公开(公告)号：EP2960237A1

公开(公告)日：2015-12-30

申请号：EP15174323.4

申请日：2012-12-13

申请人： Daiichi Sankyo Company, Limited

发明人： TORIYAMA, Fumihiko ,  KUWAHARA, Yasuhisa

IPC分类号： C07D309/28

CPC分类号： C07D309/28 ,  C07D309/14 ,  C07D407/06 ,  Y10T428/2982

摘要： The present invention provides a method for manufacturing a compound (10):

by reacting a compound (7):

with triphenylphosphine followed by reacting with a base and water to produce a compound (8):

and adding an acid to an aqueous solution containing the compound (8) to remove carbonic acid and reacting the compound represented by the formula (8) with a compound (9):

in the aqueous solution from which carbonic acid has been removed.

摘要翻译： 本发明提供了制备化合物（10）的方法：使化合物（7）：与三苯基膦反应，然后与碱和水反应以产生化合物（8）：和将酸加入到含有 化合物（8）除去碳酸，使化学式（8）所示的化合物与化合物（9）反应：除去了碳酸的水溶液中。

公开(公告)号：EP2530156B1

公开(公告)日：2015-11-18

申请号：EP12182258.9

申请日：2003-11-21

申请人： Matsuo, Masafumi ,  Orphan Disease Treatment Institute Co., Ltd. ,  Takeshima, Yasuhiro ,  Daiichi Sankyo Company, Limited

发明人： Matsuo, Masafumi ,  Takeshima, Yasuhiro ,  Koizumi, Makoto

IPC分类号： C12N15/11 ,  C07H21/04 ,  A61K31/7088 ,  A61K31/712 ,  A61K31/7125 ,  A61K48/00 ,  A61P21/04

CPC分类号： C07H21/04 ,  A61K38/00 ,  A61K48/00 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/3231 ,  C12N2320/33

公开(公告)号：EP2305805B1

公开(公告)日：2015-11-11

申请号：EP09773487.5

申请日：2009-06-30

申请人： Daiichi Sankyo Company, Limited

发明人： KOIZUMI, Makoto ,  HIROTA, Yasuhide

IPC分类号： C12N15/113 ,  A61K31/713

CPC分类号： C12N15/111 ,  A61K31/713 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/343 ,  C12N2320/51 ,  C12N2310/3521

摘要： [Problem to be Solved] It is intended to provide a double-stranded polynucleotide that is resistant to RNase and has RNA interference effect, etc. [Solution] The present invention provides a double-stranded polynucleotide consisting of sense and antisense strands consisting of polynucleotides comprising a nucleotide unit of DNAs and 2'-O-methyl RNAs alternately combined.

公开(公告)号：EP2374794B1

公开(公告)日：2015-11-04

申请号：EP09834889.9

申请日：2009-12-22

申请人： Daiichi Sankyo Company, Limited

发明人： NAKAO, Akira ,  GOTANDA, Kentoku ,  AOKI, Kazumasa ,  HIRANO, Shimpei ,  HIRUMA, Yoshiharu ,  SHIIKI, Takeshi

IPC分类号： C07D205/04 ,  A61K31/397 ,  A61K31/40 ,  A61K31/41 ,  A61P1/02 ,  A61P3/14 ,  A61P5/18 ,  A61P19/00 ,  A61P19/02 ,  A61P19/10 ,  A61P29/00 ,  A61P35/00 ,  C07D207/08 ,  C07D207/10 ,  C07D207/12 ,  C07D403/12 ,  C07D409/06 ,  C07D409/14

CPC分类号： C07D205/04 ,  C07D207/08 ,  C07D207/10 ,  C07D207/12 ,  C07D403/12 ,  C07D409/06 ,  C07D409/14

公开(公告)号：EP2915880A1

公开(公告)日：2015-09-09

申请号：EP13851635.6

申请日：2013-10-30

申请人： Daiichi Sankyo Company, Limited ,  National University Corporation Hokkaido University

发明人： WAKAO, Hiroshi ,  FUJITA, Hiroyoshi ,  KOSHIMIZU, Uichi ,  YOSHIKIYO, Kazunori

IPC分类号： C12N5/10 ,  A61K35/12 ,  A61P31/04 ,  A61P31/10 ,  C12N15/00 ,  C12N15/09

CPC分类号： C12N5/0636 ,  A61K35/17 ,  C07K14/7051 ,  C12N5/0696 ,  C12N2501/125 ,  C12N2501/2307 ,  C12N2501/26 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2502/1394 ,  C12N2506/11 ,  C12N2506/45 ,  C12N2510/00

摘要： The object of the present invention is to provide a method for preparing induced pluripotent stem cells from MAIT cells, and providing induced pluripotent stem cells derived from MAIT cells. Another object of the present invention is to provide a method for preparing MAIT-like cells from induced pluripotent stem cells, and providing MAIT-like cells. Differentiation of the induced pluripotent stem cells having a MAIT cell-specific TCR gene can be induced to establish MAIT-like cells.

摘要翻译： 本发明的目的是提供一种从MAIT细胞制备诱导性多能干细胞的方法，并提供衍生自MAIT细胞的诱导多能干细胞。 本发明的另一个目的是提供从诱导的多能干细胞制备MAIT样细胞并提供MAIT样细胞的方法。 可以诱导具有MAIT细胞特异性TCR基因的诱导多能干细胞的分化以建立MAIT样细胞。

公开(公告)号：EP2907824A1

公开(公告)日：2015-08-19

申请号：EP13845596.9

申请日：2013-10-10

申请人： Daiichi Sankyo Company, Limited

发明人： MASUDA, Takeshi ,  NAITO, Hiroyuki ,  NAKADA, Takashi ,  YOSHIDA, Masao ,  ASHIDA, Shinji ,  MIYAZAKI, Hideki ,  KASUYA, Yuji ,  MORITA, Koji ,  ABE, Yuki ,  OGITANI, Yusuke

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  A61K31/4745 ,  A61K31/48

CPC分类号： A61K47/6803 ,  A61K31/4745 ,  A61K31/48 ,  C07K16/2803 ,  C07K16/2827 ,  C07K16/2851 ,  C07K16/2875 ,  C07K16/2878 ,  C07K16/30 ,  C07K2317/30 ,  C07K2317/77

摘要： As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L 1 -L 2 -L P -NH-(CH 2 )n 1 -L a -L b -L c -wherein the antibody is connected to the terminal of L 1 , and the antitumor compound is connected to the terminal of L c with the nitrogen atom of the amino group at position 1 as a connecting position.

摘要翻译： 作为在抗肿瘤效果和安全性方面优异的抗肿瘤药物，提供了抗体 - 药物偶联物，其中由下式表示的抗肿瘤化合物通过具有由下式表示的结构的接头与抗体缀合： -L 1 -L 2 -LP -NH-（CH 2）n 1 -L a -L b -L ​​c - 其中抗体连接到L 1的末端，并且抗肿瘤化合物连接到L的末端 c，位置1处的氨基的氮原子作为连接位置。

公开(公告)号：EP2592076B1

公开(公告)日：2015-05-13

申请号：EP11803677.1

申请日：2011-07-08

申请人： Daiichi Sankyo Company, Limited ,  Ube Industries, Ltd.

发明人： NAKAMURA, Tsuyoshi ,  NAMIKI, Hidenori ,  TERASAKA, Naoki ,  SHIMA, Akiko ,  HAGIHARA, Masahiko ,  IWASE, Noriaki ,  TAKATA, Katsunori ,  KIKUCHI, Osamu ,  TSUBOIKE, Kazunari ,  SETOGUCHI, Hiroyuki ,  YONEDA, Kenji ,  SUNAMOTO, Hidetoshi ,  ITO, Koji

IPC分类号： C07D401/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61P3/04 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00

CPC分类号： C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07F7/1804

公开(公告)号：EP2210940B1

公开(公告)日：2015-03-11

申请号：EP08845087.9

申请日：2008-10-29

申请人： Daiichi Sankyo Company, Limited

发明人： CHIBA, Yasunori ,  JIGAMI, Yoshifumi ,  TAKAHASHI, Yoshie ,  KURODA, Kosuke ,  KOBAYASHI, Kazuo ,  ICHIKAWA, Kimihisa ,  NONAKA, Koichi ,  SUZUKI, Takeshi ,  ONO, Minako

IPC分类号： C07K14/39 ,  C07K14/395 ,  C07K16/00 ,  C12N15/67 ,  C07K14/47 ,  C12N9/02 ,  C12N9/10 ,  C12N9/14 ,  C12N9/90 ,  C12P21/02

CPC分类号： C12P21/02 ,  C07K14/39 ,  C07K14/395 ,  C07K14/47 ,  C07K16/00 ,  C12N9/0051 ,  C12N9/1048 ,  C12N9/1051 ,  C12N9/14 ,  C12N9/90 ,  C12N15/67

摘要： This invention provides a means for high-level secretory production of a protein, and, in particular, a protein having a complicated structure such as an antibody, in a host cell such as a yeast cell. This invention provides a method for high-level secretory production of a foreign protein with the use of a transformed host cell having one or more types of chaperone protein genes and via suppression of O sugar chain inherent to a host cell such as a yeast cell.

公开(公告)号：EP2842577A1

公开(公告)日：2015-03-04

申请号：EP14189625.8

申请日：2011-03-11

申请人： Daiichi Sankyo Company, Limited

发明人： Kawashima, Kayoko ,  Koshimizu, Uichi

IPC分类号： A61K48/00 ,  A61K31/7105 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61K35/76 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10

CPC分类号： C12N5/0657 ,  A61K31/7105 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61K35/34 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/11

摘要： The present invention addresses the problems of providing a method for proliferating cardiomyocytes using a miRNA that promotes the proliferation of cardiomyocytes, a vector for use in the treatment of heart disease, a pharmaceutical composition for treating heart disease, and so forth.
The present invention provides a method for proliferating cardiomyocytes using a miRNA having the cardiomyocyte proliferation promoting action, a vector for use in the treatment of heart disease that comprises said miRNA, a pharmaceutical composition for treating heart disease that comprises said vector, and so forth. A particularly preferred miRNA is one that is selected from the group consisting of mature miRNAs, i.e., miR-148a, miR-148b, miR-152, and miR-373, and precursors of said miRNAs, as well as variants and analogs thereof.

摘要翻译： 本发明解决了提供使用促进心肌细胞增殖的miRNA增殖心肌细胞的方法，用于治疗心脏病的载体，用于治疗心脏病的药物组合物等的问题。 本发明提供使用具有心肌细胞增殖作用的miRNA增殖心肌细胞的方法，用于治疗心脏病的载体，其包含所述miRNA，用于治疗包括所述载体的心脏病的药物组合物等。 特别优选的miRNA是选自成熟miRNA，即miR-148a，miR-148b，miR-152和miR-373以及所述miRNA的前体以及其变体和类似物的miRNA。

公开(公告)号：EP2837685A1

公开(公告)日：2015-02-18

申请号：EP13776053.4

申请日：2013-04-09

申请人： Daiichi Sankyo Company, Limited

发明人： OHTSUKA, Toshiaki ,  YOSHIMURA, Chigusa ,  AGATSUMA, Toshinori ,  URANO, Atsushi ,  KIMURA, Takako ,  MATSUI, Yumi ,  MATSUOKA, Tatsuji ,  HASEGAWA, Jun ,  KAMAI, Yasuki ,  KAWAIDA, Reimi

IPC分类号： C12N15/09 ,  A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08 ,  G01N33/574

摘要： The present invention provides an antibody which binds to a fibroblast growth factor receptor.

摘要翻译： 本发明提供了结合成纤维细胞生长因子受体的抗体。