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1.发明公开公开(公告)号：US20240238619A1
公开(公告)日：2024-07-18
申请号：US18563860
申请日：2022-05-26
发明人： Aditya Vasan , James Friend , Jeremy Orosco , Sreekanth Chalasani , Uri Magaram
CPC分类号： A61N7/00 , B06B1/0644 , G16B5/00 , G16H20/30 , G16H40/67 , B06B2201/76
摘要： A system of ultrasound based cellular stimulation may include a stimulation apparatus and a stimulation controller. The stimulation apparatus may include a transducer element formed from a single crystal piezoelectric material such as lithium niobate. The stimulation apparatus may deliver high magnitudes of acoustic pressure relative to its dimensions (e.g., size, weight, and/or the like) and without significant heating. The stimulation controller may determine a cellular response to ultrasound stimulation such as membrane deflection and transmembrane voltage change. The stimulation controller may determine, based on the predicted cellular response, parameters for an ultrasound stimulation treatment for a patient such as a magnitude and/or duration of an ultrasonic stimulus for achieving a desired magnitude of membrane deflection and/or transmembrane voltage changes. The ultrasound stimulation treatment may be administered to the patient by the stimulation apparatus operating in accordance with the parameters.
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公开(公告)号：US11970720B2
公开(公告)日：2024-04-30
申请号：US16797969
申请日：2020-02-21
发明人： Patrick D. Hsu , Silvana Konermann
CPC分类号： C12N9/22 , C12N15/102 , C12N15/11 , C12N15/70 , C12N15/86 , C12N15/87 , C12N2310/20 , C12N2750/14143 , C12N2800/80
摘要： Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
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公开(公告)号：US11959094B2
公开(公告)日：2024-04-16
申请号：US18311000
申请日：2023-05-02
发明人： Juan Carlos Izpisua Belmonte , Keiichiro Suzuki , Reyna Hernandez-Benitez , Jun Wu , Yuji Tsunekawa
IPC分类号： C12N15/90 , A61K48/00 , A61P25/28 , A61P35/00 , C12N9/22 , C12N15/11 , C12N15/113 , C12N15/86
CPC分类号： C12N15/907 , A61K48/00 , A61K48/005 , A61K48/0066 , A61P25/28 , A61P35/00 , C12N9/22 , C12N15/111 , C12N15/113 , C12N15/86 , C07K2319/09 , C12N2310/20 , C12N2320/35 , C12N2750/14143 , C12Y301/01
摘要： Disclosed herein are homology-independent targeted integration methods of integrating an exogenous DNA sequence into a genome of a non-dividing cell and compositions for such methods. Methods herein comprise contacting the non-dividing cell with a composition comprising a targeting construct comprising the exogenous DNA sequence and a targeting sequence, a complementary strand oligonucleotide homologous to the targeting sequence, and a nuclease, thereby altering the genome of the non-dividing cell.
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公开(公告)号：US20230399663A1
公开(公告)日：2023-12-14
申请号：US18311000
申请日：2023-05-02
发明人： Juan Carlos Izpisua Belmonte , Keiichiro Suzuki , Reyna Hernandez-Benitez , Jun Wu , Yuji Tsunekawa
IPC分类号： C12N15/90 , C12N9/22 , C12N15/113 , C12N15/86 , C12N15/11 , A61K48/00 , A61P25/28 , A61P35/00
CPC分类号： C12N15/907 , C12N9/22 , C12N15/113 , C12N15/86 , C12N15/111 , A61K48/005 , A61K48/00 , A61P25/28 , A61P35/00 , A61K48/0066 , C07K2319/09 , C12N2750/14143 , C12N2320/35 , C12N2310/20 , C12Y301/01
摘要： Disclosed herein are homology-independent targeted integration methods of integrating an exogenous DNA sequence into a genome of a non-dividing cell and compositions for such methods. Methods herein comprise contacting the non-dividing cell with a composition comprising a targeting construct comprising the exogenous DNA sequence and a targeting sequence, a complementary strand oligonucleotide homologous to the targeting sequence, and a nuclease, thereby altering the genome of the non-dividing cell.
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公开(公告)号：US20230340534A1
公开(公告)日：2023-10-26
申请号：US18315383
申请日：2023-05-10
发明人： Sreekanth CHALASANI , Carl PROCKO , Joanne CHORY , Jose Mendoza LOPEZ , Marc Duque RAMIREZ , Corinne LEE-KUBLI , Swetha MURTHY , Ardem PATAPOUTIAN , Seyed Ali Reza MOUSAVI , William T. KEENAN , Yusuf TUFAIL , Janki PATEL
CPC分类号： C12N15/86 , C12N13/00 , C07K14/4702 , C12N2750/14143
摘要： Provided and described are mechanosensory polypeptides and encoding polynucleotide products and compositions thereof, methods of expressing such polypeptides and polynucleotides in a cell type of interest, and methods of inducing and/or modifying the activity and/or function of various types of cells that express the exogenous mechanosensory polypeptides using ultrasound.
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公开(公告)号：US20230328020A1
公开(公告)日：2023-10-12
申请号：US18324926
申请日：2023-05-26
发明人： Patrick D. Hsu , Silvana Konermann
IPC分类号： H04L51/212 , C12N15/10 , C12N15/113 , C12N15/85 , C12N15/82 , C12N9/22 , H04L51/214 , H04L9/08 , H04L9/30 , H04L45/745 , H04L51/08 , H04L51/18
CPC分类号： H04L51/212 , C12N15/102 , C12N15/113 , C12N15/85 , C12N15/8201 , C12N9/22 , C12N15/8213 , H04L51/214 , H04L9/08 , H04L9/30 , H04L45/745 , H04L51/08 , H04L51/18 , C12N2310/3519 , C12N2310/20 , C12N2310/16
摘要： Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
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公开(公告)号：US11730781B2
公开(公告)日：2023-08-22
申请号：US15945079
申请日：2018-04-04
发明人： Clodagh O'Shea , Colin Powers , Lei Zhang
IPC分类号： A61K35/761 , C12N15/85
CPC分类号： A61K35/761 , C12N15/85 , C12N2710/10322 , C12N2710/10332 , C12N2710/10333 , C12N2710/10341 , C12N2710/10343 , C12N2710/10345 , C12N2810/6018
摘要： Synthetic adenoviruses having chimeric fiber proteins and liver detargeting mutations are described. The synthetic adenovirus vectors are capable of specifically infecting cells at wound sites or in regions of damaged tissue. The synthetic adenovirus vectors also are capable of expressing transgenes, such as wound healing factors, at sites of wounded or damaged tissue. Accordingly, the described vectors can be used to detect wounded or damaged tissue, and/or to promote wound healing and regeneration of damaged tissue, such as by expression of heterologous wound healing or tissue regeneration factors.
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公开(公告)号：US11690557B2
公开(公告)日：2023-07-04
申请号：US16527705
申请日：2019-07-31
发明人： Philip Low
CPC分类号： A61B5/374 , A61B5/4812 , A61B5/4815 , A61B5/7264 , A61B5/7203 , A61B5/726 , A61B5/7267 , G06F2218/12
摘要： Determining low power frequency range information from spectral data. Raw signal data can be adjusted to increase dynamic range for power within low power frequency ranges as compared to higher-power frequency ranges to determine adjusted source data valuable for acquiring low power frequency range information. Low power frequency range information can be used in the analysis of a variety of raw signal data. For example, low power frequency range information within electroencephalography data for a subject from a period of sleep can be used to determine sleep states. Similarly, automated full-frequency spectral electroencephalography signal analysis can be useful for customized analysis including assessing sleep quality, detecting pathological conditions, and determining the effect of medication on sleep states.
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公开(公告)号：US20220315901A1
公开(公告)日：2022-10-06
申请号：US17114888
申请日：2020-12-08
发明人： RONALD EVANS , MICHAEL DOWNES , YASUYUKI KIDA , TERUHISA KAWAMURA , ZONG WEI , RUTH T. YU , ANNETTE R. ATKINS
IPC分类号： C12N5/074
摘要： The invention generally features compositions comprising induced pluripotent stem cell progenitors (also termed reprogramming progenitor cells) and methods of isolating such cells. The invention also provides compositions comprising induced pluripotent stem cells (iPSCs) derived from such progenitor cells. Induced pluripotent stem cell progenitors generate iPSCs at high efficiency.
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公开(公告)号：US20220265855A1
公开(公告)日：2022-08-25
申请号：US17741311
申请日：2022-05-10
IPC分类号： A61K48/00 , C12N15/115 , C12N15/64 , C12N15/86
摘要： Provided herein are compositions and systems for reconstitution of RNA molecules, including methods for using these molecules. For example, such molecules can be used to deliver a protein coding sequence over two or more viral vectors (such as AAVs), resulting in reconstitution of the full-length protein in a cell. Such methods can be used to deliver a therapeutic protein, for example to treat a genetic disease or cancer.
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