摘要:
A sampling module for extracting interstitial fluid (ISF) from a user's body includes a housing assembly and a pressure ring assembly operatively contained within the housing assembly. The pressure ring assembly includes a penetration member configured for penetrating a target site of the user's body and, subsequently, residing in the target site and extracting ISF therefrom. The pressure ring assembly also includes a pressure ring configured for applying pressure to the user's body in a first vicinity of the target site and a floating ring with an adhesive layer disposed on it's distal end. The adhesive layer of the sampling module provides for adhesive attachment of the floating ring to the user's body in a second vicinity of the target site, thereby influencing target site deformation during use of the sampling module.
摘要:
A kinematic adhesive fluorescence measurement patch for use with a fluorescent light-emitting bead implanted within a user's body includes an adhesive plate for removable adhesion to the user's body and an optical plate. The optical plate includes a rigid member with a light emitter and light detectors attached thereto. The light emitter of the optical plate is configured for emitting light that is absorbed by the fluorescent light-emitting bead while the light detector is configured for detecting fluorescent light emitted by the fluorescent light-emitting bead. In addition, the adhesive plate and optical plate are configured for kinematic attachment, detachment and kinematic reattachment to one another via a cone-shaped indent, a slot shaped indent, and a flat independently disposed on one of the adhesive or optical plates in opposition to one of three spherical components disposed on the other of the adhesive and optical plates.
摘要:
The invention relates to an amperometric electrochemical cell having a first insulating substrate (1) carrying a first electrode (2), a second insulating substrate (11) carrying a second electrode (10), said electrodes being disposed to face each other and spaced apart by less than 500 µm, and defining a sample reservoir (4) therebetween, and wherein at least one, and preferably both, insulating substrates and the electrode carried thereon include an electromagnetic radiation transmissive portion in registration with said reservoir. The walls of the electrochemical cell (2, 12) may be formed from a thin metallic portion (3) on a transparent substrate (1). Such cells are useful in providing visual confirmation of the validity of the electrochemical measurement.
摘要:
The present invention relates to the measurement of the progress of a chemical reaction that generates an electroactive reaction product that is subsequently detected at an electrode amperometrically or coulometrically. The method is useful in applications where it is desirable to follow the progress of a chemical reaction, particularly in sensor applications where the progress of the reaction of an analyte can be useful in determining the analyte concentration. Sensors used in such applications may include a working electrode (2) and a counter electrode (3) disposed on an electrically insulating substrate (1), and may also include a second substrate (5) upon which is disposed a layer of chemical reactants (4).
摘要:
The present invention is directed to a single test system and method for determining the integrated glycemic condition of a subject by measuring the concentration of glucose and the level of protein-bound glucose in a subject's body fluid, such as whole blood. The glucose concentration is indicative of the subject's immediate glycemic condition, whereas the protein-bound glucose concentration is indicative of either intermediate or long-term glycemic condition. Optionally, other analytes indicative of glycemie condition, such as ketone bodies or fatty acid derivatives, can also be measured. The present invention also provides a method of diagnosing diabetes. The invention additionally provides a method for analyzing the concentration of fructosamine in less than or equal to five minutes without the use of a reaction accelerator.
摘要:
A fluorescence measurement analytical kit includes an adhesive fluorescence measurement patch, a fluorescent light-emitting bead and a remote module. The adhesive fluorescence measurement patch has an adhesive sheet configured for removable adhesion to the user's body, a light emitter attached to the adhesive sheet, and a light detector attached to the adhesive sheet. The light emitter is configured for emitting light that is absorbed by the fluorescent light emitting bead while the light detector is configured for detecting fluorescent light emitted by the fluorescent light-emitting bead.
摘要:
A computer system for the closed-loop support of patient self-testing includes data repository, healthcare provider interface, training interface, supplier, patient interface and analysis modules. The data repository module is configured to store patient enrollment and patient self-test information. The healthcare provider interface module is configured to receive patient enrollment and modified patient prescription information furnished by a healthcare provider and to transfer these to the data repository module. The healthcare provider interface module is also configured to communicate patient self-test result information to a healthcare provider. The training module is configured to receive patient diagnostic monitoring device training information and to transfer that information to the data repository module. The supplier module is configured to send notification information to a diagnostic monitoring device supplier, while the patient interface module is configured to receive patient self-test result information, transfer that information to the data repository module, and communicate modified patient prescription information to the patient. The analysis module is configured to validate patient's enrollment information; schedule patient training once the patient's enrollment information has been validated; evaluate patient diagnostic device training and patient self-test information stored in the data repository module; compile guideline compliance information based on patient enrollment, diagnostic device training and self-test information; and send notification information to the supplier module based on the evaluation. Also, a method for the closed-loop support of patient self-testing that includes scheduling of diagnostic monitoring device training based on validation of patient device training information.
摘要:
The present invention generally relates to biocompatible devices suitable for increasing cellular HIF-1 α protein levels. In particular, the present invention relates to an implant comprising a biocompatible support loaded with at least one pharmaceutical agent capable of increasing cellular HIF-1 α protein levels to promote vascularization at or near the implant site. Vascularization of the implanted support results in enhanced survival of cells optionally incorporated within the support. Methods for treating a disease or injury via implanting the support of the present invention are also provided.