中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

298 records (took 0.03 seconds)

    Method of forming birefringent structures in an optical element
    1.
    发明授权
    Method of forming birefringent structures in an optical element 有权

    公开(公告)号：US12265245B2

    公开(公告)日：2025-04-01

    申请号：US17628998

    申请日：2020-08-27

    Applicant: University of Southampton

    Inventor： Masaaki Sakakura ,  Lei Wang ,  Peter Kazansky ,  Yanhao Yu ,  Yuhao Lei

    IPC: G11B7/09 ,  C03C23/00 ,  G02B5/30 ,  G11B7/0045 ,  G02B5/32

    Abstract: A method of fabricating an optical element includes providing a substrate of a transparent material in which is to be formed a plurality of birefringent nanostructures spaced apart; generating from the output of a source of femtosecond laser pulses a laser beam group comprising a plurality of focused seeding beams having a circular polarisation; directing the laser beam group onto the surface of the substrate at a first position and applying one or more femtosecond laser pulses from each beam to corresponding volumes in the substrate; repeatedly translating the laser beam group relative to the substrate parallel to the line of seeding beams; translating the laser beam group relative to the substrate and repeating the repeated translation and application of the femtosecond laser pulses; wherein the relative translation of the laser beam group and the substrate aligns the writing beam with successive corresponding volumes.

    Method and apparatus for obtaining chemical and/or material specific information of a sample using light scattered by Rayleigh scattering and/or Raman scattering
    3.
    发明授权
    Method and apparatus for obtaining chemical and/or material specific information of a sample using light scattered by Rayleigh scattering and/or Raman scattering 有权

    公开(公告)号：US12196615B2

    公开(公告)日：2025-01-14

    申请号：US17800093

    申请日：2021-02-16

    Applicant: University of Southampton

    Inventor： Sumeet Mahajan ,  Niall Hanrahan ,  Konstaninos Bourdakos ,  Simon Lane

    IPC: G01J3/433 ,  G01J3/02 ,  G01J3/44 ,  G01N21/21 ,  G01N21/47 ,  G01N21/65

    Abstract: A method for obtaining chemical and/or material specific information of a sample based on scattered light. The method comprises receiving detection data comprising at least two images. Each image is indicative of the intensity of scattered light i) for incident light of a different wavelength, or ii) for incident light of a different polarization state, or iii) of a different polarization state. The scattered light comprises an elastic scattering component that is due to Rayleigh scattering of the incident light in at least a portion of the sample. Alternatively, each image is indicative of the intensity of scattered light i) of a different wavelength, or ii) for incident light of a different polarization state, or iii) of a different polarization state, wherein the scattered light comprises an inelastic scattering component that is due to Raman scattering of the incident light in at least a portion of the sample. The method further comprises determining the chemical and/or material specific information of the sample based on the change in intensity of the elastic scattering component in dependence on the change in wavelength and/or the change in polarization state of the incident and/or scattered light.

    PULSED OPTICAL SOURCE
    4.
    发明申请
    PULSED OPTICAL SOURCE 有权

    公开(公告)号：US20240413609A1

    公开(公告)日：2024-12-12

    申请号：US18697112

    申请日：2022-09-28

    Applicant: University of Southampton

    Inventor： Peter George Robin SMITH ,  Rex Hugh Seton BANNERMAN ,  Devin Hugh SMITH

    IPC: H01S5/14 ,  H01S3/067 ,  H01S3/094 ,  H01S3/0941 ,  H01S3/102 ,  H01S3/137 ,  H01S3/30

    Abstract: An optical source comprises: a pump source operable to generate laser light at a first wavelength; a single mode optical fibre arranged to receive laser light at the first wavelength from the pump source, the optical fibre being fabricated from material having a Raman gain profile for stimulated Raman scattering of light at the first wavelength, and a Brillouin gain profile for stimulated Brillouin scattering of light at the second wavelength to a third wavelength longer than the second wavelength; and a superstructured fibre Bragg grating formed in the optical fibre, the grating comprising: a periodic refractive index profile along a core of the optical fibre, giving transmission of the first wavelength to allow received laser light at the first wavelength to enter the superstructured fibre Bragg grating, reflection of the second wavelength at a first level, and reflection of the third wavelength at a second level lower than the first level; and a phase shift at an intermediate location along a length of the grating; wherein the series of pulses at the third wavelength comprise a pulsed output of the optical source.

    Nanostructured optical element, method for fabrication and uses thereof
    8.
    发明授权
    Nanostructured optical element, method for fabrication and uses thereof 有权

    公开(公告)号：US11802993B2

    公开(公告)日：2023-10-31

    申请号：US16970242

    申请日：2019-02-13

    Applicant: University of Southampton

    Inventor： Rokas Drevinskas ,  Peter Kazansky ,  Ausra Cerkauskaite

    IPC: G02B1/00 ,  G02B5/30 ,  G02B27/28

    CPC classification number: G02B1/002 ,  G02B5/3083 ,  G02B27/286

    Abstract: An optical element for modifying an incident laser beam propagated through the optical element from an input face to an output face via a geometric phase birefringent effect, the optical element comprising: a substrate of a transparent amorphous material with an input face and an opposite output face; and a structural modification in a volume of the substrate between the input face and output face comprising a plurality of randomly positioned nanostructures; wherein each nanostructure has a oblate spheroidal shape with an elliptical cross section in a plane parallel to the input face, the elliptical cross-section having a minor axis substantially not larger than 30 nm and a major axis greater than the minor axis, and each nanostructure having a length in a direction perpendicular to the input face which is substantially not larger than 100 nm.

    HIF-1 and HIF-2 inhibitors
    9.
    发明授权
    HIF-1 and HIF-2 inhibitors 有权

    公开(公告)号：US11644469B2

    公开(公告)日：2023-05-09

    申请号：US17194522

    申请日：2021-03-08

    Applicant: UNIVERSITY OF SOUTHAMPTON

    Inventor： Ali Tavassoli

    IPC: A61K38/18 ,  A61K38/08 ,  A61P35/00 ,  C07K14/47 ,  C07K7/06 ,  C07K7/02 ,  G01N33/68

    CPC classification number: G01N33/6845 ,  A61K38/08 ,  A61K38/18 ,  A61P35/00 ,  C07K7/02 ,  C07K7/06 ,  C07K14/4702 ,  G01N2500/02

    Abstract: The present invention relates to inhibitors of HIF-1 and HIF-2 and uses thereof. The present invention further relates to the inhibitors for use in treatment of diseases. An isolated polypeptide is provided, that prevents dimerization of HIF-1α with HIF-1β and HIF-2α with HIF-1β and/or inhibits the activity of HIF-1 and HIF-2, wherein the polypeptide comprises the amino acid sequence C-X1-X2-X3-Z-X4 (SEQ ID NO: 1) and wherein X1, X2, X3 and X4 are any amino acid and wherein Z is leucine, valine of isoleucine or a non-natural derivative or leucine, valine or isoleucine. The isolated polypeptide prevents dimerization of HIF-1α with HIF-1β and HIF-2α with HIF-1β and inhibits the activity of HIF-1 and HIF-2 by binding to HIF-1α or HIF-1β and/or HIF-2α or HIF-1β.

Patent Agency Ranking