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1.发明公开
公开(公告)号：EP4168528A1
公开(公告)日：2023-04-26
申请号：EP21825407.6
申请日：2021-06-16
发明人： HAM, Donhee , ABBOTT, Jeffrey, T. , WU, Wenxuan , YE, Tianyang , JUNG, Han, Sae , PARK, Hongkun
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2.发明公开T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF 审中-公开T细胞平衡基因表达，物质组合物及其使用方法
公开(公告)号：EP3262193A2
公开(公告)日：2018-01-03
申请号：EP16714607.5
申请日：2016-02-26
申请人： The Broad Institute Inc. , Massachusetts Institute of Technology , President and Fellows of Harvard College , The Brigham and Women's Hospital, Inc. , The Regents of the University of California
发明人： REGEV, Aviv , KUCHROO, Vijay, K. , GAUBLOMME, Jellert , LEE, Youjin , WANG, Chao , YOSEF, Nir , PARK, Hongkun , KAMINSKI, James
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6881 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , G01N33/5023
摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
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公开(公告)号：EP1421026B1
公开(公告)日：2009-12-16
申请号：EP02802544.3
申请日：2002-07-22
CPC分类号： H01L41/1136 , B82Y30/00 , C01G23/003 , C01G23/006 , C01G25/00 , C01G25/006 , C01G45/1264 , C01P2002/52 , C01P2002/54 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/12 , C01P2004/16 , C01P2004/50 , C01P2004/64 , C01P2006/40 , C04B35/62231 , C04B35/6225 , C04B35/62259 , C04B35/6264 , C04B2235/3208 , C04B2235/3213 , C04B2235/3215 , C04B2235/3227 , C04B2235/3232 , C04B2235/3244 , C04B2235/3262 , C04B2235/3296 , C04B2235/441 , C04B2235/449 , C04B2235/526 , C04B2235/5264 , H01L41/082 , H01L41/094 , H01L41/18 , H03H9/176 , H03H2009/02165 , H03H2009/241
摘要： Nanowires are disclosed which comprise transition metal oxides. The transition metal oxides may include oxides of group II, group III, group IV and lanthanide metals. Also disclosed are methods for making nanowires which comprise injecting decomposition agents into a solution comprising solvents and metallic alkoxide or metallic salt precursors.
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4.发明授权DEVICE CONTANING NANOSENSORS FOR DETECTING AN ANALYTE AND ITS METHOD OF MANUFACTURE 有权设备包含EKENNUNG分析物纳米传感器及其制造方法
公开(公告)号：EP1342075B1
公开(公告)日：2008-09-10
申请号：EP01990181.8
申请日：2001-12-11
发明人： LIEBER, Charles, M. , PARK, Hongkun , WEI, Qingqiao , CUI, Yi , LIANG, Wenjie
CPC分类号： H01L29/0665 , B82Y10/00 , B82Y15/00 , C30B11/00 , C30B25/005 , C30B29/605 , G01N27/4146 , G01N33/54373 , G01N2610/00 , G11C13/0014 , G11C13/0019 , G11C13/04 , G11C2213/17 , G11C2213/81 , H01L23/53276 , H01L29/0669 , H01L29/0673 , H01L29/16 , H01L29/1602 , H01L29/1606 , H01L29/207 , H01L29/267 , H01L51/0048 , H01L2924/0002 , H01L2924/12044 , H01L2924/3011 , Y10S977/762 , Y10S977/957 , H01L2924/00
摘要： Electrical devices comprised of nanowires are described, along with methods of their manufacture and use. The nanowires can be nanotubes and nanowires. The surface of the nanowires may be selectively functionalized. Nanodetector devices are described.
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5.发明公开
公开(公告)号：EP4168316A1
公开(公告)日：2023-04-26
申请号：EP21825487.8
申请日：2021-06-16
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公开(公告)号：EP4105337A1
公开(公告)日：2022-12-21
申请号：EP22175488.0
申请日：2015-09-09
申请人： The Broad Institute, Inc. , President and Fellows of Harvard College , Massachusetts Institute Of Technology
发明人： REGEV, Aviv , MACOSKO, Evan Zane , MCCARROLL, Steven Andrew , SHALEK, Alexander K , BASU, Anindita , FORD, Christopher B , PARK, Hongkun , WEITZ, David A
摘要： The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.
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公开(公告)号：EP3250936B1
公开(公告)日：2019-11-13
申请号：EP16800421.6
申请日：2016-01-29
发明人： KOLKOWITZ, Shimon, Jacob , SAFIRA, Arthur , HIGH, Alexander, A. , DEVLIN, Robert, C. , CHOI, Soonwon , UNTERREITHMEIER, Quirin, P. , PATTERSON, David , ZIBROV, Alexander, S. , MANUCHARYAN, Vladimir, E. , LUKIN, Mikhail, D. , PARK, Hongkun
IPC分类号： G01R33/032 , G01R33/12 , G01N21/64 , G01K11/00
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8.发明公开A DROPLET-BASED METHOD AND APPARATUS FOR COMPOSITE SINGLE-CELL NUCLEIC ACID ANALYSIS 审中-公开基于液滴法的复合单细胞核酸分析方法及装置
公开(公告)号：EP3191605A1
公开(公告)日：2017-07-19
申请号：EP15767655.2
申请日：2015-09-09
申请人： The Broad Institute, Inc. , President and Fellows of Harvard College , Massachusetts Institute of Technology
发明人： REGEV, Aviv , MACOSKO, Evan, Zane , MCCARROLL, Steven, Andrew , SHALEK, Alexander, K. , BASU, Anindita , FORD, Christopher, B. , PARK, Hongkun , WEITZ, David, A.
CPC分类号： C12Q1/6809 , C12N15/1096 , C12Q1/6834 , C12Q1/6869 , G06K19/06 , C12Q2521/107 , C12Q2525/15 , C12Q2525/155 , C12Q2525/161 , C12Q2525/173 , C12Q2563/149 , C12Q2563/159 , C12Q2565/629 , C12Q2563/179
摘要： The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.
摘要翻译： 本发明总体上涉及分子条形码和基于乳液的微流体的组合，以高通量方式分离，裂解，条形码并从各个细胞制备核酸。
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公开(公告)号：EP2888048A1
公开(公告)日：2015-07-01
申请号：EP13717359.7
申请日：2013-03-15
CPC分类号： B81C1/00111 , B01L3/5085 , B01L99/00 , B01L2300/0851 , B01L2300/0896 , B01L2300/163 , B01L2400/086 , B81B7/04 , B81B2201/055 , B81B2203/0361 , B81B2207/056 , B82Y15/00 , B82Y30/00 , C12M23/12 , C12M25/00 , C12N1/20 , C12N5/0068 , Y10T156/10
摘要： The present invention generally relates to nanowires and, in particular, to multiwell plates comprising nanowires, including systems and methods of making the same. Such multiwell plates can, in some cases, be used in automated equipment or high-throughput applications. For example, a plurality of cells may be placed in at least some of the wells of the multiwell plate, and one or more nanowires may be inserted into at least some of the cells within the wells of the multiwell plate. In some cases, one or more of the nanowires may have coated thereon a biological effector. The cells in each of the wells may be identical or different, and/or the biological effector may the same or different. Such multiwell plates may be used, for example, to test a biological effector against a variety of cell types, or to test a variety of biological effectors against a one or more cell types, or the like.
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公开(公告)号：EP2888047A1
公开(公告)日：2015-07-01
申请号：EP13715062.9
申请日：2013-03-15
CPC分类号： B81C1/00111 , B01L3/5085 , B01L99/00 , B01L2300/0851 , B01L2300/0896 , B01L2300/163 , B01L2400/086 , B81B7/04 , B81B2201/055 , B81B2203/0361 , B81B2207/056 , B82Y15/00 , B82Y30/00 , C12M23/12 , C12M25/00 , C12N1/20 , C12N5/0068 , Y10T156/10
摘要： The present invention generally relates to nanowire arrays and methods of fabricating such arrays. In certain embodiments, the fabrication methods can consistently form NW arrays with reproducible configurations at nanoscale sites and produce NWs of specified heights, diameters, and densities. In some cases, the methods also allow formation of NW arrays containing barriers between regions, which would be prohibitively expensive if prepared by other methods.
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