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    光学活性２級アルコールの製造方法
    1.
    发明专利
    光学活性２級アルコールの製造方法 审中-公开
    用于生产光活性二级醇的方法

    公开(公告)号：JP2015024976A

    公开(公告)日：2015-02-05

    申请号：JP2013156036

    申请日：2013-07-26

    Applicant: 関東化学株式会社 ,  Kanto Chem Co Inc ,  国立大学法人北海道大学 ,  Hokkaido Univ

    Inventor： KATAYAMA TAKEAKI ,  TSUTSUMI KUNIHIKO ,  MURATA KUNIHIKO ,  OKUMA TAKESHI ,  ARAI NORIYOSHI

    IPC: C07C29/145 ,  B01J31/22 ,  C07C33/20 ,  C07C41/18 ,  C07C43/178

    CPC classification number: C07C41/26 ,  B01J31/1815 ,  C07B53/00 ,  C07B2200/07 ,  C07C29/145 ,  C07C2531/28 ,  C07C33/22 ,  C07C33/46 ,  C07C43/23

    Abstract: 【課題】基質カルボニル化合物を高い効率で水素化し、高い光学純度の光学活性2級アルコールを製造する方法の提供。【解決手段】一般式:RuXYAB[X及びYは互いに同一又は異なり、H又はアニオン性基を示し、Aは式(2)で表される光学活性ジホスフィンを示し、Bは、式(3)で表されるアミン化合物を示す。]で表されるルテニウム錯体の存在下、基質カルボニル化合物を水素及び/又はHを供与する化合物と反応させる。(R1〜R8は炭化水素基等であり、*は不斉炭素原子を表す。)(各Dは、独立して同一又は異なり、C又はNを示し、R9〜R12は炭化水素基等であり、nは、0〜(4−(窒素原子であるDの数))の整数である。)【選択図】なし

    Abstract translation: 要解决的问题：提供一种通过以高效率氢化底物羰基化合物制备具有高光学纯度的光学活性仲醇的方法。解决方案：制备光学活性仲醇的方法包括使底物羰基化合物与氢和 /或由以下通式表示的钌络合物存在下的化合物：RuXYAB [X和Y彼此相同或不同，表示H或阴离子基团; A表示由式（2）表示的光学活性二膦; B表示式（3）表示的胺化合物]。 （式（2）中，Rto Rare为烃基等，*表示不对称碳原子。）（式（3）中，D各自独立地相同或不同，表示C或N; R〜 基团等; n为0〜（4-（D为氮原子的数）的整数）。

    Optically active ammonium salt compound, and its manufacturing intermediates
    7.
    发明专利
    Optically active ammonium salt compound, and its manufacturing intermediates 有权

    公开(公告)号：JP5379873B2

    公开(公告)日：2013-12-25

    申请号：JP2012036862

    申请日：2012-02-22

    Applicant: 日本曹達株式会社

    Inventor： 啓二 丸岡 ,  靖 久保田

    IPC: C07D487/10 ,  C07C25/18 ,  C07C43/225

    CPC classification number: B01J31/0271 ,  C07B53/00 ,  C07B2200/07 ,  C07C22/04 ,  C07C25/18 ,  C07C33/46 ,  C07C43/225 ,  C07D223/18 ,  C07D487/10

    Abstract: An optically active quaternary ammonium salt compound represented by formula (1), wherein R 1 represents a halogen, a C 1-8 alkyl which is optionally substituted and which is linear, branched, or cyclic, a C 2-8 alkenyl which is optionally substituted, a C 2-8 alkynyl which is optionally substituted, a C 6-14 aryl which is optionally substituted, a C 3-8 heteroaryl which is optionally substituted, a C 1-8 alkoxy which is optionally substituted and which is linear, branched, or cyclic, or a C 7-16 aralkyl which is optionally substituted; R 2 and R 21 each independently represents hydrogen, halogen, nitro, a C 1-8 alkyl which is optionally substituted and which is linear, branched, or cyclic, a C 2-8 alkenyl which is optionally substituted, a C 2-8 alkynyl which is optionally substituted, a C 6-14 aryl which is optionally substituted, a C 1-8 alkoxy which is optionally substituted and which is linear, branched, or cyclic, or a C 7-16 aralkyl which is optionally substituted; one of combinations of R 1 and R 21 , and R 2 and R 21 , may bond to form a C 1-6 alkylene which is optionally substituted, a C 1-6 alkylenemonooxy which is optionally substituted, or a C 1-6 alkylenedioxy which is optionally substituted; R 3 and R 4 each independently represents hydrogen, a C 6-14 aryl which is optionally substituted, a C 3-8 heteroaryl which is optionally substituted, or a C 7-16 aralkyl which is optionally substituted, with a proviso that R 3 and R 4 are not hydrogen at the same time; R 5 represents hydrogen, halogen, a C 1-8 alkyl which is optionally substituted and which is linear, branched, or cyclic, a C 1-8 alkoxy which is optionally substituted and which is linear, branched, or cyclic, a C 2-8 alkenyl which is optionally substituted, or a C 2-8 alkynyl which is optionally substituted; R 6 represents halogen, a C 1-8 alkyl which is optionally substituted and which is linear, branched, or cyclic, a C 1-8 alkoxy which is optionally substituted and which is linear, branched, or cyclic, a C 2-8 alkenyl which is optionally substituted, or a C 2-8 alkynyl which is optionally substituted, and R 5 and R 6 may bond to form an aromatic ring which is optionally substituted; ring A and ring B do not have a same substituent at the same time; symbols * and ** represent an optical activity having an axial chirality; and X - represents an anion.

    Optically active ammonium salt compound and production intermediate thereof
    9.
    发明专利
    Optically active ammonium salt compound and production intermediate thereof 有权
    光学活性铵盐化合物及其生产中间体

    公开(公告)号：JP2012153691A

    公开(公告)日：2012-08-16

    申请号：JP2012036862

    申请日：2012-02-22

    Applicant: Nippon Soda Co Ltd ,  日本曹達株式会社

    Inventor： MARUOKA KEIJI ,  KUBOTA YASUSHI

    IPC: C07D487/10 ,  C07C25/18 ,  C07C43/225

    CPC classification number: B01J31/0271 ,  C07B53/00 ,  C07B2200/07 ,  C07C22/04 ,  C07C25/18 ,  C07C33/46 ,  C07C43/225 ,  C07D223/18 ,  C07D487/10

    Abstract: PROBLEM TO BE SOLVED: To provide an optically active quaternary ammonium salt compound useful as a chiral phase-transfer catalyst, and a production intermediate of the optically active quaternary ammonium salt compound.SOLUTION: The optically active quaternary ammonium salt compound is represented by formula (1). In the formula: Ris an alkyl or alkoxy; Rand Rare hydrogen; Ris hydrogen, alkyl or alkoxy; Ris aryl or aralkyl; Rand Rare alkenyl and connects together to form an aromatic ring; * and ** show optical activity having shaft asymmetry; and Xshows an anion.

    Abstract translation: 要解决的问题：提供可用作手性相转移催化剂的光学活性季铵盐化合物和光学活性季铵盐化合物的制备中间体。 解决方案：光学活性季铵盐化合物由式（1）表示。 在式中：R 1 是烷基或烷氧基; R 2 和R 4 是氢; R 21是氢，烷基或烷氧基; R 3是芳基或芳烷基; R 5 和R 6 是烯基并连接在一起形成芳环; *和**表示具有轴不对称性的光学活动; 而X - 显示阴离子。 版权所有（C）2012，JPO＆INPIT

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