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公开(公告)号：US20080226693A1
公开(公告)日：2008-09-18
申请号：US11685832
申请日：2007-03-14
CPC分类号： B05D1/26 , A61F2/82 , A61F2250/0067 , B05D1/002
摘要： The apparatus and method for preparing a polymeric structure from which a number of medical devices may be constructed is described. The structures are preferably formed from bioabsorbable materials using low temperature fabrication processes, whereby drugs or other bio-active agents are incorporated into or onto the device and degradation of the drugs or other agents during processing is minimized. The method includes preparing a solution of at least one bioabsorbable polymer and a solvent. The solution is then deposited onto a stage and converted into a structure. The solvent is evaporated from the structure. The dried solution forms a structure that is removed from the stage and further dried before being stored in an inert environment. Thereafter, a medical device such as a stent may be constructed from the structure.
摘要翻译： 本发明描述了可构建多个医疗装置的聚合物结构的制备装置和方法。 该结构优选由使用低温制造方法的生物可吸收材料形成，由此将药物或其它生物活性剂并入装置中或装置上，并且在加工过程中药物或其它试剂的降解最小化。 该方法包括制备至少一种生物可吸收聚合物和溶剂的溶液。 然后将溶液沉积在载物台上并转化为结构。 溶剂从结构中蒸发掉。 干燥的溶液形成从载体中除去并在储存在惰性环境中之前进一步干燥的结构。 此后，可以从该结构构造诸如支架的医疗装置。
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公开(公告)号：US20080102098A1
公开(公告)日：2008-05-01
申请号：US11589665
申请日：2006-10-30
申请人： Vipul Bhupendra Dave , Chao Chen
发明人： Vipul Bhupendra Dave , Chao Chen
CPC分类号： A61K49/04 , A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2250/0067 , A61F2250/0098 , A61K49/0404 , A61K49/0476
摘要： A medical device is constructed from a polymeric composition having properties such as increased visibility of the device and the ability to deliver therapeutic and other agents. The device is constructed with additives incorporated into the polymeric structure, such as a material that increases visibility of the device, while still maintaining desired mechanical characteristics such as high radial stiffness, minimized recoil values, and improved flexibility. The device can assume a wide range of geometries that are adaptable to various loading conditions In order to include performance-enhancing additives to the medical device without affecting mechanical performance, the additives are localized in discrete regions of a polymer structure from which a medical device will be formed. For example, a medical device can be prepared from a polymer form such as a tube containing radiopaque agent localized at its ends or in a desired pattern along the device.
摘要翻译： 医疗装置由具有诸如提高装置的可见性和递送治疗剂和其它药剂的能力等特性的聚合物组合物构成。 该装置由结合到聚合物结构中的添加剂构成，例如提高装置的可视性的材料，同时仍然保持期望的机械特性，例如高径向刚度，最小反冲值和改善的柔性。 该装置可以采用适用于各种加载条件的宽范围的几何形状。为了将性能增强添加剂包括在医疗装置中而不影响机械性能，添加剂定位在聚合物结构的离散区域中，医疗装置将从该区域 形成。 例如，医疗装置可以由聚合物形式制备，例如含有不透射线剂的管，其位于其末端或沿着该装置所需的图案。
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公开(公告)号：US09393135B2
公开(公告)日：2016-07-19
申请号：US11747500
申请日：2007-05-11
申请人： Robert Burgermeister , Ramesh Marrey , Vipul Bhupendra Dave , David Overaker , Joseph H. Contiliano , Qiang Zhang
发明人： Robert Burgermeister , Ramesh Marrey , Vipul Bhupendra Dave , David Overaker , Joseph H. Contiliano , Qiang Zhang
CPC分类号： A61F2/915 , A61F2/82 , A61F2002/825 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2210/0004 , A61F2220/0008 , A61F2220/0075 , A61F2230/0013 , A61F2250/0018 , A61F2250/0028 , A61F2250/0029 , A61F2250/0036 , A61F2250/0062 , A61F2250/0067 , A61F2250/0098 , A61L31/04 , A61L31/16 , A61L31/18 , A61L2300/416
摘要： A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. Polymeric materials may be utilized to fabricate any of these devices, including stents. The stents may be balloon expandable or self-expanding. The polymeric materials may include additives such as drugs or other bioactive agents as well as radiopaque agents. By preferential mechanical deformation of the polymer, the polymer chains may be oriented to achieve certain desirable performance characteristics. The stent has a plurality of hoop components interconnected by a plurality of flexible connectors. The hoop components are formed as a continuous series of substantially longitudinally or axially oriented radial strut members and alternating substantially circumferentially oriented radial arc members. The geometry of the struts and arcs is such that when the stent is expanded, it has very high strains within a relatively small region. This strain localization results in what is often referred to as “hinging”, where the hinge is the small region within which the strains are very high.
摘要翻译： 生物相容性材料可以配置成任何数量的可植入医疗装置，包括腔内支架。 可以使用聚合材料来制造包括支架在内的任何这些装置。 支架可以是球囊扩张或自扩张。 聚合物材料可以包括添加剂如药物或其他生物活性剂以及不透射线剂。 通过聚合物的优先机械变形，聚合物链可以被取向以获得某些所需的性能特征。 支架具有通过多个柔性连接器互连的多个环部件。 环形部件形成为基本纵向或轴向定向的径向支柱构件和交替的基本上周向定向的径向弧形构件的连续系列。 支柱和弧的几何形状使得当支架膨胀时，其在相对小的区域内具有非常高的应变。 这种应变定位导致通常被称为“铰接”，其中铰链是应变非常高的小区域。
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公开(公告)号：US20100280600A1
公开(公告)日：2010-11-04
申请号：US12433082
申请日：2009-04-30
申请人： Vipul Bhupendra Dave , Robert Falotico , Chengxue li , Thai Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Bhupendra Dave , Robert Falotico , Chengxue li , Thai Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61F2/82
CPC分类号： A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/434 , A61L2300/45
摘要： Implantable medical devices may be utilized to locally delivery one or more drugs or therapeutic agents to treat a wide variety of conditions, including the treatment of the biological organism's reaction to the introduction of the implantable medical device. These therapeutic agents may be released under controlled and directional conditions so that the one or more therapeutic agents reach the correct target area, for example, the surrounding tissue and/or the bloodstream.
摘要翻译： 可植入的医疗装置可用于局部递送一种或多种药物或治疗剂以治疗各种各样的病症，包括治疗生物体对引入可植入医疗装置的反应。 这些治疗剂可以在控制和定向条件下释放，使得一种或多种治疗剂达到正确的靶区域，例如周围组织和/或血流。
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公开(公告)号：US20080097580A1
公开(公告)日：2008-04-24
申请号：US11585065
申请日：2006-10-23
申请人： Vipul Bhupendra Dave
发明人： Vipul Bhupendra Dave
CPC分类号： A61F2/91 , A61F2230/0013
摘要： An implantable medical apparatus includes a structure formed from bioabsorbable polymers. The apparatus also contains a therapeutic agent dispersed throughout the structure or coated on the structure in such a manner as to elute the therapeutic agent when implanted in an anatomical conduit. The apparatus can be constructed from a blend of polymers and other agents. The apparatus is implanted into the conduit by expansion with a balloon or some other expandable means. The morphology or arrangement of the polymeric structure ensures that the device maintains its shape characteristics to ensure proper modeling of the vessel. In particular, the crystallinity of the polymeric structure is adjusted so as to resist recoil.
摘要翻译： 可植入医疗装置包括由生物可吸收聚合物形成的结构。 该装置还包含分散在整个结构中的治疗剂或涂覆在结构上，以便当植入解剖导管时洗脱治疗剂。 该装置可以由聚合物和其它试剂的混合物构成。 通过用气球或一些其它可膨胀装置的膨胀将装置植入管道。 聚合物结构的形态或布置确保了该装置保持其形状特征以确保容器的适当建模。 特别地，调节聚合物结构的结晶度以抵抗反冲。
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6.发明申请Methods of making bioabsorbable drug delivery devices comprised of solvent cast tubes 审中-公开制造由溶剂铸管组成的生物可吸收药物递送装置的方法公开(公告)号：US20070158880A1
公开(公告)日：2007-07-12
申请号：US11327694
申请日：2006-01-06
申请人： Vipul Bhupendra Dave
发明人： Vipul Bhupendra Dave
IPC分类号： B28B3/00
摘要： A bioabsorbable drug delivery device and various methods of making the same. The devices are preferably formed from bioabsorbable materials using low temperature fabrication processes, whereby drugs or other bio-active agents are incorporated into or onto the device and degradation of the drugs or other agents during processing is minimized. The method includes preparing a solution of at least one bioabsorbable polymer and a solvent. The solution is then deposited onto a mandrel and converted into a tube. The solvent is evaporated from the tube in a nitrogen rich environment. The tube is removed from the mandrel and further dried before being stored in an inert environment.
摘要翻译： 生物吸收性药物输送装置及其制造方法。 该装置优选由使用低温制造方法的生物可吸收材料形成，由此将药物或其它生物活性剂掺入到装置中或装置上，并且在加工过程中药物或其它试剂的降解最小化。 该方法包括制备至少一种生物可吸收聚合物和溶剂的溶液。 然后将溶液沉积到心轴上并转化成管。 溶剂在氮气环境中从管蒸发。 将管从心轴上取出并进一步干燥，然后储存在惰性环境中。
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7.发明授权Process for the formation of plasticized proteinaceous materials and compositions containing the same 失效用于形成增塑的蛋白质材料和含有它的组合物的方法
公开(公告)号：US5882702A
公开(公告)日：1999-03-16
申请号：US936570
申请日：1997-09-24
IPC分类号： A23G3/34 , A23G4/00 , A23G4/08 , A23G4/14 , A23J3/00 , A23J3/22 , A23J3/26 , A23G3/30 , A23J1/00 , G01N33/00
CPC分类号： A23G4/00 , A23G3/346 , A23G4/08 , A23G4/14 , A23J3/00 , A23J3/22 , A23J3/26 , A23J3/265 , A23G2200/06 , A23G2200/10
摘要： Process for the formation of a plasticized proteinaceous material in which a plasticizer component is selectively matched with a protein component to form a blend. The blend is heated under controlled shear conditions to produce the plasticized proteinaceous material having the plasticizer component uniformly distributed within the protein component. The plasticized proteinaceous material is used for a variety of purposes including the production of gums and confectionery compositions.
摘要翻译： 用于形成增塑剂组分与蛋白质组分选择性匹配以形成共混物的增塑蛋白质材料的方法。 将混合物在受控的剪切条件下加热以产生具有均匀分布在蛋白质组分内的增塑剂组分的增塑的蛋白质材料。 增塑的蛋白质材料用于各种目的，包括生产牙龈和糖食组合物。
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公开(公告)号：US20090318955A1
公开(公告)日：2009-12-24
申请号：US12405087
申请日：2009-03-16
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B2017/00654
摘要： The present invention provides a porous structure that works very effectively to seal a puncture site with optimum porosity, absorbent capacity and perfect anatomical fit. The plug density and other fiber properties/geometry (total denier; number of filaments; etc) have provided an efficient structure that allows instantaneous absorption of blood during deployment. The final size of the plug with absorbed fluids provides an anatomical fit and seals the puncture site within few minutes after deployment.
摘要翻译： 本发明提供一种多孔结构，其非常有效地密封穿刺部位，具有最佳的孔隙率，吸收能力和完美的解剖适合性。 插头密度和其他纤维性能/几何（总旦数，长丝数等）提供了一种有效的结构，允许在展开期间瞬间吸收血液。 使用吸收液体的塞子的最终尺寸提供了解剖学配合，并在部署后几分钟内密封穿刺部位。
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公开(公告)号：US20090171388A1
公开(公告)日：2009-07-02
申请号：US12261570
申请日：2008-10-30
CPC分类号： A61F2/02 , A61B17/0057 , A61B17/12022 , A61B17/12109 , A61B17/12159 , A61B17/12172 , A61B17/12177 , A61B17/1219 , A61B2017/00004 , A61L31/041 , A61L31/141 , A61L31/148 , A61L31/16 , A61L2300/404 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/43 , A61L2430/36 , D01D5/34 , D01F1/10 , D01F1/103 , D04H1/42 , Y10T442/2525 , Y10T442/3146 , Y10T442/3154 , Y10T442/3163 , Y10T442/3171 , Y10T442/637 , Y10T442/638 , Y10T442/64 , Y10T442/641 , Y10T442/642 , C08L75/04 , C08L67/04
摘要： A biocompatible material may be configured into any number of implantable medical devices including a vascular closure device. The vascular closure device includes a fibrous structure formed from at least one randomly oriented fiber, the randomly oriented fiber comprising at least one polymer, and at least one agent, in therapeutic dosage, incorporated into at least one of the fibrous structure and the at least one randomly oriented fiber.
摘要翻译： 生物相容性材料可以被配置成任何数量的可植入医疗装置，包括血管闭合装置。 血管闭合装置包括由至少一个随机取向的纤维形成的纤维结构，所述随机取向的纤维包含至少一种聚合物，以及至少一种治疗剂量的药剂，其结合到至少一种纤维结构中，并且至少 一个随机取向的纤维。
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10.发明申请Method and apparatus for making polymeric drug delivery devices having differing morphological structures 审中-公开制备具有不同形态结构的聚合物药物递送装置的方法和装置公开(公告)号：US20080169582A1
公开(公告)日：2008-07-17
申请号：US11585056
申请日：2006-10-23
CPC分类号： B29C71/02 , B29C2071/022 , B29K2995/006 , B29L2031/753
摘要： A polymeric medical device is constructed from bioabsorbable polymers. The device is constructed from a tube comprised of at least one polymer. The polymer is treated at pre-determined heating and cooling temperatures to obtain a desired morphology. The morphology or arrangement of the polymeric structure ensures that the device maintains its shape characteristics to ensure proper modeling of the vessel. In particular, the crystallinity of the polymeric structure is adjusted so as to resist recoil. The device can also contain a therapeutic agent dispersed throughout the structure or coated on the structure in such a manner as to elute the therapeutic agent when implanted in an anatomical conduit. The device can also be constructed from a blend of polymers and other agents such as plasticizers.
摘要翻译： 聚合物医疗器械由生物可吸收聚合物构成。 该装置由包含至少一种聚合物的管构成。 在预定的加热和冷却温度下处理聚合物以获得所需的形态。 聚合物结构的形态或布置确保了该装置保持其形状特征以确保容器的适当建模。 特别地，调节聚合物结构的结晶度以抵抗反冲。 该装置还可以包含分散在整个结构中的治疗剂或涂覆在结构上，以便当植入解剖导管时洗脱治疗剂。 该装置还可以由聚合物和其它试剂如增塑剂的混合物构成。
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