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公开(公告)号：US20140155367A1
公开(公告)日：2014-06-05
申请号：US14083203
申请日：2013-11-18
申请人： Arnab Kumar Chatterjee , Advait Suresh Nagle , Prasuna Paraselli , Ravinder Reddy Kondreddi , Seh Yong Leong , Pranab Kumar Mishra , Robert Joseph Moreau , Jason Thomas Roland , Wei Lin Sandra Sim , Oliver Simon , Liying Jocelyn Tan , Bryan KS Yeung , Bin Zou , Venkatataiah Bollu
发明人： Arnab Kumar Chatterjee , Advait Suresh Nagle , Prasuna Paraselli , Ravinder Reddy Kondreddi , Seh Yong Leong , Pranab Kumar Mishra , Robert Joseph Moreau , Jason Thomas Roland , Wei Lin Sandra Sim , Oliver Simon , Liying Jocelyn Tan , Bryan KS Yeung , Bin Zou , Venkatataiah Bollu
IPC分类号： C07D471/04 , A61K31/506 , A61K31/538 , A61K31/437 , A61K45/06
CPC分类号： A61K31/437 , A61K31/444 , A61K31/538 , A61K45/06 , C07D471/04 , C07D519/00 , Y02A50/411 , A61K2300/00
摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.
摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由疟原虫等疟原虫引起的疾病的病理和/或症状的方法。
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公开(公告)号：US07691888B2
公开(公告)日：2010-04-06
申请号：US11243796
申请日：2005-10-05
申请人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
发明人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
IPC分类号： A61K31/429 , A61K31/4162 , C07D513/02 , C07D417/14
CPC分类号： C07D513/04 , C07D277/84
摘要： The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗特征为过度或异常细胞增殖的疾病，以及其用于制备具有上述 属性。
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公开(公告)号：US20150011522A1
公开(公告)日：2015-01-08
申请号：US14492736
申请日：2014-09-22
申请人： Arnab Kumar Chatterjee , Advait Suresh Nagle , Prasuna Paraselli , Ravinder Reddy Kondreddi , Seh Yong Leong , Pranab Kumar Mishra , Robert Joseph Moreau , Jason Thomas Roland , Wei Lin Sandra Sim , Oliver Simon , Liying Jocelyn Tan , Bryan KS Yeung , Bin Zou , Venkatataiah Bollu
发明人： Arnab Kumar Chatterjee , Advait Suresh Nagle , Prasuna Paraselli , Ravinder Reddy Kondreddi , Seh Yong Leong , Pranab Kumar Mishra , Robert Joseph Moreau , Jason Thomas Roland , Wei Lin Sandra Sim , Oliver Simon , Liying Jocelyn Tan , Bryan KS Yeung , Bin Zou , Venkatataiah Bollu
IPC分类号： A61K31/437 , A61K31/538 , A61K45/06 , C07D471/04
CPC分类号： A61K31/437 , A61K31/444 , A61K31/538 , A61K45/06 , C07D471/04 , C07D519/00 , Y02A50/411 , A61K2300/00
摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.
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公开(公告)号：US08871754B2
公开(公告)日：2014-10-28
申请号：US14083203
申请日：2013-11-18
申请人： Arnab Kumar Chatterjee , Advait Suresh Nagle , Prasuna Paraselli , Ravinder Reddy Kondreddi , Seh Yong Leong , Pranab Kumar Mishra , Robert Joseph Moreau , Jason Thomas Roland , Wei Lin Sandra Sim , Oliver Simon , Liying Jocelyn Tan , Bryan K S Yeung , Bin Zou , Venkatataiah Bollu
发明人： Arnab Kumar Chatterjee , Advait Suresh Nagle , Prasuna Paraselli , Ravinder Reddy Kondreddi , Seh Yong Leong , Pranab Kumar Mishra , Robert Joseph Moreau , Jason Thomas Roland , Wei Lin Sandra Sim , Oliver Simon , Liying Jocelyn Tan , Bryan K S Yeung , Bin Zou , Venkatataiah Bollu
IPC分类号： C07D471/04 , A61K31/506 , A61K31/538 , A61K31/437 , A61K45/06
CPC分类号： A61K31/437 , A61K31/444 , A61K31/538 , A61K45/06 , C07D471/04 , C07D519/00 , Y02A50/411 , A61K2300/00
摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.
摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由疟原虫等疟原虫引起的疾病的病理和/或症状的方法。
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公开(公告)号：US20160333012A1
公开(公告)日：2016-11-17
申请号：US15220149
申请日：2016-07-26
申请人： Arnab Kumar CHATTERJEE , Advait Suresh NAGLE , Prasuna Paraselli , Ravinder Reddy KONDREDDI , Seh Yong LEONG , Pranab Kumar MISHRA , Robert Joseph MOREAU , Jason Thomas ROLAND , Wei Lin Sandra SIM , Oliver SIMON , Jocelyn Liying TAN , Bryan KS YEUNG , Bin ZOU , Venkatataiah BOLLU
发明人： Arnab Kumar CHATTERJEE , Advait Suresh NAGLE , Prasuna Paraselli , Ravinder Reddy KONDREDDI , Seh Yong LEONG , Pranab Kumar MISHRA , Robert Joseph MOREAU , Jason Thomas ROLAND , Wei Lin Sandra SIM , Oliver SIMON , Jocelyn Liying TAN , Bryan KS YEUNG , Bin ZOU , Venkatataiah BOLLU
IPC分类号： C07D471/04 , A61K45/06 , A61K31/538 , A61K31/506 , A61K31/437 , C07D519/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , A61K31/538 , A61K45/06 , C07D519/00
摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.
摘要翻译： 或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由疟原虫等疟原虫引起的疾病的病理和/或症状的方法。
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公开(公告)号：US08207349B2
公开(公告)日：2012-06-26
申请号：US12685213
申请日：2010-01-11
申请人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
发明人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
IPC分类号： C07D277/60
CPC分类号： C07D513/04 , C07D277/84
摘要： The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗特征为过度或异常细胞增殖的疾病，以及其用于制备具有上述 属性。
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公开(公告)号：US20100113414A1
公开(公告)日：2010-05-06
申请号：US12685213
申请日：2010-01-11
申请人： Bodo BETZEMEIER , Trixi BRANDL , Steffen BREITFELDER , Ralph BRUECKNER , Thomas GERSTBERGER , Michael GMACHL , Matthias GRAUERT , Frank HILBERG , Christoph HOENKE , Matthias HOFFMANN , Maria IMPAGNATIELLO , Dirk KESSLER , Christian KLEIN , Bernd KRIST , Udo MAIER , Darryl McCONNELL , Charlotte REITHER , Stefan SCHEUERER , Andreas SCHOOP , Norbert SCHWEIFER , Oliver SIMON , Martin STEEGMAIER , Steffen STEURER , Irene WAIZENEGGER , Ulrike WEYER-CZERNILOFSKY , Andreas ZOEPHEL
发明人： Bodo BETZEMEIER , Trixi BRANDL , Steffen BREITFELDER , Ralph BRUECKNER , Thomas GERSTBERGER , Michael GMACHL , Matthias GRAUERT , Frank HILBERG , Christoph HOENKE , Matthias HOFFMANN , Maria IMPAGNATIELLO , Dirk KESSLER , Christian KLEIN , Bernd KRIST , Udo MAIER , Darryl McCONNELL , Charlotte REITHER , Stefan SCHEUERER , Andreas SCHOOP , Norbert SCHWEIFER , Oliver SIMON , Martin STEEGMAIER , Steffen STEURER , Irene WAIZENEGGER , Ulrike WEYER-CZERNILOFSKY , Andreas ZOEPHEL
IPC分类号： A61K31/397 , C07D417/14 , A61K31/4439 , C07D513/02 , A61K31/429 , C07D213/02 , A61K31/4545 , C07D401/14 , A61K31/444 , C07D403/02 , A61K31/497 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D267/10 , A61K31/553 , C07D223/02 , A61K31/55 , C07D243/08 , A61K31/551 , A61P35/00
CPC分类号： C07D513/04 , C07D277/84
摘要： The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗特征为过度或异常细胞增殖的疾病，以及其用于制备具有上述 属性。
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公开(公告)号：US20060100254A1
公开(公告)日：2006-05-11
申请号：US11243796
申请日：2005-10-05
申请人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
发明人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
IPC分类号： A61K31/429 , C07D513/02
CPC分类号： C07D513/04 , C07D277/84
摘要： The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in Claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 3定义如权利要求1，其适用于治疗以下特征的疾病： 过度或异常细胞增殖，以及它们用于制备具有上述性质的药物。
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