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    Self-assembled nanostructures
    43.
    发明公开
    Self-assembled nanostructures 有权
    Selbstangeordnete Nanostrukturen

    公开(公告)号：EP2316819A2

    公开(公告)日：2011-05-04

    申请号：EP10170217.3

    申请日：2010-07-21

    申请人： Xerox Corporation ,  National Research Council of Canada

    发明人： Makeiff, Darren ,  Carlini, Rina

    IPC分类号： C07C233/54 ,  C07C237/42 ,  C07C275/42 ,  C07C63/24 ,  B82Y30/00

    CPC分类号： C07C233/54 ,  C07C65/21 ,  C07C237/42 ,  C07C275/42

    摘要： Nanostructures are formed from alkylated derivatives of aromatic acids of the formula:

    wherein at least one of R 1 to R 6 represents a carboxylic acid group, a primary amide group, an ester group, an amidine group, or a salt thereof, at least one other of R 1 to R 6 is X-R c , and the remaining of R 1 to R 6 independently represent H or substituted or unsubstituted organic groups; X represents a linking group; and R c represents a substituted or unsubstituted alkyl group.

    摘要翻译： 纳米结构由下式的芳族酸的烷基化衍生物形成：其中R 1至R 6中的至少一个表示羧酸基团，伯酰胺基团，酯基团，脒基团或其盐，至少一个 R 1至R 6中的另一个为XR c，R 1至R 6的其余部分独立地表示H或取代或未取代的有机基团; X表示连接基团; R c表示取代或未取代的烷基。

    PROCESS FOR PRODUCTION OF PHENYLALANINE DERIVATIVES HAVING QUINAZOLINEDIONE SKELETONS AND INTERMEDIATES FOR THE PRODUCTION
    44.
    发明公开
    PROCESS FOR PRODUCTION OF PHENYLALANINE DERIVATIVES HAVING QUINAZOLINEDIONE SKELETONS AND INTERMEDIATES FOR THE PRODUCTION 有权
    工艺生产具有CHINAZOLINDIONGERÜSTEN苯丙氨酸衍生物和中间产品的生产

    公开(公告)号：EP2103601A1

    公开(公告)日：2009-09-23

    申请号：EP07832344.1

    申请日：2007-11-22

    申请人： Ajinomoto Co., Inc.

    发明人： KATAOKA, Noriyasu ,  OKADO, Kotaro ,  YAMADA, Tatsuhiro ,  FUJITA, Koichi ,  SUZUKI, Tamotsu ,  OKUZUMI, Tatsuya ,  SUGIKI, Masayuki ,  TATARA, Akinori

    IPC分类号： C07D239/96 ,  C07C233/51 ,  C07C237/40 ,  C07C265/12 ,  C07C271/22 ,  C07C271/28 ,  C07C275/42

    CPC分类号： C07D239/96 ,  C07C233/47 ,  C07C233/87 ,  C07C237/40 ,  C07C237/42 ,  C07C265/12 ,  C07C271/22 ,  C07C271/28 ,  C07C275/42 ,  Y02P20/55

    摘要： A method for preparing a phenylalanine derivative having a quinazoline-dione ring represented by the following formula (1) or a pharmaceutically acceptable salt thereof, comprising the following steps (a), (b) and (c):

    (a) reacting an acyl phenylalanine derivative represented by the following formula (2):

    with a carbonyl group-introducing reagent and a specific anthranilic acid derivative to thus form the corresponding carboxy-asymmetric urea derivative;
    (b) converting the carboxy-asymmetric urea derivative into the corresponding quinazoline-dione derivative in the presence of a carboxyl group-activating agent:
    (c) if desired, substituting an N-alkyl group for the hydrogen atom bonded to the nitrogen atom present in the quinazoline-dione ring of the quinazoline-dione derivative using an N-alkylation agent and then deprotecting the resulting product, when the substituent R3' which is a group corresponding to R3 is protected. According to this method, there can be obtained a phenylalanine derivative having a quinazoline-dione skeleton in a industrially favorably high yield.

    摘要翻译： 一种用于制备苯丙氨酸衍生物具有由下式表示的喹唑啉二酮环（1）或其药学上可接受的盐，其包括以下步骤（a），（b）和（c）中的方法：（A）反应成酰基 由下式（2）表示的苯丙氨酸衍生物：与羰基导入试剂和特定的邻氨基苯甲酸衍生物，以形成因此对应羧基不对称脲衍生物; （B）将所述羧基不对称脲衍生物为相应的喹唑啉二酮衍生物在羧基活化剂的存在下：如果需要清除（c）中，用N-烷基为键合到本氮原子上的氢原子 在使用N-烷基化剂，然后脱保护得到的产物，当取代基R3“是对应于R3基团被保护的喹唑啉二酮衍生物的喹唑啉二酮环。 。根据该方法，可以得到在工业上有利地高收率具有喹唑啉二酮骨架苯基丙氨酸衍生物。