公开(公告)号：EP2066628A1

公开(公告)日：2009-06-10

申请号：EP07799729.4

申请日：2007-07-20

申请人： Sanofi-Aventis

发明人： YANG, Zhaoxia ,  REILING, Stephan ,  NIEDUZAK, Thaddeus R. ,  MATHEW, Rose M. ,  JACKSON, Sharon ,  HARRIS, Keith J.

IPC分类号： C07D209/18 ,  A61K31/404 ,  A61P11/06 ,  A61P27/14 ,  A61P37/06 ,  A61P37/08

CPC分类号： C07D209/18

摘要： The present invention is directed to 2-phenyl-indole compounds (A), their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, eczema, urticaria diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which are generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like.

公开(公告)号：EP2060563A1

公开(公告)日：2009-05-20

申请号：EP07806967.1

申请日：2007-09-07

申请人： Dainippon Sumitomo Pharma Co., Ltd.

发明人： OZAWA, Michinori ,  SHIRO, Tomoya ,  SUMIYOSHI, Takaaki ,  ITOH, Mari

IPC分类号： C07D207/14 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/554 ,  A61P11/02 ,  A61P11/06 ,  A61P17/04 ,  A61P27/14 ,  A61P37/08 ,  C07D211/58 ,  C07D211/76 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

CPC分类号： C07D207/14 ,  C07D211/58 ,  C07D211/76 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to a compound represented by the following formula (I), which is useful as an antiallergic agent and/or an anti-inflammatory agent, or a physiologically acceptable salt thereof and the like:

wherein R 1 and R 2 are the same or different and each is an optionally substituted aryl group and the like, R 3 is a hydrogen atom, a C 1-6 alkyl group and the like, R 4 and R 5 are the same or different and each is a hydrogen atom, a halogen atom, a hydroxy group, a C 1-6 alkyl group and the like, X is a single bond or -C(R 6 )(R 7 )-, R 6 and R 7 are the same or different and each is a hydrogen atom, a halogen atom, an optionally substituted C 1-6 alkyl group and the like, or R 6 and R 7 optionally form, together with the carbon atom bonded thereto, an optionally substituted C 3-8 cycloalkyl group and the like, ring group A is an azetidin-1-yl group and the like, m is 0, 1 or 2, and n is 0, 1 or 2.

摘要翻译： 本发明涉及用作抗过敏剂和/或抗炎剂或其生理学上可接受的盐等的由下式（I）表示的化合物：其中R 1和R 2相同或 不同且各自为任选取代的芳基等，R 3为氢原子，C 1-6烷基等，R 4和R 5相同或不同并且各自为氢原子，卤素原子，羟基 基团，C1-6烷基等，X是单键或-C（R6）（R7） - ，R6和R7相同或不同并且各自是氢原子，卤素原子，任选取代的 C 1-6烷基等，或者R 6和R 7与其键合的碳原子一起任选地形成任选取代的C 3-8环烷基等，环A是氮杂环丁烷-1-基等 m是0,1或2，并且n是0,1或2。

公开(公告)号：EP2058317A1

公开(公告)日：2009-05-13

申请号：EP07792066.8

申请日：2007-08-07

申请人： Kyorin Pharmaceutical Co., Ltd.

发明人： KOHNO, Yasushi ,  FUJII, Kiyoshi ,  SAITO, Tatsuhiro

IPC分类号： C07F9/09 ,  A61K31/661 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P7/02 ,  A61P9/04 ,  A61P9/10 ,  A61P11/00 ,  A61P11/02 ,  A61P11/06 ,  A61P13/12 ,  A61P17/00 ,  A61P17/02 ,  A61P21/04 ,  A61P25/00 ,  A61P27/14 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/02

CPC分类号： C07F9/091

摘要： To provide an amino phosphate derivative having an excellent sphingosine-1-phosphate (S1P) receptor modulatory action.
As a result of continued intensive research to create a highly safe compound which has an S1P receptor modulatory action, is has been discovered that an amino phosphate derivative represented by the following general formula (1),

has a strong S1P receptor modulatory action.

摘要翻译： 提供具有优异的鞘氨醇-1-磷酸（S1P）受体调节作用的氨基磷酸酯衍生物。 作为继续深入研究以产生具有S1P受体调节作用的高度安全的化合物的结果，已经发现由以下通式（1）表示的氨基磷酸酯衍生物具有强的S1P受体调节作用。

公开(公告)号：EP1782801A4

公开(公告)日：2008-08-06

申请号：EP05780913

申请日：2005-08-24

申请人： SENJU PHARMA CO

发明人： MATSUHISA KEIICHI

IPC分类号： A61K31/01 ,  A61K9/107 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61P27/02 ,  A61P27/04 ,  A61P27/14 ,  A61P37/08

CPC分类号： A61K9/0048 ,  A61K31/01

摘要： An eyewash liquid for dry eye therapy, which is a solution, or emulsion, or double-phase eyewash liquid comprising squalane. In particular, there is provided an oil-in-water emulsion further comprising a water soluble polymer, such as polyvinyl alcohol. Moreover, there are disclosed the use of squalane for production of eyedrops for dry eye therapy and the method of dry eye therapy.

公开(公告)号：EP1887008A1

公开(公告)日：2008-02-13

申请号：EP06756705.7

申请日：2006-05-30

申请人： Mitsubishi Tanabe Pharma Corporation

发明人： ADACHI, Kunitomo Mitsubishi Tanabe Pharma Corporation ,  HIKAWA, Hidemasa Mitsubishi Tanabe Pharma Corporation ,  HAMADA, Maiko Mitsubishi Tanabe Pharma Corporation ,  ENDOH, Jun-ichi Mitsubishi Tanabe Pharma Corporation ,  ISHIBUCHI, Seigo Mitsubishi Tanabe Pharma Corporation ,  FUJIE, Naoto Mitsubishi Tanabe Pharma Corporation ,  TANAKA, Minoru Mitsubishi Tanabe Pharma Corporation ,  SUGAHARA, Kunio Mitsubishi Tanabe Pharma Corporation ,  OSHITA, Kouichi Mitsubishi Tanabe Pharma Corporation ,  MURATA, Meguru Mitsubishi Tanabe Pharma Corporation

IPC分类号： C07D495/14 ,  A61K31/551 ,  A61P1/04 ,  A61P3/10 ,  A61P11/02 ,  A61P11/06 ,  A61P13/12 ,  A61P17/00 ,  A61P17/04 ,  A61P19/02 ,  A61P25/00 ,  A61P27/14 ,  A61P29/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00

CPC分类号： C07D495/14

摘要： [Solving means]
A thienotriazolodiazepine compound of the following formula (I)

a pharmaceutical agent containing the compound as an active ingredient, and a production intermediate and a production method of the thienotriazolodiazepine compound.
[Effect]
Since this compound has an inhibitory action on costimulatory signal from CD28 on T cell, it is useful for the prophylaxis or suppression of rejection reaction in transplantation of organ or bone marrow and the like, and the prophylaxis or treatment of autoimmune diseases or allergic diseases.

摘要翻译： [解决方案]下述式（I）的噻吩并三唑并噻二嗪类化合物是含有该化合物作为有效成分的药剂，以及噻吩并三唑并氮杂化合物的制造中间体和制造方法。 [效果]由于该化合物对T细胞上的CD28的共刺激信号具有抑制作用，因此可用于预防或抑制移植器官或骨髓等中的排斥反应，以及预防或治疗自身免疫性疾病或 过敏性疾病

公开(公告)号：EP1550448A4

公开(公告)日：2007-11-14

申请号：EP03797700

申请日：2003-09-19

申请人： INC ADMIN AGENCY NARO

发明人： TANAKA KEIICHI ,  AMANO TAKAYUKI ,  MURAMATSU NOBORU ,  TATSUKI MIHO ,  ASAKURA TOSHIKAZU ,  ITO IWAO ,  ISHIKAWA ETSUO ,  SATO KOICHI

IPC分类号： A23L2/38 ,  A23L1/30 ,  A23L2/52 ,  A61K8/06 ,  A61K8/67 ,  A61K8/73 ,  A61K8/96 ,  A61K8/97 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/732 ,  A61P1/04 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P17/04 ,  A61P27/14 ,  A61P43/00 ,  A61Q19/00 ,  C07H3/04 ,  C07H3/06 ,  C08B37/06 ,  A61K7/00

CPC分类号： A61K8/73 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/732 ,  A61K2800/78 ,  A61Q19/00 ,  C07H3/04 ,  C07H3/06

摘要： It is intended to provide a histamine release inhibitor which contains, as the active ingredient, pectin or its salt or a pectin hydrolysate; and medicinal compositions, cosmetics, foods and drinks containing this inhibitor.

公开(公告)号：EP1827406A1

公开(公告)日：2007-09-05

申请号：EP05804597.2

申请日：2005-10-24

申请人： CIBA SPECIALTY CHEMICALS HOLDING INC. Patent Departement

发明人： BASCHONG, Werner ,  REICH, Oliver ,  MONGIAT, Sébastien

IPC分类号： A61K31/05 ,  A61K31/222 ,  A61K31/255 ,  A61K31/34 ,  A61K31/445 ,  A61P17/00 ,  A61P17/16 ,  A61P27/14 ,  A61P29/00 ,  A61P43/00

CPC分类号： A61K31/05 ,  A61K8/11 ,  A61K8/14 ,  A61K8/347 ,  A61K8/37 ,  A61K8/375 ,  A61K8/42 ,  A61K8/46 ,  A61K8/466 ,  A61K8/4926 ,  A61K8/4966 ,  A61K8/4973 ,  A61K8/498 ,  A61K8/553 ,  A61K8/671 ,  A61K8/676 ,  A61K31/165 ,  A61K31/222 ,  A61K31/255 ,  A61K31/34 ,  A61K31/445 ,  A61K2800/412 ,  A61K2800/413 ,  A61K2800/522 ,  A61Q1/02 ,  A61Q5/02 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/10

摘要： Compounds of the formulae (1), (2) and selected hindered nitroxyl, hydroxylamine and hydroxylamine salt compounds such as the compound of formula (3), wherein Gi is hydrogen; C1-C22alkyl; C1-C22alkylthio; C2-C22alkylthioalkyl; C5-C7cycloalkyl; phenyl; C7-C9phenylalkyl; or SO3M; G2 is C1-C22alkyl; C5-C7cycloalkyl; phenyl; or C7-C9phenylalkyl; E is oxyl or hydroxyl; V is -O-; or -NH-; a is 0 or 1 or 2; b, c and d and g are each independently of one another 0 or 1; e is an integer from 1 to 4; f, m, n and p are each independently of one another an integer from 1 to 3; q is 0 or an integer from 1 to 3; Q, T and G3 are as defined in claim 1; G4 and G5 are each independently of the other hydrogen; or C1-C22alkyl; exhibit marked antiinflammatory action.

公开(公告)号：EP1231920B1

公开(公告)日：2007-02-07

申请号：EP00972763.7

申请日：2000-10-14

申请人： Boehringer Ingelheim International GmbH

发明人： TRACH, Volker ,  DUSCHLER, Gerold

IPC分类号： A61K31/55 ,  A61K9/08 ,  A61P11/02 ,  A61P27/14 ,  A61P27/02

CPC分类号： F01L9/04 ,  A61K9/0043 ,  A61K9/0048 ,  A61K31/55 ,  Y10S514/912 ,  Y10T137/0318

摘要： The invention relates to topically applied aqueous solutions containing epinastine, optionally in the form of its racemate, its enantiomers or its pharmacologically suitable acid addition salts.

公开(公告)号：EP1533313A4

公开(公告)日：2007-01-24

申请号：EP03738665

申请日：2003-07-03

申请人： SUNTORY LTD

发明人： ISHIKURA YOSHIYUKI ,  TSUJI KUNIRO ,  NUKAYA HARUO

IPC分类号： A23L2/38 ,  A23L1/30 ,  A23L2/52 ,  A61K8/00 ,  A61K8/06 ,  A61K8/49 ,  A61K31/352 ,  A61P11/02 ,  A61P17/00 ,  A61P17/04 ,  A61P27/14 ,  A61P37/08 ,  A61P43/00 ,  A61Q1/00 ,  A61Q1/02 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q19/00 ,  A61Q19/10 ,  C07D493/14 ,  A23L2/00 ,  A61K7/00 ,  A61K7/02 ,  A61K7/06 ,  A61K7/075 ,  A61K7/48 ,  A61K7/50

CPC分类号： A61K8/602 ,  A23L33/11 ,  A23V2002/00 ,  A61K31/352 ,  A61Q5/02 ,  A61Q19/00 ,  C07D493/14 ,  A23V2200/304 ,  A23V2250/2116

摘要： It is intended to provide a novel flavone C-glycoside derivative or its salt showing, in particular, an antiallergic effect and a composition containing the same. Allergic diseases have been increasing in the recent years. Among all, pollenosis and atopic dermatitis are remarkably increasing to thereby result in social problems. Flavones and glycosides thereof, which are reported as having an effect of inhibiting the release of histamine from adipocytes and an immunosuppressive effect, are expected as being applicable as remedies for allergy. However, most of flavones should be taken in a large dose to exert the effects and, therefore, it has been urgently required to find out a compound exhibiting the effects at a smaller dose. Under these circumstances, it is intended to provide a novel component whereby allergic diseases can be treated in a small dose and a composition containing the same.

公开(公告)号：EP1418881A4

公开(公告)日：2006-07-05

申请号：EP02756279

申请日：2002-06-24

申请人： KARAGOEZIAN HAMPAR L

发明人： KARAGOEZIAN HAMPAR L

IPC分类号： A61K47/02 ,  A61K33/22 ,  A61K33/40 ,  A61K47/30 ,  A61K47/36 ,  A61P17/00 ,  A61P17/02 ,  A61P17/04 ,  A61P17/06 ,  A61P27/02 ,  A61P27/14 ,  A61P29/00 ,  A61P31/04 ,  A61P37/08 ,  A61K7/20 ,  A61K33/14

CPC分类号： A61K33/40 ,  Y10S514/914 ,  A61K2300/00 ,  A61K33/20

摘要： An anti-microbial liquid ophthalmic composition for direct application onto an eye of a living being. The composition includes from about 0.02 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.01 wt. % peroxy compound, at a pH between about 7.0 and 7.8. Preferably, the chlorite compound is a metal chlorite where the metal is chosen from the group consisting of sodium, potassium, calcium, and magnesium, while the peroxy compound is hydrogen peroxide. Also included are methods for treating an eye infection through application of the composition to the eye, and for cleansing a contact lens in place on an eye through application of the composition to the lens.