公开(公告)号：US6027692A

公开(公告)日：2000-02-22

申请号：US764320

申请日：1996-12-12

申请人： Robert S. Galen ,  John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

发明人： Robert S. Galen ,  John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

IPC分类号： C12Q1/34 ,  C12Q1/54 ,  G01N33/52 ,  G01N33/66 ,  G01N21/78

CPC分类号： C12Q1/34 ,  C12Q1/54 ,  G01N33/526 ,  G01N33/66 ,  C12Q2326/12 ,  C12Q2326/14 ,  C12Q2326/92 ,  G01N21/645 ,  G01N2333/42 ,  Y10S435/97 ,  Y10S436/828 ,  Y10T436/144444

摘要： The present invention is directed to a single test system and method for determining the integrated glycemic condition of a subject by measuring the concentration of glucose and the level of protein-bound glucose in a subject's body fluid, such as whole blood. The glucose concentration is indicative of the subject's immediate glycemic condition, whereas the protein-bound glucose concentration is indicative of either intermediate or long-term glycemic condition. Optionally, other analytes indicative of glycemic condition, such as ketone bodies or fatty acid derivatives, can also be measured. The present invention also provides a method of diagnosing diabetes. The invention additionally provides a method for analyzing the concentration of fructosamine in less than or equal to five minutes without the use of a reaction accelerator.

公开(公告)号：US5639672A

公开(公告)日：1997-06-17

申请号：US543482

申请日：1995-10-16

申请人： John F. Burd ,  Gebhard Neyer

发明人： John F. Burd ,  Gebhard Neyer

IPC分类号： G01N33/53 ,  C12Q1/00 ,  G01N27/327 ,  G01N27/416 ,  G01N33/553

CPC分类号： G01N33/553 ,  C12Q1/005 ,  Y10S436/806 ,  Y10S436/815 ,  Y10T436/173845 ,  Y10T436/25

摘要： The present invention relates to a method for electrochemically measuring the concentration of fructosamine, or its high alkalinity eneaminol tautomer in a body fluid sample.

摘要翻译： 本发明涉及一种电化学测量体液样品中果糖胺或其高碱度烯胺互变异构体浓度的方法。

公开(公告)号：US5725774A

公开(公告)日：1998-03-10

申请号：US418523

申请日：1995-04-07

申请人： Gebhard Neyer

发明人： Gebhard Neyer

IPC分类号： G01N33/48 ,  A61M1/02 ,  B01D39/16 ,  B01D39/18 ,  B01D69/10 ,  C12Q1/00 ,  C12Q1/54 ,  D04H1/42 ,  D04H13/00 ,  G01N33/50 ,  G01N33/52 ,  G01N33/66 ,  B01D37/00 ,  B01D39/00

CPC分类号： G01N33/5002 ,  B01D39/1623 ,  B01D39/18 ,  B01D69/10 ,  D04H1/435 ,  D04H13/00 ,  G01N33/525 ,  G01N33/526 ,  G01N33/66 ,  Y10T436/25375 ,  Y10T436/255

摘要： The present invention relates to a method and to a device for separating plasma from whole blood. The method and device utilize a permeable non-glass fiber matrix containing a polyol which is capable of clumping red blood cells. The matrix, in the absence of such a polyol, would otherwise be porous to red blood cells. The polyol-containing matrix has a first surface and a second surface such that a whole blood sample which is applied to the first surface flows directionally toward the second surface. Plasma separated from whole blood becomes available at the second surface of the matrix and can be tested for the presence of a particular analyte, such as glucose or fructosamine, as provided by multi-layer test devices of the present invention.

摘要翻译： 本发明涉及一种从全血中分离血浆的方法和装置。 该方法和装置利用含有能够聚集红细胞的多元醇的可渗透的非玻璃纤维基质。 在没有这种多元醇的情况下，该基质否则对于红细胞是多孔的。 含多元醇的基质具有第一表面和第二表面，使得施加到第一表面的全血样品朝向第二表面方向流动。 从全血分离的血浆在基质的第二表面可用，并且可以测试由本发明的多层测试装置提供的特定分析物如葡萄糖或果糖胺的存在。

公开(公告)号：US5695949A

公开(公告)日：1997-12-09

申请号：US418495

申请日：1995-04-07

申请人： Robert S. Galen ,  John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

发明人： Robert S. Galen ,  John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

IPC分类号： C12Q1/34 ,  C12Q1/54 ,  G01N33/52 ,  G01N33/66 ,  G01N31/22

CPC分类号： C12Q1/34 ,  C12Q1/54 ,  G01N33/526 ,  G01N33/66 ,  C12Q2326/12 ,  C12Q2326/14 ,  C12Q2326/92 ,  G01N21/645 ,  G01N2333/42 ,  Y10S435/97 ,  Y10S436/828 ,  Y10T436/144444

摘要： The present invention is directed to a single test system and method for determining the integrated glycemic condition of a subject by measuring the concentration of glucose and the level of protein-bound glucose in a subject's body fluid, such as whole blood. The glucose concentration is indicative of the subject's immediate glycemic condition, whereas the protein-bound glucose concentration is indicative of either intermediate or long-term glycemic condition. Optionally, other analytes indicative of glycemic condition, such as ketone bodies or fatty acid derivatives, can also be measured. The present invention also provides a method of diagnosing diabetes. The invention additionally provides a method for analyzing the concentration of fructosamine in less than or equal to five minutes without the use of a reaction accelerator.

摘要翻译： 本发明涉及用于通过测量受试者体液（例如全血）中葡萄糖浓度和蛋白质结合葡萄糖水平来测定受试者的综合血糖状况的单一测试系统和方法。 葡萄糖浓度表示受试者的立即血糖状况，而蛋白质结合的葡萄糖浓度则指示中度或长期血糖状态。 任选地，还可以测量指示血糖状况的其它分析物，例如酮体或脂肪酸衍生物。 本发明还提供了诊断糖尿病的方法。 本发明另外提供了一种在不使用反应促进剂的情况下分析小于或等于五分钟的果糖胺浓度的方法。

公开(公告)号：US5470752A

公开(公告)日：1995-11-28

申请号：US269351

申请日：1994-06-29

申请人： John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

发明人： John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

IPC分类号： G01N31/00 ,  G01N31/22 ,  G01N33/487 ,  G01N33/52 ,  G01N33/66

CPC分类号： G01N33/526 ,  Y10S435/805 ,  Y10S436/825 ,  Y10T436/255

摘要： The present invention is directed to a multi-layer test device and method for analyzing the concentration of fructosamine in a liquid sample. The multi-layer test device has a buffer layer containing a buffer having a pH value of at least 9 which is either superposed above or juxtaposed to an indicator layer containing an indicator capable of being reduced by fructosamine. Supporting the buffer layer, the indicator layer, and any additional layers in the multi-layer device is at least one support member which optionally has a detection aperture for analyzing the concentration of fructosamine on the indicator layer. An additional support member having a sample aperture can be used. Where two support members are used the multi-layers are sandwiched between the first support member having a sample aperture and the second support member optionally having a detection aperture.

摘要翻译： 本发明涉及用于分析液体样品中果糖胺浓度的多层测试装置和方法。 多层测试装置具有缓冲层，该缓冲层含有pH值至少为9的缓冲液，该缓冲层叠加在含有能够被果糖胺还原的指示剂的指示剂层上方或并置。 支撑缓冲层，指示层和多层装置中的任何附加层是至少一个支撑构件，其任选地具有用于分析指示剂层上果糖胺浓度的检测孔。 可以使用具有样品孔的另外的支撑构件。 在使用两个支撑构件的情况下，多层夹在具有样品孔的第一支撑构件和可选地具有检测孔的第二支撑构件之间。

公开(公告)号：US06958129B2

公开(公告)日：2005-10-25

申请号：US10666364

申请日：2003-09-19

申请人： Robert S. Galen ,  John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

发明人： Robert S. Galen ,  John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

IPC分类号： C12Q1/34 ,  C12Q1/54 ,  G01N33/52 ,  G01N33/66 ,  G01N31/22

CPC分类号： C12Q1/34 ,  C12Q1/54 ,  C12Q2326/12 ,  C12Q2326/14 ,  C12Q2326/92 ,  G01N21/645 ,  G01N33/526 ,  G01N33/66 ,  G01N2333/42 ,  Y10S435/97 ,  Y10S436/828 ,  Y10T436/144444

摘要： The present invention is directed to a single test system and method for determining the integrated glycemic condition of a subject by measuring the concentration of glucose and the level of protein-bound glucose in a subject's body fluid, such as whole blood. The glucose concentration is indicative of the subject's immediate glycemic condition, whereas the protein-bound glucose concentration is indicative of either intermediate or long-term glycemic condition. Optionally, other analytes indicative of glycemic condition, such as ketone bodies or fatty acid derivatives, can also be measured. The present invention also provides a method of diagnosing diabetes. The invention additionally provides a method for analyzing the concentration of fructosamine in less than or equal to five minutes without the use of a reaction accelerator.

摘要翻译： 本发明涉及一种用于通过测量受试者体液（例如全血）中葡萄糖浓度和蛋白质结合葡萄糖水平来测定受试者的综合血糖状况的单一测试系统和方法。 葡萄糖浓度表示受试者的立即血糖状况，而蛋白质结合的葡萄糖浓度则指示中度或长期血糖状态。 任选地，还可以测量指示血糖状况的其它分析物，例如酮体或脂肪酸衍生物。 本发明还提供了诊断糖尿病的方法。 本发明另外提供了一种在不使用反应促进剂的情况下分析小于或等于五分钟的果糖胺浓度的方法。

公开(公告)号：US06670192B1

公开(公告)日：2003-12-30

申请号：US09477900

申请日：2000-01-05

申请人： Robert S. Galen ,  John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

发明人： Robert S. Galen ,  John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

IPC分类号： G01D3372

CPC分类号： C12Q1/34 ,  C12Q1/54 ,  C12Q2326/12 ,  C12Q2326/14 ,  C12Q2326/92 ,  G01N21/645 ,  G01N33/526 ,  G01N33/66 ,  G01N2333/42 ,  Y10S435/97 ,  Y10S436/828 ,  Y10T436/144444

摘要： The present invention is directed to a single test system and method for determining the integrated glycemic condition of a subject by measuring the concentration of glucose and the level of protein-bound glucose in a subject's body fluid, such as whole blood. The glucose concentration is indicative of the subject's immediate glycemic condition, whereas the protein-bound glucose concentration is indicative of either intermediate or long-term glycemic condition. Optionally, other analytes indicative of glycemic condition, such as ketone bodies or fatty acid derivatives, can also be measured. The present invention also provides a method of diagnosing diabetes. The invention additionally provides a method for analyzing the concentration of fructosamine in less than or equal to five minutes without the use of a reaction accelerator.

摘要翻译： 本发明涉及用于通过测量受试者体液（例如全血）中葡萄糖浓度和蛋白质结合葡萄糖水平来测定受试者的综合血糖状况的单一测试系统和方法。 葡萄糖浓度表示受试者的立即血糖状况，而蛋白质结合的葡萄糖浓度则指示中度或长期血糖状态。 任选地，还可以测量指示血糖状况的其它分析物，例如酮体或脂肪酸衍生物。 本发明还提供了诊断糖尿病的方法。 本发明另外提供了一种在不使用反应促进剂的情况下分析小于或等于五分钟的果糖胺浓度的方法。

公开(公告)号：US5762871A

公开(公告)日：1998-06-09

申请号：US892697

申请日：1997-07-15

申请人： Gebhard Neyer

发明人： Gebhard Neyer

IPC分类号： G01N33/48 ,  A61M1/02 ,  B01D39/16 ,  B01D39/18 ,  B01D69/10 ,  C12Q1/00 ,  C12Q1/54 ,  D04H1/42 ,  D04H13/00 ,  G01N33/50 ,  G01N33/52 ,  G01N33/66

CPC分类号： G01N33/5002 ,  B01D39/1623 ,  B01D39/18 ,  B01D69/10 ,  D04H1/435 ,  D04H13/00 ,  G01N33/525 ,  G01N33/526 ,  G01N33/66 ,  Y10T436/25375 ,  Y10T436/255

摘要： The present invention relates to a method and to a device for separating plasma from whole blood. The method and device utilize a permeable non-glass fiber matrix containing a polyol which is capable of clumping red blood cells. The matrix, in the absence of such a polyol, would otherwise be porous to red blood cells. The polyol-containing matrix has a first surface and a second surface such that a whole blood sample which is applied to the first surface flows directionally toward the second surface. Plasma separated from whole blood becomes available at the second surface of the matrix and can be tested for the presence of a particular analyte, such as glucose or fructosamine, as provided by multi-layer test devices of the present invention.

摘要翻译： 本发明涉及一种从全血中分离血浆的方法和装置。 该方法和装置利用含有能够聚集红细胞的多元醇的可渗透的非玻璃纤维基质。 在没有这种多元醇的情况下，该基质否则对于红细胞是多孔的。 含多元醇的基质具有第一表面和第二表面，使得施加到第一表面的全血样品朝向第二表面方向流动。 从全血分离的血浆在基质的第二表面可用，并且可以测试由本发明的多层测试装置提供的特定分析物如葡萄糖或果糖胺的存在。