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公开(公告)号：US08796328B2
公开(公告)日：2014-08-05
申请号：US13922442
申请日：2013-06-20
Applicant: AbbVie Inc.
Inventor： Arthur Gomtsyan , Jerome Daanen , Michael E. Kort , Philip R. Kym , Eric A. Voight , Kevin R. Woller
CPC classification number: C07C317/28 , A61K31/18 , A61K31/192 , A61K31/352 , A61K31/353 , A61K31/436 , C07C311/08 , C07C2602/08 , C07D263/48 , C07D311/68 , C07D311/96 , C07D401/04 , C07D417/12 , C07D491/052
Abstract: Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, prodrugs, or combinations thereof, wherein X1, L, Rx, Ry, Rz, R1, R2, A, m, n, p, q, and r are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Abstract translation: 本文公开了式（I）化合物或其药学上可接受的盐，前药或其组合，其中X1，L，Rx，Ry，Rz，R1，R2，A，m，n，p，q和r定义在 规格。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US10266532B2
公开(公告)日：2019-04-23
申请号：US15829243
申请日：2017-12-01
Applicant: AbbVie Inc.
Inventor： Eric C. Breinlinger , Phil B. Cox , Justin D. Dietrich , Kristine E. Frank , Michael M. Friedman , Huan-Qui Li , Kenton L. Longenecker , Augustine T. Osuma , Ann Marie Rowley , Anil Vasudevan , Noel S. Wilson , Jerome Daanen , Stevan Djuric , Amanda W. Dombrowski , Arthur Gomtsyan , Robert Schmidt
IPC: C07D521/00 , C07D471/04 , C07D471/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/18 , C07D498/20 , C07D498/22 , C07D519/00 , C07D471/18 , C07D491/147 , C07D491/22
Abstract: The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.
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公开(公告)号：US20130345255A1
公开(公告)日：2013-12-26
申请号：US13922442
申请日：2013-06-20
Applicant: AbbVie Inc.
Inventor： Arthur Gomtsyan , Jerome Daanen , Michael E. Kort , Philip R. Kym , Eric A. Voight , Kevin R. Woller
IPC: C07C317/28 , A61K31/192 , A61K31/353 , A61K31/436 , A61K31/352 , C07D311/96 , C07D491/052 , A61K31/18 , C07D311/68
CPC classification number: C07C317/28 , A61K31/18 , A61K31/192 , A61K31/352 , A61K31/353 , A61K31/436 , C07C311/08 , C07C2602/08 , C07D263/48 , C07D311/68 , C07D311/96 , C07D401/04 , C07D417/12 , C07D491/052
Abstract: Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, prodrugs, or combinations thereof, wherein X1, L, Rx, Ry, Rz, R1, R2, A, m, n, p, q, and r are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Abstract translation: 本文公开了式（I）化合物或其药学上可接受的盐，前药或其组合，其中X1，L，Rx，Ry，Rz，R1，R2，A，m，n，p，q和r定义在 规格。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US20160304517A1
公开(公告)日：2016-10-20
申请号：US15130362
申请日：2016-04-15
Applicant: AbbVie Inc.
Inventor： Eric C. Breinlinger , Phil B. Cox , Jerome Daanen , Justin Dietrich , Stevan Djuric , Amanda W. Dombrowski , Kristine E. Frank , Michael M. Friedman , Arthur Gomtsyan , Huan-Qui Li , Kenton Longenecker , Augustine Osuma , Ann Marie Rowley , Robert Schmidt , Anil Vasudevan , Noel Wilson
IPC: C07D471/04 , C07D491/147 , C07D491/22 , C07D498/04 , C07D471/18 , C07D471/14 , C07D498/22 , C07D498/14 , C07D498/20 , C07D487/04 , C07D519/00
CPC classification number: C07D471/04 , C07D471/14 , C07D471/18 , C07D487/04 , C07D491/147 , C07D491/22 , C07D498/04 , C07D498/14 , C07D498/18 , C07D498/20 , C07D498/22 , C07D519/00
Abstract: The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.
Abstract translation: 本发明提供三环杂环化合物，药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号：US09156788B2
公开(公告)日：2015-10-13
申请号：US13761862
申请日：2013-02-07
Applicant: AbbVie Inc.
Inventor： Erol K. Bayburt , Bruce Clapham , Phil B. Cox , Jerome F. Daanen , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Eric A. Voight
IPC: A61K31/444 , C07D213/30 , C07D239/26 , C07D401/04 , C07D405/12 , C07D213/50 , C07D401/12
CPC classification number: C07D213/30 , C07D213/50 , C07D239/26 , C07D401/12 , C07D405/12
Abstract: Disclosed herein are modulators of TRPV3 of formula (I) wherein G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, u, and p are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Abstract translation: 本文公开了式（I）的TRPV3的调节剂，其中G1，X1，X2，X3，X4，X5，G2，Z1，Ra，Rb，u和p如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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Patent Agency Ranking
公开(公告)号：US08859584B2
公开(公告)日：2014-10-14
申请号：US13716837
申请日：2012-12-17
Applicant: AbbVie Inc.
Inventor： Kevin R. Woller , Gregory A. Gfesser , Huaqing Liu , Jerome F. Daanen , Eric A. Voight , Irene I. Drizin , Anurupa Shrestha , Kathleen H. Mortell , Philip R. Kym , Michael E. Kort , Arthur Gomtsyan
IPC: A61K31/44 , A61K31/35 , A61K31/47 , A61K31/17 , C07D215/46 , C07D498/02 , C07D311/68 , A61K45/06 , C07D311/96 , C07D311/04 , C07C275/30 , A61K31/192 , C07D311/70 , A61K31/353 , C07D491/052 , A61K31/436 , C07D215/42 , C07C275/32
CPC classification number: C07D311/04 , A61K31/17 , A61K31/192 , A61K31/353 , A61K31/436 , A61K31/47 , A61K45/06 , C07C275/30 , C07C275/32 , C07D215/42 , C07D215/46 , C07D311/68 , C07D311/70 , C07D311/96 , C07D491/052
Abstract: Disclosed herein are compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein X1, L, Rx, Ry, Rz, A, m, n, p, q, s, and positions a and b are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Abstract translation: 本文公开了式（I）化合物或其药学上可接受的盐，其中X1，L，Rx，Ry，Rz，A，m，n，p，q，s和位置a和b如本说明书中所定义 。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US20130150409A1
公开(公告)日：2013-06-13
申请号：US13761862
申请日：2013-02-07
Applicant: AbbVie Inc.
Inventor： Erol K. Bayburt , Bruce Clapham , Phil B. Cox , Jerome F. Daanen , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Eric A. Voight
IPC: A61K31/44 , C07D401/04 , A61K31/444
CPC classification number: C07D213/30 , C07D213/50 , C07D239/26 , C07D401/12 , C07D405/12
Abstract: Disclosed herein are modulators of TRPV3 of formula (I) wherein G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, u, and p are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Abstract translation: 本文公开了式（I）的TRPV3的调节剂，其中G1，X1，X2，X3，X4，X5，G2，Z1，Ra，Rb，u和p如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US09447051B2
公开(公告)日：2016-09-20
申请号：US14379155
申请日：2013-02-15
Applicant: AbbVie inc.
Inventor： Tatyana Dekhtyar , Arthur Gomtsyan , M-Akhteruzzaman Molla , Anil Vasudevan , Iok Chan Ng , Mikhail Chafeev
IPC: C07D239/32 , A61K31/505 , C07D239/48 , C07D403/12 , C07D401/14 , C07D405/14 , C07D401/12 , C07D409/14 , C07D413/12 , C07D417/14 , A61K45/06 , A61K31/506 , C07D413/14
CPC classification number: C07D239/48 , A61K31/505 , A61K31/506 , A61K45/06 , C07D239/32 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14
Abstract: This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit RSV infection and/or replication; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
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公开(公告)号：US20150025095A1
公开(公告)日：2015-01-22
申请号：US14379155
申请日：2013-02-15
Applicant: AbbVie inc.
Inventor： Tatyana Dekhtyar , Arthur Gomtsyan , M-Akhteruzzaman Molla , Anil Vasudevan , Teresa (lok Chan) Ng , Mikhail Shafeev
IPC: C07D239/48 , A61K31/506 , A61K31/505 , C07D413/14 , C07D413/12 , C07D405/14 , C07D401/14 , C07D417/14 , C07D401/12 , C07D403/12
CPC classification number: C07D239/48 , A61K31/505 , A61K31/506 , A61K45/06 , C07D239/32 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14
Abstract: This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit RSV infection and/or replication; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
Abstract translation: 本公开涉及：（a）其特别是抑制RSV感染和/或复制的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。
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公开(公告)号：US08772500B2
公开(公告)日：2014-07-08
申请号：US13658374
申请日：2012-10-23
Applicant: AbbVie Inc.
Inventor： Erol K. Bayburt , Bruce Clapham , Phil B. Cox , Jerome F. Daanen , Michael J. Dart , Gregory A. Gfesser , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Robert G. Schmidt
IPC: C07D213/00 , C07D213/28 , C07D211/74 , C07D421/00 , C07D401/00
CPC classification number: C07D213/38 , A61K31/192 , A61K31/435 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K45/06 , C07D213/30 , C07D213/34 , C07D213/72 , C07D215/14 , C07D221/04 , C07D239/26 , C07D311/04 , C07D401/06 , C07D405/06 , C07D405/08 , C07D405/10 , C07D417/08 , A61K2300/00
Abstract: Disclosed herein are modulators of TRPV3 of formula (II): wherein G1, X1, X2, X3, X4, X5, G2, Ra, Rb, and u are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Abstract translation: 本文公开了式（II）的TRPV3的调节剂：其中G1，X1，X2，X3，X4，X5，G2，Ra，Rb和u如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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