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    SUBSTRATE FOR PP2C
    5.
    发明专利
    SUBSTRATE FOR PP2C 审中-公开

    公开(公告)号：JP2003102497A

    公开(公告)日：2003-04-08

    申请号：JP2002194538

    申请日：2002-07-03

    申请人： SCHERING AG

    发明人： KRIEGLSTEIN JOSEF ,  KLUMPP SUSANNE

    IPC分类号： G01N33/50 ,  C07K14/47 ,  C12N9/16 ,  C12Q1/42 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566

    摘要： PROBLEM TO BE SOLVED: To provide a substrate for PP2C exhibiting physiological conditions related to a specific treatment, and to discover a modulation factor capable of being used for treating apoptosis, especially neuron apoptosis. SOLUTION: A combination of protein phosphatase 2C as an enzyme and phosphor BAD as a substrate. Phospho-BAD, i.e., a protein, is dephosphorylated at a position of Ser . Further, the combination can be used in an in vitro screening of a ligand which modulates protein phosphatase 2C. The screening comprises the following stages: the protein phosphatase 2C is incubated together with phosphor BAD as a substrate and a ligand of the assay; and the decrease in phosphor BAD, and/or the increase in phosphate and/or BAD are detected. As a result, a new drug for treating apoptosis can be discovered.

    Membrane receptor to steroid or sterol
    6.
    发明专利
    Membrane receptor to steroid or sterol 审中-公开
    膜受体与STEROID或STEROL

    公开(公告)号：JP2003079384A

    公开(公告)日：2003-03-18

    申请号：JP2002124705

    申请日：2002-04-25

    申请人： Schering Ag ,  シエーリング アクチエンゲゼルシャフト

    发明人： WEISS BERTRAM ,  LESSL MONIKA ,  FRITZEMEIER KARL-HEINRICH ,  TOSCHI LUISELLA

    IPC分类号： G01N33/50 ,  A61K31/7088 ,  A61K38/00 ,  A61P5/38 ,  A61P9/00 ,  A61P13/00 ,  A61P15/08 ,  A61P19/10 ,  A61P25/28 ,  A61P29/00 ,  A61P37/00 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28 ,  C07K16/40 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/12 ,  C12N15/09 ,  C12Q1/48 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566

    CPC分类号： C07K14/721

    摘要： PROBLEM TO BE SOLVED: To provide four kinds of splice mutants of a membrane receptor to a steroid or a sterol, and to provide a usage of the same. SOLUTION: A receptor polypeptide to a steroid or a sterol contains various domains, that is leucine rich repetition domains, ankyrin domains and a kinase domain. The polypeptide has a membrane binding property. After the polypeptide is bound to a steroid or a sterol, the kinase domain phosphorylates serine and threonine radicals of a protein to elicit an intracellular signal cascade. The polypeptide contains 600 amino acids, and it contains island domains found between leucine rich repeat domains of the polypeptide. An island domain relates to steroid bonding or sterol bonding. The polypeptide is useful for screening and manufacturing a medicine for a steroid hormone depending disease, and it can be used for such purposes.

    摘要翻译： 要解决的问题：提供四种类型的类固醇或固醇的膜受体的剪接突变体，并提供其用途。 解决方案：类固醇或固醇的受体多肽含有多个结构域，即富含亮氨酸的重复结构域，锚蛋白结构域和激酶结构域。 多肽具有膜结合性质。 多肽与类固醇或固醇结合后，激酶结构域磷酸化蛋白质的丝氨酸和苏氨酸基团以引发细胞内信号级联。 该多肽含有600个氨基酸，并且其含有在多肽的富含亮氨酸的重复结构域之间发现的岛结构域。 岛域涉及类固醇结合或固醇结合。 该多肽可用于筛选和制造用于类固醇激素依赖性疾病的药物，并且其可用于此目的。

    METHOD FOR DIAGNOSING HETEROTOPIC ENDOMETRIO IN VITRO
    9.
    发明专利
    METHOD FOR DIAGNOSING HETEROTOPIC ENDOMETRIO IN VITRO 审中-公开

    公开(公告)号：JP2002325600A

    公开(公告)日：2002-11-12

    申请号：JP2001292209

    申请日：2001-09-25

    申请人： SCHERING AG

    发明人： HESS-STUMPP HOLGER ,  HAENDLER BERNARD ,  KRAETZSCHMAR JOERN ,  KREFT BERTHOLT ,  WINTERHAGER ELKE ,  REGIDOR PEDRO ,  SCOTTI SIMONE

    IPC分类号： G01N33/53 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/6809 ,  C12Q1/6837 ,  C12Q1/6883 ,  G01N33/566 ,  G01N33/68 ,  G01N37/00

    摘要： PROBLEM TO BE SOLVED: To provide a new means for diagnosing heterotopic endometriosis. SOLUTION: This means for diagnosing the heterotopic endometriosis in vitro is characterized by measuring the amount of at least one genetic product selected from the group consisting of fibronectin, insulin-like proliferation factor- bound protein-2, membrane-penetrating receptor PTK7, platelet-originated proliferation factor receptor alpha, collagen XVIII type alpha 1, subtilisin-like protein (PACE 4), laminin M chain (merosin), elastin, IV type collagen alpha 2, p27 interferon alpha-derived gene, reticulocalbin, aldehyde dehydrogenase 6, gravin, nidogen, and phospholipase C epsilon in a patient sample, comparing the measured amount with the amount of the genetic product in a control sample, and allowing to suggest the presence of the heterotopic endometriosis by showing that the amount of the genetic product in the patient sample is less than the amount of the genetic product in the control sample.

    INJECTOR AND HOLDER USED THEREFOR
    10.
    发明专利
    INJECTOR AND HOLDER USED THEREFOR 失效

    公开(公告)号：JP2001198216A

    公开(公告)日：2001-07-24

    申请号：JP2000014941

    申请日：2000-01-24

    申请人： SCHERING AG

    发明人： KICHISE SATORU ,  IMAI HIDEHIRO ,  KAKIMI MITSURU

    IPC分类号： A61B17/11 ,  A61M5/145

    摘要： PROBLEM TO BE SOLVED: To provide an injector, which can administer a drug safely and reliably to a living body according to a prescribed method and dosage and can alleviate handling complicatedness and low mechanical reliability, and a holder used therefor. SOLUTION: This injector is constituted by a first syringe 1, a second syringe 2, a Y-shaped connector 3, valve means 4 having functions of allowing or stopping a flow of a liquid and a holder for holding integrally these components. A cylinder end of the first syringe 1 is connected to a first connecting pipe 31 of the Y-shaped connector 3. A cylinder end of the second syringe 2 is connected to a connecting pipe 42 of the valve means 4. A connecting pipe 41 of the valve means 4 is connected to one side of a pipe member 11. The other side of the pipe member 11 is connected to a second connecting pipe 32 of the Y-shaped connector 3. The Y-shaped connector 3 is provided with a one-way valve, which prevents the liquid that flows in from a second connecting port 3b and/or a third connecting port in a third connecting pipe 33 from flowing out from a first connecting port 3a.