摘要:
PROBLEM TO BE SOLVED: To provide a new compound having an anion having a structure of bonding a perfluoroalkane sulfonyl group and another substituent with nitrogen atom. SOLUTION: This compound is expressed by formula: Y +- N(CF 3 )SO 2 R f , and is produced by the reaction of M +- N(SO 2 R f )(CF 3 ) with Y +- B. Further, the compound is expressed by Y +- N(SO 2 Rf)(CN). The compound is produced by the reaction of M +- N(SO 2 Rf)(CN) with Y +- B and among the above formulae, Rf is the perfluoroalkyl group; Y + is an organic or inorganic cation; and - B is an organic or inorganic anion; and M + is a cation of an alkali metal or a silver cation. COPYRIGHT: (C)2007,JPO&INPIT
摘要:
PROBLEM TO BE SOLVED: To obtain a composition containing a multifunctional protease inhibitor for suppressing the decomposition of Cu/Zn superoxide dismutase-1 enzyme by including the multifunctional protease (hereinafter referred to as MPC) inhibitor and a carrier. SOLUTION: This composition is obtained by including a MPC inhibitor and a pharmaceutically permissible carrier. As the above MPC inhibitor, e.g. a compound of the formula R1 is -C≡N or the like; R2 is H, hydroxyl or a (cyclo)alkyl; R3 is -(CH2)m-NH-C(=N-R5)-NH2 [R5 is -NO2 or the like; (m) is 3-10] or the like; R4 is -CH(CH2-R7)-Q [R7 is phenyl or the like; Q is -CH-R8 (R8 is =O or the like) or the like]; (n) is 3-10} is illustrated. This compound is used as an aqueous physiological buffer solution containing the compound in a proportion of about 0.1-10 w/v% when parenterally administrated. It is administrated usually at a daily dose of about 1 μg-1 g, preferably about 0.01-100 mg, per body weight 1 kg.
摘要:
PROBLEM TO BE SOLVED: To obtain a new compound acting as an inhibitor against sodium- dependent bicarbonate/chloride (hydrochloride) exchangers or sodium/bicarbonate symporters and useful for the treatment or prevention of diseases developing according to ischemic status, damaged respiratory impulse, myocardial infarction, stenocardia, and the like. SOLUTION: This new compound is shown by formula I (R1 is H or the like; or R1 and R3 form, together with a carbon atom which has bound them, a 3-7C cycloalkyl or the like; R2 to R5 are each H or the like; R6 and R7 are each H or the like), e.g. 4'-cyclohexylidenemethylbiphenyl-2-sulfonyl cyanamide. The compound of formula I is obtained by reaction of a compound of formula II (e.g. 4'-cyclohexylidenemethylbiphenyl-2-sulfonamide) with cyanogen bromide in a dipolar aprotic solvent stable to cyanogen bromide such as acetonitrile using a strong auxiliary base which is not so highly nucleophilic such as K2 CO3 pref. at 60-120 deg.C.
摘要:
PURPOSE:To obtain a new guanidine derivative having the carcinostatic activity. CONSTITUTION:The compound of the formula (R and R are H, halogen, 1-6C alkyl which may be branched or respectively bound to form a ring; R is 5-8C cycloalkyl or phenyl which may be substituted with halogen or 1-4C alkyl; R and R are H or 1-6C alkyl which may be branched or aralkyl having 1-4C alkyl), e.g. 1-amino-1-methyl-3-(4-chlorophenyl)-2-(5-indanesulfonyl)guanidine. This compound is obtained by reacting, e.g. a sulfonamide compound with an isothiocyanate compound according to a conventional method, further reacting the resultant sulfonylurea compound with an alkyl halide and then reacting the obtained S-alkyl-N,N'-substituted-isothiourea with a hydrazine compound.