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    FLUORESCENT MICROSCOPIC IMAGING METHOD AND APPARATUS
    63.
    发明公开
    FLUORESCENT MICROSCOPIC IMAGING METHOD AND APPARATUS 审中-公开
    荧光显微成像方法和装置

    公开(公告)号：EP3318865A1

    公开(公告)日：2018-05-09

    申请号：EP16817065.2

    申请日：2016-05-20

    Applicant: Shanghai Ruiyu Biotech Co. Ltd.

    Inventor： LUO, Puwen ,  XIA, Haohan

    IPC: G01N21/64

    CPC classification number: G01N21/6458 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/061 ,  G01N2201/062 ,  G02B21/06 ,  G02B21/16 ,  G02B21/36

    Abstract: A fluorescent microscopic imaging method and apparatus, comprising: according to experiment requirements, illuminating at least one monochromatic fluorescence excitation light source (101) of the same colour from amongst a plurality of monochromatic fluorescence excitation light sources (101) as a target light source, the monochromatic fluorescence excitation light emitted by each monochromatic fluorescence excitation light source (101) being obliquely emitted onto a preset detection area of a sample plate to be detected; on the side of the sample plate to be detected furthest from the target light source, collecting the fluorescence of the particles in the preset detection area excited by the irradiation of the monochromatic fluorescence excitation light emitted by the target light source, and amplifying the preset detection area to a preset multiple; implementing light-filtering processing of the excited fluorescence of the particles in the preset detection area; and acquiring a fluorescent image of the preset detection area. A two-colour mirror is not required, and the fluorescence microscope apparatus therefore has a simple structure and low cost, preventing light energy loss. As the monochromatic fluorescence excitation light is obliquely emitted onto the sample plate to be detected, a small amount of monochromatic fluorescence excitation light is emitted into an objective lens after passing through the sample plate to be detected.

    Abstract translation: 1。一种荧光显微镜成像方法及装置，其特征在于，包括：根据实验要求，从多个单色荧光激发光源（101）中照射至少一个相同颜色的单色荧光激发光源（101）作为目标光源， 每个单色荧光激发光源（101）发出的单色荧光激发光斜向发射到待检样板的预设检测区域上; 在距离目标光源最远的待检测样板侧，收集目标光源发射的单色荧光激发光照射所激发的预设检测区域内的颗粒荧光，并放大预设检测值 面积达到预设倍数; 对所述预设检测区域内的粒子激发荧光进行滤光处理; 并获取预设检测区域的荧光图像。 不需要双色镜，因此荧光显微镜装置结构简单，成本低，防止光能损失。 当单色荧光激发光倾斜地发射到待检样板上时，少量的单色荧光激发光穿过待检样板发射到物镜中。

    AUTOMATED DEFECT DETECTION AND MAPPING FOR OPTICAL FILTERS
    65.
    发明公开
    AUTOMATED DEFECT DETECTION AND MAPPING FOR OPTICAL FILTERS 审中-公开
    光学滤波器的自动缺陷检测和映射

    公开(公告)号：EP3304057A1

    公开(公告)日：2018-04-11

    申请号：EP16729170.7

    申请日：2016-06-03

    Applicant: Materion Corporation

    Inventor： SPRAGUE, Robert

    IPC: G01N21/958 ,  G01J3/51 ,  G01M11/02 ,  G01N21/31

    CPC classification number: G01N21/8806 ,  G01M11/0278 ,  G01M11/0285 ,  G01N21/255 ,  G01N21/958 ,  G01N2021/9511 ,  G01N2201/061 ,  G01N2201/068

    Abstract: Devices and methods are disclosed for characterizing point flaws (including pinholes and point defects) of an optical filter. A passband test is performed, including: illuminating the optical filter with passband illumination whose spectral range at least overlaps a passband of the optical filter; acquiring a passband map of the optical filter using a two-dimensional array of photodetectors while illuminating the optical filter with the passband illumination; and identifying point defects of the optical filter as low intensity locations of the passband map. A stopband test is performed, including: illuminating the optical filter with stopband illumination whose spectral range lies entirely outside of the passband of the optical filter; acquiring a stopband map of the optical filter using the two-dimensional array of photodetectors while illuminating the optical filter with the stopband illumination; and identifying pinholes of the optical filter as high intensity locations of the stopband map.

    LED-BASED FIBER PROPERTY MEASUREMENT
    66.
    发明公开
    LED-BASED FIBER PROPERTY MEASUREMENT 审中-公开
    基于LED的纤维特性测量

    公开(公告)号：EP3274697A1

    公开(公告)日：2018-01-31

    申请号：EP16715230.5

    申请日：2016-03-23

    Applicant: Uster Technologies AG

    Inventor： DEHKORDI, Peyman ,  ZHAO, Weichang ,  RAIRIGH, Daniel, J. ,  RINEHART, Kent, A. ,  RILEY, Roger, C.

    IPC: G01N21/89

    CPC classification number: G01N21/8806 ,  G01N21/27 ,  G01N21/8915 ,  G01N33/36 ,  G01N2201/061 ,  G01N2201/0627

    Abstract: The apparatus is for measuring at least one of color and trash in a fiber sample. A light emitting diode light source generates an incident light that is directed toward the fiber sample, and reflected by the fiber sample, thereby producing a reflected light. A sensor receives the reflected light and produces a signal. A controller controls the light source and the sensor, and at least one of receives and adjusts the signal. At least one of the incident light, the reflected light and the signal is conditioned to compensate for differences between the light emitting diode light source and a xenon light source. Thus, drawbacks of the xenon light source used to date can be avoided.

    METHOD AND APPARATUSES FOR OPTICAL PUPIL SYMMETRIZATION
    68.
    发明公开
    METHOD AND APPARATUSES FOR OPTICAL PUPIL SYMMETRIZATION 审中-公开
    用于光学瞳孔对称的方法和设备

    公开(公告)号：EP3234694A1

    公开(公告)日：2017-10-25

    申请号：EP15797657.2

    申请日：2015-11-19

    Applicant: ASML Holding N.V.

    Inventor： SHMAREV, Yevgeniy, Konstantinovich ,  SMIRNOV, Stanislav

    IPC: G03F7/20

    CPC classification number: G03F7/70133 ,  G01N21/4738 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/068 ,  G02B5/04 ,  G02B27/106 ,  G03F7/70091 ,  G03F7/70191 ,  G03F7/70208

    Abstract: An inspection apparatus may determine precise OV measurements of a target on a substrate using an optical pupil symmetrizer to reduce the inspection apparatus's sensitivity to asymmetry and non-uniformity of the illumination beam in the pupil plane. The inspection apparatus includes an illumination system that forms a symmetrical illumination pupil by (1) splitting an illumination beam into sub-beams, (2) directing the sub-beams along different optical branches, (3) inverting or rotating at least one of the sub-beams in two dimensions, and recombining the sub-beams along the illumination path to symmetrize the intensity distribution. The illumination system is further configured such that the first and second sub-beams have an optical path difference that is greater than a temporal coherence length of the at least one beam and less than a depth of focus in the pupil plane of the objective optical system.

    Abstract translation: 检查设备可以使用光学瞳孔对称器来确定衬底上的目标的精确OV测量结果，以减小检查设备对光瞳平面中的照明光束的不对称性和不均匀性的敏感度。 检查设备包括照明系统，该照明系统通过（1）将照明光束分成子光束，（2）将子光束引导到不同的光学分支，（3）将光束中的至少一个 二维子光束，并沿照明路径重新组合子光束以对称强度分布。 照明系统进一步被配置成使得第一和第二子光束具有大于至少一个光源的时间相干长度并且小于物镜光学的光瞳平面中的焦深的光程差 系统。

    ILLUMINATION FILTER SYSTEM AND OBSERVATION SYSTEM FOR A MULTISPECTRAL FLUORESCENCE MICROSCOPE
    69.
    发明公开
    ILLUMINATION FILTER SYSTEM AND OBSERVATION SYSTEM FOR A MULTISPECTRAL FLUORESCENCE MICROSCOPE 审中-公开
    多光谱荧光显微镜的照明滤光系统和观测系统

    公开(公告)号：EP3206061A1

    公开(公告)日：2017-08-16

    申请号：EP16155623.8

    申请日：2016-02-15

    Applicant: Leica Instruments (Singapore) Pte. Ltd.

    Inventor： KUSTER, Manfred ,  THEMELIS, George

    IPC: G02B5/28 ,  A61B1/04 ,  G01N21/64 ,  G02B21/16

    CPC classification number: G02B21/16 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/045 ,  A61B1/0646 ,  A61B5/0071 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6471 ,  G01N2201/061 ,  G02B5/28 ,  G02B21/0012

    Abstract: The present invention relates to an Illumination filter system (2) for medical imaging, in particular multispectral fluorescence imaging, as performed e.g. in a microscope 1 or endoscope, such as a surgical microscope, in particular a surgical multispectral fluorescence microscope, comprising a first optical filter (35). The present invention also relates to an observation system (3) for medical imaging, in particular multispectral fluorescence imaging, as performed e.g. in a microscope (1) or endoscope, in particular a multispectral fluorescence microscope, comprising a beam splitter (21) adapted to split a light image (13) into a first light portion (16, 17) along a first light path (18) and a second light portion (20) along a second light path (19). To improve known illumination filter systems and observation systems, so these systems work with one light source only, are capable of capturing simultaneously at least one fluorescence signal and a signal of visible reflected light and allow a homogeneous illumination for obtaining different images from the object illuminated, the first optical filter (36) is adapted to quench light of at least one fluorescence excitation band within the visible spectrum in the illumination filter system (2) of the present invention, and the first light portion (16, 17) comprises at least one fluorescence emission band (Em.1, Em.2) in the visible spectrum and the second light portion (20) portion comprises a visible reflected light (VISR) in the observation system (3) of the present invention.

    Abstract translation: 本发明涉及一种用于医学成像，特别是多光谱荧光成像的照明滤波器系统（2），例如， 在显微镜1或内窥镜中，例如手术显微镜，特别是手术多光谱荧光显微镜，其包括第一滤光器（35）。 本发明还涉及用于医学成像，特别是多光谱荧光成像的观察系统（3） 在显微镜（1）或内窥镜中，特别是多光谱荧光显微镜中，包括适于沿着第一光路（18）将光图像（13）分成第一光部分（16,17）的分束器（21） 和沿着第二光路（19）的第二光部分（20）。 为了改进已知的照明滤光系统和观察系统，所以这些系统仅与一个光源一起工作，能够同时捕获至少一个荧光信号和可见反射光的信号，并且允许均匀照明以从物体照明获得不同的图像 ，第一光学滤波器（36）适于猝灭本发明的照明滤波器系统（2）中的可见光谱内的至少一个荧光激发带的光，并且第一光部分（16,17）至少包括 可见光谱中的一个荧光发射带（Em.1，Em.2）和第二轻部分（20）部分包括本发明的观测系统（3）中的可见反射光（VISR）。

    METHODS AND SYSTEMS IN EGG HATCHING
    70.
    发明公开
    METHODS AND SYSTEMS IN EGG HATCHING 审中-公开
    EGG孵化中的方法和系统

    公开(公告)号：EP3190875A1

    公开(公告)日：2017-07-19

    申请号：EP15771723.2

    申请日：2015-08-03

    Applicant: Viscon B.V.

    Inventor： SMAAL, Bastiaan Arie

    IPC: A01K41/00 ,  A01K41/06 ,  A01K43/00

    CPC classification number: A01K41/00 ,  A01K31/002 ,  A01K41/065 ,  A01K43/00 ,  A01K45/005 ,  G01N21/59 ,  G01N33/085 ,  G01N2201/061

    Abstract: The present disclosure relates to methods and systems in egg hatching, based on hatching eggs in a tray (2), comprising arranging eggs in a pattern in or on the tray, comprising egg supporting positions and holes together defining the pattern, wherein the holes are dimensioned to allow chicks (27) after hatching to pass there through into a crate (4), detecting at least one of numbers of unhatched eggs (22) in or on the tray; numbers of dead chicks in the crate; and numbers of objectionable chicks in the crate, and supplementing or removing chicks to or from the crate in correspondence therewith.

    Abstract translation: 本公开涉及基于孵化蛋中托盘（2）的卵孵化的方法和系统，包括将蛋排列成托盘中或托盘上的图案，包括一起限定图案的蛋支撑位置和孔，其中孔 其尺寸设定为允许孵化后的小鸡（27）通过其进入板条箱（4），检测托盘内或托盘上的未孵化的蛋（22）中的至少一个; 箱子里的死鸡数量; 以及箱子中令人反感的小鸡的数量，并且相应地补充或移出小鸡。

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