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公开(公告)号：US08084553B2
公开(公告)日：2011-12-27
申请号：US12008375
申请日：2008-01-10
Applicant: Rong-Chang Liang , John J. McNamara , Yurong Ying , Chung-Jen Hou
Inventor： Rong-Chang Liang , John J. McNamara , Yurong Ying , Chung-Jen Hou
CPC classification number: C08G59/245 , C08G59/3218 , C08L63/00 , C09J163/00 , C08L2666/22
Abstract: The invention provides an improvement to the useable lifetimes of phenolic-epoxy, phenolic-benzoxazine, phenolic-epoxy-benzoxazine mixtures and other phenolic mixtures through the use of protected phenolics, where a phenolic compound, polymer, or resin is released on demand by the addition of a deblocking agent.
Abstract translation: 本发明通过使用受保护的酚醛树脂来改进酚醛环氧树脂，酚 - 苯并恶嗪，酚 - 环氧 - 苯并恶嗪混合物和其它酚类混合物的使用寿命，其中根据需要释放酚类化合物，聚合物或树脂 加入去块剂。
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公开(公告)号：US20090181165A1
公开(公告)日：2009-07-16
申请号：US12008375
申请日：2008-01-10
Applicant: Rong-Chang Liang , John J. McNamara , Yurong Ying , Chung-Jen Hou
Inventor： Rong-Chang Liang , John J. McNamara , Yurong Ying , Chung-Jen Hou
IPC: B05D5/12 , C07D303/16 , C08G59/02 , C08G65/22
CPC classification number: C08G59/245 , C08G59/3218 , C08L63/00 , C09J163/00 , C08L2666/22
Abstract: The invention provides an improvement to the useable lifetimes of phenolic-epoxy, phenolic-benzoxazine, phenolic-epoxy-benzoxazine mixtures and other phenolic mixtures through the use of protected phenolics, where a phenolic compound, polymer, or resin is released on demand by the addition of a deblocking agent.
Abstract translation: 本发明通过使用受保护的酚醛树脂来改进酚醛环氧树脂，酚 - 苯并恶嗪，酚 - 环氧 - 苯并恶嗪混合物和其它酚类混合物的使用寿命，其中根据需要释放酚类化合物，聚合物或树脂 加入去块剂。
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公开(公告)号：US07396465B2
公开(公告)日：2008-07-08
申请号：US11742749
申请日：2007-05-01
Applicant: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
Inventor： Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
CPC classification number: B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
Abstract translation: 本发明提供了具有约25mg / ml或更大的蛋白结合能力的带正电荷的微多孔膜，其包含亲水性多孔基底和向膜提供固定的正电荷的交联涂层。 本发明还提供一种带正电的微多孔膜，其包括多孔基材和包含阳离子阳离子基团的交联涂层。 本发明的膜可用于各种应用，包括离子交换层析，大分子转移，以及生物分子如蛋白质，核酸，内毒素等的检测，过滤和纯化。
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公开(公告)号：US07132049B2
公开(公告)日：2006-11-07
申请号：US11037356
申请日：2005-01-19
Applicant: Chung-Jen Hou , Peter Konstantin , Yujing Yang
Inventor： Chung-Jen Hou , Peter Konstantin , Yujing Yang
CPC classification number: B01D67/0088 , B01D15/362 , B01D61/00 , B01D61/007 , B01D61/14 , B01D67/0009 , B01D71/08 , B01D71/40 , B01D2323/12 , B01D2323/30 , B01D2325/14 , B01D2325/36 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/267 , B01J20/28035 , B01J20/2804 , B01J20/28078 , B01J20/2808 , B01J20/286 , B01J20/3208 , B01J20/3212 , B01J20/327 , B01J20/3274 , B01J20/3282 , B01J39/20 , B01J39/26 , B01J47/12 , B01J2220/44 , B01J2220/54 , C07K1/34 , Y10T436/143333
Abstract: The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e.g., from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.
Abstract translation: 本发明在某些实施方案中提供了一种带负电荷的微多孔膜，其包含多孔基底和具有固定负电荷的交联涂层。 交联涂层可以例如由含有阴离子基团的不饱和单体，N-（羟甲基） - 和/或N-（烷氧基甲基） - 丙烯酰胺，亲水性不饱和单体和引发剂的聚合组合物制备。 在一些实施方案中，本发明进一步提供了一种带负电荷的微多孔膜，其包含多孔基材和由聚合组合物制备的交联涂层，所述聚合组合物包含具有阴离子基团的不饱和单体，N-（羟甲基） - 或N-（烷氧基甲基） - 丙烯酰胺，多糖和引发剂。 本发明的膜适用于离子交换色谱法，例如分离和纯化带正电荷的物质如蛋白质。
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公开(公告)号：US20050211621A1
公开(公告)日：2005-09-29
申请号：US11035950
申请日：2005-01-18
Applicant: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
Inventor： Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
IPC: B01D15/36 , B01D61/00 , B01D61/14 , B01D63/14 , B01D67/00 , B01D69/02 , B01D69/10 , B01D69/12 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01J20/28 , B01J41/12 , B01J41/20 , B01J47/12
CPC classification number: B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
Abstract translation: 本发明提供了具有约25mg / ml或更大的蛋白结合能力的带正电荷的微多孔膜，其包含亲水性多孔基底和向膜提供固定的正电荷的交联涂层。 本发明还提供一种带正电的微多孔膜，其包括多孔基材和包含阳离子阳离子基团的交联涂层。 本发明的膜可用于各种应用，包括离子交换层析，大分子转移，以及生物分子如蛋白质，核酸，内毒素等的检测，过滤和纯化。
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Patent Agency Ranking
6.发明授权Filter device and filter element comprising at least one negatively charged membrane 有权过滤装置和过滤元件包括至少一个带负电荷的膜公开(公告)号：US06860393B2
公开(公告)日：2005-03-01
申请号：US10895048
申请日：2004-07-21
Applicant: Chung-Jen Hou , Peter Konstantin , Yujing Yang
Inventor： Chung-Jen Hou , Peter Konstantin , Yujing Yang
IPC: B01D15/36 , B01D61/00 , B01D61/14 , B01D67/00 , B01D71/08 , B01D71/40 , B01J20/28 , B01J20/32 , B01J39/20 , B01J39/26 , B01J47/12 , C07K1/34 , B01D63/14 , B01D63/10 , B01D71/00
CPC classification number: B01D67/0088 , B01D15/362 , B01D61/00 , B01D61/007 , B01D61/14 , B01D67/0009 , B01D71/08 , B01D71/40 , B01D2323/12 , B01D2323/30 , B01D2325/14 , B01D2325/36 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/267 , B01J20/28035 , B01J20/2804 , B01J20/28078 , B01J20/2808 , B01J20/286 , B01J20/3208 , B01J20/3212 , B01J20/327 , B01J20/3274 , B01J20/3282 , B01J39/20 , B01J39/26 , B01J47/12 , B01J2220/44 , B01J2220/54 , C07K1/34 , Y10T436/143333
Abstract: The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e.g., from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.
Abstract translation: 本发明在某些实施方案中提供了一种带负电荷的微多孔膜，其包含多孔基底和具有固定负电荷的交联涂层。 交联涂层可以例如由含有阴离子基团的不饱和单体，N-（羟甲基） - 和/或N-（烷氧基甲基） - 丙烯酰胺，亲水性不饱和单体和引发剂的聚合组合物制备。 在一些实施方案中，本发明进一步提供了一种带负电荷的微多孔膜，其包含多孔基材和由聚合组合物制备的交联涂层，所述聚合组合物包含具有阴离子基团的不饱和单体，N-（羟甲基） - 或N-（烷氧基甲基） - 丙烯酰胺，多糖和引发剂。 本发明的膜适用于离子交换色谱法，例如分离和纯化带正电荷的物质如蛋白质。
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公开(公告)号：US06783937B1
公开(公告)日：2004-08-31
申请号：US09914165
申请日：2001-12-12
Applicant: Chung-Jen Hou , Peter Konstantin , Yujing Yang
Inventor： Chung-Jen Hou , Peter Konstantin , Yujing Yang
IPC: C12Q168
CPC classification number: B01D67/0088 , B01D15/362 , B01D61/00 , B01D61/007 , B01D61/14 , B01D67/0009 , B01D71/08 , B01D71/40 , B01D2323/12 , B01D2323/30 , B01D2325/14 , B01D2325/36 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/267 , B01J20/28035 , B01J20/2804 , B01J20/28078 , B01J20/2808 , B01J20/286 , B01J20/3208 , B01J20/3212 , B01J20/327 , B01J20/3274 , B01J20/3282 , B01J39/20 , B01J39/26 , B01J47/12 , B01J2220/44 , B01J2220/54 , C07K1/34 , Y10T436/143333
Abstract: The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e.g., from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.
Abstract translation: 本发明在某些实施方案中提供了一种带负电荷的微多孔膜，其包含多孔基底和具有固定负电荷的交联涂层。 交联涂层可以例如由含有阴离子基团的不饱和单体，N-（羟甲基） - 和/或N-（烷氧基甲基） - 丙烯酰胺，亲水性不饱和单体和引发剂的聚合组合物制备。 在一些实施方案中，本发明进一步提供了一种带负电荷的微多孔膜，其包含多孔基材和由聚合组合物制备的交联涂层，所述聚合组合物包含具有阴离子基团的不饱和单体，N-（羟甲基） - 或N-（烷氧基甲基） - 丙烯酰胺，多糖和引发剂。 本发明的膜适用于离子交换色谱法，例如分离和纯化带正电荷的物质如蛋白质。
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公开(公告)号：US4980067A
公开(公告)日：1990-12-25
申请号：US276831
申请日：1988-11-28
Applicant: Kenneth C. Hou , Chung-Jen Hou , Haunn-Lin Chen
Inventor： Kenneth C. Hou , Chung-Jen Hou , Haunn-Lin Chen
CPC classification number: B01J20/28033 , B01J20/28052 , B01J20/2808 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/327 , B01J20/3272 , B01J20/3278 , B01J39/22 , B01J41/16 , B01J47/123 , C08F251/00 , C08G81/02
Abstract: A microporous membrane modified by coating or grafting thereon a polyionene material. The thus-modified microporous membrane is useful for separating microorganism-originated contaminants from biological liquids.
Abstract translation: 通过在其上涂覆或接枝聚苯乙烯材料而改性的微孔膜。 这样改性的微孔膜可用于从生物液体中分离微生物来源的污染物。
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公开(公告)号：US20110007955A1
公开(公告)日：2011-01-13
申请号：US12832972
申请日：2010-07-08
Applicant: Winston Z. Ho , John Collins , Chung-Jen Hou
Inventor： Winston Z. Ho , John Collins , Chung-Jen Hou
IPC: G06K9/00
CPC classification number: G06K19/06028 , B01J2219/00497 , B01J2219/00547 , B01J2219/00585 , B01J2219/00605 , B01J2219/00693 , B01J2219/00722 , B01L3/54 , C40B20/04 , C40B50/16
Abstract: A Light Transmitted Assay Beads or digital magnetic microbead having a digitally coded structure that is partially transmissive and opaque to light. When hundreds or thousands of LITAB are settled down to the bottom of a microwell in a microplate or a planar surface, the barcode can be decoded by image processed accurately and reliable. Microplate is a standard bioassay format; each plate can have 96, 384, or 1536 patient samples. Therefore, a large number of targets in a sample can be analyzed in one single microwell. The image decoding algorithms comprise of four main processes (1) enhancement of image (2) segmentation of beads (3) extraction of barcode slits, and (4) decoding of barcodes. The bead image is taken from the bottom of an optically clear microplate, and barcode pattern can be decoded by image software. Therefore, the whole bead bioassay experiment can be performed in the microplate without taking the beads out.
Abstract translation: 光透射测定具有数字编码结构的珠或数字磁微珠，其部分透射并且对于光不透明。 当数百或数千个LITAB沉降到微孔板或平面表面的微孔底部时，条形码可以通过精确可靠的图像进行解码。 微孔板是标准的生物测定方法; 每个板可以具有96,384或1536个患者样品。 因此，可以在单个微孔中分析样品中的大量靶标。 图像解码算法包括四个主要过程（1）图像增强（2）珠粒分割（3）条形码切片提取，以及（4）条形码解码。 从光学透明微板的底部取出珠粒图像，并且可以通过图像软件对条形码图案进行解码。 因此，可以在微量培养板中进行全部小珠生物测定实验，而不用将珠子取出。
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公开(公告)号：US07094347B2
公开(公告)日：2006-08-22
申请号：US11035950
申请日：2005-01-18
Applicant: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
Inventor： Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
CPC classification number: B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
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