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公开(公告)号：EP3505176A1
公开(公告)日：2019-07-03
申请号：EP18203666.5
申请日：2013-03-09
发明人： Bancel, Stephane , Chakraborty, Tirtha , De Fougerolles, Antonin , Elbashir, Sayda M. , John, Matthias , Roy, Atanu , Whoriskey, Susan , Wood, Kristy M. , Hatala, Paul , Schrum, Jason P. , Ejebe, Kenechi , Ellsworth, Jeff Lynn , Guild, Justin
IPC分类号： A61K38/00 , C07K14/47 , C12N15/85 , A61K31/7115 , C12N9/88 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/127 , A61K31/7088 , C07K2/00 , C12N15/117 , C12P21/00 , A61K31/7105 , C12N15/88 , C12N15/00 , A61K38/17 , A61K9/51 , C07K14/495 , C12N9/02 , C07H21/02
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：EP3384938A1
公开(公告)日：2018-10-10
申请号：EP18159455.7
申请日：2012-09-11
CPC分类号： A61K48/005 , A61K45/06 , A61K48/0066 , C07K14/4723 , C12N2320/32
摘要： Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of viruses. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent viral infection, or to improve a subject's health or wellbeing.
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公开(公告)号：EP3052479A4
公开(公告)日：2017-10-25
申请号：EP14850808
申请日：2014-10-02
发明人： CONLEE CHRISTOPHER R , FRALEY ANDREW W , ROY ATANU
IPC分类号： C07D241/00 , A01N43/04 , C07F9/02 , C07H19/00 , C07H19/04
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公开(公告)号：EP3169693A1
公开(公告)日：2017-05-24
申请号：EP15822890.8
申请日：2015-07-16
IPC分类号： C07H21/02
CPC分类号： C07K14/535 , C07H21/02
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of chimeric polynucleotide molecules, which allow for customized placement, position and percent load of chemical modifications, which improve, alter or optimize certain physicochemical and pharmaceutical properties of the polynucleotides. In one non-limiting embodiment, such chimeric polynucleotides take the form or function as modified mRNA molecules which encode a polypeptide of interest. In one embodiment, such chimeric polynucleotides are substantially noncoding.
摘要翻译： 本发明涉及用于制备，制造和治疗用途的嵌合多核苷酸分子的组合物和方法，其允许改善，改变或优化多核苷酸的某些物理化学和药学性质的化学修饰的定制位置，位置和负载百分比。 在一个非限制性实施方案中，此类嵌合多核苷酸采取形式或功能作为编码感兴趣多肽的经修饰的mRNA分子。 在一个实施方案中，此类嵌合多核苷酸基本上是非编码的。
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公开(公告)号：EP3043826A4
公开(公告)日：2017-05-24
申请号：EP14843848
申请日：2014-09-12
CPC分类号： A61K48/0066 , A61K9/0019 , A61K31/198 , A61K31/401 , A61K31/405 , A61K31/4172 , A61K38/00
摘要： The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides formulations containing amino acids.
摘要翻译： 本发明涉及用于制备，制造和治疗使用含有氨基酸的多核苷酸制剂的组合物和方法。
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公开(公告)号：EP3157573A2
公开(公告)日：2017-04-26
申请号：EP15809963.0
申请日：2015-06-19
发明人： ROY, Atanu , CONLEE, Christopher R. , DE FOUGEROLLES, Antonin , FRALEY, Andrew W. , BUTORA, Gabor , STANTON, Matthew
CPC分类号： A61K48/0066 , C07D239/54 , C07D405/04 , C07D473/16 , C07D473/18 , C07D473/30 , C07D473/34 , C07D473/38 , C07D473/40 , C07D487/04 , C07D487/16 , C07D498/22 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07H19/06 , C07H19/067 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/167 , C07H19/20 , C07H19/23 , C07H21/02 , C12N15/11 , C12N15/67 , C12N15/87 , C12N2310/334 , C12N2310/3341 , C12N2310/335
摘要： The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
摘要翻译： 本公开提供了可替代的核苷，核苷酸和核酸，以及使用它们的方法。
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7.发明公开
公开(公告)号：EP3053585A1
公开(公告)日：2016-08-10
申请号：EP16158226.7
申请日：2014-06-19
IPC分类号： A61K31/7088 , C12N15/85
CPC分类号： C07H21/02 , A61K9/5123 , A61K31/7115 , C12N15/85
摘要： The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
摘要翻译： 本公开提供了替代核苷，核苷酸和核酸，以及使用它们的方法。
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公开(公告)号：EP3052479A2
公开(公告)日：2016-08-10
申请号：EP14850808.8
申请日：2014-10-02
IPC分类号： C07D241/00 , C07F9/02 , A01N43/04 , C07H19/00 , C07H19/04
摘要： The present disclosure provides alternative nucleosides, nucleotides, and polynucleotides, and methods of use thereof.
摘要翻译： 本公开提供替代核苷，核苷酸和多核苷酸及其使用方法。
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公开(公告)号：EP3041938A1
公开(公告)日：2016-07-13
申请号：EP14766338.9
申请日：2014-09-03
CPC分类号： C07K14/535 , A61K48/00 , C12N15/63 , C12N15/67
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of circular polynucleotides.
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公开(公告)号：EP2834358A4
公开(公告)日：2016-03-09
申请号：EP13772943
申请日：2013-03-09
发明人： BANCEL STEPHANE , CHAKRABORTY TIRTHA , DE FOUGEROLLES ANTONIN , ELBASHIR SAYDA M , JOHN MATTHIAS , ROY ATANU , WHORISKEY SUSAN , WOOD KRISTY M , HATALA PAUL , SCHRUM JASON P , EJEBE KENECHI , ELLSWORTH JEFF LYNN , GUILD JUSTIN
IPC分类号： A61K48/00 , A61K9/127 , A61K31/7115 , A61K38/17 , A61K38/45 , C07K14/435 , C07K14/47 , C07K14/485 , C07K14/705 , C12N9/10 , C12N9/16 , C12N9/24 , C12N9/42 , C12N9/64 , C12N9/88 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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