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公开(公告)号：EP2888351A2
公开(公告)日：2015-07-01
申请号：EP13831449.7
申请日：2013-08-13
发明人： NAESBY, Michael , FOLLY, Christophe , NIELSEN, Curt Aimé Friis , HATSCH, Anaelle , SCHWAB, Markus , ZELDER, Oskar , HAEFNER, Stefan , SCHRÖDER, Hartwig , HOFF, Birgit , MOLT, Andrea , DITRICH, Klaus , BREUER, Michael , HARTMANN, Holger , KÖRBER, Karsten
IPC分类号： C12N1/21 , C12N1/15 , C12N1/16 , C12N15/80 , C12N15/81 , C12N15/31 , C12N15/52 , C12P1/00 , C12P17/10 , C07K14/195 , C07K14/37 , A61K31/48 , C07K16/00
CPC分类号： C12P17/12 , C07D209/90 , C07D487/06 , C07K16/40 , C12N9/0004 , C12N9/001 , C12N9/1007 , C12N9/1085 , C12N9/90 , C12N15/52 , C12P17/10 , C12P17/182 , C12Y205/01
摘要： Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
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2.发明公开
公开(公告)号：EP3714959A1
公开(公告)日：2020-09-30
申请号：EP19166238.6
申请日：2019-03-29
申请人： BASF SE
发明人： WEINGARTEN, Melanie , IFFLAND, Gabriele , SA GOMES, Pedro , PUHL, Michael , SIEGEL, Wolfgang , GARELLA, Linda , COOPER, Bryan , MUELLER, Patric , ZELDER; Oskar , SCHRÖDER, Hartwig
摘要： The present invention relates to an improved process for isolating aliphatic, mono- or polycyclic small molecules, in particular, Cycloclavine or Cornexistin and/or Hydroxycornexistin, from the aqueous fermentation broth of a eukaryotic microorganism. Said process comprises contacting a liquid phase of said fermentation broth containing said active ingredient with a suitable adsorbent, desorbing said active ingredient from said adsorbent, optionally performing a second chromatographic purification step, and isolating the active ingredient in substantially pure form. The thus obtained purified small molecules may be further used in biocidal, i.p. insecticidal or herbicidal compositions.
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公开(公告)号：EP3052630A1
公开(公告)日：2016-08-10
申请号：EP14847532.0
申请日：2014-09-11
申请人： BASF SE
发明人： SCHRÖDER, Hartwig , HARTMANN, Holger , WANG, Qingzhao , RATANI, Shakir , GUO, Zheyuan , POMPEJUS, Markus
IPC分类号： C12N15/31 , C12N15/52 , C12N15/64 , C12N15/70 , C12N1/21 , C07K14/245 , C12P13/04 , C12P13/06 , C12R1/19
CPC分类号： C12N15/70 , C07K14/245 , C12N9/0036 , C12N9/16 , C12P7/40 , C12P7/46 , C12P7/56 , C12P13/06 , C12P13/08 , C12P13/20
摘要： The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
摘要翻译： 提供了重组核酸分子，重组微生物和生产丙氨酸的方法。 还提供了重组核酸分子或重组微生物用于发酵生产丙氨酸的用途。
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4.发明公开GENETICALLY MODIFIED MICROORGANISMS CAPABLE OF PRODUCING BETA-GLUCANS AND METHODS FOR PRODUCING BETA-GLUCANS 审中-公开基因修饰的β-葡聚糖的微生物及其制备方法β-葡聚糖
公开(公告)号：EP2870239A1
公开(公告)日：2015-05-13
申请号：EP13734062.6
申请日：2013-07-03
申请人： Wintershall Holding GmbH , BASF SE
发明人： BROCKMANN, Beata , HEROLD, Andrea , ZELDER, Oskar , HAEFNER, Stefan , FLECK, Christian , SCHRÖDER, Hartwig , GRANSTRÖM, Mari , SCHMIDT, Julia, Kristiane
CPC分类号： C12P19/04 , C12N9/1051 , C12Y204/01034
摘要： The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that said genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-&bgr;-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-&bgr;-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-&bgr;-D-glucan synthase-activity or the use of such a polypeptide for producing &bgr;-glucans. Furthermore, the present invention relates to methods for producing &bgr;-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-&bgr;-D-glucan synthase-activity thereby increasing the expression of said polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-&bgr;-D-glucan synthase-activity into a microorganism being able to synthesize &bgr;-glucans.
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公开(公告)号：EP2396401A1
公开(公告)日：2011-12-21
申请号：EP10708150.7
申请日：2010-02-12
申请人： BASF SE
发明人： SCHRÖDER, Hartwig , HAEFNER, Stefan , ABENDROTH, Gregory von , HOLLMANN, Rajan , RADDATZ, Aline , ERNST, Hansgeorg , GURSKI, Hans
CPC分类号： C12P7/46 , C12N1/32 , C12N9/1029 , C12R1/01 , C12Y203/01054
摘要： The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.
摘要翻译： 本发明涉及能够利用甘油作为发酵生产琥珀酸的碳源的细菌菌株，其中所述菌株被遗传修饰，使得它们包含其内源性丙酮酸 - 甲酸裂解酶活性的失调，以及 涉及通过利用这种微生物生产有机酸，特别是琥珀酸的方法。 本发明还涉及通过阳离子交换层析对所生产的有机酸的下游加工。
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公开(公告)号：EP2240594A1
公开(公告)日：2010-10-20
申请号：EP09708144.2
申请日：2009-02-04
申请人： BASF SE
摘要： The present invention relates to a novel method for the fermentative production of dipicolinate by cultivating a recombinant microorganism expressing an enzyme having dipicolinate synthetase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as a method of preparing polyester or polyamide copolymers making use of dipicolinate as obtained by fermentative production.
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8.发明公开USE OF A BACILLUS METI GENE TO IMPROVE METHIONINE PRODUCTION IN MICROORGANISMS 审中-公开使用芽孢杆菌METI基因增加MICRO-蛋氨酸
公开(公告)号：EP1907557A2
公开(公告)日：2008-04-09
申请号：EP06800083.5
申请日：2006-07-18
申请人： BASF SE
发明人： ZELDER, Oskar , HEROLD, Andrea , KLOPPROGGE, Corinna , SCHRÖDER, Hartwig , YOCUM, R., Rogers , WILLIAMS, Mark, K.
CPC分类号： C12P13/12 , C07K14/32 , C07K14/34 , C12P3/00 , C12P5/023 , C12P7/04 , C12P7/06 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/28 , C12P7/48 , C12P7/52 , C12P7/54 , C12P7/56 , C12P13/04 , C12P23/00 , Y02E50/10 , Y02E50/17 , Y02E50/343
摘要： The present invention pertains to improved microorganisms and methods for the production of methionine and other sulfur containing fine chemicals using the metl gene from Bacillus subtilis or a gene related to metI. In some embodiments of the present invention, the metI gene or another gene is integrated in a fashion that allows for co-production of a water soluble compound such as methionine or other amino acid and a caortenoid compound.
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公开(公告)号：EP3102675B1
公开(公告)日：2019-03-27
申请号：EP15709418.6
申请日：2015-02-02
申请人： BASF SE
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10.发明公开IMPROVED MICROORGANISMS FOR SUCCINIC ACID PRODUCTION 审中-公开VERBESSERTE MIKROORGANISMENFÜRDIE PRODUKTION VONBERNSTEINSÄURE
公开(公告)号：EP3102675A1
公开(公告)日：2016-12-14
申请号：EP15709418.6
申请日：2015-02-02
申请人： BASF SE
发明人： KRAWCZYK, Joanna Martyna , HAEFNER, Stefan , SCHRÖDER, Hartwig , DANTAS COSTA, Esther , ZELDER, Oskar , VON ABENDROTH, Gregory , WITTMANN, Christoph , STELLMACHER, René , BECKER, Judith , LANGE, Anna , LYONS, Benjamin J. , LYONS, Thomas J. , DE CRECY, Eudes , HUGHES, Ewa
CPC分类号： C12N9/1205 , C12N15/52 , C12P7/46 , C12Y207/0104
摘要： The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
摘要翻译： 本发明涉及与其野生型相比具有由pykA基因编码的酶的活性降低的修饰微生物。 本发明还涉及有机化合物的制造方法和改性微生物的使用。
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