公开(公告)号：US12296171B2

公开(公告)日：2025-05-13

申请号：US17872319

申请日：2022-07-25

Applicant: Galvani Bioelectronics Limited

Inventor： Matteo Donega ,  Daniel John Chew ,  Isha Gupta

IPC: A61N1/36 ,  A61N1/05

Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is associated with a neurovascular bundle, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders. The invention provides improved ways of treating inflammatory disorders which minimize off-target effects.

公开(公告)号：US12296162B2

公开(公告)日：2025-05-13

申请号：US17595169

申请日：2020-05-07

Applicant: GALVANI BIOELECTRONICS LIMITED ,  Cindy Au

Inventor： Cindy Au

IPC: A61N1/05 ,  B29C45/14 ,  B29C45/16 ,  B29K83/00 ,  B29L31/00

Abstract: A method for use in making an electrode assembly (20) comprises the steps of applying an electrode (24) on a first layer of material (22); laser welding a lead (23) to the electrode; applying an adhesive backfill (26) over the electrode and the lead; and applying a second layer of material (28) over the adhesive backfill and a portion of the first layer to prevent a leakage path between the electrode and the second layer.

公开(公告)号：US20250082937A1

公开(公告)日：2025-03-13

申请号：US18791161

申请日：2024-07-31

Applicant: Galvani Bioelectronics Limited ,  Case Western Reserve University

Inventor： Alessandra Giarola ,  Yee-Hsee Hsieh ,  Stephen J. Lewis ,  Arun Sridhar

IPC: A61N1/36 ,  A61B5/00 ,  A61B5/08 ,  A61N1/00 ,  A61N1/05 ,  A61N1/18

Abstract: This disclosure provides an apparatus or system for the modulation of neural activity in the cervical sympathetic chain (CSC) or superior cervical ganglion (SCG) or SCG post-ganglionic branch(es) and for the treatment of sleep apnoea, as well as methods for their use.

公开(公告)号：US12083340B2

公开(公告)日：2024-09-10

申请号：US18141045

申请日：2023-04-28

Applicant: Galvani Bioelectronics Limited

Inventor： Daniel John Chew ,  Matteo Donega ,  Isha Gupta

IPC: A61N1/00 ,  A61N1/05 ,  A61N1/20 ,  A61N1/36

CPC classification number: A61N1/36071 ,  A61N1/0553 ,  A61N1/0556 ,  A61N1/205 ,  A61N1/36135 ,  A61N1/3616 ,  A61N1/36171

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen provides a useful way to treat acute medical conditions. The disclosed systems and methods stimulate the neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, such that the electrical signal produces an improvement in a physiological parameter indicative of treatment of an acute medical condition.

公开(公告)号：US12070604B2

公开(公告)日：2024-08-27

申请号：US17450308

申请日：2021-10-08

Applicant: Galvani Bioelectronics Limited

Inventor： Brian Pepin ,  Shiv Sabesan

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/375

CPC classification number: A61N1/36139 ,  A61N1/0534 ,  A61N1/36007 ,  A61N1/36031 ,  A61N1/36067 ,  A61N1/36135 ,  A61N1/3614 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36062 ,  A61N1/36064 ,  A61N1/36071 ,  A61N1/36085 ,  A61N1/36096 ,  A61N1/3752

Abstract: This disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Embodiments are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters.

公开(公告)号：US11878160B2

公开(公告)日：2024-01-23

申请号：US15752502

申请日：2016-08-18

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Michael John Carr ,  Kevin K. Kwong ,  Gerald E. Hunsberger

IPC: A61N1/20 ,  A61N1/36 ,  A61B5/388 ,  A61B5/08 ,  A61B5/087 ,  A61B5/091 ,  A61B5/145 ,  A61B5/00

CPC classification number: A61N1/205 ,  A61B5/087 ,  A61B5/0816 ,  A61B5/091 ,  A61B5/14542 ,  A61B5/388 ,  A61B5/4035 ,  A61B5/4836 ,  A61N1/3611 ,  A61N1/36053 ,  A61N1/36057 ,  A61N1/36171 ,  A61B5/08

Abstract: The present invention provides devices and methods that can prevent or ameliorate bronchoconstriction by stimulating neural activity, in contrast to those techniques based on denervation, ablation or blocking of neural activity. Methods and devices according to the invention may act responsively or on demand, can preserve neuronal structure and function and will be associated with minimal collateral side-effects. In particular, the invention provides devices and methods in which a signal is delivered to the vagus nerve, for example the cervical vagus nerve or the pulmonary branch of the vagus nerve, in order to stimulate neural activity in the vagal nerve.

公开(公告)号：US11844952B2

公开(公告)日：2023-12-19

申请号：US17164350

申请日：2021-02-01

Applicant: Galvani Bioelectronics Limited

Inventor： Rizwan Bashirullah

IPC: A61N1/372 ,  A61N1/378 ,  A61N1/36 ,  A61N1/05 ,  H04B5/00 ,  A61N1/375 ,  A61B5/00

CPC classification number: A61N1/3787 ,  A61B5/0026 ,  A61B5/0031 ,  A61N1/0556 ,  A61N1/3605 ,  A61N1/375 ,  A61N1/3754 ,  A61N1/3756 ,  A61N1/37223 ,  H04B5/0081 ,  A61B2560/0219 ,  A61M2205/3538 ,  A61M2205/3569 ,  H04B5/0075

Abstract: Implantable systems are described that include a stimulation device positionable in vivo and configured to communicatively couple to electrodes configured to stimulate or block body tissue and an auxiliary device positionable in vivo and including one or more coils configured to wirelessly couple, in vivo, to the stimulation device and to wirelessly couple to an ex vivo device. The auxiliary device may include a coil driver and a power source controlled by a processor and memory for storing data instructions for the coil driver and for storing data received from the stimulation device. The auxiliary device may also include a radio transceiver and an antenna. The stimulation device may include a housing, a coil, a power source and an integrated circuit for controlling the electrodes. The stimulation device may be coupled to a cuff via a lead and physically coupled to the auxiliary device.

公开(公告)号：USD1001417S1

公开(公告)日：2023-10-17

申请号：US29710833

申请日：2019-10-25

Applicant: Galvani Bioelectronics Limited

Designer： Morten Hansen ,  Jay Canham

Abstract: FIG. 1 is a perspective view of a CHARGER POSITIONING BELT according to a first embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 2 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 3 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 4 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 5 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 6 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 7 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 8 is a perspective view of a CHARGER POSITIONING BELT according to a second embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 9 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 10 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 11 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 12 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 13 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 14 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 15 is a perspective view of a CHARGER POSITIONING BELT according to a third embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 16 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 17 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 18 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 19 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 20 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 21 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 22 is a perspective view of a CHARGER POSITIONING BELT according to a fourth embodiment.
FIG. 23 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 22.
FIG. 24 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 22, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 25 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 22.
FIG. 26 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 22.
FIG. 27 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 22.
FIG. 28 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 22.
FIG. 29 is a perspective view of a CHARGER POSITIONING BELT according to a fifth embodiment.
FIG. 30 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 29.
FIG. 31 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 29, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 32 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 29.
FIG. 33 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 29.
FIG. 34 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 29.
FIG. 35 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 29.
FIG. 36 is a perspective view of a CHARGER POSITIONING BELT according to a sixth embodiment.
FIG. 37 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 36.
FIG. 38 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 36, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 39 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 36.
FIG. 40 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 36.
FIG. 41 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 36.
FIG. 42 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 36.
FIG. 43 is a top view of a CHARGER POSITIONING BELT according to a seventh embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 44 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 43.
FIG. 45 is a perspective view of the CHARGER POSITIONING BELT depicted in FIG. 43.
FIG. 46 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 43.
FIG. 47 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 46.
FIG. 48 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 43.
FIG. 49 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 43.
FIG. 50 is a perspective view of a CHARGER POSITIONING BELT according to an eighth embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 51 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 50.
FIG. 52 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 50.
FIG. 53 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 50.
FIG. 54 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 50.
FIG. 55 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 50.
FIG. 56 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 50.
FIG. 57 is a perspective view of a CHARGER POSITIONING BELT according to an ninth embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 58 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 57.
FIG. 59 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 57.
FIG. 60 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 57.
FIG. 61 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 57.
FIG. 62 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 57.
FIG. 63 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 57.
The broken lines depict portions of the article that form no part of the claimed design.

公开(公告)号：USD998933S1

公开(公告)日：2023-09-19

申请号：US29710835

申请日：2019-10-25

Applicant: Galvani Bioelectronics Limited

Designer： Morten Hansen ,  Jay Canham

Abstract: FIG. 1 is a perspective view of a CHARGER POSITIONING BELT according to a first embodiment.
FIG. 2 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 3 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 4 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 5 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 6 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 7 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 8 is a perspective view of a CHARGER POSITIONING BELT according to a second embodiment.
FIG. 9 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 10 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 11 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 12 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 13 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 14 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 15 is a perspective view of a CHARGER POSITIONING BELT according to a third embodiment.
FIG. 16 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 17 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 18 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 19 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 20 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 21 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 22 is a rear detailed perspective partial view of an end of the CHARGER POSITIONING BELT depicted in all three of the embodiments, with the remainder of the charger positioning belt broken away and the band removed for convenience of illustration.
The broken lines depict portions of the article that form no part of the claimed design.

公开(公告)号：US11724102B2

公开(公告)日：2023-08-15

申请号：US17872829

申请日：2022-07-25

Applicant: Galvani Bioelectronics Limited

Inventor： Matteo Donega ,  Daniel John Chew ,  Margarita J. Vervoordeldonk ,  Isha Gupta

IPC: A61N1/00 ,  A61N1/05 ,  A61N1/36 ,  A61N1/378

CPC classification number: A61N1/0556 ,  A61N1/0553 ,  A61N1/36053 ,  A61N1/36057 ,  A61N1/36071 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/36171 ,  A61N1/3787

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.