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公开(公告)号：EP2888351A2
公开(公告)日：2015-07-01
申请号：EP13831449.7
申请日：2013-08-13
发明人： NAESBY, Michael , FOLLY, Christophe , NIELSEN, Curt Aimé Friis , HATSCH, Anaelle , SCHWAB, Markus , ZELDER, Oskar , HAEFNER, Stefan , SCHRÖDER, Hartwig , HOFF, Birgit , MOLT, Andrea , DITRICH, Klaus , BREUER, Michael , HARTMANN, Holger , KÖRBER, Karsten
IPC分类号： C12N1/21 , C12N1/15 , C12N1/16 , C12N15/80 , C12N15/81 , C12N15/31 , C12N15/52 , C12P1/00 , C12P17/10 , C07K14/195 , C07K14/37 , A61K31/48 , C07K16/00
CPC分类号： C12P17/12 , C07D209/90 , C07D487/06 , C07K16/40 , C12N9/0004 , C12N9/001 , C12N9/1007 , C12N9/1085 , C12N9/90 , C12N15/52 , C12P17/10 , C12P17/182 , C12Y205/01
摘要： Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
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2.发明公开GENE CLUSTER FOR BIOSYNTHESIS OF CORNEXISTIN AND HYDROXYCORNEXISTIN 审中-公开基因簇生物合成的Cornexistin和HYDROXYCORNEXISTIN
公开(公告)号：EP2922954A1
公开(公告)日：2015-09-30
申请号：EP13857215.1
申请日：2013-11-13
申请人： BASF SE
发明人： ZELDER, Oskar , HOFF, Birgit , SCHRöDER, Hartwig , MOLT, Andrea , HARTMANN, Holger , DITRICH, Klaus , BREUER, Michael , REINGRUBER, Rüdiger , WEBER, Jakob
IPC分类号： C12N15/11 , C12N15/63 , C12N15/67 , A01N37/00 , C07D307/77
CPC分类号： C12P17/04 , A01N37/42 , A01N37/46 , A01N63/04 , C07D307/93 , C07K14/37 , C12N15/52 , C12N15/67 , C12N15/80
摘要： The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.
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公开(公告)号：EP3080273A1
公开(公告)日：2016-10-19
申请号：EP14869746.9
申请日：2014-12-08
申请人： BASF SE
发明人： SCHRÖDER, Hartwig , HARTMANN, Holger , WANG, Qingzhao , RATANI, Shakir , GUO, Zheyuan , POMPEJUS, Markus
IPC分类号： C12N15/31 , C12N15/52 , C12N15/64 , C12N15/70 , C12N1/21 , C07K14/245 , C12P13/04 , C12P13/06 , C12R1/19
CPC分类号： C12P13/06 , C07K14/245 , C12N1/20 , C12N9/0016 , C12P7/04 , C12P7/46 , C12P7/56 , C12P13/08 , C12P13/20 , C12Y104/01001
摘要： The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
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公开(公告)号：EP3384003A1
公开(公告)日：2018-10-10
申请号：EP16808598.3
申请日：2016-12-02
申请人： BASF SE
CPC分类号： C07K14/37 , C12N1/14 , C12N9/2437 , C12N15/01 , C12N15/80 , C12P19/14 , C12P21/00 , C12P21/02 , C12Q1/34
摘要： The present invention relates to a method of producing a recombinant polypeptide in a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 1 (CLR1) and to express the recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR1 and to the use of this filamentous fungus in the production of a recombinant polypeptide.
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公开(公告)号：EP3390639A1
公开(公告)日：2018-10-24
申请号：EP16809010.8
申请日：2016-12-08
申请人： BASF SE
摘要： The present invention generally relates to the field of fermentation technology and microorganisms useful for such fermentations. The invention also relates to materials including nucleic acids and proteins useful for altering fermentation characteristics of microorganisms, and to microorganisms comprising such nucleic acids and/or proteins.
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公开(公告)号：EP3384002A1
公开(公告)日：2018-10-10
申请号：EP16808597.5
申请日：2016-12-02
申请人： BASF SE
摘要： The present invention relates to a method of producing a recombinant polypeptide a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 2 (CLR2) and to express said recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR2 and the use of this filamentous fungus in the production of a recombinant polypeptide.
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公开(公告)号：EP3303372A2
公开(公告)日：2018-04-11
申请号：EP16728651.7
申请日：2016-06-02
申请人： BASF SE
发明人： WANG, Qingzhao , RATANI, Shakir Siraj , GUO, Zheyuan , SCHROEDER, Hartwig , HARTMANN, Holger , POMPEJUS, Markus
IPC分类号： C07K14/245 , C12N1/20 , C12N15/70 , C12P13/06
CPC分类号： C12P13/06 , C07K14/245 , C12N1/20 , C12N15/70
摘要： Recombinant microorganism for improved production of fine chemicals The present invention relates to a recombinant nucleic acid molecule, a recombinant micro-organism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
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公开(公告)号：EP3052630A1
公开(公告)日：2016-08-10
申请号：EP14847532.0
申请日：2014-09-11
申请人： BASF SE
发明人： SCHRÖDER, Hartwig , HARTMANN, Holger , WANG, Qingzhao , RATANI, Shakir , GUO, Zheyuan , POMPEJUS, Markus
IPC分类号： C12N15/31 , C12N15/52 , C12N15/64 , C12N15/70 , C12N1/21 , C07K14/245 , C12P13/04 , C12P13/06 , C12R1/19
CPC分类号： C12N15/70 , C07K14/245 , C12N9/0036 , C12N9/16 , C12P7/40 , C12P7/46 , C12P7/56 , C12P13/06 , C12P13/08 , C12P13/20
摘要： The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
摘要翻译： 提供了重组核酸分子，重组微生物和生产丙氨酸的方法。 还提供了重组核酸分子或重组微生物用于发酵生产丙氨酸的用途。
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