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    APPLICATION CONTAINER
    1.
    发明公开
    APPLICATION CONTAINER 审中-公开

    公开(公告)号：US20240269444A1

    公开(公告)日：2024-08-15

    申请号：US18559843

    申请日：2022-07-11

    申请人： Sato Pharmaceutical Co., Ltd.

    发明人： Kota Sakata ,  Kiyohiko Rikiishi ,  Yoshinori Itoh ,  Yoshitoshi Koyama

    IPC分类号： A61M35/00

    CPC分类号： A61M35/00

    摘要： An application container (1) of the present invention includes: an inner plug member (20) mounted on a mouth portion (10) of a container main body (2) and formed with a communication hole (21) and a discharge hole (22); a holder (30) that includes an accommodating portion (31) and a plug body (35) and is formed with a communication path (40) between the holder (30) and the inner plug member (20); an application member (50) disposed in the accommodating portion (31); a biasing member (60) configured to bias the holder (30) upward with respect to the inner plug member (20); an overcap (4) mounted on the mouth portion (10) of the container main body (2); and a seal portion (80) configured to block communication between the communication path (40) and an outside, in a state where the overcap (4) is removed from the mouth portion (10) and the plug body (35) closes the communication hole (21).

    Method for producing difluoromethylene compound
    2.
    发明授权
    Method for producing difluoromethylene compound 有权

    公开(公告)号：US11084792B2

    公开(公告)日：2021-08-10

    申请号：US16608802

    申请日：2018-04-27

    申请人： SATO PHARMACEUTICAL CO., LTD.

    发明人： Keita Nagai ,  Toshihiko Ozaki

    IPC分类号： C07D231/56

    摘要： The present invention provides a method for producing a difluoromethylene compound and an intermediate thereof, which are useful in the field of pharmaceuticals.
    Specifically provided is a method for producing a difluoromethylene compound, including a step of allowing a compound represented by formula (6): [wherein L1 represents a halogen atom, a cyano group, a lower alkyl group, a halo-lower alkyl group, a cycloalkyl group, a lower alkoxy group, a halo-lower alkoxy group, or a hydroxy lower alkyl group; R1 represents a lower alkyl group, a halogen atom, a halo-lower alkyl group, a cycloalkyl group, a cyano group, or a hydroxy lower alkyl group; and W represents a nitrogen atom or a methine group] to react with a compound represented by formula (7): [wherein R2 represents a lower alkyl group, a halo-lower alkyl group, a cycloalkyl group, a lower alkenyl group, or an aralkyl group; and R3 represents a chlorine atom, a bromine atom, or an iodine atom].

    PHARMACEUTICAL COMPOSITIONS CONTAINING 2-PYRIDONE DERIVATIVES AS EFFECTIVE COMPONENTS
    5.
    发明申请
    PHARMACEUTICAL COMPOSITIONS CONTAINING 2-PYRIDONE DERIVATIVES AS EFFECTIVE COMPONENTS 审中-公开
    含有2-吡啶酮衍生物作为有效成分的药物组合物

    公开(公告)号：US20090298889A1

    公开(公告)日：2009-12-03

    申请号：US11917262

    申请日：2006-06-30

    申请人： Masatoshi Kato ,  Hiroyuki Kusakabe ,  Satoshi Yanagihara ,  Hidenori Akizawa ,  Yushi Tamoto

    发明人： Masatoshi Kato ,  Hiroyuki Kusakabe ,  Satoshi Yanagihara ,  Hidenori Akizawa ,  Yushi Tamoto

    IPC分类号： A61K31/4412 ,  C07D213/70

    CPC分类号： C07D213/70 ,  C07D213/89 ,  C07D401/04 ,  C07D417/04

    摘要： The present invention herein provides a 2-pyridone derivative which has a cell adhesion-inhibitory activity and which is useful for preventing and/or treating pathema or disease conditions including, for instance, inflammations which relate to leukocytic infiltration. The 2-pyridone derivative is a compound represented by the following general formula (1). In the formula, R1 represents, for instance, a phenyl or pyridyl group, R2 represents, for instance, a phenyl group, R3 represents, for instance, a lower alkyl group, R4 represents, for instance, a lower alkyl group, R5 represents, for instance, a lower alkyl group, and R6 represents, for instance, a lower alkyl group.

    摘要翻译： 本发明提供具有细胞粘附抑制活性的2-吡啶酮衍生物，其可用于预防和/或治疗pathema或疾病状况，包括例如与白细胞浸润有关的炎症。 2-吡啶酮衍生物是由以下通式（1）表示的化合物。 在该式中，R 1表示例如苯基或吡啶基，R 2表示例如苯基，R 3表示例如低级烷基，R 4表示例如低级烷基，R 5表示 ，例如低级烷基，R6表示例如低级烷基。

    CONDENSED RING COMPOUNDS THAT INHIBIT H-PGDS
    8.
    发明公开
    CONDENSED RING COMPOUNDS THAT INHIBIT H-PGDS 审中-公开

    公开(公告)号：US20230339937A1

    公开(公告)日：2023-10-26

    申请号：US18002232

    申请日：2021-06-18

    申请人： SATO PHARMACEUTICAL CO., LTD.

    发明人： Motoaki BABA ,  Takuma OKUI ,  Yoshiki ITOH

    IPC分类号： C07D471/04 ,  C07D491/048 ,  C07D495/04

    CPC分类号： C07D471/04 ,  C07D491/048 ,  C07D495/04

    摘要： The present invention provides a compound having a hematopoietic prostaglandin D synthase (H-PGDS) inhibitory activity and being useful for preventing or treating a disease involving the enzyme, and a pharmaceutical composition comprising the compound. Specifically, the present invention provides a compound represented by Formula (I) below or a pharmaceutically acceptable salt thereof:




    [wherein R1 represents a hydrogen atom and the like, R2 represents a hydrogen atom and the like, R3 represents a hydrogen atom and the like, R4 represents a hydrogen atom and the like, R5 represents a hydrogen atom and the like, W represents an oxygen atom and the like, and X represents a C1-6 alkyl group and the like.]