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    Method and apparatus for determining the bioactivity of biological samples
    81.
    发明公开
    Method and apparatus for determining the bioactivity of biological samples 失效
    用于确定生物样品生物活性的方法和装置

    公开(公告)号：EP0301699A3

    公开(公告)日：1990-02-28

    申请号：EP88305732.5

    申请日：1988-06-23

    Applicant: Utah State University Foundation

    Inventor： Richardson, Gary H.

    IPC: G01N21/51 ,  G01N21/25 ,  G01N33/04 ,  G01N33/15

    CPC classification number: G01N21/4738 ,  C12M41/36 ,  G01N21/25 ,  G01N33/04 ,  G01N2201/0446 ,  G01N2201/122

    Abstract: Methods and apparatus for determining the bioactivity of liquid biological mixtures. The method of the present invention involves obtaining a suitable quantity of liquid biological mixture. Once the sample is obtained, visual spectrum light is directed into the liquid biological mixture and reflectance of the light from the mixture is detected and quantified. The apparatus of the present invention incorporates a microcolorimeter with high energy source as a reflectance detector. The microcolorimeter is able to measure energy in a smaller area, such as 3 to 8 millimeters in diameter, and provide estimates of bioactivity in less than 30 minutes to 32 hours, as opposed to the 24 hour to 9 days which is typical of traditional microbiological methods. The method of the present invention could involve continuous measurements by recycling plates past the detector at regular intervals until the end point is detected. Thus, the detector could be fitted with an appropriate incubator environment which would have controlled robotic devices to receive, identify, and position plates for storage, reading and for discard. Data is collected and compared by computer. The computer calculates the desired information on bioactivity. By providing a detector that produces "tristimulus" color values it is possible to use traditional dyes used in microbiological research and testing. Even abandoned dyes could be restored to useful measurement including litmus, methylene blue, and resazurin.

    Multiwell plates containing membrane inserts
    82.
    发明公开
    Multiwell plates containing membrane inserts 失效
    Membran-Einlagen beinhaltendemehrlöchrigePlatte。

    公开(公告)号：EP0296415A2

    公开(公告)日：1988-12-28

    申请号：EP88109232.4

    申请日：1988-06-09

    Applicant: PALL CORPORATION

    Inventor： Matkovich, Vlado I. ,  Degen, Peter J.

    IPC: G01N21/03 ,  G01N21/31

    CPC classification number: G01N33/54366 ,  B01L2200/16 ,  G01N21/03 ,  G01N33/5304 ,  G01N2021/0325 ,  G01N2021/0346 ,  G01N2201/0446 ,  Y10S436/809

    Abstract: A multiwell plate (10) suitable for use in a spec­trometer which uses a vertical beam of light comprising a first plate having a plurality of wells (20) for receiving sample, wherein the wells (20) have transparent bottom sur­faces (30) to allow for the transmission of a vertical beam of light, and a unitary insert (40) comprises a biochemi­cally compatible microporous surface capable of binding biological materials shaped to fit into at least one well (20) of the plate (10) without interfering with the vertical beam of light.

    Abstract translation: 一种适用于使用垂直光束的光谱仪的多孔板（10），其包括具有用于接收样品的多个孔（20）的第一板，其中所述孔（20）具有透明底表面（30）以允许 用于透射垂直光束，并且整体插入物（40）包括能够结合成形为适合板（10）的至少一个孔（20）的生物材料的生物化学相容的微孔表面，而不干扰垂直光 光束。

    Photometric reading device
    83.
    发明公开
    Photometric reading device 失效
    光学读取装置

    公开(公告)号：EP0240219A3

    公开(公告)日：1988-09-14

    申请号：EP87302454

    申请日：1987-03-23

    Applicant: FISONS plc

    Inventor： Bowley, Alan Reginald

    IPC: G01N21/82 ,  G01N21/25

    CPC classification number: G01N21/253 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/0621

    Abstract: A photometric reading device comprises a plurality of reading elements (30), each comprising a light emitting diode and a corresponding photodiode on opposing sides of a sample pathway along which a sample microplate (l0) can travel. The microplate (l0) includes rows of sample wells arranged transverse to the line of relative motion of the microplate (l0) and the reading elements (30). The reading elements (30) are arranged such that, during continuous relative motion of the reading elements (30) and the microplate (l0), the reading elements (30) come into registration sequentially with the wells in the first row of wells in the microplate (l0), then with the wells in the second row of wells, and so on.

    Method for securing of location
    84.
    发明公开
    Method for securing of location 失效
    Verfahren zur Ortssicherung。

    公开(公告)号：EP0182075A2

    公开(公告)日：1986-05-28

    申请号：EP85112856.1

    申请日：1985-10-10

    Applicant: EFLAB OY

    Inventor： Kovanen, Ilkka ,  Kainiemi, Aimo

    IPC: G01N21/25

    CPC classification number: G01N21/253 ,  G01N2021/5984 ,  G01N2201/0446

    Abstract: Method for securing the location of a sample pit (10) in an optical apparatus of measurement. The apparatus is provided with a measurement tip (6), which is lowered partly into the sample pit. Measurement is possible only when the measurement tip is in its lower position.

    Abstract translation: 用于将测试坑（10）的位置固定在测量光学装置中的方法。 该设备设置有测量尖端（6），其部分地降低到样品坑中。 仅当测量尖端处于其较低位置时才能进行测量。

    APPARATUS FOR THE MEASUREMENT OF FLUORESCENCE
    85.
    发明公开
    APPARATUS FOR THE MEASUREMENT OF FLUORESCENCE 失效
    用于测量荧光。

    公开(公告)号：EP0088781A1

    公开(公告)日：1983-09-21

    申请号：EP82902816.0

    申请日：1982-09-20

    Applicant: EFLAB OY

    Inventor： VIRNES, Martti

    IPC: G01N21

    CPC classification number: G01N21/6452 ,  G01N2021/6473 ,  G01N2201/0446

    Abstract: Appareil de mesure de la fluorescence émise par un échantillon liquide, cet appareil comprenant une source de lumière (1) à partir de laquelle on fait passer la lumière de mesure verticalement au travers d'un système optique (2), d'un monochromateur (3) et au travers de l'échantillon placé dans un plateau à cuvette (4) puis le rayon lumineux de mesure arrive sur un monochromateur de mesure (5) et un détecteur (6). Selon l'invention, pour chaque processus de mesure, la source lumineuse (1), le système optique (2), le monochromateur (3), l'échantillon à mesurer, le monochromateur de mesure (5) et le détecteur (6) peuvent être amenés sur la même ligne droite verticale les uns par rapport aux autres et dans cette séquence.

    OPTICAL SYSTEM AND ASSAY CHIP FOR PROBING, DETECTING, AND ANALYZING MOLECULES
    87.
    发明公开
    OPTICAL SYSTEM AND ASSAY CHIP FOR PROBING, DETECTING, AND ANALYZING MOLECULES 审中-公开
    光学系统和分析芯片用于探测，检测和分析分子

    公开(公告)号：EP3194933A1

    公开(公告)日：2017-07-26

    申请号：EP15753280.5

    申请日：2015-08-07

    Applicant: Quantum-si Incorporated

    Inventor： ROTHBERG, Jonathan M. ,  KABIRI, Ali ,  SICKLER, Jason W. ,  GYARFAS, Brett J. ,  LACKEY, Jeremy ,  SCHMID, Gerard ,  GLENN, Paul E. ,  WEST, Lawrence C. ,  CIPRIANY, Benjamin ,  FIFE, Keith G.

    IPC: G01N21/64 ,  C12Q1/68

    CPC classification number: G01N21/6408 ,  C12Q1/6874 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/648 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2201/0446 ,  G01N2201/062

    Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.

    Abstract translation: 用于分析单个分子并进行核酸测序的装置和方法。 一种装置可以包括测定芯片，其包括多个像素，其中样品阱被配置为接收样品，该样品在被激发时发射发射能量; 至少一个用于在特定方向上引导发射能量的元件; 以及发射能量沿着该光路从样品阱朝向传感器行进。 该设备还包括与测定芯片连接的仪器。 该仪器包括用于激励每个样品孔中的样品的激发光源; 多个传感器对应于样品井。 每个传感器可以检测来自相应样品孔中的样品的发射能量。 该仪器包括至少一个光学元件，该光学元件将来自每个样品阱的发射能量引向多个传感器中的相应传感器。

    USE OF RAMAN SPECTROSCOPY TO MONITOR CULTURE MEDIUM
    88.
    发明公开
    USE OF RAMAN SPECTROSCOPY TO MONITOR CULTURE MEDIUM 审中-公开
    用拉曼光谱用于监测培养基

    公开(公告)号：EP2972238A4

    公开(公告)日：2016-11-16

    申请号：EP14765091

    申请日：2014-03-14

    Applicant: BIOGEN MA INC

    Inventor： MORETTO JUSTIN ,  BERRY BRANDON ,  DOANE ALEX

    IPC: G01N21/65 ,  G01J3/44

    CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2201/0446 ,  G01N2201/06113

    Abstract: In one aspect, the disclosure provides a method of defining a Raman signature of a culture component, the method comprising: obtaining a Raman spectrum of a culture component in a non-interfering or minimally-interfering solution, identifying peaks in the Raman spectrum that are associated with the culture component, obtaining a Raman spectrum of a culture medium comprising the culture component, and, removing peaks of the culture component in the Raman spectrum of the culture medium that are distorted compared to the peaks identified in the Raman spectrum of the culture component in a non-interfering or minimally-interfering solution.

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