摘要:
Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronate compounds and their use as therapeutic agents.
摘要:
The Present Invention relies upon a physical process for preparing reduced fat, high fiber, high protein, low calorie roasted snack nuts. The process of the Present Invention exhibits significantly lower process times and higher yields than the prior art processes. The process comprises expelling the oil from nutmeat kernels (defatting) using a novel pressing process that takes less than a minute. The defatting process deforms the nuts. The nuts are reformed to their original shape using water. Then the reformed nuts are annealed using cold water to produce hardened nuts. The nuts are then dried and post-processed with coatings and roasting using state-of-the-art technology. The yield of snack nuts produced by this process is generally greater than eighty percent.
摘要:
A computer implemented method, system, and/or computer program product optimize a shared service delivery system. A model of an existing shared service delivery system is created. Capacity of the existing shared service delivery system is defined according to required resources for existing projects, new projects, and proposed projects. Existing cells of practitioners in the existing shared service delivery system are identified, and any gaps or gluts of capacity in the existing cells of practitioners are identified according to a general predetermined resource requirement for the shared service delivery system.
摘要:
A highly tensile dielectric layer is generated on a heat sensitive substrate while not exceeding thermal budget constraints. Cascaded ultraviolet (UV) irradiation is used to produce highly tensile films to be used, for example, in strained NMOS transistor architectures. Successive UV radiation of equal or shorter wavelengths with variable intensity and duration selectively breaks bonds in the Si—N matrix and minimizes shrinkage and film relaxation. Higher tensile stress than a non-cascaded approach may be obtained.
摘要:
An automatic release system for a riser includes a guide funnel assembly that receives a shaft coupled to the riser. A pull-head is located inside at least a portion of the shaft and coupled to the shaft. The pull-head is coupled to a pulling mechanism. One or more spring-loaded dogs are mounted on the outside of the shaft. The dogs radially move in and out through one or more openings in the shaft aligned with the dogs and engage a groove on the pull-head when radially moved in through the openings. One or more stopper mechanisms are mounted on the outside of the shaft and aligned with the dogs. In a first position, the stopper mechanisms inhibit the dogs from disengaging from the groove in the pull-head. In a second position, the stopper mechanisms allow the dogs to disengage from the groove in the pull-head.
摘要:
A reversible mop head assembly for use with a mop handle is disclosed. The mop head assembly includes a transverse support shaft, a pair of end caps positioned at opposite ends of the transverse support shaft, a pair of opposed substrate support surfaces positioned between and supported by the end caps, and a head mount coupled to the transverse support shaft centrally between the end caps.
摘要:
Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
摘要:
The method of preparing compounds of Formula I is described: wherein: M and V are cis to one another and MPO3H2 is a phosphonic acid selected from the group consisting of 9-(2-phosphonylmethoxyethyl)adenine, and (R)-9-(2-phosphonylmethoxypropyl)adenine; wherein V is phenyl, optionally substituted with 1-2 substituents selected from a group consisting of fluoro, chloro, and bromo; comprising: coupling a chiral 1-phenylpropane-1,3-diol, wherein the phenyl may be optionally substituted, with MPOCl2 or an N-6 substituted analogue thereof. Additionally, methods and salt forms are described that enable isolation and purification of the desired isomer.
摘要翻译:描述了制备式I化合物的方法:其中:M和V彼此是顺式的,MPO 3 H 2是选自以下的膦酸: 9-(2-膦酰基甲氧基乙基)腺嘌呤和(R)-9-(2-膦酰基甲氧基丙基)腺嘌呤; 其中V是苯基,任选被1-2个选自氟,氯和溴的取代基取代; 包括:将其中苯基可以任选取代的手性1-苯基丙烷-1,3-二醇与MPOCl 2 N或其N-6取代的类似物偶联。 另外,描述了能够分离和纯化所需异构体的方法和盐形式。
摘要:
Compounds of Formula I, their preparation and synthetic intermediates, and their use in the synthesis of prodrugs: wherein: V and L are trans relative to one another; V is selected from group consisting of carbocyclic aryl, substituted carbocyclic aryl, heteroaryl, and substituted heteroaryl; and L is a leaving group selected from the group consisting of halogen, alkyl sulfonate, aryloxy optionally substituted with 1-2 substituents, N-containing heteroaryl, and N-hydroxy-nitrogen containing heteroaryl; and salts thereof.
摘要:
Novel purine compounds of Formula 1, pharmaceutically acceptable prodrugs and salts thereof, and their use as fructose 1,6-bisphosphatase inhibitors.