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1.发明授权
公开(公告)号：EP0904262B1
公开(公告)日：2004-04-21
申请号：EP97903805.6
申请日：1997-01-13
发明人： BILLER, Scott, A. , DICKSON, John, K. , LAWRENCE, R., Michael , MAGNIN, David, R. , POSS, Michael, A. , ROBL, Jeffrey, A. , SLUSARCHYK, William, A. , SULSKY, Richard, B. , TINO, Joseph, A.
IPC分类号： C07C217/04 , C07D471/04 , C07D471/10 , C07D233/78 , C07D401/08 , C07D403/08 , A61K31/24 , A61K31/445 , A61K31/415 , A61K31/44 , A61K31/47
CPC分类号： C07F7/1856 , A61K31/191 , A61K31/366 , A61K31/404 , A61K31/4468 , C07C17/093 , C07C47/453 , C07C49/563 , C07C49/567 , C07C49/573 , C07C69/00 , C07C205/11 , C07C205/43 , C07C205/55 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/62 , C07C233/63 , C07C233/78 , C07C235/40 , C07C235/56 , C07C237/22 , C07C237/24 , C07C255/41 , C07C259/08 , C07C271/22 , C07C291/04 , C07C311/19 , C07C311/21 , C07C311/37 , C07C311/42 , C07C311/46 , C07C317/12 , C07C321/22 , C07C323/60 , C07C2601/02 , C07C2601/14 , C07C2603/00 , C07C2603/18 , C07C2603/32 , C07C2603/74 , C07D207/335 , C07D207/38 , C07D209/08 , C07D209/16 , C07D209/34 , C07D209/38 , C07D209/46 , C07D209/48 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/89 , C07D221/16 , C07D231/56 , C07D233/24 , C07D233/64 , C07D233/84 , C07D233/88 , C07D233/90 , C07D235/06 , C07D235/08 , C07D235/16 , C07D235/24 , C07D235/26 , C07D235/28 , C07D235/30 , C07D239/38 , C07D239/42 , C07D239/47 , C07D249/12 , C07D249/14 , C07D249/18 , C07D253/07 , C07D263/38 , C07D263/46 , C07D263/58 , C07D271/07 , C07D277/36 , C07D277/56 , C07D277/74 , C07D285/08 , C07D285/125 , C07D295/108 , C07D295/155 , C07D295/185 , C07D307/14 , C07D311/84 , C07D317/30 , C07D317/58 , C07D319/06 , C07D327/06 , C07D333/20 , C07D335/14 , C07D401/12 , C07D403/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07C25/22
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公开(公告)号：EP3580232A1
公开(公告)日：2019-12-18
申请号：EP18708002.3
申请日：2018-02-08
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公开(公告)号：EP3383860A1
公开(公告)日：2018-10-10
申请号：EP16813199.3
申请日：2016-12-02
IPC分类号： C07D401/14 , C07D401/10 , C07D403/06 , C07D403/10 , C07D239/54 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/14 , A61K31/513 , A61P9/10 , A61P9/12 , A61P9/04
CPC分类号： C07D403/06 , C07D239/54 , C07D401/10 , C07D401/14 , C07D403/10 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/14
摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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4.发明公开IMIDAZOTHIADIAZOLE AND IMIDAZOPYRIDAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION 有权IMIDAZOTHIADIAZOL-和咪唑并哒嗪衍生物作为蛋白酶活化受体4（PAR4）抑制剂用于治疗血小板聚集
公开(公告)号：EP2855489A1
公开(公告)日：2015-04-08
申请号：EP13719360.3
申请日：2013-04-24
发明人： PRIESTLEY, Eldon Scott , POSY, Shoshana L. , TREMBLAY, Francois , MARTEL, Alain , MARINIER, Anne , MILLER, Michael, M. , LAWRENCE, R., Michael
IPC分类号： C07D519/00 , A61K31/433 , A61K31/4439 , C07D513/04 , A61K31/5025 , C07D487/04 , A61P7/02
CPC分类号： C07D513/04 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K38/12 , C07D487/04
摘要： The present invention provides imidazothiadiazole compounds of Formula (I); Wherein W,Y, R
0 , R
2 , R
4 , R
a , R
b , X
1 , X
2 , X
3 and X
4 are as defined herein,, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.-
5.发明授权IMIDAZOTHIADIAZOLE AND IMIDAZOPYRIDAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION 有权IMIDAZOTHIADIAZOL-和咪唑并哒嗪衍生物作为蛋白酶活化受体4（PAR4）抑制剂用于治疗血小板聚集
公开(公告)号：EP2855489B1
公开(公告)日：2017-01-04
申请号：EP13719360.3
申请日：2013-04-24
发明人： PRIESTLEY, Eldon Scott , POSY, Shoshana L. , TREMBLAY, Francois , MARTEL, Alain , MARINIER, Anne , MILLER, Michael, M. , LAWRENCE, R., Michael
IPC分类号： C07D519/00 , A61K31/433 , A61K31/4439 , C07D513/04 , A61K31/5025 , C07D487/04 , A61P7/02
CPC分类号： C07D513/04 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K38/12 , C07D487/04
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公开(公告)号：EP1706398B1
公开(公告)日：2014-05-21
申请号：EP05711663.4
申请日：2005-01-20
发明人： HERPIN, Timothy, F. , MORTON, George, C. , REHFUSS, Robert, P. , LAWRENCE, R., Michael , POSS, Michael, A. , ROBERGE, Jacques, Y. , GUNGOR, Timur
IPC分类号： C07D401/12 , C07D413/12 , C07D409/14 , C07D401/14 , C07D491/04 , C07D417/12 , C07D405/14 , C07D235/30 , C07D471/04 , C07D417/14 , C07D513/04 , C07D413/14 , C07D409/12 , A61K31/4184 , A61K31/423
CPC分类号： C07D401/12 , C07D235/30 , C07D401/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/04 , C07D513/04
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公开(公告)号：EP0886637B9
公开(公告)日：2005-05-04
申请号：EP96903604.5
申请日：1996-02-01
发明人： WETTERAU, John, R. II , SHARP, Daru, Young , GREGG, Richard, E. , BILLER, Scott, A. , DICKSON, John, A. , LAWRENCE, R., Michael , MAGNIN, David, R. , POSS, Michael, A. , ROBL, Jeffrey, A. , SULSKY, Richard, B. , TINO, Joseph, A. , LAWSON, John, E. , HOLAVA, Henry, M. , PARTYKA, Richard, A.
IPC分类号： C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D211/58 , A61K31/445
CPC分类号： C07D401/04 , C07D211/58 , C07D211/60 , C07D211/94 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D419/12 , G01N2800/044
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公开(公告)号：EP0886637B1
公开(公告)日：2004-12-01
申请号：EP96903604.5
申请日：1996-02-01
发明人： WETTERAU, John, R. II , SHARP, Daru, Young , GREGG, Richard, E. , BILLER, Scott, A. , DICKSON, John, A. , LAWRENCE, R., Michael , MAGNIN, David, R. , POSS, Michael, A. , ROBL, Jeffrey, A. , SULSKY, Richard, B. , TINO, Joseph, A. , LAWSON, John, E. , HOLAVA, Henry, M. , PARTYKA, Richard, A.
IPC分类号： C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D211/58 , A61K31/445
CPC分类号： C07D401/04 , C07D211/58 , C07D211/60 , C07D211/94 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D419/12 , G01N2800/044
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9.发明公开COMPOUNDS USEFUL AS MODULATORS OF MELANOCORTIN RECEPTORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME 审中-公开用作黑皮质素合适的化合物的调节剂和含有药物组合物
公开(公告)号：EP1363898A1
公开(公告)日：2003-11-26
申请号：EP02723310.5
申请日：2002-03-02
发明人： YU, Guixue , MACOR, John, , HERPIN, Timothy , LAWRENCE, R., Michael , MORTON, George, C. , RUEL, Rejean , POINDEXTER, Graham, S. , RUEDIGER, Edward, H. , THIBAULT, Carl
IPC分类号： C07D401/00 , A61K31/445
CPC分类号： C07D401/12 , A61K38/00 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/10 , C07D487/04 , C07D491/10 , C07D495/04 , C07K5/06139 , C07K5/06191 , Y02A50/411 , Y02A50/463
摘要： Compounds having the formula (I),-NR11R12; G is a novel side chain selected from C2-6alkenyl, A3-aryl, -OR18, heteroaryl, A1-cyano, A2-OR17, A1-C(=O)R18, A1-CO2R18, A1-C(=O)NR18R19, A1-OC(=O)R18, A1-NR18C(=O)R19, A1-OC(=O)NR18R19, A1-NR18CO2R19, A1-NR18SO2R17, A1-SO2R17, A1-NR20C(=O)NR18R19, and A1-SR18; or when y is 0 or when W is not NHR22, G may be A1-heterocyclo, wherein A1 is a bond, C1-6alkylene or C2-alkenylene, A2 is C1-6alkylene or C2-6alkenylene, and A3 is C2-6alkenylene; W is selected from -NR21R22, -OR23, -NR21C(=O)R24, -NR21CO2R24, amidino, guanidino, or a heteroaryl, heterocyclo or C3-7cycloalkyl as defined in the specification, and X and R1 through R24 are as defined in the specification, are effective as modulators of melanocortin-receptors, particularly MC-1R and MC-4R.
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公开(公告)号：EP1358178A2
公开(公告)日：2003-11-05
申请号：EP02717381.4
申请日：2002-01-28
IPC分类号： C07D401/06 , C07D409/14 , C07D413/14 , C07D417/14 , C07D401/14 , C07D211/56 , C07D409/12 , C07D471/08 , C07D405/12 , C07D491/08 , A61K31/4545 , A61P7/02
CPC分类号： C07D211/56 , C07D401/06 , C07D401/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D491/08
摘要： Sulfonamide lactams of the formula (I) wherein X, R?1, R2, R3, R4, R4a, R5, R5a, R6, R6a, R7 and R8¿ are as described herein, are provided which inhibitors of Factor Xa and are useful as anticoagulants in the treatment of cardiovascular diseases associated with thromboses.
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