公开(公告)号：US20250115579A1

公开(公告)日：2025-04-10

申请号：US18829953

申请日：2024-09-10

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jian Qiu ,  Qi Wei ,  Matt Tschantz ,  Heping Shi ,  Youtong Wu ,  Huiling Tan ,  Lijun Sun ,  Chuo Chen ,  Zhijian Chen

IPC: C07D401/14 ,  C07D215/38 ,  C07D215/42 ,  C07D215/46 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/048 ,  C07F9/6503 ,  C07F9/6506

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20250115546A1

公开(公告)日：2025-04-10

申请号：US18809438

申请日：2024-08-20

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Kyoji TSUCHIKAMA ,  Yasuaki ANAMI ,  Chisato TSUCHIKAMA ,  Ningyang ZHANG ,  Zhiqiang AN

IPC: C07C247/04 ,  A61K31/40 ,  A61K45/06 ,  A61K47/68 ,  A61P35/00 ,  C07D209/20 ,  C07D403/12

Abstract: In one aspect, the present disclosure provides compounds of the formula: wherein the variables are as defined herein.
In another aspect, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure provides antibody drug conjugates comprising compounds of the present disclosure. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds and anti-body drug conjugates disclosed herein.

公开(公告)号：US20250111960A1

公开(公告)日：2025-04-03

申请号：US18827374

申请日：2024-09-06

Applicant: Rutgers, The State University of New Jersey ,  The Board of Regents of The University of Texas System

Inventor： Jennifer K. Lynch-Branzoi ,  Ali Ashraf ,  Ashiqur Rahman ,  Nazmul Islam

IPC: H01B1/20 ,  B01F23/50 ,  B01F23/53 ,  B01F23/70 ,  B01F27/232 ,  B01F101/00 ,  C08J3/22 ,  C08K9/00 ,  G01L1/14 ,  G01L1/22 ,  G01N27/30 ,  G06F3/0354

Abstract: Sensors employing elastomers enhanced with electrically conductive 2D nanoparticles are provided. The nanoparticles are formed by applying shear to layered materials present in elastomer precursors (e.g., elastomeric monomer(s) and/or curing agent(s)). Subsequent exfoliation of the layers occurs directly within the precursor and/or curing agent. The cured elastomer nanocomposites can be employed for electrochemical sensing, flexible touchpads, pressure sensors, and wireless sensors, amongst other applications.

公开(公告)号：US20250099095A1

公开(公告)日：2025-03-27

申请号：US18728046

申请日：2023-02-02

Applicant: The Board of Regents of the University of Texas System

Inventor： Philippe E. Zimmern

IPC: A61B17/04 ,  A61B17/00 ,  A61F2/00

Abstract: Suture tensioning systems, methods, and devices include a suture device for extracting a suture thread from a patient and then determining a location to secure the suture knot based on a balanced tension measurement. The suture device has a needle pass mount with needle passes, and a slidable eyelet assembly positioned opposite the needle passes. The eyelet assembly includes gripping portions for moving the eyelet assembly relative to other components of the suture device. Accordingly, eyelets extending from the eyelet assembly move through the needle pass mounts and extend out the needle passes. With the suture thread secured in the extended eyelet, the eyelet assembly is retracted. The suture thread is attached to a tensioning bar and tension meter. The tension meter indicates if the suture tension is within a threshold range and comparable to the opposite side, and a precise tying location for the suture knot is determined.

公开(公告)号：US20250092468A1

公开(公告)日：2025-03-20

申请号：US18965965

申请日：2024-12-02

Applicant: The Board of Regents of The University of Texas System

Inventor： Min Soo KIM ,  James BRUGAROLAS ,  Tae Hyun HWANG ,  Yang XIE

IPC: C12Q1/6886 ,  A61P35/00 ,  C12N15/52 ,  C40B40/08 ,  G01N33/50 ,  G16B25/00 ,  G16B25/10 ,  G16B25/20 ,  G16B30/00 ,  G16H50/20 ,  G16H50/30

Abstract: Described herein are methods and systems for identifying and/or treating subjects having cancer who are more likely to respond to treatment with an inhibitor of the transcription factor HIF-2α.

公开(公告)号：US12251383B2

公开(公告)日：2025-03-18

申请号：US17469457

申请日：2021-09-08

Applicant: The Board of Regents of the University of Texas System

Inventor： Alemayehu Gorfe Abebe ,  Michael J. McCarthy ,  Cynthia V. Pagba ,  Priyanka Prakash Srivastava

IPC: A61K31/519

Abstract: In one aspect, the disclosure relates to compounds that are inhibitors of KRAS, and the disclosed compounds are allosteric inhibitors of KRAS which render them extremely useful for therapeutic intervention in a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, e.g., cancer. In various aspects, the disclosed compounds are substituted 7-(piperazin-1-yl)pyrazolo[1,5-a]pyrimidine analogs. In further aspects, the disclosed compounds can be used in methods of treating a cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20250069706A1

公开(公告)日：2025-02-27

申请号：US18729385

申请日：2023-01-30

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Bo LI

IPC: G16B40/30 ,  G16B20/20

Abstract: A novel framework to transform a T-cell receptor (TCR) repertoire sample into a fixed-length vector. Short peptide sequences with different lengths in each TCR may be encoded into a numeric vector with fixed dimensions. A large amount of existing TCRs from healthy individuals may be pooled to generate a distribution of the encoding vector in a high-dimensional Euclidean space. Unsupervised clustering may be performed on the “points” in this space (each point is a TCR) to group them into antigen-specific clusters. The centroid of each cluster may be defined as a repertoire functional unit (“RFU”). For a new TCR repertoire sample, each TCR may be assigned to its most similar RFU group, and the RFU counts may be normalized by the number of sequences in the repertoire. The output data may be a fixed-length RFU vector, with each number representing the relative abundance of the given RFU in the repertoire.

公开(公告)号：US12237051B2

公开(公告)日：2025-02-25

申请号：US18505757

申请日：2023-11-09

Applicant: University of Central Florida Research Foundation, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Degui Zhi ,  Shaojie Zhang ,  Ardalan Naseri ,  Ahsan Sanaullah ,  Erwin Holzhauser

IPC: G16B10/00 ,  G06F16/22 ,  G06F16/24 ,  G16B20/20 ,  G16B30/00

Abstract: A system for indexing, updating, and search haplotypes for genetic genealogical discovery in genotype databases. The system includes a pool of genetic indexes, a haplotype ingestion engine, and a haplotype query engine. The haplotypes of a number of individuals in a genotype database are indexed by a pool of multiple panels, and each panel pool can be dynamically updated by the insertion or deletion of individual haplotypes. A genetic genealogical search of a query haplotype against the database is achieved by first projecting the query onto a subset of panels in the pool, then conducting long match queries over each panel, and finally aggregating the identified long matches into Identical-by-Descent segments, i.e., DNA matches, between the query and the haplotypes in the database.

公开(公告)号：US12202895B2

公开(公告)日：2025-01-21

申请号：US17275838

申请日：2019-09-12

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  IMMUNE-ONC THERAPEUTICS, INC.

Inventor： Zhiqiang An ,  Chengcheng Zhang ,  Ningyan Zhang ,  Xun Gui ,  Mi Deng ,  Tao Huang ,  Qiang Liu ,  X. Charlene Liao

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61K47/68 ,  A61K47/69 ,  A61K51/10 ,  A61P35/02 ,  G01N33/574

Abstract: The present disclosure provides an isolated monoclonal antibody or an antigen-binding fragment thereof that binds specifically to leukocyte immunoglobulin-like receptor 4 (LILRB4). In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, modulates the activation of LILRB4. In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, activates LILRB4. In certain embodiments, the antibody or antigen binding fragment, when bound to LILRB4, suppresses activation of LILRB4. In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, specifically blocks binding of ApoE to LILRB4. In another aspect, there is provided a method of treating or ameliorating the effects of a cancer in a subject, comprising administering to the subject a therapeutically effective amount of the antibody or an antigen-binding fragment thereof or an engineered cell as provided herein.

公开(公告)号：US12161618B2

公开(公告)日：2024-12-10

申请号：US18093840

申请日：2023-01-06

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： James B. Brugarolas ,  Haley Hill ,  Tao Wang

IPC: A61K31/135 ,  A61K31/275 ,  A61P35/00 ,  G01N33/50 ,  A61K45/06

Abstract: The present disclosure provides methods of identifying patients who have partial or total resistance to HIF-2 inhibitors or who develop partial or total resistance to HIF-2 inhibitors after treatment and providing suitable treatment to these patients.