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公开(公告)号：US09403898B2
公开(公告)日：2016-08-02
申请号：US13319027
申请日：2010-05-07
Applicant: Lee Edward Blackwell , Jason Cameron , Phillip Harvey Morton , Steven James Burton , Richard Anthony Dodd , Mark Jonathan Burton
Inventor： Lee Edward Blackwell , Jason Cameron , Phillip Harvey Morton , Steven James Burton , Richard Anthony Dodd , Mark Jonathan Burton
CPC classification number: C07K16/00 , C07K14/765 , C07K16/18 , C07K16/44 , C07K2317/41 , C07K2317/569 , C07K2317/622 , C07K2319/20 , C07K2319/31 , C07K2319/43
Abstract: An improved method for purifying albumin, a variant or fragment thereof, a fusion protein comprising albumin, a variant or fragment thereof, or a conjugate comprising albumin, a variant or fragment thereof is disclosed.
Abstract translation: 公开了一种用于纯化白蛋白，其变体或片段，包含白蛋白的融合蛋白，其变体或片段或包含白蛋白，其变体或片段的缀合物的改进方法。
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公开(公告)号：US08707515B2
公开(公告)日：2014-04-29
申请号：US13479960
申请日：2012-05-24
Applicant: Jason Cameron Payne , Karyne Poissant Prevratil , Howard Clark Schwartz
IPC: H01R13/00
CPC classification number: H02G15/007 , G02B6/4442 , G02B6/4471 , G02B6/4477 , H02G15/013
Abstract: A strain relief device for securing three radially arrayed flat cables coming into a closure includes a body having three armatures extending radially. Each armature includes at least two cantilevered segments extending from the at least one armature in opposing directions. At least one cable may be received in a receiving area partially defined by the armature and the cantilevered segment. Compressive force acting on the strain relief device secures the cables in the receiving area relative to the strain relief device.
Abstract translation: 用于固定进入封闭件的三个径向排列的扁平电缆的应变消除装置包括具有径向延伸的三个电枢的主体。 每个电枢包括至少两个在相反方向上从所述至少一个电枢延伸的悬臂段。 至少一个电缆可以被接收在由电枢和悬臂段部分限定的接收区域中。 作用在应变消除装置上的压缩力相对于应变消除装置固定接收区域中的电缆。
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公开(公告)号：US08607837B2
公开(公告)日：2013-12-17
申请号：US13148327
申请日：2010-02-05
Applicant: Anthony John Ruddell , Per Ola Eriksson , Jason Cameron Schulte , Gavin Jeffery Tang Sue Yek
Inventor： Anthony John Ruddell , Per Ola Eriksson , Jason Cameron Schulte , Gavin Jeffery Tang Sue Yek
IPC: B32B38/00
CPC classification number: C25C7/08 , Y10T29/49023 , Y10T29/49721 , Y10T29/49753 , Y10T29/49815 , Y10T29/49817 , Y10T29/49819 , Y10T29/49821 , Y10T29/49822 , Y10T29/5137 , Y10T29/5139 , Y10T29/53274 , Y10T29/53278 , Y10T29/53283 , Y10T29/53596 , Y10T29/53683 , Y10T156/11 , Y10T156/1174 , Y10T156/1179 , Y10T156/19 , Y10T156/195 , Y10T156/1956
Abstract: An apparatus for stripping metal from a cathode plate, the apparatus comprising stripping means adapted for positioning between the metal and the cathode plate in order to separate the metal from the cathode plate, and wherein movement of the stripping means is achieved through movement of a robotic arm.
Abstract translation: 一种用于从阴极板剥离金属的装置，该装置包括适于在金属和阴极板之间定位的剥离装置，以将金属与阴极板分离，并且其中通过机器人的移动来实现剥离装置的移动 臂。
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公开(公告)号：US20120037319A1
公开(公告)日：2012-02-16
申请号：US13148327
申请日：2010-02-05
Applicant: Anthony John Ruddell , Per Ola Eriksson , Jason Cameron Schulte , Gavin Jeffery Tang Sue Yek
Inventor： Anthony John Ruddell , Per Ola Eriksson , Jason Cameron Schulte , Gavin Jeffery Tang Sue Yek
IPC: B32B38/10
CPC classification number: C25C7/08 , Y10T29/49023 , Y10T29/49721 , Y10T29/49753 , Y10T29/49815 , Y10T29/49817 , Y10T29/49819 , Y10T29/49821 , Y10T29/49822 , Y10T29/5137 , Y10T29/5139 , Y10T29/53274 , Y10T29/53278 , Y10T29/53283 , Y10T29/53596 , Y10T29/53683 , Y10T156/11 , Y10T156/1174 , Y10T156/1179 , Y10T156/19 , Y10T156/195 , Y10T156/1956
Abstract: An apparatus for stripping metal from a cathode plate, the apparatus comprising stripping means adapted for positioning between the metal and the cathode plate in order to separate the metal from the cathode plate, and wherein movement of the stripping means is achieved through movement of a robotic arm.
Abstract translation: 一种用于从阴极板剥离金属的装置，该装置包括适于在金属和阴极板之间定位的剥离装置，以将金属与阴极板分离，并且其中通过机器人的移动来实现剥离装置的移动 臂。
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公开(公告)号：US20110301329A1
公开(公告)日：2011-12-08
申请号：US13175155
申请日：2011-07-01
Applicant: Hendrik Van Urk , David John Mead , Philip Harvey Morton , Andrew John Cartwright , Jason Cameron , David James Ballance , Michel Gaston Joseph Grandgeorge , Stephen Berezenko , John Rodney Woodrow , Darrell Sleep , Jean-Luc Bernard Veron
Inventor： Hendrik Van Urk , David John Mead , Philip Harvey Morton , Andrew John Cartwright , Jason Cameron , David James Ballance , Michel Gaston Joseph Grandgeorge , Stephen Berezenko , John Rodney Woodrow , Darrell Sleep , Jean-Luc Bernard Veron
CPC classification number: B01D15/3804 , B01D15/362 , B01D15/363 , C07K14/76 , C07K14/765
Abstract: A process is provided for the preparation of a highly pure albumin solution the process comprising subjecting albumin (preferably expressed and secreted by transformed yeast) to a series of chromatographic steps. Preferably, the process comprises the steps of positive mode cation exchange chromatography, positive mode anion exchange chromatography, positive mode affinity chromatography, negative mode affinity chromatography (preferably using immobilised aminophenylboronic acid), negative mode cation exchange chromatography, and negative or positive mode anion exchange chromatography. A process for reducing the level of nickel in an albumin solution is also disclosed, as is a recombinant albumin coding sequence comprising two or more in-frame translation stop codons. Also disclosed is a process for producing recombinant albumin, the process comprising culturing a fungal cell expressing a is recombinant albumin coding sequence, wherein the cell has a reduced capacity of mannosylation of the recombinantly-expressed albumin.
Abstract translation: 提供了一种制备高纯度白蛋白溶液的方法，该方法包括使白蛋白（优选由转化酵母表达和分泌）经历一系列色谱步骤。 优选地，该方法包括以下步骤：阳离子阳离子交换层析，阳性阴离子交换层析，阳性模式亲和层析，负模式亲和色谱法（优选使用固定化氨基苯基硼酸），阴离子阳离子交换色谱法和阴性或阳性阴离子交换 色谱法。 还公开了一种用于降低白蛋白溶液中镍含量的方法，重组白蛋白编码序列还包含两个或更多个帧内翻译终止密码子。 还公开了一种生产重组白蛋白的方法，所述方法包括培养表达α的真菌细胞是重组白蛋白编码序列，其中所述细胞具有降低的重组表达白蛋白的甘露糖基化能力。
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Patent Agency Ranking
公开(公告)号：US10233228B2
公开(公告)日：2019-03-19
申请号：US13640235
申请日：2011-04-08
Applicant: Andrew Plumridge , Darrell Sleep , Inger Sandlie , Jan Terje Andersen , Jason Cameron , Leslie Evans , Steven Athwal , Elizabeth Allan , Esben Peter Friis
Inventor： Andrew Plumridge , Darrell Sleep , Inger Sandlie , Jan Terje Andersen , Jason Cameron , Leslie Evans , Steven Athwal , Elizabeth Allan , Esben Peter Friis
IPC: C07K14/765
Abstract: The application discloses albumin derivatives comprising or consisting of domain III and at least one further domain wherein the derivative or variant is not a naturally occurring albumin derivative or variant. The derivatives may be used in conjugates and fusion polypeptides.
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公开(公告)号：US09029102B2
公开(公告)日：2015-05-12
申请号：US13175155
申请日：2011-07-01
Applicant: Hendrik Van Urk , Philip Harvey Morton , Andrew John Cartwright , Jason Cameron , David James Ballance , Michael Gaston Joseph Grandgeorge , Stephen Berezenko , John Rodney Woodrow , Jean-Luc Bernard Veron
Inventor： Hendrik Van Urk , Philip Harvey Morton , Andrew John Cartwright , Jason Cameron , David James Ballance , Michael Gaston Joseph Grandgeorge , Stephen Berezenko , John Rodney Woodrow , Jean-Luc Bernard Veron
IPC: C12N15/14 , C07K14/00 , B01D15/38 , B01D15/36 , C07K14/765
CPC classification number: B01D15/3804 , B01D15/362 , B01D15/363 , C07K14/76 , C07K14/765
Abstract: A process is provided for the preparation of a highly pure albumin solution the process comprising subjecting albumin (preferably expressed and secreted by transformed yeast) to a series of chromatographic steps. Preferably, the process comprises the steps of positive mode cation exchange chromatography, positive mode anion exchange chromatography, positive mode affinity chromatography, negative mode affinity chromatography (preferably using immobilized aminophenylboronic acid), negative mode cation exchange chromatography, and negative or positive mode anion exchange chromatography. A process for reducing the level of nickel in an albumin solution is also disclosed, as is a recombinant albumin coding sequence comprising two or more in-frame translation stop codons. Also disclosed is a process for producing recombinant albumin, the process comprising culturing a fungal cell expressing a is recombinant albumin coding sequence, wherein the cell has a reduced capacity of mannosylation of the recombinantly-expressed albumin.
Abstract translation: 提供了一种制备高纯度白蛋白溶液的方法，该方法包括使白蛋白（优选由转化酵母表达和分泌）经历一系列色谱步骤。 优选地，该方法包括以下步骤：阳离子阳离子交换层析，阳性阴离子交换层析，阳性模式亲和层析，负模式亲和色谱法（优选使用固定化氨基苯基硼酸），阴离子阳离子交换色谱法和阴性或阳性阴离子交换 色谱法。 还公开了一种用于降低白蛋白溶液中镍含量的方法，重组白蛋白编码序列还包含两个或更多个帧内翻译终止密码子。 还公开了一种生产重组白蛋白的方法，所述方法包括培养表达α的真菌细胞是重组白蛋白编码序列，其中所述细胞具有降低的重组表达白蛋白的甘露糖基化能力。
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公开(公告)号：US08748380B2
公开(公告)日：2014-06-10
申请号：US13504326
申请日：2010-11-01
Applicant: Andrew Plumridge , Darrell Sleep , Jason Cameron , Inger Sandlie , Jan Terje Andersen , Esben Peter Friis
Inventor： Andrew Plumridge , Darrell Sleep , Jason Cameron , Inger Sandlie , Jan Terje Andersen , Esben Peter Friis
IPC: A61K38/38 , A61K47/48 , C07K14/76 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07H21/04 , C12P21/06 , C12P21/04
CPC classification number: C07K14/765 , A61K45/06 , C07K14/54 , C07K2319/20 , C07K2319/31
Abstract: The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin.
Abstract translation: 本发明涉及与母体白蛋白相比具有改变的血浆半衰期的亲本白蛋白的变体。 本发明还涉及包含所述变体白蛋白的融合多肽和缀合物。
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公开(公告)号：US20130028930A1
公开(公告)日：2013-01-31
申请号：US13640235
申请日：2011-04-08
Applicant: Andrew Plumridge , Darrell Sleep , Inger Sandlie , Jan Terje Andersen , Jason Cameron , Leslie Evans , Steven Athwal , Elizabeth Allan , Esben Peter Friis
Inventor： Andrew Plumridge , Darrell Sleep , Inger Sandlie , Jan Terje Andersen , Jason Cameron , Leslie Evans , Steven Athwal , Elizabeth Allan , Esben Peter Friis
CPC classification number: C07K14/765 , C07K2319/00
Abstract: The application discloses albumin derivatives comprising or consisting of domain III and at least one further domain wherein the derivative or variant is not a naturally occurring albumin derivative or variant. The derivatives may be used in conjugates and fusion polypeptides.
Abstract translation: 本申请公开了包含或由结构域III和至少一个其它结构域组成的白蛋白衍生物，其中该衍生物或变体不是天然存在的白蛋白衍生物或变体。 衍生物可用于缀合物和融合多肽。
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公开(公告)号：US20120220530A1
公开(公告)日：2012-08-30
申请号：US13504326
申请日：2010-11-01
Applicant: Andrew Plumridge , Darrell Sleep , Jason Cameron , Inger Sandlie , Jan Terje Andersen , Esben Peter Friis
Inventor： Andrew Plumridge , Darrell Sleep , Jason Cameron , Inger Sandlie , Jan Terje Andersen , Esben Peter Friis
CPC classification number: C07K14/765 , A61K45/06 , C07K14/54 , C07K2319/20 , C07K2319/31
Abstract: The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin.
Abstract translation: 本发明涉及与母体白蛋白相比具有改变的血浆半衰期的亲本白蛋白的变体。 本发明还涉及包含所述变体白蛋白的融合多肽和缀合物。
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