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    System, device and method for detection of several individual analytes in a solution, and a disposable flow cell for use therein
    1.
    发明授权
    System, device and method for detection of several individual analytes in a solution, and a disposable flow cell for use therein 失效
    用于检测溶液中的几种单独的分析物的系统，装置和方法以及用于其中的一次性流通池

    公开(公告)号：US07771657B2

    公开(公告)日：2010-08-10

    申请号：US10517321

    申请日：2003-06-18

    申请人： Per Månsson ,  Henrik Andersson ,  Jan Smith ,  Kjeld Jensen ,  Teodor Aastrup

    发明人： Per Månsson ,  Henrik Andersson ,  Jan Smith ,  Kjeld Jensen ,  Teodor Aastrup

    IPC分类号： G01N21/00 ,  G01N27/00 ,  G01N31/00 ,  G01N33/22 ,  G01N33/53 ,  G01N33/567 ,  C12Q1/00 ,  C12Q1/68

    CPC分类号： G01N35/1097 ,  G01N5/02 ,  G01N29/036 ,  G01N33/946 ,  G01N2291/106

    摘要： A system, device and method for detection of several individual analytes in a test solution aliquot (83) with an array of individually operated piezoelectric crystal microbalances are described. The system comprises a connecting station (100) that receives a plurality of individually specific piezoelectric crystal microbalance flow-trough cells (10), each containing a piezoelectric crystal (50) carrying electrodes (56,62) and a coating (66,46) exposing a first member of an interaction pair specific for an individual analyte being a second member of the interaction pair. Flowing means (70) flows a solution (75) and the test solution aliquot (83) to and through a cell compartment of each of the cells (10) via the connecting station (100). Power and measurement means (130) oscillate the piezoelectric crystal(s) (50). A change in oscillating characteristics of the crystal(s) (50), following interaction between the first and second members of the interaction pair, detects presence of the individual analyte(s). Further, disposable flow cells (10) for use in an array of individually operated piezoelectric crystal microbalances (112) is described.

    摘要翻译： 描述了具有独立操作的压电晶体微量平衡阵列的测试溶液等分试样（83）中检测几种单独分析物的系统，装置和方法。 该系统包括接收多个单独特定的压电晶体微量天平流槽电池（10）的连接站（100），每个单元包含承载电极（56,62）和涂层（66,46）的压电晶体（50） 暴露对于作为相互作用对的第二成员的单个分析物特异性的相互作用对的第一成员。 流动装置（70）通过连接站（100）将溶液（75）和测试溶液等分试样（83）流经并通过每个电池（10）的电池室。 功率和测量装置（130）振荡压电晶体（50）。 在相互作用对的第一和第二成员之间的相互作用之后，晶体（50）的振荡特性的变化检测各个分析物的存在。 此外，描述了用于独立操作的压电晶体微量平衡阵列（112）的一次性流通池（10）。

    Sensor
    2.
    发明申请
    Sensor 有权
    传感器

    公开(公告)号：US20100116035A1

    公开(公告)日：2010-05-13

    申请号：US12598424

    申请日：2008-04-30

    申请人： Henrik Anderson ,  Henrik Björkman ,  Teodor Aastrup

    发明人： Henrik Anderson ,  Henrik Björkman ,  Teodor Aastrup

    IPC分类号： G01N29/02 ,  G01N21/00 ,  G01N33/00

    CPC分类号： G01N29/022 ,  G01N29/222 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0426

    摘要： A sensor element carrier for use in a mass-sensitive chemical sensor instrument comprises a base component and a lid component, the base component being adapted to receive, in use, a sensor, the signal generated by which depends on the mass of material adsorbed at a sensing surface thereof, the base component or the lid component having formed therein, in a recessed area, at least one channel for the ingress of sample fluid, the recessed area forming, in use and in conjunction with the sensing surface of the sensor, a sample chamber, the sensor being held, in use, between the base component and the lid component and the approach of the base component and lid component being limited on assembly of the sensor element by means of substantially rigid portions of each which come into abutment, thereby limiting the minimum height of the sample chamber for a given set of sensor, base and lid components.

    摘要翻译： 用于质量敏感的化学传感器仪器中的传感器元件载体包括基座部件和盖部件，所述基部部件适于在使用中接收传感器，所产生的信号取决于吸附在其上的材料的质量 其感测表面，其中形成的基部部件或盖部件在凹陷区域中，用于样品流体进入的至少一个通道，在使用中并与传感器的感测表面结合的凹陷区域， 样品室，传感器在使用中保持在基部部件和盖部件之间，并且基部部件和盖部件的接近在传感器元件组装时受到限制，每个传感器元件基本上刚性的部分抵接 从而限制了给定的一组传感器，底座和盖部件的样品室的最小高度。

    Sensor
    3.
    发明授权
    Sensor 有权
    传感器

    公开(公告)号：US08196455B2

    公开(公告)日：2012-06-12

    申请号：US12598424

    申请日：2008-04-30

    申请人： Henrik Anderson ,  Henrik Björkman ,  Teodor Aastrup

    发明人： Henrik Anderson ,  Henrik Björkman ,  Teodor Aastrup

    IPC分类号： G01N29/00

    CPC分类号： G01N29/022 ,  G01N29/222 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0426

    摘要： A sensor element carrier for use in a mass-sensitive chemical sensor instrument comprises a base component and a lid component, the base component being adapted to receive, in use, a sensor, the signal generated by which depends on the mass of material adsorbed at a sensing surface thereof, the base component or the lid component having formed therein, in a recessed area, at least one channel for the ingress of sample fluid, the recessed area forming, in use and in conjunction with the sensing surface of the sensor, a sample chamber, the sensor being held, in use, between the base component and the lid component and the approach of the base component and lid component being limited on assembly of the sensor element by means of substantially rigid portions of each which come into abutment, thereby limiting the minimum height of the sample chamber for a given set of sensor, base and lid components.

    摘要翻译： 用于质量敏感的化学传感器仪器中的传感器元件载体包括基座部件和盖部件，所述基部部件适于在使用中接收传感器，所产生的信号取决于吸附在其上的材料的质量 其感测表面，其中形成的基部部件或盖部件在凹陷区域中，用于样品流体进入的至少一个通道，在使用中并与传感器的感测表面一起形成的凹陷区域， 样品室，传感器在使用中保持在基部部件和盖部件之间，并且基部部件和盖部件的接近在传感器元件组装时受到限制，每个传感器元件基本上刚性的部分抵接 从而限制了给定的一组传感器，底座和盖部件的样品室的最小高度。

    PIEZOELECTRIC RESONATOR
    7.
    发明申请
    PIEZOELECTRIC RESONATOR 有权
    压电谐振器

    公开(公告)号：US20120090389A1

    公开(公告)日：2012-04-19

    申请号：US13329894

    申请日：2011-12-19

    申请人： TEODOR AASTRUP ,  JAN SMITH ,  HENRIK ANDERSON

    发明人： TEODOR AASTRUP ,  JAN SMITH ,  HENRIK ANDERSON

    IPC分类号： G01N29/02

    CPC分类号： H03H9/132 ,  G01N9/002 ,  G01N11/16 ,  G01N29/022 ,  G01N29/036 ,  G01N29/222 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/0421 ,  G01N2291/0422 ,  H03H9/19

    摘要： A piezoelectric resonator for use in a sensor arrangement for detecting or measuring an analyte in a medium, comprises a quartz crystal plate, having a first crystal surface and a second crystal surface. The first crystal surface is provided with a first electrode, which has a surface area of less than 15 mm2 and the second crystal surface is provided with a second electrode. The first electrode may have a rectangular surface shape. A flow cell for use in an apparatus for detecting or measuring an analyte in a medium, comprises walls that form a sensing chamber together with the resonator, and inlet and outlet openings for leading a fluid through the sensing chamber. A part of the resonator constitutes one of the walls of the sensing chamber and is arranged such that the first electrode is situated inside the sensing chamber.

    摘要翻译： 一种用于检测或测量介质中的分析物的传感器装置中的压电谐振器，包括具有第一晶体表面和第二晶体表面的石英晶体板。 第一晶体表面设置有表面积小于15mm 2的第一电极，第二晶体表面设置有第二电极。 第一电极可以具有矩形表面形状。 用于检测或测量介质中的分析物的装置中的流动池包括与谐振器一起形成检测室的壁和用于引导流体通过感测室的入口和出口。 谐振器的一部分构成感测室的一个壁，并且被布置为使得第一电极位于感测室内。

    Piezoelectric sensor arrangement
    8.
    发明申请
    Piezoelectric sensor arrangement 有权
    压电传感器布置

    公开(公告)号：US20060141608A1

    公开(公告)日：2006-06-29

    申请号：US10539065

    申请日：2003-12-18

    申请人： Teodor Aastrup ,  Jan Smith ,  Henrik Anderson

    发明人： Teodor Aastrup ,  Jan Smith ,  Henrik Anderson

    IPC分类号： C12M1/34

    CPC分类号： G01N29/036 ,  G01N2291/0256

    摘要： A piezoelectric sensor arrangement for analysis of fluid samples includes a signal source, a measuring device and a docking system. The sensor arrangement comprises a first part provided with means for receiving a sensor element that exposes a piezoelectric quartz crystal, a second part comprising fluid channels for the sample and a flow cell element, which preferably is removable and which comprises a recess, and inlet and outlet fluid channels for leading a fluid through the recess. The first and second parts are movable in relation to each other between a closed position and an open position and are arranged such that in the closed position the recess of the flow cell element is sealingly covered by the piezoelectric quartz crystal so that a flow cell is formed by said flow cell element and the quartz crystal.

    摘要翻译： 用于分析流体样品的压电传感器装置包括信号源，测量装置和对接系统。 该传感器装置包括：第一部分，其设置有用于接收暴露压电石英晶体的传感器元件的装置;第二部分包括用于样品的流体通道;以及流动池元件，其优选地是可移除的并且包括凹槽， 出口流体通道，用于引导流体通过凹槽。 第一和第二部分可以在关闭位置和打开位置之间相对于彼此移动，并且被布置成使得在关闭位置中，流动电池元件的凹部被压电石英晶体密封地覆盖，使得流动池是 由所述流动池元件和石英晶体形成。

    Piezoelectric resonator
    9.
    发明申请
    Piezoelectric resonator 审中-公开
    压电谐振器

    公开(公告)号：US20060107733A1

    公开(公告)日：2006-05-25

    申请号：US10542616

    申请日：2004-02-11

    申请人： Teodor Aastrup ,  Jan Smith ,  Henrik Anderson

    发明人： Teodor Aastrup ,  Jan Smith ,  Henrik Anderson

    IPC分类号： G01N29/02

    CPC分类号： H03H9/132 ,  G01N9/002 ,  G01N11/16 ,  G01N29/022 ,  G01N29/036 ,  G01N29/222 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/0421 ,  G01N2291/0422 ,  H03H9/19

    摘要： A piezoelectric resonator for use in a sensor arrangement for detecting or measuring an analyte in a medium, comprises a quartz crystal plate, face. The first crystal surface is provided with a first electrode, which has a surface area of less than 15 mm2 and the second crystal surface is provided with a second electrode. The first electrode may have a rectangular surface shape. A flow cell for use in an apparatus for detecting or measuring an analyte in a medium, comprises walls that form a sensing chamber together with the resonator, and inlet and outlet openings for leading a fluid through the sensing chamber. A part of the resonator constitutes one of the walls of the sensing chamber and is arranged such that the first electrode is situated inside the sensing chamber.

    摘要翻译： 用于检测或测量介质中的分析物的传感器装置中的压电谐振器包括石英晶片，面。 第一晶体表面设置有表面积小于15mm 2的第一电极，第二晶体表面设置有第二电极。 第一电极可以具有矩形表面形状。 用于检测或测量介质中的分析物的装置中的流动池包括与谐振器一起形成检测室的壁和用于引导流体通过感测室的入口和出口。 谐振器的一部分构成感测室的一个壁，并且被布置为使得第一电极位于感测室内。