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    N-SUBSTITUTED AMINOMETHYL CYCLOPROPYL KETONE DERIVATIVE OR ITS SALT AND PRODUCTION METHOD USED FOR THEM
    35.
    发明专利
    N-SUBSTITUTED AMINOMETHYL CYCLOPROPYL KETONE DERIVATIVE OR ITS SALT AND PRODUCTION METHOD USED FOR THEM 失效

    公开(公告)号：JP2002322136A

    公开(公告)日：2002-11-08

    申请号：JP2001124499

    申请日：2001-04-23

    申请人： DAICEL CHEM

    发明人： TANAKA HIROMI ,  HAN RITSUZUI ,  IKURA SEI

    IPC分类号： C07C221/00 ,  C07B61/00 ,  C07C213/00 ,  C07C215/20 ,  C07C225/06 ,  C07C225/10

    摘要： PROBLEM TO BE SOLVED: To provide a new N-substituted aminomethyl cyclopropyl ketone derivative or its salt which are usable for obtaining an aminomethyl cyclopropyl ketone derivative, a 2-amino-1-cyclopropyl ethanol derivative or their salts. SOLUTION: The N-substituted aminomethyl cyclopropyl ketone derivative and its hydrohalide salt are represented by general formula (1). [wherein, R , R , and R are each independently H or an aliphatic hydrocarbon group; R and R are each independently H or an arylmethyl group which may have a substituent, C at the methyl position of the arylmethyl group combins with at least a H atom or a substitutable arylmethyl group, at least one of R and R is an arylmethyl group which may have a substituent].

    PRODUCTION OF OPTICALLY ACTIVE BETA-AMINOKETONES AND OPTICALLY ACTIVE PALLADIUM BINUCLEAR COMPLEX AND ITS PRODUCTION
    38.
    发明专利
    PRODUCTION OF OPTICALLY ACTIVE BETA-AMINOKETONES AND OPTICALLY ACTIVE PALLADIUM BINUCLEAR COMPLEX AND ITS PRODUCTION 失效

    公开(公告)号：JPH11302236A

    公开(公告)日：1999-11-02

    申请号：JP20881998

    申请日：1998-07-24

    申请人： SAGAMI CHEM RES

    发明人： SODEOKA MIKIKO ,  HAGIWARA EMIKO ,  FUJII AKIO

    IPC分类号： B01J31/22 ,  C07B53/00 ,  C07B61/00 ,  C07C221/00 ,  C07C225/06 ,  C07C227/18 ,  C07C229/18 ,  C07C229/60 ,  C07C303/36 ,  C07C311/16 ,  C07F15/00

    摘要： PROBLEM TO BE SOLVED: To efficiently synthesize the subject compounds useful as an intermediate for producing medicines, etc., by reacting a silyl enol ether with an imine in the presence of a specific catalyst. SOLUTION: A silyl enol ether represented by formula I [R is a substituted silyl; R is a (substituted) alkyl, a (substitute) alkenyl or the like; R and R are each H, a (substituted) alkyl, a (substituted) alkenyl or the like] is reacted with an imine represented by formula II [R is a (substituted) alkyl, a (substituted) alkenyl or the like; R is H, a (substituted) alkyl, a (substituted) alkenyl or the like] in the presence of a catalyst comprising a palladium- optically active phosphine ligand to afford the objective compounds represented by formula III. In the above reaction, e.g. N,N-dimethylformamide is preferably used as a solvent and the reaction is preferably carried out in the presence of a base such as calcium carbonate at a reactional temperature within the range of ambient temperature to 70 deg.C.