公开(公告)号：EP1190083A2

公开(公告)日：2002-03-27

申请号：EP00942269.2

申请日：2000-07-05

申请人： GLAXO GROUP LIMITED

发明人： GREAVES, David RobertSir William Dunn Sch. Path. ,  THOMSEN, Lindy ,  CATCHPOLE, Ian Richard ,  FORD, Martin James

IPC分类号： C12N15/85 ,  C12N15/12 ,  C12N5/10 ,  A61K31/17

CPC分类号： C07K14/4705 ,  A61K48/00 ,  A61K2039/51 ,  C12N15/85 ,  C12N2830/00 ,  C12N2830/42 ,  C12N2830/46 ,  C12N2830/85

摘要： The present invention provides novel DNA constructs comprising a transcriptional regulatory sequence comprising a polynucleotide derivable from the eIF4A1 gene promoter. In preferred embodiments, the polynucleotide further comprises a polynucleotide derivable from the eIF4A gene introns, particularly intron 1. Host cells harbouring the constructs are also provided. These novel constructs have applications in gene therapy, DNA vaccines and in the commercial production of proteins.

公开(公告)号：EP1155038A1

公开(公告)日：2001-11-21

申请号：EP00910690.7

申请日：2000-02-22

申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.),formerly SMITHKLINE BIOLOGICALS (S.A.) ,  PEPTIDE THERAPEUTICS LIMITED

发明人： FRIEDE, MartinCorporate Intellectual Property ,  MASON, SeanPeptide Therapeutics Limited ,  TURNELL, William GordonPeptide Therapeutics Ltd. ,  VAN MECHELEN, Marcelle P.SmithKline Beecham ,  VINALS Y DE BASSOLS, Carlota,Smithkline Beecham

IPC分类号： C07K16/00 ,  C07K16/42 ,  A61K39/00 ,  A61K39/385 ,  A61K39/395 ,  G01N33/577 ,  G01N33/68 ,  A61P37/08

CPC分类号： C07K16/00 ,  A61K2039/505 ,  A61K2039/6068 ,  C07K2317/52

摘要： The present invention relates to the provision of novel medicaments for the treatment, prevention or amelioration of allergic disease. In particular, the novel medicaments are epitopes or mimotopes derived from the Cε3 or Cε4 domains of IgE. These novel regions may be the target for both passive and active immunoprophylaxis or immunotherapy. The invention further relates to methods for production of the medicaments, pharmaceutical compositions containing them and their use in medicine. Also forming an aspect of the present invention are ligands, especially monoclonal antibodies, which are capable of binding the IgE regions of the present invention, and their use in medicine as passive immunotherapy or immunoprophylaxis.

公开(公告)号：EP1148876A1

公开(公告)日：2001-10-31

申请号：EP00913335.6

申请日：2000-02-02

申请人： SmithKline Beecham Corporation

发明人： LAGO, Amparo, M.

IPC分类号： A61K31/41 ,  A61K31/135 ,  C07D257/04 ,  C07C255/00

CPC分类号： C07C255/57 ,  C07C255/54 ,  C07C255/56

摘要： Novel calcilytic compounds are provided.

公开(公告)号：EP0576478B2

公开(公告)日：2001-04-18

申请号：EP92906441.8

申请日：1992-03-17

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： FRANCOTTE, Myriam ,  PRIEELS, Jean-Paul ,  SLAOUI, Moncef ,  GARCON-JOHNSON, Nathalie, Marie-Josephe, Claude

IPC分类号： A61K39/245

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/541 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/57 ,  C12N2710/16634

摘要： Novel herpes simplex (HSV) vaccine formulations are provided. These comprise HSV glycoprotein gD or immunological fragments in conjunction with 3 Deacylated monophosphoryl lipid A.

公开(公告)号：EP0868918A3

公开(公告)日：2000-04-26

申请号：EP98201308.8

申请日：1994-12-20

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： Momin, Patricia Marie ,  Garcon, Marie-Josephe

IPC分类号： A61K39/39

CPC分类号： A61K39/39 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  Y02A50/412

摘要： The present invention provides vaccine compositions comprising an oil-in-water emulsion optionally with 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccines compositions are potent inducers of a range of immune responses.

摘要翻译： 本发明提供了疫苗组合物，其包含任选具有3脱-O-酰化的单磷酰脂质A和QS21的水包油乳剂。 疫苗组合物是一系列免疫应答的有效诱导剂。

公开(公告)号：EP0977589A1

公开(公告)日：2000-02-09

申请号：EP98939511.6

申请日：1998-06-09

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： BOON, Thierry,Ludwig Inst. for Cancer Research ,  SILLA, Silvia,Ludwig Inst. for Cancer Research ,  UYTTENHOVE, Catherine,Ludwig Inst.for Cancer Res.

IPC分类号： A61K39/39

CPC分类号： A61K39/39 ,  A61K2039/55538 ,  A61K2039/55572 ,  A61K2039/55577

摘要： The present invention provides improved adjuvant compositions comprising QS21/3DMPL and Interleukin 12. These find utility in a range of prophylatic and therapeutic vaccines, including cancer vaccines.

公开(公告)号：EP0598816B1

公开(公告)日：1999-06-23

申请号：EP92917879.6

申请日：1992-08-11

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A. ,  Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. ,  Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

发明人： LOBET, Yves ,  SIMON, Markus ,  SCHAIBLE, Ulrich ,  WALLICH, Reinhard Deutsches Krebsforschungszentrum ,  KRAMER, Michael

IPC分类号： C12N15/31 ,  C12N15/62 ,  A61K39/02

CPC分类号： C07K16/1207 ,  A61K38/00 ,  A61K39/00 ,  C07K14/005 ,  C07K14/20 ,  C07K2319/40 ,  C12N2760/16022 ,  C12Q1/689 ,  C12R1/01 ,  Y02A50/401 ,  Y02A50/57 ,  Y10S530/806 ,  Y10S530/82 ,  Y10S530/825

摘要： The invention relates to novel Borrelia, and OspA antigens derived therefrom. These antigens show little homology with known OspA's and are therefore useful as vaccine and diagnostic reagents. Multicomponent vaccines based on OspA's from different Borrelia groups are also disclosed.

公开(公告)号：EP0614465B1

公开(公告)日：1999-03-17

申请号：EP92923486.2

申请日：1992-11-11

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： DE WILDE, Michel ,  COHEN, Joseph SmithKline Beecham Biologicals s.a.

IPC分类号： C07K14/445 ,  C12N15/62 ,  A61K39/015 ,  C12N7/04

CPC分类号： C07K14/445 ,  A61K39/00 ,  C07K14/005 ,  C07K2319/40 ,  C12N7/00 ,  C12N2730/10122 ,  C12N2730/10123 ,  Y02A50/412

摘要： A novel hybrid protein is provided which comprises a portion of the CS protein of P. falciparum and the surface antigen of Hepatitis B virus. The use of this protein for vaccination purposes is disclosed.

公开(公告)号：EP0874051A2

公开(公告)日：1998-10-28

申请号：EP98201598.4

申请日：1992-08-11

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A. ,  Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. ,  Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

发明人： Lobet, Yves, SmithKline Beecham Biologicals s.a. ,  Simon, Markus ,  Schaible, Ulrich ,  Kramer, Michael ,  Wallich, Reinhard, D. K. S. des öffentlichen Rec.

IPC分类号： C12N15/32 ,  C12N15/44 ,  C12N15/62 ,  C07K14/20 ,  C07K14/11 ,  C12R1/01 ,  A61K39/02 ,  C12N1/20

CPC分类号： C07K16/1207 ,  A61K38/00 ,  A61K39/00 ,  C07K14/005 ,  C07K14/20 ,  C07K2319/40 ,  C12N2760/16022 ,  C12Q1/689 ,  C12R1/01 ,  Y02A50/401 ,  Y02A50/57 ,  Y10S530/806 ,  Y10S530/82 ,  Y10S530/825

摘要： The invention relates to novel Borrelia, and OspA antigens derived therefrom. These antigens show little homology with known OspA's and are therefore useful as vaccine and diagnostic reagents. Multicomponent vaccines based on OspA's from different Borrelia groups are also disclosed.

摘要翻译： 本发明涉及新颖的疏螺旋体和由其衍生的OspA抗原。 这些抗原与已知的OspA几乎没有同源性，因此可用作疫苗和诊断试剂。 还公开了基于来自不同Borrelia组的OspA的多组分疫苗。

公开(公告)号：EP0822831A1

公开(公告)日：1998-02-11

申请号：EP96910019.0

申请日：1996-04-01

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： GARCON, Nathalie, Marie-Josephe, Claude ,  FRIEDE, Martin

IPC分类号： A61K39 ,  A61P31 ,  A61P35 ,  A61P37

CPC分类号： A61K39/015 ,  A61K39/12 ,  A61K39/245 ,  A61K39/292 ,  A61K39/39 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/55577 ,  C12N2710/16634 ,  C12N2730/10134 ,  Y02A50/412 ,  Y02A50/464

摘要： The invention relates to a vaccine composition comprising a antigen, an immunologically active saponin fraction and a sterol.