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公开(公告)号：US20070207493A1
公开(公告)日：2007-09-06
申请号：US11742749
申请日：2007-05-01
Applicant: Xiaosong WU , Chung-Jen HOU , Jayesh DHARIA , Peter KONSTANTIN , Yujing YANG
Inventor： Xiaosong WU , Chung-Jen HOU , Jayesh DHARIA , Peter KONSTANTIN , Yujing YANG
IPC: C12Q1/68 , G01N33/567
CPC classification number: B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
Abstract translation: 本发明提供了具有约25mg / ml或更大的蛋白结合能力的带正电荷的微多孔膜，其包含亲水性多孔基底和向膜提供固定的正电荷的交联涂层。 本发明还提供一种带正电的微多孔膜，其包括多孔基材和包含阳离子阳离子基团的交联涂层。 本发明的膜可用于各种应用，包括离子交换层析，大分子转移，以及生物分子如蛋白质，核酸，内毒素等的检测，过滤和纯化。
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公开(公告)号：US07189322B2
公开(公告)日：2007-03-13
申请号：US11042512
申请日：2005-01-26
Applicant: Xiaosong Wu , Joe L. Kinsey, Jr. , Michael Ishee , Peter Konstantin , Joel Shertok , Yujing Yang
Inventor： Xiaosong Wu , Joe L. Kinsey, Jr. , Michael Ishee , Peter Konstantin , Joel Shertok , Yujing Yang
CPC classification number: B01D69/02 , A61L2/0017 , B01D67/0009 , B01D71/38 , B01D71/82 , B01D2323/30 , B01D2325/14 , B01D2325/16 , B01D2325/36 , Y10T436/255
Abstract: The present invention provides a hydrophilic charged microporous membrane comprising a porous hydrophobic substrate and a coating comprising a charge-providing agent. The present invention further provides a hydrophilic charged membrane comprising a porous hydrophobic substrate and a hydrophilic charge-providing agent distributed within the substrate. The present invention further provides a filter as well as a filter device comprising the inventive hydrophilic charged membrane. The present invention further provides a process for treating a fluid containing bacterial contaminants such as endotoxins comprising contacting the membrane with the fluid to provide a bacterial contaminant depleted fluid.
Abstract translation: 本发明提供了一种亲水性带电微孔膜，其包含多孔疏水性底物和包含电荷提供剂的涂层。 本发明还提供了一种亲水性带电膜，其包含多孔疏水性底物和分布在基材内的亲水性电荷提供剂。 本发明还提供一种过滤器以及包括本发明的亲水带电膜的过滤装置。 本发明还提供了一种用于处理含有细菌污染物如内毒素的流体的方法，包括使膜与流体接触以提供细菌污染物耗尽的流体。
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公开(公告)号：US20060249445A1
公开(公告)日：2006-11-09
申请号：US11480977
申请日：2006-07-06
Applicant: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
Inventor： Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
IPC: B01D71/06
CPC classification number: B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
Abstract translation: 本发明提供了具有约25mg / ml或更大的蛋白结合能力的带正电荷的微多孔膜，其包含亲水性多孔基底和向膜提供固定的正电荷的交联涂层。 本发明还提供一种带正电的微多孔膜，其包括多孔基材和包含阳离子阳离子基团的交联涂层。 本发明的膜可用于各种应用，包括离子交换层析，大分子转移，以及生物分子如蛋白质，核酸，内毒素等的检测，过滤和纯化。
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公开(公告)号：US06849185B1
公开(公告)日：2005-02-01
申请号：US09959882
申请日：2000-05-12
Applicant: Xiaosong Wu , Joe L. Kinsey, Jr. , Michael Ishee , Peter Konstantin , Joel Shertok , Yujing Yang
Inventor： Xiaosong Wu , Joe L. Kinsey, Jr. , Michael Ishee , Peter Konstantin , Joel Shertok , Yujing Yang
CPC classification number: B01D69/02 , A61L2/0017 , B01D67/0009 , B01D71/38 , B01D71/82 , B01D2323/30 , B01D2325/14 , B01D2325/16 , B01D2325/36 , Y10T436/255
Abstract: The present invention provides a hydrophilic charged microporous membrane comprising a porous hydrophobic substrate and a coating comprising a charge-providing agent. The present invention further provides a hydrophilic charged membrane comprising a porous hydrophobic substrate and a hydrophilic charge-providing agent distributed within the substrate. The present invention further provides a filter as well as a filter device comprising the inventive hydrophilic charged membrane. The present invention further provides a process for treating a fluid containing bacterial contaminants such as endotoxins comprising contacting the membrane with the fluid to provide a bacterial contaminant depleted fluid.
Abstract translation: 本发明提供了一种亲水性带电微孔膜，其包含多孔疏水性底物和包含电荷提供剂的涂层。 本发明还提供了一种亲水性带电膜，其包含多孔疏水性底物和分布在基材内的亲水性电荷提供剂。 本发明还提供一种过滤器以及包括本发明的亲水带电膜的过滤装置。 本发明还提供了一种用于处理含有细菌污染物如内毒素的流体的方法，包括使膜与流体接触以提供细菌污染物耗尽的流体。
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公开(公告)号：US06780327B1
公开(公告)日：2004-08-24
申请号：US09914163
申请日：2001-12-12
Applicant: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
Inventor： Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
IPC: B01D6114
CPC classification number: B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
Abstract translation: 本发明提供了具有约25mg / ml或更大的蛋白结合能力的带正电荷的微孔膜，其包含亲水性多孔基质和向膜提供固定的正电荷的交联涂层。 本发明还提供一种带正电的微多孔膜，其包括多孔基材和包含阳离子阳离子基团的交联涂层。 本发明的膜可用于各种应用，包括离子交换层析，大分子转移，以及生物分子如蛋白质，核酸，内毒素等的检测，过滤和纯化。
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Patent Agency Ranking
6.发明授权Integrity testable filtration unit using supported hydrophilic porous membranes 失效使用支撑的亲水性多孔膜的完整性可测试过滤单元公开(公告)号：US06186341B1
公开(公告)日：2001-02-13
申请号：US09083562
申请日：1998-05-22
Applicant: Peter Konstantin , Oscar-Werner Reif , Jürgen Rupp , Peter Soelkner
Inventor： Peter Konstantin , Oscar-Werner Reif , Jürgen Rupp , Peter Soelkner
IPC: B01D2900
CPC classification number: B01D63/061 , B01D63/067 , B01D65/003
Abstract: The hydrophilicity of porous separation membranes is maintained by bonding the membranes to thermoplastic fiber substrates at least on their peripheries before the membrane peripheries are sealed in a thermoplastic resin. The membranes are capable of being integrity tested.
Abstract translation: 多孔分离膜的亲水性通过在膜周围被密封在热塑性树脂中之前至少在它们的周围粘合到热塑性纤维基材来保持。 膜能够进行完整性测试。
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公开(公告)号：US5575910A
公开(公告)日：1996-11-19
申请号：US523361
申请日：1995-09-05
Applicant: Massoud Karbachsch , Peter Konstantin , G unter Pradel , Dieter Schmidt
Inventor： Massoud Karbachsch , Peter Konstantin , G unter Pradel , Dieter Schmidt
CPC classification number: B01J20/28033 , B01D15/00 , B01J20/28052
Abstract: There is disclosed a filtration unit for the selective separation of substances from fluids by membrane adsorbers, comprising a plurality of filtration chambers arranged in parallel and using membrane adsorber packs having a variable number of porous laminar sections, and wherein at each membrane adsorber pack, the same pressure drop is maintained between feed and permeate.
Abstract translation: 公开了一种用于通过膜吸附器从流体中选择性分离物质的过滤单元，其包括平行布置的多个过滤室和使用具有可变数目的多孔层流区段的膜吸附器组件，并且其中在每个膜吸附器组件 在进料和渗透物之间保持相同的压降。
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公开(公告)号：US07223341B2
公开(公告)日：2007-05-29
申请号：US11480977
申请日：2006-07-06
Applicant: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
Inventor： Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
CPC classification number: B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
Abstract translation: 本发明提供了具有约25mg / ml或更大的蛋白结合能力的带正电荷的微多孔膜，其包含亲水性多孔基底和向膜提供固定的正电荷的交联涂层。 本发明还提供一种带正电的微多孔膜，其包括多孔基材和包含阳离子阳离子基团的交联涂层。 本发明的膜可用于各种应用，包括离子交换层析，大分子转移，以及生物分子如蛋白质，核酸，内毒素等的检测，过滤和纯化。
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公开(公告)号：US06851561B2
公开(公告)日：2005-02-08
申请号：US10891098
申请日：2004-07-15
Applicant: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
Inventor： Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
IPC: B01D15/36 , B01D61/00 , B01D61/14 , B01D63/14 , B01D67/00 , B01D69/02 , B01D69/10 , B01D69/12 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01J20/28 , B01J41/12 , B01J41/20 , B01J47/12 , B01D63/06 , B01D71/56
CPC classification number: B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
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公开(公告)号：US6083393A
公开(公告)日：2000-07-04
申请号：US958654
申请日：1997-10-27
Applicant: Xiaosong Wu , Joel Shertok , Peter Konstantin
Inventor： Xiaosong Wu , Joel Shertok , Peter Konstantin
CPC classification number: B01D67/0006 , B01D67/0011 , B01D69/141 , B01D71/40 , B01D71/68 , B01D2323/12 , B01D2323/30 , B01D2323/40 , B01D2325/34 , B01D2325/36
Abstract: A hydrophilic porous membrane is provided which comprises a network of a non-crystalline hydrophobic polymer and an in situ crosslinked hydrophilic acrylate polymer. A method of preparing such a hydrophilic porous membrane also is provided, wherein a reaction solution of a non-crystalline hydrophobic polymer, a crosslinkable polyfunctional acrylate, a polymerization initiator, and, optionally, a monofunctional monomer, is polymerized in situ and cast to provide a hydrophilic porous membrane.
Abstract translation: 提供亲水性多孔膜，其包含非结晶疏水性聚合物网络和原位交联的亲水丙烯酸酯聚合物。 还提供了一种制备这种亲水性多孔膜的方法，其中将非结晶疏水性聚合物，可交联的多官能丙烯酸酯，聚合引发剂和任选的单官能单体的反应溶液原位聚合并浇铸以提供 亲水性多孔膜。
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