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    A micro-reactor for observing particles in a fluid
    1.
    发明公开
    A micro-reactor for observing particles in a fluid 审中-公开
    用于观察流体中的微粒的微反应器

    公开(公告)号：EP2322271A1

    公开(公告)日：2011-05-18

    申请号：EP10188635.6

    申请日：2010-10-25

    申请人： FEI COMPANY ,  Stichting Het Nederlands Kanker Instituut

    发明人： Van Veen, Gerard ,  Dona, Pleun ,  De Jong, Frank ,  Peters, Jacobus

    IPC分类号： B01J19/00 ,  B01L3/00 ,  H01J37/20

    CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00905 ,  B01J2219/0097 ,  B01L3/502761 ,  B01L7/54 ,  B01L2200/0668 ,  B01L2300/0822 ,  B01L2400/0415 ,  B01L2400/0439 ,  B01L2400/0442 ,  B01L2400/0487 ,  G01N2021/058 ,  H01J37/20 ,  H01J37/26 ,  H01J2237/2004 ,  Y10T436/143333

    摘要： The invention relates to a micro-reactor (100) for observing small particles, cells, bacteria, viruses or protein molecules in a fluid. The micro-reactor shows a first channel (106) formed between two layers (102, 104) for containing the fluid, with an inlet (112) and an outlet (114), the two layers separated by a first distance. A likewise second channel (108) with an inlet (118) and an outlet (116) is placed adjacent to the first channel. A gap connects the first channel and the second channel, at the gap at least one layer showing a window (120) transparent to the method of inspection and at the window the two layers being separated by a very small distance of, for example, 1 µm or less.
    The micro-reactor may be used with an optical microscope (in which all particles are in focus), inspection with a Scanning Transmission Electron Microscope (in which the range of the electrons is limited), inspection with soft X-rays in the 250-500 eV range (also showing a limited range), etc.
    A method of using the micro-reactor includes applying a gradient over the gap, thereby causing the particles to cross the gap. The gradient may be static or dynamic, and may be a gradient in concentration, of a chemical or biological material, in pressure, in temperature, in electric potential, or in magnetic field. By detecting a property of the particles upstream in the first channel, e.g. using fluorescent labels on the particles, and then applying a pressure burst over the channels when the property meets certain preset criteria, only selected particles can be placed in the gap.

    摘要翻译： 本发明涉及用于观察流体中的小颗粒，细胞，细菌，病毒或蛋白质分子的微反应器（100）。 微反应器示出在两个层（102,104）之间形成的用于容纳流体的第一通道（106），其具有入口（112）和出口（114），这两层分开第一距离。 同样具有入口（118）和出口（116）的第二通道（108）与第一通道相邻放置。 间隙连接第一通道和第二通道，在间隙中至少一层显示对检查方法透明的窗口（120），并且在窗口处两层间隔非常小的距离，例如1 μm或更小。 微反应器可以与光学显微镜一起使用（其中所有颗粒都聚焦），使用扫描透射电子显微镜（其中电子范围受限）检查，使用软X射线在250- 500eV范围（也显示有限的范围）等。使用微反应器的方法包括在间隙上施加梯度，由此导致颗粒穿过间隙。 梯度可以是静态的或动态的，并且可以是浓度，化学或生物材料，压力，温度，电势或磁场中的梯度。 通过检测第一通道中上游颗粒的特性，例如， 在颗粒上使用荧光标记，然后当性质符合某些预设标准时在通道上施加压力脉冲，只有选定的颗粒可以放置在间隙中。

    VACUUM COMPATIBLE X-RAY SHIELD
    2.
    发明公开
    VACUUM COMPATIBLE X-RAY SHIELD 审中-公开

    公开(公告)号：EP4184527A2

    公开(公告)日：2023-05-24

    申请号：EP22208535.9

    申请日：2022-11-21

    申请人： FEI Company

    发明人： Dona, Pleun ,  Smit, Casper ,  de Groot, Rients Jan

    IPC分类号： G21F1/00 ,  G21F3/00 ,  H01J37/16

    摘要： Methods and apparatus are disclosed for providing an X-ray shield within an ultra-high vacuum enclosure. A shell is fabricated, leak-tested, filled with an X-ray shielding material, and sealed. An elongated twisted X-ray shield can be deployed within a pump-out channel of an electron microscope or similar equipment. The shield can incorporate lead within a stainless-steel shell, with optional low-Z cladding outside the shell. Further variations are disclosed.

    AXIAL ALIGNMENT ASSEMBLY, AND CHARGED PARTICLE MICROSCOPE COMPRISING SUCH AN ALIGNMENT ASSEMBLY
    3.
    发明公开
    AXIAL ALIGNMENT ASSEMBLY, AND CHARGED PARTICLE MICROSCOPE COMPRISING SUCH AN ALIGNMENT ASSEMBLY 审中-公开

    公开(公告)号：EP3913654A1

    公开(公告)日：2021-11-24

    申请号：EP20175865.3

    申请日：2020-05-20

    申请人： FEI Company

    发明人： Dona, Pleun ,  Smit, Casper Maria

    IPC分类号： H01J37/04 ,  H01J37/14 ,  H01J37/16

    摘要： The invention relates to an axial alignment assembly (100) comprising a first body and a second body. The first body has a substantially cylindrical outer jacket, as well as a first alignment axis. The second body comprises a substantially cylindrical inner jacket, and has a second alignment axis. The second body is positioned with respect to said first body in such a way that said inner jacket faces said outer jacket and in between said inner jacket and said outer jacket a substantially annular recess is formed. The axial alignment assembly further comprises a plurality of resilient elements that are positioned within said annular recess, wherein each resilient element is in contact with said outer jacket of said first body and with said inner jacket of said second body. Each resilient element exerts a force onto said outer jacket and onto said inner jacket for aligning said first alignment axis and said second alignment axis.

    Sample carrier and sample holder
    5.
    发明公开
    Sample carrier and sample holder 审中-公开
    Probenträgerund Probenhalter

    公开(公告)号：EP1863066A1

    公开(公告)日：2007-12-05

    申请号：EP06114632.0

    申请日：2006-05-29

    申请人： FEI COMPANY

    发明人： Dona, Pleun

    IPC分类号： H01J37/20

    CPC分类号： H01J37/20 ,  H01J2237/2801

    摘要： The invention relates to a composite structure of a sample carrier 20 and a sample holder 30 for use in a TEM, for example. The sample carrier is hereby separately embodied from the sample holder. Although such compositions are already known, the known compositions are very fragile constructions. The sample carrier according to the invention can be formed from a strip of metal, and is a simple and cheap element. Using resilient force, it clamps onto or into the sample holder. The portion of the sample holder to which the sample carrier couples also has a simple form. The sample carrier can couple to the sample holder in vacuum using a coupling tool.

    摘要翻译： 本发明涉及例如用于TEM的样品载体20和样品架30的复合结构。 样品载体在此独立于样品架。 虽然这些组合物是已知的，但是已知的组合物是非常脆弱的结构。 根据本发明的样品载体可以由金属条形成，并且是简单且便宜的元件。 使用弹性力，它夹在样品架上或样品架上。 样品载体耦合的样品架的部分也是简单的形式。 样品载体可以使用耦合工具在真空中耦合到样品架。

    LASER-BASED PHASE PLATE IMAGE CONTRAST MANIPULATION
    7.
    发明公开
    LASER-BASED PHASE PLATE IMAGE CONTRAST MANIPULATION 审中-公开

    公开(公告)号：EP3739613A1

    公开(公告)日：2020-11-18

    申请号：EP20174128.7

    申请日：2020-05-12

    申请人： FEI Company

    发明人： Buijsse, Bart ,  Hendriksen, Bastiaan Lambertus Martinus ,  Dona, Pleun

    IPC分类号： H01J37/04 ,  H01J37/28

    摘要： Methods and systems for implementing laser-based phase plate image contrast enhancement are disclosed herein. An example method at least includes forming at least one optical peak in a diffraction plane of an electron microscope, and directing an electron beam through the at least one optical peak at a first location, where the first location determines an amount of phase manipulation the optical peak imparts to an electron of the electron beam.

    A micro-reactor for observing particles in a fluid
    9.
    发明公开
    A micro-reactor for observing particles in a fluid 审中-公开
    Mikroreaktor zur Beobachtung von Partikeln在einerFlüssigkeit

    公开(公告)号：EP2316565A1

    公开(公告)日：2011-05-04

    申请号：EP09174002.7

    申请日：2009-10-26

    申请人： FEI COMPANY

    发明人： Dona, Pleun ,  Van Veen, Gerard ,  Peters, Jacobus ,  De Jong, Alan

    IPC分类号： B01J19/00 ,  B01L3/00 ,  H01J37/20

    CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00905 ,  B01J2219/0097 ,  B01L3/502761 ,  B01L7/54 ,  B01L2200/0668 ,  B01L2300/0822 ,  B01L2400/0415 ,  B01L2400/0439 ,  B01L2400/0442 ,  B01L2400/0487 ,  G01N2021/058 ,  H01J37/20 ,  H01J37/26 ,  H01J2237/2004 ,  Y10T436/143333

    摘要： The invention relates to a micro-reactor (100) for observing small particles, cells, bacteria, viruses or protein molecules in a fluid. The micro-reactor shows a first channel (106) formed between two layers (102, 104) for containing the fluid, with an inlet (112) and an outlet (114), the two layers separated by a first distance. A likewise second channel (108) with an inlet (118) and an outlet (116) is placed adjacent to the first channel. A gap connects the first channel and the second channel, at the gap at least one layer showing a window (120) transparent to the method of inspection and at the window the two layers being separated by a very small distance of, for example, 1 µm or less.
    The micro-reactor may be used with an optical microscope (in which all particles are in focus), inspection with a Scanning Transmission Electron Microscope (in which the range of the electrons is limited), inspection with soft X-rays in the 250-500 eV range (also showing a limited range), etc.
    A method of using the micro-reactor includes applying a gradient over the gap, thereby causing the particles to cross the gap. The gradient may be static or dynamic, and may be a gradient in concentration, of a chemical or biological material, in pressure, in temperature, in electric potential, or in magnetic field. By detecting a property of the particles upstream in the first channel, e.g. using fluorescent labels on the particles, and then applying a pressure burst over the channels when the property meets certain preset criteria, only selected particles can be placed in the gap.

    摘要翻译： 本发明涉及用于在流体中观察小颗粒，细胞，细菌，病毒或蛋白质分子的微反应器（100）。 微反应器示出了形成在用于容纳流体的两个层（102,104）之间的第一通道（106），其具有入口（112）和出口（114），两个层分开第一距离。 具有入口（118）和出口（116）的同样的第二通道（108）被放置成与第一通道相邻。 间隙连接第一通道和第二通道，在间隙处，至少一层显示对于检查方法是透明的窗口（120），并且在窗口处，两层被隔开非常小的距离，例如1 μm以下。 微反应器可以与光学显微镜一起使用（其中所有颗粒都在焦点中），用扫描透射电子显微镜（其中电子的范围被限制）进行检查，在250- 500eV范围（也显示有限范围）等。使用微反应器的方法包括在间隙上施加梯度，从而使颗粒穿过间隙。 梯度可以是静态或动态的，并且可以是化学或生物材料在压力，温度，电位或磁场中的浓度梯度。 通过检测第一通道上游的颗粒的性质，例如， 在颗粒上使用荧光标记，然后当性能达到某些预设标准时，在通道上施加压力突发，只有选定的颗粒才能放置在间隙中。

    Transfer mechanism for transferring a specimen
    10.
    发明公开
    Transfer mechanism for transferring a specimen 审中-公开
    Transfermechanismus zum Transferieren einer Probe

    公开(公告)号：EP1883095A1

    公开(公告)日：2008-01-30

    申请号：EP06117867.9

    申请日：2006-07-26

    申请人： FEI COMPANY

    发明人： Van Gaasbeek, Erik ,  Dona, Pleun ,  Van de Water, Gerbert ,  Van den Oetelaar, Johannes ,  Barends, Paul ,  Van Hees, Ian

    IPC分类号： H01J37/20 ,  H01L21/68 ,  H01L21/687

    CPC分类号： H01J37/20

    摘要： The invention relates to a transfer mechanism for transferring a specimen (2) from a first position in a first holder ( 40 ) to a second position in a second holder ( 10 ) and/or vice versa, each holder ( 10 , 40 ) equipped to detachably hold the specimen, the transfer of the specimen between the holders taking place in a transfer position different from the second position, characterized in that when the specimen is transferred between the holders ( 10 , 40 ) a mechanical guidance mechanism positions the holders with a mutual accuracy higher than the mutual accuracy in the second position, and said mechanical guidance mechanism not positioning at least one of the holders ( 10 , 40 ) when the specimen is in the second position.
    The mechanical guidance mechanism may comprise extra parts ( 50 ).
    At least one of the holders ( 40 ) may be equipped to hold a multitude of specimens.

    摘要翻译： 本发明涉及一种用于将样品（2）从第一保持器（40）中的第一位置转移到第二保持器（10）中的第二位置和/或反之亦然的转移机构，每个保持器（10,40）装备有 为了可拆卸地保持试样，试样在不同于第二位置的转移位置发生的保持器之间的转移，其特征在于，当试样在保持器（10,40）之间转移时，机械引导机构将保持器 相对精度高于第二位置的相互精度，并且当样本处于第二位置时，所述机械引导机构不定位至少一个保持器（10,40）。 机械引导机构可以包括额外的部件（50）。 保持器（40）中的至少一个可以被装备成容纳多个标本。