摘要:
A regulator for regulating physiological functions, such as activity of increasing an intracellular calcium ion concentration, activity of promoting growth hormone secretion, activity of promoting eating, regulatory activity relating to fat accumulation, activity of ameliorating heart function and activity of stimulating gastric acid secretion, of ghrelin, which regulator comprises a fatty acid of carbon number 2-35 or its derivative, and use thereof.
摘要:
A profile element pipe for hydraulic bulging of the present invention has a peripheral length with an outer diameter gradually increasing or decreasing from one axial side toward the other thereof and has a parallel part formed on at least one end thereof. According to a bulging device and a bulging method using this profile element pipe, for example, even when a profile steel pipe having a cross sectional shape varying in the axial direction as in a tapered pipe is hydraulically bulged, a bulging in which an internal pressure loading and an shaft pressing are combined with each other can be performed to provide a larger expansion ratio than a conventional case and a joining and socket connection thereof to the other part can also be easily performed.
摘要:
The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要:
According to a bulging device and a bulging method using a profile element pipe, for example, even when a profile steel pipe having a cross sectional shape varying in the axial direction as in a tapered pipe is hydraulically bulged, a bulging in which an internal pressure loading and an axial pressing are combined with each other can be performed to provide a larger expansion ratio than a conventional case and a joining and socket connection thereof to the other part can also be easily performed.
摘要:
A sheet hydroforming method is disclosed wherein two stacked metallic sheets are clamped between a pair of upper and lower dies 10, 11 and a fluid is introduced and pressurized between mating surfaces of the metallic sheets, causing the metallic sheets to bulge into a space defined by die cavities 10b and 11b. A thru-hole 11d for introducing the fluid is formed in one of the dies so as to lead to a holding surface of the die, while a pierced hole for introducing the fluid is formed in one of the metallic sheets in a portion of the one metallic sheet which portion is in contact with a holding surface 10a (10b) of one of the dies, the pierced hole being positioned with the thru-hole 11d, then the fluid is introduced in a pressurized state between mating surfaces of the metallic sheets from the thru-hole through the pierced hole, thereby causing the metallic sheets to bulge. According to this method, a pressurized fluid can be introduced between the mating surfaces of blanks easily without leakage of the fluid. Not only the efficiency of the sheet hydroforming method but also the dent resistance of a formed part can be improved.
摘要:
A method and apparatus for hydroforming a metallic tube including the steps of: preliminarily expanding the metallic tube over an axial section longer than the length of the expanded portion of a final product as measured in the axial direction of the metallic tube; and compressing the preliminarily expanded portion in the axial direction of the metallic tube so as to form the shape of the expanded portion of the final product. According to the method and apparatus of the invention, frictional resistance between the metallic tube and processing tools can be reduced, and moreover, the internal pressure within the metallic tube can be reduced during expansion processing. Furthermore, the cost for the manufacture of metallic die is reduced, and in addition, yield is improved
摘要:
A heat sink fin assembly of the corrugated type for cooling an LSI package comprises a flat base plate and a heat dissipating member made of a thin metal sheet having convex and concave portions which are comprised of a repeated series of side wall portions, top portions, and bottom portions. The base plate and the heat dissipating member are integrated with each other by bonding.
摘要:
A fin assembly for use as a heat sink and production thereof are disclosed. The fin assembly comprises a plurality of heat dissipating plates formed by means of a multi-wire saw, and the heat dissipating plates each has a thickness of no more than 1 mm and being spaced apart by a gap of no more than 1.5 mm.
摘要:
The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要:
The present invention provides a variety of useful polypeptides. In particular, a polypeptide comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, its amide, or a salt thereof can be used as an agent for preventing/treating hypotension; an agent for preventing/treating obesity, hyperphagia, etc.; an agent for preventing/treating lethargy, time-zone change syndrome (jet lag), etc.; an agent for preventing/treating sterility, etc. A compound or its salt that promotes the activity of a polypeptide comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by any of SEQ ID NOS: 7 to 12 and 37 to 42, its partial peptide, or a salt thereof is useful as an agent for preventing/treating, e.g., menopausal symptoms or hyperthyroidism. A compound or its salt that inhibits the activity of said polypeptide is useful as an agent for preventing/treating, e.g., sterility or hypothyroidism.
摘要翻译:本发明提供了多种有用的多肽。 特别地,可以使用包含与SEQ ID NO:1,SEQ ID NO:2或SEQ ID NO:3所示的氨基酸序列相同或基本上相同的氨基酸序列的多肽,其酰胺或其盐 作为预防/治疗低血压的药剂; 用于预防/治疗肥胖症,食欲过多等的药剂; 预防/治疗嗜睡,时区变化综合征(时差)等的药剂; 用于预防/治疗不育症的药剂等。一种促进包含与SEQ ID NO:7至12和37中任一项所示的氨基酸序列相同或基本上相同的氨基酸序列的多肽的活性的化合物或其盐 至42,其部分肽或其盐可用作预防/治疗例如绝经症状或甲状腺功能亢进的药剂。 抑制所述多肽的活性的化合物或其盐可用作预防/治疗例如不育或甲状腺功能减退的药剂。