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    LYMPHOCYTIC ACTIVATION INHIBITOR AND REMEDIAL AGENT FOR AUTOIMMUNE DISEASE
    7.
    发明公开
    LYMPHOCYTIC ACTIVATION INHIBITOR AND REMEDIAL AGENT FOR AUTOIMMUNE DISEASE 审中-公开
    LYMPHOZYTEN-AKTIVIERUNGSHEMMER在MITTEL ZUR BEHANDLUNG VON AUTOIMMUNKRANKHEITEN

    公开(公告)号：EP1430894A1

    公开(公告)日：2004-06-23

    申请号：EP02798032.5

    申请日：2002-09-05

    申请人： Eisai Co. Ltd

    发明人： HANADA, Takahisa ,  YAMAUCHI, Toshihiko ,  CHIBA, Kenichi ,  OWA, Takashi ,  HIDA, Takayuki ,  MIYAMOTO, Norimasa

    IPC分类号： A61K31/404 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K45/00 ,  A61P1/00 ,  A61P1/02 ,  A61P3/10 ,  A61P5/50 ,  A61P19/02 ,  A61P19/04 ,  A61P25/00 ,  A61P27/02

    CPC分类号： A61K31/4439 ,  A61K31/404 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/437 ,  A61K45/06

    摘要： A lymphocyte activation inhibitor and a therapeutic agent for an autoimmune disease, each comprising, as an active ingredient, a sulfonamide derivative or sulfonic acid ester derivative represented by the following general formula (I):
    wherein the ring A represents a monocyclic or bicyclic aromatic ring which may be substituted,
    the ring B represents a 6-membered unsaturated hydrocarbon ring or a 6-membered unsaturated heterocyclic ring containing one nitrogen atom as a heteroatom, each of which may be substituted,
    the ring C represents a 5-membered heterocyclic ring containing one or two nitrogen atoms, which may be substituted,
    W represents a single bond or -CH=CH-,
    X represents -N(R 1 )- or an oxygen atom,
    Y represents a carbon atom or a nitrogen atom,
    Z represents -N(R 2 )- or a nitrogen atom, and
    R 1 and R 2 may be identical or different and each represents a hydrogen atom or a lower alkyl group, or a pharmacologically acceptable salt thereof, or a hydrate thereof.

    摘要翻译： 淋巴细胞活化抑制剂和自身免疫性疾病的治疗剂，各自包含作为活性成分的由以下通式（I）表示的磺酰胺衍生物或磺酸酯衍生物：，其中环A表示单环或 可以被取代的双环芳环，环B表示含有一个氮原子作为杂原子的6元不饱和烃环或6元不饱和杂环，其各自可以被取代，环C表示5元环 含有一个或两个氮原子的可以被取代的杂环W表示单键或-CH = CH-，X表示-N（R 1） - 或氧原子，Y表示碳原子或氮 原子，Z表示-N（R 2） - 或氮原子，R 1和R 2可以相同或不同，各自表示氢原子或低级烷基，或药理学上可接受的盐 或其水合物。

    FUSED HETEROTRICYCLIC COMPOUNDS, PROCESS FOR PREPARING THE COMPOUNDS AND DRUGS CONTAINING THE SAME
    8.
    发明公开
    FUSED HETEROTRICYCLIC COMPOUNDS, PROCESS FOR PREPARING THE COMPOUNDS AND DRUGS CONTAINING THE SAME 有权
    ANNE内衬杂环，法制造化合物和药物含

    公开(公告)号：EP1238979A1

    公开(公告)日：2002-09-11

    申请号：EP00983479.7

    申请日：2000-12-13

    申请人： Eisai Co., Ltd.

    发明人： HIBI, Shigeki ,  HOSHINO, Yorihisa ,  YOSHIUCHI, Tatsuya ,  SHIN, Kogyoku ,  KIKUCHI, Kouichi ,  SOEJIMA, Motohiro ,  TABATA, Mutsuko ,  TAKAHASHI, Yoshinori ,  SHIBATA, Hisashi ,  HIDA, Takayuki ,  HIRAKAWA, Tetsuya ,  INO, Mitsuhiro

    IPC分类号： C07D487/14 ,  C07D471/14 ,  C07D473/02 ,  C07D495/14 ,  A61K31/437 ,  A61K31/519 ,  A61P1/04 ,  A61P1/08 ,  A61P1/10 ,  A61P1/12 ,  A61P1/14 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00

    CPC分类号： C07D471/14 ,  C07D487/14 ,  C07D491/14

    摘要： The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof.
    Wherein A, B and D are the same as or different from each other and each represents a group represented by the formula - (CR 1 R 2 ) m - (wherein R 1 and R 2 are the same as or different from each other and each represents a C 1-6 alkyl group etc.), -NR 3 - (wherein R 3 represetns hydrogen etc.) etc.; E and G are the same as or different from each other and each represents a group represented by the formula - (CR 6 R 7 ) p - (wherein R 6 and R 7 are the same as or different from each other and each represents hydrogen etc.; and p represents an integer of 0, 1 or 2); J represents a carbon atom or nitrogen atom, each substituted with C 1-6 alkyl group optionally substituted with a halogen atom, etc.; K and L are the same as or different from each other and each represents carbon atom or nitrogen atom; M means hydrogen, a halogen atom, an optionally substituted C 1-6 alkyl group etc.; and the partial structure ----- means a single or double bond.

    摘要翻译： 本发明提供具有优异的促肾上腺皮质激素释放因子受体拮抗作用的新型化合物。 即，它提供了由下式表示的化合物，其药理学上可接受的盐或其水合物。 其中A，B和D是相同或不同的海誓山盟并且每个darstellt由下式表示的基团 - （CR <1> [R <2>）米（worin - [R <1>和R <2 >是相同的或从海誓山盟不同，并且各自darstellt C 1-6烷基等），-NR <3> - （worin - [R <3> represetns氢等），等; E和G是相同的或从海誓山盟不同，并且各自darstellt由下式表示的基团 - （CR <6> - [R <7>）对 - （worin - [R <6>和R <7>是相同的或 从彼此，并且每个darstellt氢等不同;并且p darstellt为0的整数，1或2）; Ĵdarstellt一个碳原子或氮原子，各自具有substituiertem C1-6烷基被卤原子等OPTIONALLY substituiertem。 K和L是相同的或从海誓山盟不同，并且各自darstellt碳原子或氮原子; M表示氢，卤原子，以任选substituiertem C 1-6烷基等; 与该部分结构-----表示单键或双键。