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    METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR IMPROVING THE ACCURACY OF GLUCOSE SENSORS USING INSULIN DELIVERY OBSERVATION IN DIABETES
    1.
    发明申请
    METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR IMPROVING THE ACCURACY OF GLUCOSE SENSORS USING INSULIN DELIVERY OBSERVATION IN DIABETES 有权
    方法，系统和计算机程序产品，用于提高糖尿病胰岛素输送观察葡萄糖传感器的准确性

    公开(公告)号：US20130079613A1

    公开(公告)日：2013-03-28

    申请号：US13637359

    申请日：2011-03-24

    申请人： Boris P. Kovatchev ,  Marc D. Breton ,  Stephen D. Patek ,  Colleen H. Karvetski

    发明人： Boris P. Kovatchev ,  Marc D. Breton ,  Stephen D. Patek ,  Colleen H. Karvetski

    IPC分类号： A61B5/145 ,  A61M5/142 ,  A61M1/36 ,  A61B5/00

    CPC分类号： A61B5/14532 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7225 ,  A61B5/725 ,  A61B2560/0223 ,  A61M1/36 ,  A61M5/142

    摘要： Method and System for providing a signal from an insulin pump, artificial pancreas, or another insulin delivery device as a source of information for improving the accuracy of a continuous glucose sensor (CGS). The effect of using insulin information to enhance sensor accuracy is most prominent at low blood glucose levels, i.e. in the hypoglycemic range, which is critical for any treatment. A system for providing a filtering/state estimation methodology that may be used to determine a glucose state estimate at time t-τ. The estimation may be extrapolated to some future time t and then the extrapolated value is used to extract the blood glucose component. The blood glucose component of the extrapolation and the output of the CGS are weighted and used to estimate the blood glucose level of a subject.

    摘要翻译： 用于从胰岛素泵，人造胰腺或另一胰岛素递送装置提供信号的方法和系统作为用于提高连续葡萄糖传感器（CGS）的精度的信息来源。 使用胰岛素信息来提高传感器精度的效果在低血糖水平，即在降血糖范围内是最显着的，这在任何治疗中都是至关重要的。 一种用于提供可用于在时间t-τ确定葡萄糖状态估计的过滤/状态估计方法的系统。 估计可以外推到将来的某个时间t，然后外推值用于提取血糖分量。 对外推的血糖成分和CGS的输出进行加权，并用于估计受试者的血糖水平。

    Method, System, and Computer Program Product For Tracking of Blood Glucose Variability in Diabetes
    2.
    发明申请
    Method, System, and Computer Program Product For Tracking of Blood Glucose Variability in Diabetes 有权
    方法，系统和计算机程序产品用于跟踪糖尿病血糖变异性

    公开(公告)号：US20110264378A1

    公开(公告)日：2011-10-27

    申请号：US13131467

    申请日：2009-11-24

    申请人： Marc D. Breton ,  Boris P. Kovatchev

    发明人： Marc D. Breton ,  Boris P. Kovatchev

    IPC分类号： G06F19/00 ,  G01N33/48

    CPC分类号： G16H40/63 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/7275 ,  G06F19/00 ,  G16H10/20 ,  G16H50/20

    摘要： An embodiment may be in the field of glycemic analysis and control. More specifically, an embodiment or approach may provide a novel method, system, and computer program for the visual and quantitative tracking of blood glucose variability in diabetes from self-monitoring blood glucose (SMBG) data and/or continuous glucose monitoring (CGM) data. More particularly, an embodiment or aspects thereof may use glucose measurements obtained from self-monitoring data and/or CGM data of an individual or a group of individuals to track and analyze blood glucose variability.

    摘要翻译： 一个实施方案可能在血糖分析和控制领域。 更具体地，实施例或方法可以提供用于从自我监测血糖（SMBG）数据和/或连续葡萄糖监测（CGM）数据来视觉和定量跟踪糖尿病血糖变异性的新方法，系统和计算机程序 。 更具体地，其实施方案或其方面可以使用从个体或一组个体的自我监测数据和/或CGM数据获得的葡萄糖测量值来跟踪和分析血糖变异性。

    LQG Artificial Pancreas Control System and Related Method
    6.
    发明申请
    LQG Artificial Pancreas Control System and Related Method 审中-公开
    LQG人工胰腺控制系统及相关方法

    公开(公告)号：US20100249561A1

    公开(公告)日：2010-09-30

    申请号：US12665420

    申请日：2008-06-20

    申请人： Stephen D. Patek ,  Marc D. Breton

    发明人： Stephen D. Patek ,  Marc D. Breton

    IPC分类号： A61B5/00 ,  A61M5/14

    CPC分类号： A61M5/1723 ,  A61B5/14532 ,  G06F19/00 ,  G06F19/3456 ,  G16H50/20 ,  G16H50/50

    摘要： The invention relates to a methods and systems for determining an insulin dosing recommendation. The invention employs Linear Quadratic methodology to determine the insulin dosing recommendation based on a patient's present physiological state, which is estimated by an adaptive filter methodology employing a dynamic model, which utilizes real-time measurements of blood glucose concentration.

    摘要翻译： 本发明涉及一种用于确定胰岛素给药建议的方法和系统。 本发明采用线性二次方法来确定基于患者现有生理状态的胰岛素给药推荐，其通过使用动态模型的自适应滤波器方法估计，其利用血糖浓度的实时测量。

    Tracking the probability for imminent hypoglycemia in diabetes from self-monitoring blood glucose (SMBG) data
    9.
    发明授权
    Tracking the probability for imminent hypoglycemia in diabetes from self-monitoring blood glucose (SMBG) data 有权

    公开(公告)号：US10431342B2

    公开(公告)日：2019-10-01

    申请号：US13394091

    申请日：2010-09-02

    申请人： Boris P. Kovatchev ,  Marc D. Breton

    发明人： Boris P. Kovatchev ,  Marc D. Breton

    IPC分类号： G01N33/48 ,  G16H50/50 ,  G06F19/00 ,  A61B5/00

    摘要： A method, system and related computer program product for tracking the probability of hypoglycemia from routine self-monitoring of blood glucose (SMBG) data in patients with diabetes. A specific bivariate probability distribution of low BG events based jointly on the Low BG Index (LBGI) and the Average Daily Risk Range (ADRR) is used to predict hypoglycemia probability of occurrence from inputted SMBG data. The SMBG data is retrieved from a series of SMBG data of a patient available from the patient's glucose meter and allows tracking of the probability for future hypoglycemia over a predetermined duration, e.g., a 24 or 48 hour period. The tracking includes presentation of visual and/or numerical output, as we construction of hypoglycemia risk trajectories that would enable warning messages for crossing of predefined thresholds, such as 50% likelihood for upcoming hypoglycemia below 50 mg/dl.

    Method, system, and computer program product for the detection of physical activity by changes in heart rate, assessment of fast changing metabolic states, and applications of closed and open control loop in diabetes
    10.
    发明授权
    Method, system, and computer program product for the detection of physical activity by changes in heart rate, assessment of fast changing metabolic states, and applications of closed and open control loop in diabetes 有权
    用于通过心率变化检测身体活动的方法，系统和计算机程序产品，快速变化的代谢状态的评估以及闭合和开放的控制回路在糖尿病中的应用

    公开(公告)号：US08585593B2

    公开(公告)日：2013-11-19

    申请号：US12516044

    申请日：2007-11-27

    申请人： Boris P. Kovatchev ,  Marc D. Breton

    发明人： Boris P. Kovatchev ,  Marc D. Breton

    IPC分类号： A61B5/05

    CPC分类号： A61B5/4839 ,  A61B5/024 ,  A61B5/14532 ,  A61B5/222 ,  A61B5/4866 ,  G06F19/00 ,  G06F19/3456 ,  G16H50/50

    摘要： A method, system, and computer program product related to the detection of physical activity using changes in heart rate. The method, system, and computer program product evaluates short term glucose demand and long term insulin action due to physical activity. The method, system, and computer program product is further related to the improvement of open and closed loop control of diabetes by accounting for the metabolic changes due to physical activity. The method, system, and computer program product is directed to detecting in real time the short and long term effects of physical activity on insulin action via heart rate analysis, and recommending changes in insulin dosing to compensate for the effects of physical activity. With these recommendations, the open and closed loop control of diabetes can be improved and steps can be taken to prevent hypoglycemia that may result from increased insulin sensitivity due to physical activity.

    摘要翻译： 与使用心率变化的身体活动检测相关的方法，系统和计算机程序产品。 方法，系统和计算机程序产品评估短期葡萄糖需求和由于身体活动导致的长期胰岛素作用。 方法，系统和计算机程序产品进一步涉及由于身体活动导致的代谢变化，改善糖尿病的开放和闭环控制。 方法，系统和计算机程序产品旨在通过心率分析实时检测身体活动对胰岛素作用的短期和长期影响，并建议胰岛素给药的变化以补偿身体活动的影响。 通过这些建议，可以改善糖尿病的开放和闭环控制，并且可以采取措施来预防由于身体活动而增加的胰岛素敏感性可能导致的低血糖。