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    VERFAHREN ZUR HERSTELLUNG N-HETEROZYKLISCHER OPTISCH AKTIVER ALKOHOLE
    7.
    发明公开
    VERFAHREN ZUR HERSTELLUNG N-HETEROZYKLISCHER OPTISCH AKTIVER ALKOHOLE 审中-公开
    METHOD FOR PRODUCING N-杂环的光学活性醇

    公开(公告)号：EP2643467A1

    公开(公告)日：2013-10-02

    申请号：EP11784705.3

    申请日：2011-11-22

    申请人： BASF SE

    发明人： SCHNEIDER, Nina ,  BONNEKESSEL, Melanie ,  BREUER, Michael ,  DÄUWEL, Jürgen ,  DITRICH, Klaus ,  KARL, Ulrich ,  STÄB, Tobias

    IPC分类号： C12P7/22 ,  C12N9/04

    CPC分类号： C12N9/0006 ,  C07D211/22 ,  C07D213/30 ,  C12P7/22 ,  C12P17/10 ,  C12P17/12 ,  C12P41/002

    摘要： Method for producing N-heterocyclic optically active alcohols of the formula (I), where R
    1 represents alkyl groups which in turn can be monosubstituted or polysubstituted by alkyl, halogen, SH.SR
    3 , OH, OR
    3 , NO
    2 , CN, CO, COOR
    3 , NR
    3 R
    4 or NR
    3 R
    3 R
    5+ X
    - , where R
    3 , R
    4 and R
    5 independently of one another are H or a low-alkyl or low-alkoxy radical and X
    - is a counterion, R
    2 is N-containing heteroaryl groups which in turn can be monosubstituted or polysubstituted by alkyl, halogen, SH.SR
    3 , OH, OR
    3 , NO
    2 , CN, CO, COOR
    3 , NR
    3 R
    4 or NR
    3 R
    3 R
    5+ X
    - , where R
    3 , R
    4 and R
    5 independently of one another are H or a low-alkyl or low-alkoxy radical and X
    - is a counterion, by reduction of the corresponding ketone, wherein the reduction is carried out using a dehydrogenase having the polypeptide sequence SEQ ID NO: 2 or NO: 4, or having a polypeptide sequence in which up to 25% of the amino acid radicals are modified in comparison with SEQ ID NO: 2 or NO: 4 by deletion, insertion, substitution or a combination thereof.