公开(公告)号：EP0606566B1

公开(公告)日：2001-12-12

申请号：EP93119140.7

申请日：1993-11-27

申请人： Nobel Biocare AB (reg. no. 556002-0231)

发明人： Aronsson, Björn-Owe ,  Johansson, Patrik ,  Kasemo, Bengt ,  Lausmaa, Jukka

IPC分类号： A61L27/00 ,  A61L2/14

CPC分类号： A61L27/10 ,  A61F2/30767 ,  A61F2/3094 ,  A61F2310/00023 ,  A61F2310/00598 ,  A61L2/14 ,  A61L27/06 ,  A61L27/306 ,  C23C4/00 ,  C23C8/10 ,  C23C8/36 ,  Y10S623/901

摘要： The invention relates to a method and device for preparing implant surfaces of metallic or ceramic material, preferably titanium, using gas-discharge plasma with the aim of obtaining a well-defined and reproducible implant surface. After machining and any washing procedures which may be necessary, the implants (2) are conveyed to a vacuum chamber (K2) in which the plasma preparation is carried out in two steps. Firstly, a treatment with an inert gas plasma is effected so that existing surface contamination layers and oxide layers are removed from the implant. A reoxidation is then effected using an oxidizing plasma or by means of thermal oxidation. The plasma preparation and any remaining preparation steps which may be necessary, and handling of the implants (2), are carried out in accordance with a closed procedure without intermediate exposure to uncontrolled environmental atmospheres. In this way, a higher grade of controlled surface characteristics and reproducibility is obtained for the surface of the implant as compared with previously used methods. The properties of the plasma-prepared surface can be preserved right up to the moment of use.

公开(公告)号：EP1123072A1

公开(公告)日：2001-08-16

申请号：EP99949609.4

申请日：1999-09-10

申请人： Usbiomaterials Corporation

发明人： GREENSPAN, David, C. ,  WEST, Jon, K. ,  LEE, Sean ,  MEYERS, James, L. ,  DIAMOND, Mason

IPC分类号： A61F13/00 ,  A61K7/48

CPC分类号： A61Q1/02 ,  A23L33/10 ,  A61K8/25 ,  A61K9/0014 ,  A61K9/0019 ,  A61L26/0004 ,  A61L26/0066 ,  A61L26/0095 ,  A61L27/10 ,  A61L27/446 ,  A61L27/54 ,  A61L31/026 ,  A61L31/128 ,  A61L31/16 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61Q5/00 ,  A61Q17/005 ,  A61Q19/00 ,  C03C4/0007

摘要： Compositions and methods for treating wounds to significantly reduce the healing time, reduce the incidence of scar formation, improve the success of skin grafts, reduce the inflammatory response and providing anti-bacterial treatments to a patient in need thereof, that include small non-interlinked particles of bioactive glass or highly porous bioactive glass, are disclosed. Anti-bacterial solutions derived from bioactive glass, and methods of preparation and use thereof, are also disclosed. The compositions include non-interlinked particles of bioactive glass, alone or in combination with anti-bacterial agents and/or anti-inflammatory agents. The compositions can include an appropriate carrier for topical administration. Anti-bacterial properties can be imparted to implanted materials, such as prosthetic implants, sutures, stents, screws, plates, tubes, and the like, by incorporating small bioactive glass particles or porous bioactive glass into or onto the implanted materials. Anti-bacterial properties can also be imparted to devices used for in vitro and ex vivo cell culture by incorporating non-interlinked particles of bioactive glass into the devices. Anti-bacterial compositions derived from aqueous extracts of bioactive glass are also disclosed. These compositions can be used, for example, in food preparation, solutions used for cell culture, and buffer solutions, such as i.v. solutions.

公开(公告)号：EP1120122A1

公开(公告)日：2001-08-01

申请号：EP99969680.0

申请日：1999-09-29

申请人： Takeda Chemical Industries, Ltd.

发明人： MAKINO, Haruhiko ,  NAKAMURA, Takashi ,  KATO, Hirohumi ,  HOSHINO, Tetsuo

IPC分类号： A61L27/00 ,  A61F2/28 ,  C07F9/6561

CPC分类号： C07F9/6561 ,  A61F2/28 ,  A61F2/30767 ,  A61F2002/2835 ,  A61L27/28 ,  A61L27/54 ,  A61L2300/216 ,  A61L2300/412 ,  A61L27/10 ,  A61L27/04 ,  A61L27/58 ,  A61L27/18 ,  C08L67/04

摘要： Bone repair materials/artificial bone compositions prepared by adding a benzothiopyran derivative or a benzothiepin derivative to a bone repair material or an artificial bone or coating a bone repair material or an artificial bone with a benzothiopyran derivative or a benzothiepin derivative for inducing the reparation of a defective site of a natural bone and strengthening the binding of the artificial bone to the natural bone in bone graft for treating fracture, etc.

摘要翻译： 骨修复材料/人造骨组合物通过将苯并噻喃衍生物或苯并噻吩衍生物加入到骨修复材料或人造骨中或用苯并噻喃衍生物或苯并噻吩衍生物涂覆骨修复材料或人造骨来诱导修复 天然骨缺损部位，加强人造骨与骨移植物中天然骨结合治疗骨折等。

公开(公告)号：EP1035878A2

公开(公告)日：2000-09-20

申请号：EP98964460.4

申请日：1998-11-30

申请人： Geramtec AG Innovative Ceramic Engineering

发明人： DEPPISCH, Werner ,  PFAFF, Hans-Georg ,  WILLMANN, Gerd

IPC分类号： A61L27/00 ,  A61F2/32

CPC分类号： A61L27/10 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/3662 ,  A61F2002/30332 ,  A61F2002/30968 ,  A61F2002/3611 ,  A61F2002/3625 ,  A61F2002/365 ,  A61F2220/0033 ,  A61F2310/00011 ,  A61F2310/00029 ,  A61F2310/00203 ,  A61F2310/00239 ,  A61L27/105 ,  C04B35/4885

摘要： Prostheses with artificial joints have only a few metallic and ceramic materials whose compatibility with human or animal tissue has been established. These materials, however, cannot be combined with one another in any manner if a friction pairing occurs as a result, for example, in the case of artificial joints. With artificial joints, joint partners are required to have good mechanical properties as well as tribological properties. According to the invention, a sintered material is thus provided which is comprised of zircon oxide with an addition of 0.1 to 40 wt. % aluminum oxide. This sintered material enables an artificial joint of a prosthesis whose other ceramic materials are comprised of aluminum oxide or zircon oxide with the given proportions of aluminum oxide to be assembled with joint partners.

公开(公告)号：EP0975284A1

公开(公告)日：2000-02-02

申请号：EP98911817.9

申请日：1998-03-20

申请人： Usbiomaterials Corporation

发明人： ZHONG, Jipin ,  GREENSPAN, David, C.

IPC分类号： A61F2/28

CPC分类号： A61L27/12 ,  A61F2/30767 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2210/0004 ,  A61F2310/00796 ,  A61L27/10 ,  C03B19/1065 ,  C03B19/12 ,  C03C1/006 ,  C03C4/0007

摘要： A process for making bioactive glasses is described including preparing a reaction mixture of reactants capable of forming a sol-gel, ageing the reaction mixture, near equilibrium drying a gel resulting from the reaction mixture, and heating the near equilibrium-dried gel described. Also described are near equilibrium-dried bioactive glass compositions.

公开(公告)号：EP0955961A2

公开(公告)日：1999-11-17

申请号：EP97912864.0

申请日：1997-10-21

申请人： SDGI Holdings, Inc.

发明人： PAFFORD, John ,  BOYD, Lawrence, M. ,  MCKAY, William, F. ,  RAY, Eddie, F., III ,  VAN HOECK, James, E.

IPC分类号： A61B17 ,  A61F2 ,  A61L27 ,  A61L31 ,  A61B19

CPC分类号： A61F2/30767 ,  A61B17/1671 ,  A61B17/1757 ,  A61B2017/0256 ,  A61B2090/034 ,  A61F2/28 ,  A61F2/30724 ,  A61F2/442 ,  A61F2/4455 ,  A61F2/446 ,  A61F2/447 ,  A61F2/4611 ,  A61F2/468 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/2839 ,  A61F2002/30004 ,  A61F2002/30057 ,  A61F2002/30062 ,  A61F2002/30075 ,  A61F2002/30112 ,  A61F2002/30136 ,  A61F2002/30153 ,  A61F2002/30187 ,  A61F2002/30224 ,  A61F2002/30235 ,  A61F2002/30261 ,  A61F2002/30271 ,  A61F2002/30677 ,  A61F2002/30772 ,  A61F2002/30774 ,  A61F2002/30787 ,  A61F2002/30797 ,  A61F2002/30813 ,  A61F2002/30836 ,  A61F2002/30841 ,  A61F2002/30848 ,  A61F2002/3085 ,  A61F2002/30866 ,  A61F2002/30879 ,  A61F2002/30892 ,  A61F2002/30904 ,  A61F2002/3092 ,  A61F2002/30929 ,  A61F2002/4475 ,  A61F2002/448 ,  A61F2002/4623 ,  A61F2002/4627 ,  A61F2002/4628 ,  A61F2002/4649 ,  A61F2210/0004 ,  A61F2210/0061 ,  A61F2230/0004 ,  A61F2230/0019 ,  A61F2230/0034 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2250/0014 ,  A61F2310/00161 ,  A61F2310/00293 ,  A61F2310/00365 ,  A61F2310/00491 ,  A61F2310/00544 ,  A61F2310/00796 ,  A61L27/10 ,  A61L27/12 ,  A61L27/16 ,  A61L27/18 ,  A61L27/24 ,  A61L27/54 ,  A61L31/024 ,  A61L31/026 ,  A61L31/044 ,  A61L31/047 ,  A61L31/048 ,  A61L31/06 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/802 ,  A61L2430/38 ,  Y10S606/907 ,  Y10S606/908 ,  Y10S606/909 ,  Y10S606/91 ,  A61L27/227

摘要： Spinal spacers (20) are provided for fusion of a motion segment. The spacers include a load bearing member (21) having a wall (22) sized for engagement within a space between adjacent vertebrae to maintain the space and an effective amount of an osteogenic composition (30) to stimulate osteoinduction. The osteogenic composition includes a substantially pure osteogenic factor in a pharmaceutically acceptable carrier. In one embodiment the load bearing member includes a bone graft impregnated in an osteogenic composition. In another embodiment, the osteogenic composition (30) is packed within a chamber (25) defined in the graft. Any suitable configuration of a bone graft is contemplated, including bone dowels, D-shaped spacers and cortical rings.

公开(公告)号：EP0947489A1

公开(公告)日：1999-10-06

申请号：EP97913437.6

申请日：1997-11-25

申请人： KABUSHIKI KAISYA ADVANCE

发明人： UMEZU, Yoshikazu ,  ARAI, Takehiko

IPC分类号： C04B38/00

CPC分类号： C04B38/009 ,  A61K9/1611 ,  A61L27/10 ,  A61L27/12 ,  A61L27/54 ,  C04B2111/00836 ,  C04B35/447 ,  C04B40/0078

摘要： Spherical-shape ceramics obtained by dropping starting ceramics into a low temperature medium or composite spherical-shape ceramics having a composite layer obtained by applying a hydrothermal treatment thereto.

摘要翻译： 通过将起始陶瓷滴加到通过对其进行水热处理获得的具有复合层的低温介质或复合球形陶瓷中获得的球形陶瓷。

公开(公告)号：EP0871504A2

公开(公告)日：1998-10-21

申请号：EP96915566.0

申请日：1996-05-08

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： MARCOLONGO, Michele, S. ,  DUCHEYNE, Paul ,  KO, Frank ,  LACOURSE, William

IPC分类号： A61L27 ,  A61F2 ,  A61L31 ,  C03C4 ,  C03C13 ,  C08J5 ,  D03D1 ,  D03D15 ,  D04C1 ,  D04H13

CPC分类号： C03C4/0007 ,  A61F2/3094 ,  A61F2/30965 ,  A61F2/367 ,  A61F2002/30289 ,  A61F2002/3082 ,  A61F2230/0091 ,  A61L27/025 ,  A61L27/10 ,  A61L27/422 ,  A61L27/443 ,  A61L27/446 ,  C03C13/00 ,  C03C2213/02 ,  D03D9/00 ,  D03D15/00 ,  D03D15/0011 ,  D03D15/0027 ,  D10B2101/06 ,  D10B2101/08 ,  D10B2101/12 ,  D10B2331/021 ,  D10B2401/041 ,  D10B2401/061 ,  D10B2401/063 ,  D10B2509/00 ,  Y10T428/29 ,  Y10T428/2929 ,  Y10T428/2931 ,  Y10T428/2964 ,  Y10T428/2965 ,  Y10T428/2967 ,  Y10T428/2969 ,  Y10T428/2973 ,  Y10T428/2978 ,  Y10T428/30 ,  Y10T442/3049 ,  Y10T442/3236 ,  A61F2/28 ,  C08L81/06 ,  C08L71/12

摘要： Composite materials formed from bone bioactive glass or ceramic fibers and structural fibers are disclosed. In preferred embodiments, a braid or mesh of interwoven bone bioactive glass or ceramic fibers and structural fibers is impregnated with a polymeric material to provide a composite of suitable biocompatibility and structural integrity. Most preferably, the mesh or braid is designed so that the bioactive fibers are concentrated at the surface of the implant to create a surface comprised of at least 30 % bioactive material, thereby providing enhanced bone ingrowth. The interweaving between the bone bioactive glass or ceramic fibers and the core of structural fibers overcomes the problems found in prior composite systems where the bioactive material delaminates from the polymer. Preferred bioactive materials include calcium phosphate ceramics and preferred structural fibers include carbon fibers. Further preferred bioactive materials include aluminum oxide at greater than 0.2 %, by mole. Improved prosthetic implants and methods of affixing an implant are thus also disclosed.

公开(公告)号：EP0730681A4

公开(公告)日：1998-07-15

申请号：EP95901248

申请日：1994-11-14

申请人： UNIV PENNSYLVANIA

发明人： MARCOLONGO MICHELE S ,  DUCHEYNE PAUL ,  KO FRANK ,  LACOURSE WILLIAM

IPC分类号： A61L27/00 ,  A61F2/00 ,  A61F2/30 ,  A61F2/32 ,  A61F2/36 ,  A61L27/02 ,  A61L27/10 ,  A61L27/42 ,  A61L27/44 ,  A61L31/00 ,  A61L31/12 ,  C03C4/00 ,  C03C13/00 ,  C08J5/04 ,  D03D1/00 ,  D03D15/00 ,  D04C1/02 ,  D04H13/00 ,  D03D3/00 ,  D03D17/00 ,  D03D25/00 ,  D04B1/00 ,  D04H1/00 ,  D04H3/00 ,  D04H5/00 ,  D04H11/00

CPC分类号： C03C4/0007 ,  A61F2/3094 ,  A61F2/30965 ,  A61F2/367 ,  A61F2002/30289 ,  A61F2002/3082 ,  A61F2230/0091 ,  A61L27/025 ,  A61L27/10 ,  A61L27/422 ,  A61L27/443 ,  A61L27/446 ,  C03C13/00 ,  C03C2213/02 ,  D03D9/00 ,  D03D15/00 ,  D03D15/0011 ,  D03D15/0027 ,  D10B2101/06 ,  D10B2101/08 ,  D10B2101/12 ,  D10B2331/021 ,  D10B2401/041 ,  D10B2401/061 ,  D10B2401/063 ,  D10B2509/00 ,  Y10T428/29 ,  Y10T428/2929 ,  Y10T428/2931 ,  Y10T428/2964 ,  Y10T428/2965 ,  Y10T428/2967 ,  Y10T428/2969 ,  Y10T428/2973 ,  Y10T428/2978 ,  Y10T428/30 ,  Y10T442/3049 ,  Y10T442/3236 ,  A61F2/28 ,  C08L81/06 ,  C08L71/12

摘要： Composite materials formed from bone bioactive glass or ceramic fibers and structural fibers are disclosed. In preferred embodiments, a braid or mesh of interwoven bone bioactive glass or ceramic fibers and structural fibers is impregnated with a polymeric material to provide a composite of suitable biocompatibility and structural integrity. Most preferably, the mesh or braid is designed so that the bioactive fibers are concentrated at the surface of the implant (200) to create a surface comprised of at least 30 % bioactive material, thereby providing enhanced bone ingrowth. The interweaving between the bone bioactive glass or ceramic fibers and the core of structural fibers overcomes the problems found in prior composite systems where the bioactive material delaminates from the polymer. Preferred bioactive materials include calcium phosphate ceramics and preferred structural fibers include carbon fibers. Improved prosthetic implants (200) and methods of affixing an implant (200, are thus also disclosed.

公开(公告)号：EP0849239A1

公开(公告)日：1998-06-24

申请号：EP97204032.3

申请日：1997-12-19

申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO

发明人： Terpstra, Rinse Alle ,  Timmer, Klaas ,  Roman, Yvette Gertrude ,  Meinema, Harmen Anne

IPC分类号： C04B35/447 ,  C04B35/80 ,  A61L27/00

CPC分类号： A61L27/10 ,  C04B35/447 ,  C04B35/803 ,  C04B41/5048 ,  C04B41/52

摘要： The invention relates to a method for manufacturing a fiber-reinforced bioactive ceramic implant, wherein a base form is made from fibrous material and interspaces between the different fibers are filled using chemical vapor phase infiltration. Preferably, a calcium-phosphate compound is brought between the fibers, which are preferably of the continuous-fiber type.

摘要翻译： 本发明涉及一种用于制造纤维增强生物活性陶瓷植入物的方法，其中基体形式由纤维材料制成，并且使用化学气相渗透填充不同纤维之间的间隙。 优选地，在优选为连续纤维型的纤维之间带有磷酸钙化合物。