumpen-/Mischerkörper (9), welcher zusammen mit der Antriebsmembran (10) mindestens eine Pump-/Mischerkammer (300) bildet dadurch gekennzeichnet, dass in die Mikropumpe/ den Mikromischer mindestens ein Messfühler (400) integriert ist. Als Messfühler wird bevorzugt eine Elektrodenanordnung gewählt, welche die Anwendung elektrochemischer Messverfahren ermöglicht. Dies kann z. B. eine parallele Platten Anordnung sein. Weiterhin wird die Anwendung von Auswerteverfahren der multivariaten Statistik oder der Mustererkennung vorgeschlagen.

摘要翻译： 微膜泵和/或微混合器包括致动膜（10）; 至少一个入口和出口; 以及泵/混合器主体，其与膜一起形成泵/混合室。 传感器（400）布置在泵/混合器中。 还包括用于生产该装置的方法的独立权利要求，包括制造包括金属化层，电极和表面层的阀单元，泵体单元和膜单元; 并连接完成的处理单元。