公开(公告)号：EP1133516A1

公开(公告)日：2001-09-19

申请号：EP99971814.1

申请日：1999-11-05

申请人： MYRIAD GENETICS, INC. ,  THE HOSPITAL FOR SICK CHILDREN

发明人： TAVTIGIAN, Sean, V. ,  TENG, David, H., F. ,  SIMARD, Jacques ,  ROMMENS, Johanna, M.

IPC分类号： C07H21/04 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86 ,  C07K14/00 ,  C07K16/00 ,  A61K31/70

CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K14/47 ,  C07K16/3069

摘要： The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human prostate cancer predisposing gene (HPC2), some alleles of which cause susceptibility to cancer, in particular prostate cancer. More specifically, the present invention relates to germline mutations in the HPC2 gene and their use in the diagnosis of predisposition to prostate cancer. The invention also relates to presymptomatic therapy of individuals who carry deleterious alleles of the HPC2 gene. The invention further relates to somatic mutations in the HPC2 gene in human prostate cancer and their use in the diagnosis and prognosis of human prostate cancer. Additionally, the invention relates to somatic mutations in the HPC2 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the HPC2 gene, (including gene therapy, protein replacement therapy, protein mimetics, and inhibitors). The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the HPC2 gene for mutations, which are useful for diagnosing the predisposition to prostate cancer.

公开(公告)号：EP1104456A1

公开(公告)日：2001-06-06

申请号：EP99941010.3

申请日：1999-08-10

申请人： CHIRON CORPORATION

发明人： WILLIAMS, Lewis, T. ,  GIEDLIN, Martin ,  ESCOBEDO, Jaime ,  COLLINS, Amy, L. ,  FONG, Timothy

IPC分类号： C12N5/06 ,  C12N15/79

CPC分类号： C12N15/85 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  Y02A50/463

摘要： The present invention provides a method for presentation of multiple disease associated antigens in antigen-presenting cells which can be used to generate a prophylactic or therapeutic immune response against the disease with which the antigens are associated. The method employs differential screening of nucleic acid sequences expressed by target and non-target cells. By identifying nucleic acid sequences preferentially expressed in a target cell population and expressing the identified sequences in antigen-presenting cells, one can stimulate an immune response directed at a target cell population without being limited to single, previously identified antigens.

公开(公告)号：EP1094108A3

公开(公告)日：2001-05-09

申请号：EP01100962.8

申请日：1995-02-17

申请人： Maxygen, Inc.

发明人： Stemmer, William P.C. ,  Crameri, Andreas

IPC分类号： C12N15/10 ,  C12N15/12 ,  C07K16/18 ,  C12Q1/68

CPC分类号： C40B40/02 ,  C07K14/43595 ,  C07K14/545 ,  C07K16/00 ,  C07K2317/565 ,  C07K2317/622 ,  C12N9/2471 ,  C12N9/86 ,  C12N15/1027 ,  C12N15/1034 ,  C12N15/1037 ,  C12Q1/68 ,  C12Q1/6811 ,  C12Y302/01023 ,  C12Y305/02006 ,  C40B40/08 ,  C40B50/06

摘要： The present invention provides a population of polynucleotides resulting from shuffling sequences from substrate polynucleotides encoding antibody chains, whereby the population of polynucleotides comprises recombinant polynucleotides encoding antibody chains having different combinations of heavy chain CDRs and/or light chain CDRs than are encoded by the substrate polynucleotides. Such a population of polynucleotides may be employed to provide an antibody display library.

公开(公告)号：EP1062339A2

公开(公告)日：2000-12-27

申请号：EP99912374.8

申请日：1999-03-09

申请人： Chiron Corporation

发明人： CEN, Hui,Chiron Corp.,Intellectual Prop. R338 ,  GARCIA, P., D.,Chiron Corp.,Intel. Pro. R338 ,  GRIESHAMMER, U.,Chiron Corp. ,  KASSAM, A.,Chiron Corp.,Intellectual Prop. R338 ,  LEE, P. P.,Chiron Corp.,Intellectual Prop. R338 ,  POT, D.,Chiron Corp.,Intellectual Property R338 ,  GOSPODAROWICZ, D.,Chiron Corp. ,  MARTIN, K.,Chiron Corp.,Intellectual Prop. R338

IPC分类号： C12N15/12 ,  C07K14/50 ,  C07K16/22 ,  C12N5/10 ,  A61K31/70 ,  A61K35/12 ,  A61K38/18 ,  C12Q1/68 ,  G01N33/68

CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K48/00

摘要： This invention relates to human fibroblast growth factor (FGF 98), and to variants thereof and to polynucleotides encoding FGF 98. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies.

公开(公告)号：EP1007732A1

公开(公告)日：2000-06-14

申请号：EP98902586.1

申请日：1998-01-16

申请人： Maxygen, Inc.

发明人： DELCARDAYRE, Stephen, B. ,  TOBIN, Mathew, B. ,  STEMMER, Willem, P., C. ,  NESS, Jon, E. ,  MINSHULL, Jeremy ,  PATTEN, Phillip

IPC分类号： C12Q1/68 ,  C12N15/00

CPC分类号： A01H1/00 ,  A01K2217/05 ,  C12N15/1027 ,  C12N15/8271 ,  C12N15/8273 ,  C12N15/8279 ,  C12Q1/6811

摘要： The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.

摘要翻译： 本发明提供了使用重组和选择/筛选的迭代循环来进行整个细胞和生物体以获得期望特性的方法。 这种性质的实例包括增强的重组性，基因组拷贝数和蛋白质和次级代谢物的表达和/或分泌能力。

公开(公告)号：EP1003889A1

公开(公告)日：2000-05-31

申请号：EP98938342.7

申请日：1998-07-31

申请人： CHIRON CORPORATION

发明人： CRAWFORD, Kenneth, A.,Chiron Corporation ,  BISHOP, Robert,Chiron Corporation

IPC分类号： C12N15/81 ,  C07K14/39 ,  C07K16/14 ,  C12N1/19

CPC分类号： C07K14/65 ,  C07K14/39 ,  C07K2319/02 ,  C12N9/16 ,  C12N15/81 ,  C12N15/815

摘要： Regulatory nucleotide sequences for a novel Pichia pastoris gene, designated PpSEC10 gene, and the nucleotide sequences and respective amino acid sequences for the secretion leader and the mature Sec10p protein components of the precursor polypeptide encoded by this novel gene are provided. These compositions are useful in methods for expression and secretion of proteins when assembled in proper reading frame, individually or in combination, within a DNA construct that further comprises a nucleotide sequence encoding a protein of interest. Vectors comprising the DNA constructs of the invention can be used to transform a yeast host cell, which can then be cultured to obtain the secreted protein of interest. Kits useful in this method and in methods of detection of the Sec10p protein using antibodies are also disclosed.

公开(公告)号：EP0979286A2

公开(公告)日：2000-02-16

申请号：EP98918891.7

申请日：1998-04-30

申请人： Kosan Biosciences ,  THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY

发明人： KHOSLA, Chaitan ,  ASHLEY, Gary ,  FU, Hong ,  KAO, Camilla, M. ,  MCDANIEL, Robert

IPC分类号： C12N15/52 ,  C12N15/76 ,  C12N9/00 ,  C12N1/21 ,  C12P17/06 ,  C07D309/00 ,  C07D313/04 ,  C07D493/10 ,  C07D313/00 ,  C07H17/04

CPC分类号： C07H17/08 ,  C07D323/00 ,  C12N15/52 ,  C40B40/00

摘要： Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.

摘要翻译： 聚酮化合物组合文库可通过适当操作宿主模块化聚酮化合物合酶基因簇，如编码红霉素PKS的基因簇获得。 组合文库可用作药物活性化合物的来源。 另外，使用这种方法制备新颖的聚酮化合物和抗生素。

公开(公告)号：EP0973904A1

公开(公告)日：2000-01-26

申请号：EP98910322.1

申请日：1998-03-04

申请人： CHIRON CORPORATION

发明人： DWARKI, Varavani,Chiron Corporation ,  MANNING, William C.,Chiron Corporation ,  KOTHS, Kirston E.,Chiron Corporation

IPC分类号： C12N15/27 ,  C07K14/53 ,  A61K48/00 ,  A61K38/19

CPC分类号： C07K14/53 ,  A61K38/193 ,  A61K48/00 ,  C12N2799/022 ,  Y02A50/409 ,  A61K2300/00

摘要： The invention is a method and composition for reducing a population of diseased cells by administration of a gene delivery vehicle capable of expressing an M-CSF alpha mutant having a decreased capacity to be proteolytically processed and released from a cell membrane. The invention is also a combination of therapeutic agents including gene delivery vehicles expressing M-CSF alpha or an M-CSF alpha mutant in combination, for example, either with a soluble M-CSF, an M-CSF alpha convertase inhibitor, or a gene delivery vehicle expressing prodrug activator such as thymidine kinase followed by administration of the prodrug.

公开(公告)号：EP0972024A1

公开(公告)日：2000-01-19

申请号：EP98903409.5

申请日：1998-01-08

申请人： BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM ,  MYRIAD GENETICS, INC.

发明人： STECK, Peter ,  PERSHOUSE, Mark, A. ,  JASSER, Samar, A. ,  YUNG, W., K., Alfred ,  TAVTIGIAN, Sean, V.

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  C12N15/11 ,  C12N15/86 ,  A61K38/17 ,  C12Q1/68 ,  G01N33/53 ,  A01K67/027

CPC分类号： C12N9/16 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4703 ,  C12N2799/021

摘要： A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated that a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.

公开(公告)号：EP0970232A2

公开(公告)日：2000-01-12

申请号：EP98902548.1

申请日：1998-01-14

申请人： Chiron Corporation

发明人： Jolly, Douglas J. ,  Moore, Margaret Dow ,  Chada, Sunil

IPC分类号： C12N15/86 ,  C12N15/12 ,  C12Q1/68 ,  A61K48/00 ,  C07K14/755

CPC分类号： C12N15/86 ,  A61K38/00 ,  A61K38/27 ,  A61K38/44 ,  A61K38/45 ,  A61K38/465 ,  A61K38/47 ,  A61K38/482 ,  A61K48/00 ,  C07K14/755 ,  C12N2740/13043 ,  C12N2840/20 ,  C12N2840/44

摘要： The present invention provides methods for delivering a gene delivery vehicle to a warm-blooded animal, comprising the step of administering to a warm-blooded animal a gene delivery vehicle which directs the expression of a non-immunogenic selectable marker. Within other aspects, methods are provided for delivering a gene delivery vehicle to a warm-blooded animal, comprising the step of administering to a warm-blooded animal a gene delivery vehicle which directs the expression of a non-immunogenic molecule which is capable of activating an otherwise inactive compound into an active compound.