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    VMP-LIKE SEQUENCES OF PATHOGENIC BORRELIA SPECIES AND STRAINS
    2.
    发明申请
    VMP-LIKE SEQUENCES OF PATHOGENIC BORRELIA SPECIES AND STRAINS 有权
    致病性BORRELIA物种和菌株的VMP样序列

    公开(公告)号：US20120088289A1

    公开(公告)日：2012-04-12

    申请号：US13324357

    申请日：2011-12-13

    申请人： Steven J. Norris

    发明人： Steven J. Norris

    IPC分类号： C12N1/21 ,  C12N15/31

    CPC分类号： C07K14/20 ,  A61K39/00 ,  A61K39/02 ,  C07K17/08 ,  C07K17/12 ,  C08G69/48 ,  G01N33/56911 ,  G01N33/6854 ,  G01N2333/20 ,  G01N2469/20 ,  G01N2800/26 ,  Y02A50/40 ,  Y02A50/401 ,  Y02A50/57

    摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.

    摘要翻译： 本发明涉及编码病原性疏螺旋体的Vmp样多肽的DNA序列，重组载体中的DNA序列用于表达多肽的用途，编码的氨基酸序列，将DNA和氨基酸序列应用于产生多肽作为抗原 用于免疫预防，免疫治疗和免疫诊断。 还公开了使用核酸序列作为检测引起莱姆病，复发性发热或相关病症的生物的探针或引物，以及旨在促进使用所述多肽，DNA区段和抗体的方法的试剂盒。

    VMP-LIKE SEQUENCES OF PATHOGENIC BORRELIA SPECIES AND STRAINS
    4.
    发明申请
    VMP-LIKE SEQUENCES OF PATHOGENIC BORRELIA SPECIES AND STRAINS 有权
    致病性BORRELIA物种和菌株的VMP样序列

    公开(公告)号：US20110124047A1

    公开(公告)日：2011-05-26

    申请号：US12962154

    申请日：2010-12-07

    申请人： Steven J. Norris

    发明人： Steven J. Norris

    IPC分类号： C12P21/02 ,  C07H21/04 ,  C07H21/02 ,  C12N1/21

    CPC分类号： C07K14/20 ,  A61K39/00 ,  A61K39/02 ,  C07K17/08 ,  C07K17/12 ,  C08G69/48 ,  G01N33/56911 ,  G01N33/6854 ,  G01N2333/20 ,  G01N2469/20 ,  G01N2800/26 ,  Y02A50/40 ,  Y02A50/401 ,  Y02A50/57

    摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.

    摘要翻译： 本发明涉及编码病原性疏螺旋体的Vmp样多肽的DNA序列，重组载体中的DNA序列用于表达多肽的用途，编码的氨基酸序列，将DNA和氨基酸序列应用于产生多肽作为抗原 用于免疫预防，免疫治疗和免疫诊断。 还公开了使用核酸序列作为检测引起莱姆病，复发性发热或相关病症的生物的探针或引物，以及旨在促进使用所述多肽，DNA区段和抗体的方法的试剂盒。

    VMP-like sequences of pathogenic Borrelia species and strains
    6.
    发明授权
    VMP-like sequences of pathogenic Borrelia species and strains 有权
    VMP样序列的致病性疏螺类种和菌株

    公开(公告)号：US08076470B2

    公开(公告)日：2011-12-13

    申请号：US12962154

    申请日：2010-12-07

    申请人： Steven J. Norris

    发明人： Steven J. Norris

    IPC分类号： C07H21/04 ,  C07H21/02 ,  A61K39/02

    CPC分类号： C07K14/20 ,  A61K39/00 ,  A61K39/02 ,  C07K17/08 ,  C07K17/12 ,  C08G69/48 ,  G01N33/56911 ,  G01N33/6854 ,  G01N2333/20 ,  G01N2469/20 ,  G01N2800/26 ,  Y02A50/40 ,  Y02A50/401 ,  Y02A50/57

    摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.

    摘要翻译： 本发明涉及编码病原性疏螺旋体的Vmp样多肽的DNA序列，重组载体中的DNA序列用于表达多肽的用途，编码的氨基酸序列，将DNA和氨基酸序列应用于产生多肽作为抗原 用于免疫预防，免疫治疗和免疫诊断。 还公开了使用核酸序列作为检测引起莱姆病，复发性发热或相关病症的生物的探针或引物，以及旨在促进使用所述多肽，DNA区段和抗体的方法的试剂盒。

    VMP-like sequences of pathogenic Borrelia species and strains
    8.
    发明授权
    VMP-like sequences of pathogenic Borrelia species and strains 有权
    VMP样序列的致病性疏螺类种和菌株

    公开(公告)号：US07847084B2

    公开(公告)日：2010-12-07

    申请号：US10539956

    申请日：2003-12-22

    申请人： Steven J. Norris

    发明人： Steven J. Norris

    IPC分类号： C07H21/02 ,  C07H21/04 ,  A61K39/02

    CPC分类号： C07K14/20 ,  A61K39/00 ,  A61K39/02 ,  C07K17/08 ,  C07K17/12 ,  C08G69/48 ,  G01N33/56911 ,  G01N33/6854 ,  G01N2333/20 ,  G01N2469/20 ,  G01N2800/26 ,  Y02A50/40 ,  Y02A50/401 ,  Y02A50/57

    摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.

    摘要翻译： 本发明涉及编码病原性疏螺旋体的Vmp样多肽的DNA序列，重组载体中的DNA序列用于表达多肽的用途，编码的氨基酸序列，将DNA和氨基酸序列应用于产生多肽作为抗原 用于免疫预防，免疫治疗和免疫诊断。 还公开了使用核酸序列作为检测引起莱姆病，复发性发热或相关病症的生物的探针或引物，以及旨在促进使用所述多肽，DNA区段和抗体的方法的试剂盒。