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    Organ regeneration device
    1.
    发明授权
    Organ regeneration device 有权
    器官再生装置

    公开(公告)号：US08652524B2

    公开(公告)日：2014-02-18

    申请号：US12325015

    申请日：2008-11-28

    申请人： Ichiro Ono ,  Yoshikiyo Akasaka ,  Takehiko Nakajima

    发明人： Ichiro Ono ,  Yoshikiyo Akasaka ,  Takehiko Nakajima

    IPC分类号： A61K9/14 ,  A61K47/42 ,  A61K47/02 ,  A61K31/7088 ,  A61K38/18 ,  A61K35/12

    CPC分类号： A61K31/7088 ,  A61K38/18 ,  A61K38/1825 ,  A61K38/1875 ,  A61K48/0075 ,  A61K48/0091 ,  A61K2300/00

    摘要： An organ regeneration device adapted to be used by placing it into a defective portion of an organ to regenerate the organ is provided. The organ regeneration device has a base body having a shape corresponding to a shape of the defective portion of the organ. The organ regeneration device also has particles carried on the base body, wherein the particles are composed of a different material from that of the base body. The organ regeneration device also has a growth-related substance contained in the organ regeneration device for growth and differentiation of cells around the defective portion. The growth-related substance contains an angiogenesis factor. Further, the growth-related substance contains nucleic acid containing a base sequence coding for amino-acid sequence of a growth factor different from the angiogenesis factor. Furthermore, the nucleic acid is introduced into a host cell.

    摘要翻译： 提供了一种适于通过将其置于器官的缺陷部分以再生器官而使用的器官再生装置。 器官再生装置具有与器官的有缺陷部的形状对应的形状的基体。 器官再生装置还具有承载在基体上的颗粒，其中颗粒由与基体不同的材料构成。 器官再生装置还具有包含在器官再生装置中的生长相关物质，用于在缺陷部分周围的细胞的生长和分化。 生长相关物质含有血管生成因子。 此外，生长相关物质含有含有编码不同于血管生成因子的生长因子的氨基酸序列的碱基序列的核酸。 此外，将核酸引入宿主细胞。

    Surface-treated powder and cosmetic preparation
    2.
    发明授权
    Surface-treated powder and cosmetic preparation 有权
    表面处理粉末和化妆品制剂

    公开(公告)号：US07722899B2

    公开(公告)日：2010-05-25

    申请号：US10479993

    申请日：2002-06-03

    申请人： Ichiro Ono ,  Masanao Kamei ,  Kiyomi Tachibana

    发明人： Ichiro Ono ,  Masanao Kamei ,  Kiyomi Tachibana

    IPC分类号： A61K9/14 ,  A61K8/02 ,  A61Q5/00 ,  A61Q19/00 ,  A61Q15/00

    CPC分类号： A61K8/11 ,  A61K8/19 ,  A61K8/895 ,  A61K2800/412 ,  A61Q1/00 ,  Y10S514/844

    摘要： A surface-treated powder powder which is surface-treated with an acrylic/silicone copolymer having at least one hydrolyzable silyl group in the molecule, and a cosmetic material containing this powder.The surface-treated powder of this invention preferably contains 0.1-30 wt parts of the acrylic/silicone copolymer relative to 100 wt parts of the powder prior to surface treatment. The acrylic/silicone copolymer preferably comprises a trunk polymer comprising an acrylic polymer, and a branched polymer comprising an organic polysiloxane.The surface activity of the surface-treated powder of this invention is very well blocked, and it has excellent water resistance and sebum resistance. In addition, the cosmetic material of this invention containing this surface-treated powder has good cosmetic lasting properties, and is highly stable over time.

    摘要翻译： 用分子中具有至少一个可水解甲硅烷基的丙烯酸/硅氧烷共聚物进行表面处理的表面处理粉末粉末和含有该粉末的化妆品。 本发明的表面处理粉末相对于表面处理前的100重量份粉末优选含有0.1-30重量份的丙烯酸/硅氧烷共聚物。 丙烯酸/硅氧烷共聚物优选包括包含丙烯酸类聚合物的树脂聚合物和包含有机聚硅氧烷的支化聚合物。 本发明的表面处理粉末的表面活性非常好地被阻断，并且具有优异的耐水性和耐皮脂性。 此外，含有该表面处理粉末的本发明的化妆品材料具有良好的化妆品持久性，并且随着时间的推移高度稳定。

    Organic silicone resin powder
    5.
    发明授权
    Organic silicone resin powder 失效
    有机硅树脂粉

    公开(公告)号：US06399081B1

    公开(公告)日：2002-06-04

    申请号：US09504949

    申请日：2000-02-16

    申请人： Tetsuo Nakanishi ,  Ichiro Ono ,  Shinji Miyadai

    发明人： Tetsuo Nakanishi ,  Ichiro Ono ,  Shinji Miyadai

    IPC分类号： A61K600

    CPC分类号： A61K8/895 ,  A61Q1/06 ,  A61Q1/10 ,  A61Q1/12 ,  A61Q3/02 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q15/00 ,  A61Q19/00 ,  A61Q19/10

    摘要： An organic silicone resin powder having a tabular shape the aspect ratio of which is greater than about 1 and comprising a copolymer produced by polymerization reaction between an organopolysiloxane containing at least one reactive group and at least one kind of monomer or oligomer capable of reacting to said reactive group, which can fully achieve its excellent effects when mixed in cosmetic materials, waxes and coating colors, especially in cosmetic materials.

    摘要翻译： 一种有机硅树脂粉末，其长宽比大于约1的片状，并且包含通过含有至少一个反应性基团的有机聚硅氧烷与至少一种能够对所述的至少一种反应性基团反应的至少一种单体或低聚物之间的聚合反应而产生的共聚物 反应性基团，在化妆品，蜡和涂料颜色混合时，特别是化妆品中，可以充分发挥其优异的效果。

    Microneedle assembly formulation for skin treatment
    9.
    发明授权
    Microneedle assembly formulation for skin treatment 有权

    公开(公告)号：US09795774B2

    公开(公告)日：2017-10-24

    申请号：US13696621

    申请日：2012-06-28

    申请人： Kanji Takada ,  Ichiro Ono

    发明人： Kanji Takada ,  Ichiro Ono

    IPC分类号： A61M37/00 ,  A61K9/70 ,  A61K45/06 ,  A61K9/00 ,  A61K38/18

    CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61K9/70 ,  A61K38/1825 ,  A61K45/06 ,  A61M2037/0046

    摘要： A problem to be solved of the present invention is to provide a drug formulation and a method of administering an active ingredient which allow the active ingredient to be delivered evenly into the site of action in the skin with high efficiency while ensuring stability of the active ingredient over a long time, and which are easily handled and are less stressful for patients. Mean for solving the problem is a microneedle assembly formulation for skin treatment comprising a platform and a plurality of conical or pyramidal microneedles formed on the platform containing a base composed of a bio-soluble and thread-forming polymer substance and an objective substance retained in the base, wherein the objective substance is a substance effective for prevention or treatment of skin senescence, or treatment of skin scar.

    MICRONEEDLE ASSEMBLY FORMULATION FOR SKIN TREATMENT
    10.
    发明申请
    MICRONEEDLE ASSEMBLY FORMULATION FOR SKIN TREATMENT 有权
    用于皮肤治疗的MICRONEEDLE组装配方

    公开(公告)号：US20130072902A1

    公开(公告)日：2013-03-21

    申请号：US13696621

    申请日：2012-06-28

    申请人： Kanji Takada ,  Ichiro Ono

    发明人： Kanji Takada ,  Ichiro Ono

    IPC分类号： A61M37/00

    CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61K9/70 ,  A61K38/1825 ,  A61K45/06 ,  A61M2037/0046

    摘要： A problem to be solved of the present invention is to provide a drug formulation and a method of administering an active ingredient which allow the active ingredient to be delivered evenly into the site of action in the skin with high efficiency while ensuring stability of the active ingredient over a long time, and which are easily handled and are less stressful for patients. Mean for solving the problem is a microneedle assembly formulation for skin treatment comprising a platform and a plurality of conical or pyramidal microneedles formed on the platform containing a base composed of a bio-soluble and thread-forming polymer substance and an objective substance retained in the base, wherein the objective substance is a substance effective for prevention or treatment of skin senescence, or treatment of skin scar.

    摘要翻译： 本发明要解决的问题是提供一种药物制剂和施用活性成分的方法，所述活性成分允许活性成分以高效率均匀地输送到皮肤中的作用部位，同时确保活性成分的稳定性 很长时间，容易处理，对患者压力较小。 解决问题的意思是用于皮肤处理的微针组装配方，其包括平台和形成在平台上的多个锥形或金字塔形微针，其包含由生物可溶和线形成聚合物物质组成的基质和保留在 碱，其中目标物质是有效预防或治疗皮肤衰老的物质，或治疗皮肤瘢痕。