-
1.发明公开
公开(公告)号：EP4455264A1
公开(公告)日：2024-10-30
申请号：EP22911317.0
申请日：2022-12-21
发明人： SUGITA, Tomotoshi , SANPEI, Sotaro
摘要： The present invention relates to a microorganism having a reduced or inactivated activity of a protein according to any one of the following [1] to [3] and improved productivity of lacto-N-triose II or an oligosaccharide having a lacto-N-triose II (LNTII) skeleton as compared with a parent strain: [1] a protein consisting of the amino acid sequence represented by SEQ ID NO: 2 or 4, [2] a mutant protein having an oligosaccharide transporting activity and consisting of an amino acid sequence in which 1 to 20 amino acids are deleted, substituted, inserted, or added in the amino acid sequence represented by SEQ ID NO: 2 or 4, and [3] a homologous protein having an oligosaccharide transporting activity and consisting of an amino acid sequence having an identity of 90% or more with the amino acid sequence represented by SEQ ID NO: 2 or 4.
-
-
公开(公告)号：EP4417622A1
公开(公告)日：2024-08-21
申请号：EP22885830.4
申请日：2022-10-24
发明人： MA, Bruce Yong , CAO, Peipei , HANG, Jianhua , GE, Chennan , ZHANG, Tao , SUN, Fang , YAO, Xiang
IPC分类号： C07K16/28 , C07K16/46 , C12N15/13 , C12N15/63 , C12N1/15 , C12N1/19 , C12N1/21 , A61K39/395 , A61P35/00
CPC分类号： A61K39/395 , A61P35/00 , C07K16/00 , C07K16/28 , C07K16/46 , C12N15/63 , C12N15/74 , C12N15/80 , C12N15/81 , C12N15/85
摘要： Provided are antibodies or antigen-binding fragments that bind to human CD26, bispecific T-cell engagers comprising the sequence of such antibodies or antigen-binding fragments, and applications of such antibodies or antigen-binding fragments in the preparation of drugs for the treatment of tumors with high expression of CD26.
-
公开(公告)号：EP4407039A1
公开(公告)日：2024-07-31
申请号：EP22872950.5
申请日：2022-09-21
申请人： Kao Corporation
CPC分类号： Y02E50/10 , C07K14/195 , C12N9/2414 , C12N9/2408 , C12N15/80 , C12P19/14 , C12N9/2434 , C12N9/24
摘要： Provided is a method for producing a saccharifying enzyme which prevents an increase in viscosity caused by pectin in the biomass saccharification process.
A method for producing a biomass saccharifying enzyme, comprising culturing a recombinant filamentous fungus into which one or both of a polygalacturonase gene selected from the following gene group (a) and a pectin lyase gene selected from the following gene group (b) are introduced:
(a) PgaB gene, PgaI gene, and PgaII gene; and
(b) PelD gene and PelF gene.-
公开(公告)号：EP4400589A1
公开(公告)日：2024-07-17
申请号：EP22867379.4
申请日：2022-09-07
发明人： ODAKA, Rei , SANO, Ryoko , IWASAKI, Takumi , BABA, Masahiro , SABURI, Wataru , MORI, Haruhide
IPC分类号： C12N15/56 , A23C7/04 , A23C9/12 , A23C21/02 , A23C23/00 , A23L33/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/38 , C12N15/63
CPC分类号： A23C7/04 , A23C9/12 , A23C21/02 , A23C23/00 , A23L33/00 , C12N5/10 , C12N9/24 , C12N9/2468 , C12N15/63 , C12N15/80 , C12N15/81 , C12N15/74
摘要： Provided is a lactase preparation having an excellent lactose decomposing action in milk. A lactase according to an aspect of the present invention has, as lactase activity, any one of the following activities (1) to (6) or a combination of two or more thereof:
(1) when the lactase is added to cow's milk, an added amount of protein in the lactase at which a residual lactose concentration reaches 0.1% or less after 16 hours at 10°C is 15.1 mg/L or less;
(2) when the lactase is added to cow's milk, the added amount of protein in the lactase at which the residual lactose concentration reaches 0.01% or less after 16 hours at 10°C is 30.2 mg/L or less;
(3) when the lactase is added to cow's milk, the added amount of protein in the lactase at which the residual lactose concentration reaches 0.1% or less after 24 hours at 10°C is 10.1 mg/L or less;
(4) when the lactase is added to cow's milk, the added amount of protein in the lactase at which the residual lactose concentration reaches 0.01% or less after 24 hours at 10°C is 15.1 mg/L or less;
(5) when the lactase is added to cow's milk in an amount that makes a final concentration 1.4 LYU/ml, the residual lactose concentration reaches 0.1% or less after 24 hours at 10°C; and
(6) when the lactase is added to cow's milk in the amount that makes a final concentration 2.1 LYU/ml, the residual lactose concentration reaches 0.01% or less after 24 hours at 10°C.-
公开(公告)号：EP4400587A1
公开(公告)日：2024-07-17
申请号：EP22867164.0
申请日：2022-08-19
IPC分类号： C12N15/54 , B60C1/00 , C08K3/00 , C08K5/00 , C08L21/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N11/02 , C12N15/63 , C12P5/02
CPC分类号： B60C1/00 , C08K3/00 , C08K5/00 , C08L21/00 , C12N5/10 , C12N9/10 , C12N11/02 , C12N15/63 , C12N15/80 , C12N15/81 , C12N15/74 , C12P5/02
摘要： The present invention aims to provide a method for producing a trans-polyisoprenoid (trans-1,4-polyisoprene) with a molecular weight of more than 105 in an enzymatic manner. The present invention relates to a method for producing a trans-polyisoprenoid, which includes binding to a lipid membrane in vitro a trans-prenyltransferase (tPT) family protein capable of producing a product with a molecular weight of 104 or more when not bound to any lipid membrane.
-
公开(公告)号：EP3628679B1
公开(公告)日：2024-07-17
申请号：EP18810206.5
申请日：2018-05-21
CPC分类号： C12N1/125 , C12R2001/8920210501 , C07K14/405 , C12P7/6434 , C12P7/6432
-
公开(公告)号：EP4379054A1
公开(公告)日：2024-06-05
申请号：EP22849476.1
申请日：2022-07-26
发明人： KABAYAMA, Hiroyuki
IPC分类号： C12N15/12 , C07K7/00 , C07K14/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12N15/62 , C12N15/63
CPC分类号： C07K14/00 , C07K16/00 , C12N15/80 , C12N15/81 , C07K14/435 , C07K7/00 , C12N15/62 , C12N15/63 , C12N15/74 , C12N5/10
摘要： The present disclosure provides a peptide tag, and a nucleic acid encoding the peptide tag. The peptide tag of the present disclosure can reduce an aggregation property of a protein in a cell. Specifically, the peptide tag of the present disclosure can be a peptide tag in which 5% or more and less than 45% of amino acids contained in an amino acid sequence thereof are acidic amino acids, and (b) 20% or more of the amino acids contained in the amino acid sequence are amino acids selected from the group consisting of F, P, Y, G, S, Q, N, and A.
-
公开(公告)号：EP4342989A1
公开(公告)日：2024-03-27
申请号：EP22804768.4
申请日：2022-05-20
发明人： SAITO, Yuji , HIRAOKA, Koji , OGASAWARA, Shinya
IPC分类号： C12N15/13 , C07K16/10 , C12M1/34 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/63 , C12P21/08 , C12Q1/02 , G01N33/569
摘要： Disclosed is an anti-norovirus antibody that reacts with noroviruses of many genotypes and can collectively detect the noroviruses. The anti-norovirus antibody or an antigen-binding fragment thereof undergoes antigen-antibody reaction with the peptides composed of the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2, respectively. The anti-norovirus antibody, which can broadly bind to noroviruses and detect a wide range of human noroviruses with high specificity and sensitivity, and a norovirus immunoassay and a norovirus immunoassay device, both using the anti-norovirus antibody, are provided.
-
公开(公告)号：EP4327823A1
公开(公告)日：2024-02-28
申请号：EP22791768.9
申请日：2022-04-21
发明人： TENDA, Yoshiyuki , YURI, Masatoshi , YAGI, Shigenori , SATAKE, Yoshiki , HIRAYAMA, Kazunori , SHIRAI, Hiroki , SASAKI, Hiroki , CHIWAKI, Fumiko , KOMATSU, Masayuki
IPC分类号： A61K39/395 , A61P35/00 , C07K16/46 , C12N5/10 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/13 , C12N15/62 , C12N15/63 , C12P21/08
摘要： An object of the present invention is to provide an anti-CLDN4/anti-CD137 bispecific antibody usable in treatment of cancer.
An anti-CLDN4/anti-CD137 bispecific antibody produced using an anti-CLDN4 antibody binding to CLDN4 and an anti-CD 137 antibody binding to CD137 had agonistic activity for CD 137, promoted production of interferon y by a T cell, and exhibited cytotoxic activity against a cancer cell expressing CLDN4 on a cell surface thereof. Besides, it was shown that the anti-CLDN4/anti-CD137 bispecific antibody can be safely administered to monkeys. Therefore, the anti-CLDN4/anti-CD137 bispecific antibody is usable in treatment of human cancer.
-
-
-
-
-
-
-
-
-
搜索结果
4276 条记录 (耗时 0.025 秒)
