公开(公告)号：US20120004197A1

公开(公告)日：2012-01-05

申请号：US13256549

申请日：2010-03-31

申请人： Masanori Ashikawa ,  Junya Tagashira ,  Akiyasu Koketsu ,  Toshiharu Morimoto ,  Takahiro Kitamura ,  Syunji Takemura ,  Gen Watanabe ,  Tatsuaki Nishiyama ,  Satoshi Goda ,  Masaki Yamabi ,  Takeshi Doi ,  Hiroyuki Ishiwata

发明人： Masanori Ashikawa ,  Junya Tagashira ,  Akiyasu Koketsu ,  Toshiharu Morimoto ,  Takahiro Kitamura ,  Syunji Takemura ,  Gen Watanabe ,  Tatsuaki Nishiyama ,  Satoshi Goda ,  Masaki Yamabi ,  Takeshi Doi ,  Hiroyuki Ishiwata

IPC分类号： A61K31/4706 ,  C07D413/12 ,  C07D215/14 ,  C07D215/233 ,  C07D401/12 ,  A61P7/06 ,  C07D413/14 ,  A61K31/5377 ,  A61K31/47 ,  A61K31/496 ,  A61K31/69 ,  C07D215/44 ,  C07F5/02

CPC分类号： C07D215/42 ,  A61K31/47 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/69 ,  C07D215/233 ,  C07D215/44 ,  C07D215/46 ,  C07D215/48 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12

摘要： Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin. Specifically disclosed is and EPO production enhancer and/or a hemoglobin production enhancer comprising a 1-acyl-4-(substituted oxy, substituted amino, or substituted thio)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by general formula (1) [wherein R1, R2, R2′, R3 and R3′ independently represent a hydrogen atom, a C1-6 alkyl group, or the like; R4, R5, R6, R7, R8, R9 and R10 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, or the like; A represents N—R11, a sulfur atom, or an oxygen atom; R11 represents a hydrogen atom, a C1-6 alkyl group, or the like; B represents a C6-14 aryl group, or a 5- to 10-membered heterocyclic group; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.

摘要翻译： 公开了具有低分子量且具有增强EPO产生活性和/或提高血红蛋白生成活性的化合物。 具体公开的是EPO生产增强剂和/或包含1-酰基-4-（取代的氧基，取代的氨基或取代的硫代）-1,2,3,4-四氢喹啉衍生物，更具体地是四氢喹啉化合物的血红蛋白生成增强剂 由通式（1）表示[其中R1，R2，R2'，R3和R3'独立地表示氢原子，C1-6烷基等; R 4，R 5，R 6，R 7，R 8，R 9和R 10独立地表示氢原子，卤素原子，C 1-6烷基等; A表示N-R11，硫原子或氧原子; R 11表示氢原子，C 1-6烷基等; B表示C 6-14芳基或5至10元杂环基; n表示0或1的整数]，四氢喹啉化合物的盐或四氢喹啉化合物或其盐的溶剂合物。

公开(公告)号：US07755593B2

公开(公告)日：2010-07-13

申请号：US10598102

申请日：2005-02-15

申请人： Takeshi Yamamoto ,  Aki Miake ,  Toshiya Takahashi ,  Megumi Itoh ,  Mitsukazu Okuda ,  Takeshi Doi

发明人： Takeshi Yamamoto ,  Aki Miake ,  Toshiya Takahashi ,  Megumi Itoh ,  Mitsukazu Okuda ,  Takeshi Doi

IPC分类号： G09G3/36 ,  G09G5/00

CPC分类号： G09G3/3406 ,  G09G2300/026

摘要： A liquid crystal display device (100) includes mean value computing sections (9a, 9b) and an optical intensity regulation section (11). The mean value computing section (9a) outputs a mean luminance level (A1) for the pixels forming an image display produced in a driver seat display area (2). The mean value computing section (9b) outputs a mean luminance level (A2) for the pixels forming an image display produced in a front passenger seat display area (3). The optical intensity regulation section (11) controls (regulates) the output optical intensity of backlights (4a, 4b) according to the mean luminance level (A1) and the mean luminance level (A2). As a result, the luminance of the image display in the front passenger seat display area (3) is further limited than the luminance of the image display in the driver seat display area (2). The control ensures high visibility of image displays for the driver.

摘要翻译： 液晶显示装置（100）包括平均值计算部（9a，9b）和光强度调节部（11）。 平均值计算部（9a）输出构成驾驶席位显示区域（2）中生成的图像显示的像素的平均亮度水平（A1）。 平均值计算部（9b）输出形成在乘客座位显示区域（3）中产生的图像显示的像素的平均亮度水平（A2）。 光强度调节部（11）根据平均亮度等级（A1）和平均亮度等级（A2）来控制（调节）背光源（4a，4b）的输出光强度。 结果，前乘客座椅显示区域（3）中的图像显示的亮度比驾驶员座椅显示区域（2）中的图像显示的亮度进一步被限制。 该控件确保驱动程序的图像显示器的高可见性。

公开(公告)号：US07633501B2

公开(公告)日：2009-12-15

申请号：US11438779

申请日：2006-05-22

申请人： Susan A. Wood ,  Heidi Zhang ,  Anat Caspi ,  Takeshi Doi ,  Harlan M. Romsdahl

发明人： Susan A. Wood ,  Heidi Zhang ,  Anat Caspi ,  Takeshi Doi ,  Harlan M. Romsdahl

IPC分类号： G06T15/00 ,  G01N23/00 ,  G06K9/00 ,  A61B5/05 ,  G06F3/00

CPC分类号： G06T7/0012 ,  A61B6/032 ,  A61B6/037 ,  A61B6/463 ,  A61B6/466 ,  G06F3/0481 ,  G06F3/04855 ,  G06F19/00 ,  G06F2203/04805 ,  G06K9/00 ,  G06K9/3233 ,  G06K2009/366 ,  G06K2209/05 ,  G06T15/08 ,  G06T19/00 ,  G06T2207/30061 ,  G06T2210/41 ,  G06T2219/004 ,  G06T2219/028 ,  Y10S378/901

摘要： A computer-aided diagnostic method and system provide image annotation information that can include an assessment of the probability, likelihood or predictive value of detected or identified suspected abnormalities as an additional aid to the radiologist. More specifically, probability values, in numerical form and/or analog form, are added to the locational markers of the detected and suspected abnormalities. The task of a physician using such a system as disclosed is believed to be made easier by displaying markers representing different regions of interest.

公开(公告)号：US20070160271A1

公开(公告)日：2007-07-12

申请号：US11323939

申请日：2005-12-29

申请人： Takeshi Doi ,  Vilim Simcic ,  Jimmy Roehrig

发明人： Takeshi Doi ,  Vilim Simcic ,  Jimmy Roehrig

IPC分类号： G06K9/00

CPC分类号： G06F19/321 ,  G06F19/00 ,  G16H50/20

摘要： Facilitating viewer comparison of a plurality of medical images of at least one body part on a softcopy review workstation is described. First and second medical images are displayed such that the second medical image appears as a spatially registered underlay to the first medical image exposed through an aperture therein. The aperture comprises at least one edge that is viewer-manipulable in a back-and-forth manner so that the first and second medical images can be visually compared with minimal eye movement. For a temporal comparison embodiment, the first and second medical images comprise identical views of the same body part acquired at different times. For a cross-modality comparison embodiment, the first and second medical images are acquired substantially concurrently, or at different times, using different medical imaging modalities. For a bilateral comparison embodiment, the first and second images are corresponding views of two laterally corresponding body parts.

摘要翻译： 描述了在软拷贝检查工作站上促进对至少一个身体部位的多个医学图像的观看者比较。 显示第一和第二医疗图像，使得第二医疗图像作为空间注册的底层显示出通过其中的孔暴露的第一医疗图像。 所述孔包括至少一个能够以往复方式观察者操纵的边缘，使得可以在视觉上比较第一和第二医学图像与最小的眼睛运动。 对于时间比较实施例，第一和第二医学图像包括在不同时间获取的相同身体部位的相同视图。 对于交叉模态比较实施例，使用不同的医学成像模式基本同时或不同时间获取第一和第二医学图像。 对于双向比较实施例，第一和第二图像是两个横向对应的身体部分的对应视图。

公开(公告)号：US20070132572A1

公开(公告)日：2007-06-14

申请号：US10598110

申请日：2005-02-16

申请人： Megumi Itoh ,  Toshiya Takahashi ,  Mitsukazu Okudo ,  Takeshi Yamamoto ,  Aki Miake ,  Takeshi Doi

发明人： Megumi Itoh ,  Toshiya Takahashi ,  Mitsukazu Okudo ,  Takeshi Yamamoto ,  Aki Miake ,  Takeshi Doi

IPC分类号： B60Q1/00 ,  G06T1/00

CPC分类号： B60K35/00 ,  B60K2370/11 ,  G09G5/00 ,  G09G5/024 ,  G09G2320/0626 ,  G09G2320/066 ,  G09G2320/0666 ,  G09G2340/14 ,  G09G2360/16

摘要： An instrument panel image display device displays an instrument panel image by which various information is provided to a driver. In this device, the instrument panel image includes a plurality of gauge-like images displayed at specific positions in the instrument panel image display device. Further, this device includes an image data changing section for changing image data, which generates each gauge-like image, into image data, which generates another gauge-like image. This makes it possible to display a new instrument panel image by combining various gauge-like images. That is, in this instrument panel image display device, it is possible to more freely select the instrument panel image.

摘要翻译： 仪表板图像显示装置显示向驾驶员提供各种信息的仪表板图像。 在该装置中，仪表板图像包括在仪表板图像显示装置的特定位置处显示的多个量规图像。 此外，该装置包括用于将产生每个规格图像的图像数据改变成图像数据的图像数据改变部分，其生成另一个规格图像。 这使得可以通过组合各种规格图像来显示新的仪表板图像。 也就是说，在该仪表板图像显示装置中，可以更自由地选择仪表板图像。

公开(公告)号：US20070003124A1

公开(公告)日：2007-01-04

申请号：US11438779

申请日：2006-05-22

申请人： Susan Wood ,  Heidi Zhang ,  Anat Caspi ,  Takeshi Doi ,  Harlan Romsdahl

发明人： Susan Wood ,  Heidi Zhang ,  Anat Caspi ,  Takeshi Doi ,  Harlan Romsdahl

IPC分类号： G06K9/00

CPC分类号： G06T7/0012 ,  A61B6/032 ,  A61B6/037 ,  A61B6/463 ,  A61B6/466 ,  G06F3/0481 ,  G06F3/04855 ,  G06F19/00 ,  G06F2203/04805 ,  G06K9/00 ,  G06K9/3233 ,  G06K2009/366 ,  G06K2209/05 ,  G06T15/08 ,  G06T19/00 ,  G06T2207/30061 ,  G06T2210/41 ,  G06T2219/004 ,  G06T2219/028 ,  Y10S378/901

摘要： A computer-aided diagnostic method and system provide image annotation information that can include an assessment of the probability, likelihood or predictive value of detected or identified suspected abnormalities as an additional aid to the radiologist. More specifically, probability values, in numerical form and/or analog form, are added to the locational markers of the detected and suspected abnormalities. The task of a physician using such a system as disclosed is believed to be made easier by displaying markers representing different regions of interest.

摘要翻译： 计算机辅助诊断方法和系统提供图像注释信息，其可以包括对所检测或识别的可疑异常的概率，似然性或预测值的评估，作为对放射科医生的额外辅助。 更具体地，以数字形式和/或类似形式的概率值被添加到检测到和怀疑的异常的位置标记中。 通过显示表示不同感兴趣区域的标记，使用这种所公开的系统的医师的任务被认为更容易。

公开(公告)号：US07072501B2

公开(公告)日：2006-07-04

申请号：US10261183

申请日：2002-09-30

申请人： Susan A. Wood ,  Heidi Zhang ,  Anat Caspi ,  Takeshi Doi ,  Harlan M. Romsdahl

发明人： Susan A. Wood ,  Heidi Zhang ,  Anat Caspi ,  Takeshi Doi ,  Harlan M. Romsdahl

IPC分类号： G06K9/00

CPC分类号： G06T7/0012 ,  A61B6/032 ,  A61B6/037 ,  A61B6/463 ,  A61B6/466 ,  G06F3/0481 ,  G06F3/04855 ,  G06F19/00 ,  G06F2203/04805 ,  G06K9/00 ,  G06K9/3233 ,  G06K2009/366 ,  G06K2209/05 ,  G06T15/08 ,  G06T19/00 ,  G06T2207/30061 ,  G06T2210/41 ,  G06T2219/004 ,  G06T2219/028 ,  Y10S378/901

摘要： A computer-aided diagnostic method and system provide image annotation information that can include an assessment of the probability, likelihood or predictive value of detected or identified suspected abnormalities as an additional aid to the radiologist. More specifically, probability values, in numerical form and/or analog form, are added to the locational markers of the detected and suspected abnormalities. The task of a physician using such a system as disclosed is believed to be made easier by displaying markers representing different regions of interest.

公开(公告)号：US06734730B2

公开(公告)日：2004-05-11

申请号：US10308003

申请日：2002-12-03

申请人： Takeshi Doi ,  Kenji Maio

发明人： Takeshi Doi ,  Kenji Maio

IPC分类号： H03G516

CPC分类号： H03G1/0088 ,  H03F3/72 ,  H03G3/3042

摘要： In order to provide a high sensitivity variable gain amplifier, there is provided a structure in which at least one path comprising at least a stage of the voltage-input/voltage-output amplifier+ a stage of voltage-input/current-output amplifier and a path comprising a stage of the voltage-input/current-output amplifier are connected in parallel between the input terminal and output terminal or, a structure in which a plurality of paths each comprising at least a stage of voltage-input/voltage-output amplifier+a stage of voltage-input/current-output amplifier are connected in parallel between the input terminal and output terminal. A gain is switched by selecting and operating any one of paths. When any one path is selected, an input impedance viewed from the input terminal is suppressed almost not to change or an output impedance viewed from the output terminal is suppressed almost not to change. Thereby, a high sensitivity wireless receiver can be realized.

摘要翻译： 为了提供高灵敏度可变增益放大器，提供了一种结构，其中至少一个路径包括电压输入/电压 - 输出放大器的至少一个级+电压输入/电流输出放大器的级和 包括电压输入/电流输出放大器的级的路径并联连接在输入端子和输出端子之间，或者其结构中，多个通路各自包括至少一级的电压输入/电压输出放大器 电压输入/电流输出放大器的一级在输入端子和输出端子之间并联连接。 通过选择和操作任何路径来切换增益。 当选择任何一个路径时，抑制从输入端子观察的输入阻抗几乎不变化，或者抑制从输出端子观察的输出阻抗几乎不改变。 因此，可以实现高灵敏度的无线接收器。

公开(公告)号：US06552188B2

公开(公告)日：2003-04-22

申请号：US09893699

申请日：2001-06-29

申请人： Tatsuhiko Kodama ,  Masahiro Tamura ,  Toshiaki Oda ,  Yukiyoshi Yamazaki ,  Masahiro Nishikawa ,  Shunji Takemura ,  Takeshi Doi ,  Yoshinori Kyotani

发明人： Tatsuhiko Kodama ,  Masahiro Tamura ,  Toshiaki Oda ,  Yukiyoshi Yamazaki ,  Masahiro Nishikawa ,  Shunji Takemura ,  Takeshi Doi ,  Yoshinori Kyotani

IPC分类号： A61K31496

CPC分类号： C07D213/81 ,  C07D213/36 ,  C07D213/82 ,  C07D401/12

摘要： Cyclic diamine compounds of formula (1) are disclosed: wherein A is (CH2)n, (CH2)n—CH═CH, CO—(CH2)n or CO—(CH2)n—CH═CH, in which n is a number of 0 to 3; Z represents a formula (2) or (3): in which R1, R2, R4, R5 and R6 are individually a hydrogen atom, alkyl group, alkoxy group, halogen atom or nitro group; R3is a hydrogen atom, alkyl group, alkoxy group, halogen atom, nitro group, naphthyl group, or phenyl group which may be substituted by 1 to 3 substituents selected from the group consisting of alkyl groups, alkoxy groups, halogen atoms, a nitro group and a phenyl group; and X and Y are individually CH or a nitrogen atom; and m is 1 or 2; an acid-addition salt thereof, or a hydrate thereof, and a medicine containing such a compound.

摘要翻译： 公开了式（1）的环二胺化合物：其中A是（CH 2）n，（CH 2）n -CH = CH，CO-（CH 2）n或CO-（CH 2）n -CH = CH，其中n是 数字0到3; Z表示式（2）或（3）：其中R1，R2，R4，R5和R6分别为氢原子，烷基，烷氧基，卤素原子或硝基; R3是氢原子，烷基，烷氧基，卤素原子，硝基，萘基或可以被1〜3个选自烷基，烷氧基，卤原子，硝基的取代基取代的苯基 和苯基; X和Y分别是CH或氮原子; m为1或2;其酸加成盐或其水合物，以及含有这种化合物的药物。

公开(公告)号：US06498169B1

公开(公告)日：2002-12-24

申请号：US09983928

申请日：2001-10-26

申请人： Tatsuhiko Kodama ,  Masahiro Tamura ,  Toshiaki Oda ,  Yukiyoshi Yamazaki ,  Masahiro Nishikawa ,  Shunji Takemura ,  Takeshi Doi ,  Yoshinori Kyotani ,  Masao Ohkuchi

发明人： Tatsuhiko Kodama ,  Masahiro Tamura ,  Toshiaki Oda ,  Yukiyoshi Yamazaki ,  Masahiro Nishikawa ,  Shunji Takemura ,  Takeshi Doi ,  Yoshinori Kyotani ,  Masao Ohkuchi

IPC分类号： A61K314545

CPC分类号： C07D401/06 ,  A61K31/4545 ,  C07D211/58 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14

摘要： A cyclic amine compound represented by the following general formula (1): wherein, R1, R2 and R3 each independently represent a hydrogen atom or an alkoxy group; W1 an W2 each independently represent N or CH; X represents O, NR4, CONR4 or NR4CO; R4 each independently represents a hydrogen atom, or an alkyl, aryl, heteroaryl, aralkyl, or heteroalkyl group; and l, m and n each represents a number of 0 to 1, a salt thereof and a hydrate thereof are provided. These compounds have inhibitory effects on both cell adhesion and cell infiltration and are useful as anti-asthmatic agents, anti-allergic agents, anti-rheumatic agents, anti-arteriosclerotic agents, anti-inflammatory agents, anti-Sjogren's syndrome agents or the like.

摘要翻译： 由以下通式（1）表示的环胺化合物：其中，R 1，R 2和R 3各自独立地表示氢原子或烷氧基; W 1，W 2各自独立地表示N或CH; X表示O，NR 4，CONR 4或 NR4CO; R4各自独立地表示氢原子，或烷基，芳基，杂芳基，芳烷基或杂烷基; 和l，m和n各自表示0至1的数，其盐和其水合物。这些化合物对细胞粘附和细胞浸润均具有抑制作用，可用作抗哮喘剂，抗过敏剂， 抗风湿剂，抗动脉硬化剂，抗炎剂，抗干燥素综合征剂等。