公开(公告)号：EP1024148A4

公开(公告)日：2000-12-20

申请号：EP98947782

申请日：1998-10-07

申请人： MEITO SANGYO KK ,  OTSUKA PHARMA CO LTD

发明人： MACHIDA HARUO ,  KATO SHIGEAKI ,  HIRATA YUUKI ,  AOKI MITSUO ,  KOBATAKE HIDEKI

IPC分类号： A61K31/721 ,  C08B37/02 ,  A61K31/715

CPC分类号： C08B37/0021 ,  A61K31/721

摘要： The present invention relates to dextran whose boron content is reduced to a value less than 0.30 mu g/g (dry basis) calculated on the basis of boron atom, a process for producing the same, and dextran with which a container is filled in a solution state. Dextran of the present invention is obtained by treating a boron-containing dextran with a lower alcohol, and said dextran has such a characteristic that deposition is inhibited or the deposition rate is drastically reduced when using it in the form of a solution. Therefore, an isotonic sodium chloride solution of said dextran is suitably used as substitute plasma or external perfusate in an operation.

摘要翻译： 硼原子换算成硼含量低于0.30μg/ g（干燥状态）的葡聚糖; 生产该工艺的方法; 和处于溶液状态并容纳在容器中的葡聚糖。 该葡聚糖通过用低级醇处理富含硼的葡聚糖来获得。 葡聚糖的特征是在溶液状态下使用时抑制沉淀，或沉淀速率显着降低。 因此，因为这种葡聚糖在例如生理盐水中的溶液作为高储存稳定性，所以它适合用作等离子体膨胀器或用于手术的体外循环液等。

公开(公告)号：EP1541672A4

公开(公告)日：2006-06-14

申请号：EP03741533

申请日：2003-07-22

申请人： MEITO SANGYO KK

发明人： YASUDA KENJI ,  OGAWA TOMOHIKO ,  HASEGAWA MASAKATSU

IPC分类号： A23K1/16 ,  A23L1/054 ,  A23L1/30 ,  A61P1/00 ,  A61P1/04 ,  A61P1/10 ,  A61P1/14 ,  A61P1/16 ,  A61P3/00 ,  A61P3/06 ,  A61P9/12 ,  A61P13/02 ,  A61P29/00 ,  A61P31/00 ,  A61P31/18 ,  A61P35/00 ,  A61P37/02 ,  A61P37/04 ,  A61P37/08 ,  A61P39/06 ,  A61P43/00 ,  C12N1/20 ,  C12N1/38

CPC分类号： C12N1/38 ,  A23K20/163 ,  A23L29/273 ,  A23L33/135 ,  A23V2002/00 ,  C12N1/20 ,  A23V2200/3204 ,  A23V2250/5042 ,  A23V2200/3202

摘要： A dextran-containing composition for promoting bacterial proliferation which aims at selectively proliferating L. casei subsp. casei. By using this composition, L. casei subsp. casei can be selectively proliferated and fixed in the intestines of human or animals without taking L. casei subsp. casei as needed. It is also possible thereby to selectively grow and proliferate indigenous L. casei subsp. casei in the intestine. Thus, various biological activities of L. casei subsp. casei can be sustained in vivo.

公开(公告)号：EP1133991A4

公开(公告)日：2004-12-22

申请号：EP99956339

申请日：1999-11-25

申请人： MEITO SANGYO KK

发明人： FUKATA TSUNEO ,  OGAWA TAKAO ,  HIROSE KIMIO ,  KITO KYOJI

IPC分类号： A61K35/74 ,  A61P1/00

CPC分类号： A61K35/744

摘要： Provided is a bacteriostatic composition for salmonellae containing, as the active ingredient, a fermented broth obtained by effecting fermentation with the use of a lactic acid bacteriium belonging to the genus Leuconostoc, Streptococcus or Streptobacterium in a sucrose-containing medium, or a preparation originating in the supernatant obtained by subjecting the fermented broth to fractional precipitation from a water-miscible organic solvent.

公开(公告)号：EP0726276A4

公开(公告)日：1997-12-29

申请号：EP94927784

申请日：1994-09-28

申请人： MEITO SANGYO KK ,  KYOWA MEDEX CO LTD ,  KYOWA HAKKO KOGYO KK

发明人： OGAWA TOMOHIKO

IPC分类号： A61K39/02 ,  A61K8/64 ,  A61K31/70 ,  A61K35/74 ,  A61K38/00 ,  A61K39/00 ,  A61K39/40 ,  A61P1/02 ,  A61Q11/00 ,  C07K7/06 ,  C07K14/195 ,  C07K14/41 ,  C07K17/00 ,  G01N33/569 ,  A61K7/16

CPC分类号： G01N33/56955 ,  A61K8/64 ,  A61K38/00 ,  A61K39/00 ,  A61Q11/00 ,  C07K14/195 ,  Y02P20/55

摘要： A peptide containing 5 to 10 amino acid residues corresponding to the fragment originating in the amino acid residues of a 41-KD subunit protein constituting the fimbriae of Porphyromonas gingivalis, a derivative thereof, and salts of these compounds. The invention also provides a composition containing these substances for diagnosing periodontal diseases, a vaccine containing a part of them for preventing periodontal diseases, and an oral composition for preventing or treating periodontal diseases containing an antibody obtained by immunizing an animal with this peptide. As compared with the above protein and a peptide comprising 20 amino acid residues thereof, the invention peptide is reduced in nonspecific reactivities and can safely be used in preparing the above compositions.

公开(公告)号：EP0928809A4

公开(公告)日：2000-10-11

申请号：EP97937830

申请日：1997-08-28

申请人： MEITO SANGYO KK ,  MARUNO SHIGEO

发明人： MARUNO SHIGEO ,  HASEGAWA MASAKATSU ,  HANAICHI TAKAMASA ,  MURASE KATSUTOSHI ,  YAMADA HISATO ,  NAGAE HIDEO ,  KITO KYOJI

IPC分类号： A61K49/18 ,  C08K3/22 ,  C08L5/00 ,  A61K49/00 ,  C08B37/00 ,  C08K3/08

CPC分类号： A61K49/1863 ,  C08K3/22 ,  C08K2003/222 ,  C08L5/00

摘要： A polysaccharide/magnetic metal oxide composite comprising a polysaccharide derivative prepared by carboxylalkyl-etherification or unsubstituted or substituted aminoalkyl-etherification (wherein the carboxyl group and/or the amino group may be in salt form) of a polysaccharide. The composite has slow blood clearance and low toxicity and is useful as a contrast medium for nuclear magnetic resonance imaging.

公开(公告)号：EP0753577A4

公开(公告)日：1997-11-12

申请号：EP95913362

申请日：1995-03-29

申请人： KYOWA HAKKO KOGYO KK ,  KYOWA MEDEX CO LTD ,  MEITO SANGYO KK

发明人： MORI HIDEHARU ,  HASEGAWA MAMORU ,  FUKUI MASANORI ,  YASUDA KENJI ,  YAMADA KEIKO ,  HOKUKOKU HIDESABURO ,  OGAWA TOMOHIKO

IPC分类号： A61K38/00 ,  C07K14/195 ,  C12N1/21 ,  C12N15/31 ,  G01N33/569

CPC分类号： G01N33/56955 ,  A61K38/00 ,  C07K14/195 ,  Y10S530/82 ,  Y10S530/825

摘要： A DNA coding for cell-surface polypeptides of Porphyromonas gingivalis, and a recombinant DNA containing the above DNA integrated thereinto. A microorganism containing the recombinant DNA can produce cell-surface polypeptides of periodontal disease bacteria, useful for preventing and diagnosing periodontal diseases, in a large quantity.

摘要翻译： 编码牙龈卟啉单胞菌细胞表面多肽的DNA，以及含有整合在其中的上述DNA的重组DNA。 含有重组DNA的微生物可大量生产用于预防和诊断牙周病的牙周病细菌的细胞表面多肽。

公开(公告)号：EP0656368A4

公开(公告)日：1996-05-08

申请号：EP94906771

申请日：1993-08-04

申请人： MEITO SANGYO KK

发明人： HASEGAWA MASAKATSU ,  ITO YOSHIO ,  YAMADA HISATO ,  NAGAE HIDEO ,  TOZAWA NAHOKO ,  HINO YUKARI TAISHI ,  KITO KYOJI ,  HOKUKOKU SHUSABURO ,  LAWACZECK RUDIGER ,  EBERT WOLFGANG ,  PFEFFERER DETLEF ,  WAGNER SUSANNE ,  KRESSE MAYK

IPC分类号： A61K49/04 ,  A61K49/12 ,  A61K49/18 ,  C08B37/02 ,  C08L5/00

CPC分类号： C08L5/00 ,  A61K49/0423 ,  A61K49/126 ,  A61K49/1863 ,  B82Y5/00 ,  C08B37/0021 ,  Y10T436/24

摘要： A composite having a small particle diameter and composed of a water-soluble carboxypolysaccharide and a magnetic iron oxide having a core diameter ranging from about 2 to about 7 nm, wherein the overall diameter ranges from about 10 to about 50 nm, the ratio of the overall diameter to the core diameter is about 15 or less, and the T2 relaxation capacity ranges from about 10 to about 150 (mM.sec)-1. The composite is reduced in toxicity and side effects and is useful as iron preparation, X-ray contrast medium, MRI contrast medium, reagent for blood stream measurement, drug carrier, and so forth in the fields of medicine, biology and engineering.

公开(公告)号：EP0525199A4

公开(公告)日：1994-08-17

申请号：EP92903328

申请日：1992-01-17

申请人： MEITO SANGYO KK

发明人： KITO KYOJI BENTENGAOKA ,  NAGAE HIDEO - HIGASHINO-CHO -C ,  HASEGAWA MASAKATSU DOUTOKUSHIN ,  ITO YOSHIO - YAMAHANA-CHO SHOW ,  MIZUTANI AKIHIRO TOGAN-CHO -CH ,  HIROSE KIMIO AWANONISHI -CHOME ,  OHGAI MASAHIRO SHIGA-CHO -CHOM ,  YAMASHITA YASUJI SASAZUKA-CHO ,  TOZAWA NAHOKO - HIGASHIYAMA-CH ,  YAMADA KEIKO - MAKISHINDEN-CHO ,  HOKUKOKU SHUSABURO WAKABADAI -

IPC分类号： A61K9/50 ,  A61K47/48 ,  A61K49/18 ,  A61K49/00

CPC分类号： A61K49/1863 ,  A61K9/5094 ,  G01N2400/22 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/80 ,  Y10S436/806 ,  Y10T436/24

摘要： A composition containing ultrafine particles of a magnetic metal oxide, characterized by comprising an aqueous sol of a composite consisting of the ultrafine particles and a polysaccharide, its derivative and/or a protein, and an organic monocarboxylic acid. This composition is useful in the fields of medicines, diagnostic chemicals and so forth, because it is free from side effects such as platelet agglutination, is excellent in the safety for living organism, and does not adversely affect the living organisms even when administered in the blood vessel.

公开(公告)号：EP0543020B1

公开(公告)日：1997-12-29

申请号：EP92911159

申请日：1992-06-08

申请人： MEITO SANGYO KK

发明人： HASEGAWA MASAKATSU ,  NAGAE HIDEO ,  ITO YOSHIO ,  MIZUTANI AKIHIRO ,  HIROSE KIMIO ,  OHGAI MASAHIRO ,  YAMASHITA YASUJI ,  TOZAWA NAHOKO ,  YAMADA KEITO ,  KITO KYOJI BENTENGAOKA MORIYAM ,  HOKUKOKU SHUSABURO WAKABADAI -

IPC分类号： C07D239/34 ,  A01N43/54 ,  A01N43/66 ,  A61K33/26 ,  A61K41/00 ,  A61K49/18 ,  C07D239/38 ,  C07D239/47 ,  C07D239/56 ,  C07D239/60 ,  C07D251/30 ,  C07F9/6512 ,  C07F9/6521 ,  C08B31/18 ,  C08B37/02 ,  C08K3/22 ,  C08L3/10 ,  C08L5/00 ,  A61K49/00 ,  C08B37/00 ,  C08B37/12 ,  C08B37/18

CPC分类号： A61K49/1863 ,  A01N43/54 ,  A01N43/66 ,  A61K33/26 ,  A61K41/0052 ,  C07D239/60 ,  C07D251/30 ,  C07F9/65122 ,  C08B37/0021 ,  C08K3/22 ,  C08L3/10 ,  C08L5/00 ,  G01N2400/16 ,  G01N2400/22 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/86 ,  Y10T436/24 ,  A61K31/715 ,  A61K2300/00

摘要： An oxidized composite comprising a water-soluble carboxypolysaccharide and ultrafine magnetic iron oxide particles. It has an extremely reduces toxicity and an excellent stability, exhibits scarcely any or no hypotensive activity even if directly administered into the blood vessel of an animal, is reduced in the activity of platelet agglutination, and is useful in the medical field as, for example, a contrast medium for MRI and a pyrogenic agent for thermotherapy.