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公开(公告)号：US12114641B2
公开(公告)日：2024-10-15
申请号：US17127014
申请日：2020-12-18
CPC分类号： A01K13/003 , A01K5/02 , A01K31/002 , A01K39/012 , A01K45/00 , A01K45/002 , A61D1/025 , A61D7/00 , B05B9/04
摘要： The disclosure relates to a spray applicator system for accurately and precisely dosing liquid formulations, including vaccines and probiotic formulations, to caged avian animals. In particular, the disclosure relates to spray applicators, having improved acceptance by the avian animals, relative to more disruptive prior spray applicators. The disclosed automated caged spray applicator system is designed to attach to and function with automated poultry feeding systems, routinely used in poultry house settings.
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公开(公告)号：US12018048B2
公开(公告)日：2024-06-25
申请号：US17643251
申请日：2021-12-08
IPC分类号： C07K11/02 , A01N43/72 , A61K38/15 , A61K45/06 , A61P33/10 , A61P43/00 , C07D273/00 , C07D413/14
CPC分类号： C07K11/02 , A01N43/72 , A61K38/15 , A61K45/06 , C07D273/00 , C07D413/14
摘要： Cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds are provided that are effective against parasites that harm animals, including humans. The compounds and compositions may be used for combating parasites in or on animals including mammals and birds. Also provided are improved methods for eradicating, controlling and preventing parasite infestation in animals, including birds and mammals.
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公开(公告)号：US11858963B2
公开(公告)日：2024-01-02
申请号：US17215636
申请日：2021-03-29
发明人： Luis Alejandro Hernandez , Christine Margaret Muehlenthaler , Eric Martin Vaughn , Gregory Haiwick
IPC分类号： C07K14/005 , C12N7/00 , A61K39/12 , C12P21/02 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , C12N7/00 , C12P21/02 , A61K39/00 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C12N2710/14043 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2799/026
摘要： Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of the same PCV2b and/or different subtype; the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of the same PCV2b or a different subtype; and/or the prevention or treatment of a disease caused by an infection with PCV2 of the same PCV2b and/or a different subtype. The present invention in particular relates to PCV2 subtype b (PCV2b) ORF2 proteins characterized in that they contain at least one mutation in the BC loop that such that the expressed protein is preferably expressed in a higher amount compared to a PCV2 ORF2 protein that does not contain such mutation.
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公开(公告)号：US11813322B2
公开(公告)日：2023-11-14
申请号：US16893706
申请日：2020-06-05
IPC分类号： A61K39/155 , A61K47/18 , A61K47/26 , A61K47/42
CPC分类号： A61K39/155 , A61K47/183 , A61K47/26 , A61K47/42
摘要： The present invention relates generally to the fields of immunology and vaccine technology. More specifically, the present invention relates to stabilized liquid immunogenic compositions and vaccines having a live attenuated viral antigen, and methods of using the same. The live attenuated viral antigen can be a live peste des petits ruminants (PPR) virus.
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公开(公告)号：US11589586B2
公开(公告)日：2023-02-28
申请号：US16638957
申请日：2018-08-14
发明人： Alan Long , Hyoung Ik Lee
IPC分类号： A01N43/80 , A01N43/90 , C07D413/04 , C07D491/107
摘要： The present invention relates to pesticidal and parasiticidal isoxazoline of formula (I) and salts thereof: wherein variables R1, P, Y and Q are described herein are as defined in the description. The invention also relates to parasiticidal and pesticidal compositions comprising the isoxazoline compounds of formula (I), processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.
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公开(公告)号：US11510978B2
公开(公告)日：2022-11-29
申请号：US16262774
申请日：2019-01-30
IPC分类号： A61K39/255 , A61K39/12 , A61K39/00
摘要： The present invention provides an effective vaccine for Marek's disease, which may be prepared using a recombinant Marek's Disease Virus (MDV), strain CVI988, having been transformed with a foreign DNA construct that includes a long terminal repeat sequence of a reticuloendotheliosis virus. This safe viral agent elicits a highly protective immune response in a chicken against virulent MDV challenge without causing a significant degree of pathogenicity. Suitable formulations of the vaccine for use in chickens include an effective immunization dosage of this novel viral agent, along with a pharmaceutically acceptable carrier or diluent.
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公开(公告)号：US11497732B2
公开(公告)日：2022-11-15
申请号：US16534912
申请日：2019-08-07
发明人： Loic Patrick Le Hir de Fallois , Charles Q. Meng , Susan Mancini Cady , Peter Cheifetz , Izabela Galeska
IPC分类号： A61K31/422 , A61K47/14 , C07D491/107 , C07D261/04 , C07D471/04 , A01N43/80 , A61K9/00 , A61K47/10 , A61K31/415 , A61K31/42 , C07D413/04 , A61K9/10 , A61K9/08 , A61K9/107
摘要： This invention relates to long-acting injectable compositions for combating parasites in animals, comprising at least one isoxazoline active agent, a liquid PEG and/or a neutral oil, optionally a co-solvent, and optionally a pharmaceutically acceptable additive or excipient. This invention also provides new isoxazoline active agents with long-lasting efficacy against ectoparasites. The invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the novel isoxazoline compounds and long-acting injectable compositions of the invention to the animal in need thereof.
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公开(公告)号：US20220031439A1
公开(公告)日：2022-02-03
申请号：US17450882
申请日：2021-10-14
摘要： The invention relates to a liquid applicator, for administering liquids, including vaccines, to animals. In particular, the applicator is useful for delivering liquids to mouths of animals.
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公开(公告)号：US11147273B2
公开(公告)日：2021-10-19
申请号：US16017880
申请日：2018-06-25
发明人： Kour Chand Jindal , Jian Han , Kim Agnew
摘要： The present invention encompasses a stabilized parasiticidal granule composition comprising a macrocyclic lactone compound and an insect growth regulator. The invention also encompasses methods of making and methods of using the granule for treating, controlling or preventing parasitic infestation or parasitic infection in an animal.
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公开(公告)号：US20210315678A1
公开(公告)日：2021-10-14
申请号：US17120963
申请日：2019-07-03
发明人： Veronique Bregeon
摘要： The present invention relates to a stand-up pouch, for holding and dispensing fluid veterinary formulations, made of a flexible film material.
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