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    ANTITUMOR AGENTS
    7.
    发明公开
    ANTITUMOR AGENTS 有权
    ANTITUMORALE MITTEL

    公开(公告)号：EP1407784A4

    公开(公告)日：2006-12-13

    申请号：EP02738789

    申请日：2002-06-24

    申请人： AJINOMOTO KK

    发明人： NIHEI YUKIO ,  MORINAGA YOSHIHIRO ,  SUZUKI MANABU ,  SUGA YASUYO

    IPC分类号： A61K45/06 ,  A61K45/08 ,  A61P35/00

    CPC分类号： A61K31/05 ,  A61K31/167 ,  A61K31/573 ,  A61K45/06 ,  A61K2300/00

    摘要： Antitumor agents with a combined use of a tublin polymerization inhibitor having an antitumor activity with an antiinflammatory agent. These two active ingredients may be contained in a single preparation. Alternatively, two preparations containing the respective ingredients to be administered separately may be combined with each other. In case of using a tublin polymerization inhibitor as the active ingredient of an antitumor agent, the toxicity of the tublin polymerization inhibitor at the pharmaceutically effective dose can be largely relieved while maintaining the pharmaceutically effective dose and the fatal dose can be increased to thereby broaden the safety range. Moreover, antitumor methods (treatment methods for the treatment, improvement, inhibition of progress, prevention, etc. of tumor in vivo), use of the above two active ingredients in drugs such as antitumor agents, and combined use of the above two active ingredients as drugs such as antitumor agents either simultaneously or separately.

    摘要翻译： 结合使用具有抗肿瘤活性的tublin聚合抑制剂和抗炎剂的抗肿瘤剂。 这两种活性成分可以包含在单一制剂中。 或者，含有待分别给药的各种成分的两种制剂可彼此组合。 在使用tublin聚合抑制剂作为抗肿瘤剂的活性成分的情况下，可以大大缓解药学有效量的tublin聚合抑制剂的毒性，同时维持药物有效剂量并且可以增加致命剂量从而扩大 安全范围。 此外，还可以使用上述两种有效成分在抗肿瘤剂等药物中的用途，以及上述两种有效成分的组合使用方法（肿瘤的治疗，改善，抑制进展，预防等的治疗方法） 作为药物如抗肿瘤剂同时或分开。