摘要:
The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
摘要:
There is provided a novel intermediate for producing pesticides. A method for producing 1,3-bis(substituted phenyl)-3-substituted-3-hydroxypropan-1-one compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method for producing 1,3-bis(substituted phenyl)-3-substituted-2-propen-2-one compound of Formula (2) comprises dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C 1 -C 6 alcohol and an aprotic polar solvent in the presence of a base and water.
摘要:
A modified metal complex obtained by subjecting a metal complex containing an organic compound having one nitrogen-containing aromatic heterocycle and four or more structures selected from the group consisting of a phenol ring, a thiophenol ring, an aniline ring and a nitrogen-containing aromatic heterocycle in its molecule as a ligand to any one treatment of a heating treatment, a radiation irradiation treatment and a discharge treatment until a mass reduction rate after the treatment becomes 1 mass% or more and 90 mass% or less, thereby the complex shows a carbon content after the treatment of 5 mass% or more; and a modified metal complex obtained by the step of subjecting a metal complex comprising an organic compound having two or more phenol rings and three or more nitrogen-containing aromatic heterocycles in its molecule as a ligand to any one treatment of a heating treatment, a radiation irradiation treatment and a discharge treatment until a mass reduction rate after the treatment becomes 1 mass% or more and 90 mass% or less, thereby the complex shows a carbon content after the treatment of 5 mass% or more.
摘要:
A metal complex represented by the following formula (1):
wherein R 1 to R 6 each independently represent a hydrogen atom or a substituent; Y 1 and Y 2 each independently represent any one of the following groups:
wherein R α represents a hydrogen atom or a hydrocarbon group having 1 to 4 carbon atoms; P 1 and P 2 each represent a group of atoms necessary for forming a heterocyclic ring together with Y 1 or Y 2 and the two carbon atoms at a position adjacent to Y 1 or Y 2 ; P 1 and P 2 may be linked to each other to form a ruing; M represents a transition metal element or typical metal element; m represents 1 or 2; X represents a counter ion or a neutral molecule; n represents the number of X's in the complex, and an integer of 0 or more; and Q 1 and Q 2 each independently represent an aromatic heterocyclic group.
摘要翻译:由下式(1)表示的金属络合物:其中R 1至R 6各自独立地表示氢原子或取代基; Y 1和Y 2各自独立地表示以下基团中的任何一个:其中R±表示氢原子或具有1至4个碳原子的烃基; P 1和P 2各自表示与Y 1或Y 2一起形成杂环所必需的一组原子,在与Y 1或Y 2相邻的位置上的两个碳原子; P 1和P 2可以彼此连接以形成轮胎; M表示过渡金属元素或典型的金属元素; m表示1或2; X表示抗衡离子或中性分子; n表示复合物中X的数目,0以上的整数; Q 1和Q 2各自独立地表示芳香族杂环基。
摘要:
Compounds of Formula I, wherein Ar, L, m, R1, R2, R3, W, X, Y, Z are as defined in the claims, are described that are active on at least one of PPARα, PPARδ and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ and PPARγ.
摘要:
The invention relates to the field of medicine, namely to new biologically active compounds, particularly to 2,4,6-trimethyl-3-hydroxypiridine derivatives and salts thereof (compound 1), having antioxidant, geroprotective and anti-ischemic action. The salts of compound (1) are prepared by reacting equimolecular quantities of 2,4,6-trimethyl-3-hydroxypiridine and dicarboxylic in solution of the lower spirit at the temperature of 60-100°C with following processing of the reactionary bulk by organic solvent and incubating within 2-5 h at 10-15°C.
摘要:
The invention relates to compounds of the formula (I), in which R1, R2, X, A, B, Z and Y1 to Y4 have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof. Because of their properties as inhibitors of chemokine receptors, especially as CXCR2 inhibitors, the compounds of the formula I and the pharmaceutically acceptable salts and prodrugs thereof are suitable for the prevention and treatment of chemokine mediated diseases.
摘要:
Reverse hydroxamic acid derivatives having specific structures represented by the general formula (Ia): (Ia) (wherein A represents hydrogen, etc.; Ar1 represents arylene, etc.; Ar2 represents optionally substituted aryl, heteroaryl, etc.; R1 represents hydrogen, alkyl, etc.; and R2a represents substituted cycloalkyl, heterocycloalkyl, etc.) and the general formula (I): (I) (wherein A, Ar1, ar2, and R1 are the same as defined above and R2 represents hydrogen, R2a, etc.) and salts of the derivatives. They have TNF-α converting enzyme (TACE) inhibitory activity.