Patent search ap:("ヘキスト・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング") AND inv:"フオルクマル・ヴエーナー" Page 1

1.

发明专利
Leukocyte adhesion inhibitors and heterocyclic compounds as vla-4 antagonists 失效

公开(公告)号：JP4510160B2

公开(公告)日：2010-07-21

申请号：JP32970197

申请日：1997-11-14

Applicant: ヘキスト・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング

Inventor： クリストフ・ヒユルス , デイルク・ザイフゲ , ハンス・ウルリヒ・シユテイルツ , フオルクマル・ヴエーナー

IPC: C07D233/72 , C07D233/76 , A61K31/415 , A61K31/4166 , A61K38/00 , A61K38/05 , A61K38/06 , A61K38/07 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P19/02 , A61P29/00 , A61P33/02 , A61P33/06 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D233/54 , C07K5/02 , C07K5/023 , C07K5/06 , C07K5/08 , C07K5/10 , C07K5/117

CPC classification number: C07K5/1024 , C07K5/0202

2.

发明专利
Leukocyte adhesion inhibitor and a new heterocyclic compounds as vla-4 antagonist 失效

公开(公告)号：JP4101914B2

公开(公告)日：2008-06-18

申请号：JP32970397

申请日：1997-11-14

Applicant: ヘキスト・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング

Inventor： クリストフ・ヒユルス , デイルク・ザイフゲ , ハンス・ウルリヒ・シユテイルツ , フオルクマル・ヴエーナー

IPC: C07D277/20 , C07K5/078 , A61K38/00 , A61K38/05 , A61K38/06 , A61K38/07 , A61P1/00 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P19/00 , A61P19/02 , A61P25/00 , A61P29/00 , A61P33/02 , A61P33/06 , A61P35/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D233/54 , C07D233/72 , C07D277/34 , C07K5/06 , C07K5/097 , C07K5/107 , C07K5/11 , C07K5/117

CPC classification number: C07K5/1016 , A61K38/00 , C07K5/1019

Abstract: Use of N-substituted pyrrolidone, imidazolidinone, oxazolidinone or thiazolidinone derivatives of formula (I), in all stereoisomer or mixture forms, or their salts as medicaments is new. W = R1-A-CR13 or R1A-CH=C; Y = CO, CS or CH2; Z = O, S or CH2 etc.; A = direct bond, 3-12C cycloalkylene, (1-6C) alkylene-(3-12C) cycloalkylene, phenylene, or the divalent residue of a 5- or 6-membered ring containing 1 or 2 N (optionally mono- or disubstituted) etc.; B = 1-6C alkylene (optionally substituted), 2-6C alkenylene, phenylene, phenylene-(1-3C) alkyl or (1-3C) alkylene-phenylene; D = CR2R3, NR3 or CH=CR3; E = tetrazolyl, SO3H etc.; R = H, alkyl, cycloalkyl, cycloalkylalkyl, Ar, Ar-alkyl, Het' or Het '-alkyl (where alkyl residues are optionally substituted by one or more F); R1 = SR21, SSR21, SOR22, SO2R22, S-OR21, SO-OR21, SO2-OR21, SCOR21, SCOOR22, SCSSR22, OCOR21, OCSR21, OCOOR22, OSO2R22, OSO-R22, OP(O)(OR21)2, P(O)(OR21)2, P(O)(R22)OR21, CN, halo etc.; R2 = H, alkyl, Ar, Ar-alkyl or 3-8C cycloalkyl; R3 = H, alkyl, Ar, Ar-alkyl, 3-8C cycloalkyl, alkenyl, alkynyl, alkenylcarbonyl, alkynylcarbonyl, pyridyl etc.; R13 = H, 1-6C alkyl, Ar, Ar-alkyl, 3-8C cycloalkyl or (3-8C) cycloalkylalkyl; R21 = H, alkyl, hydroxyalkyl, alkenyl, cycloalkyl, cycloalkylalkyl, Ar, Ar-alkyl, Het' or Het'-alkyl (where alkyl residues are optionally substituted by one or more F); b, c, d, f = 0 or 1 provided not all are 0; e, g,h = 0-6; Ar = optionally substituted 6-14C aryl; Het' = optionally substituted heteroaryl; unless specified otherwise alkyl moieties have 1-8C, alkenyl or alkynyl moieties 2-8C, cycloalkyl moieties 3-12C and bi- or tri-cycloalkyl moieties 6-12C.